Gene Details:

• Gene ID: Zm00001eb076570
• Gene Symbol: ZmTFCB tfcb1
• Gene Name: tubulin-folding cofactor B1
• Genome: Zm-B73-REFERENCE-NAM-5.0
• Species: Zea mays

Functional Descriptions:

• Expression of the ZmTFCB gene decreased in the smk-wl10 mutant, which arrested embryo, endosperm and basal endosperm transfer layer developments.
• Mutation in ZmTFCB affects the basic development of organs, particularly the reproductive organs.
• ZmTFCB is targeted mainly to the cytosol. It facilitates α-tubulin folding and heterodimer formation through sequential interactions with the cytosolic chaperonin-containing TCP-1 ε subunit ZmCCT5 and ZmTFCE, thus affecting the organization of both the spindle and phragmoplast MT array and the cortical MT polymerization and array formation, which consequently mediated cell division and cell growth.
• We detected a physical association between ZmTFCB and the maize MT plus-end binding protein END-BINDING1 (ZmEB1), indicating that ZmTFCB1 may modulate MT dynamics by sequestering ZmEB1.
• ZmTFCB is required for cell division and cell growth through modulating MT homeostasis, an evolutionarily conserved machinery with some species-specific divergence.
• Thus, our work identifies a novel epiallele of the maize ZmTFCB gene, which might represent a common phenomenon in the epigenetic regulation of important traits such as kernel development in maize.

Function-related keywords:

• growth ,  development ,  cell-division ,  reproductive ,  homeostasis ,  embryo ,  endosperm ,  reproductive-development ,  reproductive-growth ,  endosperm-development ,  cytosol ,  embryo-development ,  tubulin

Literature:

• Maize tubulin folding cofactor B is required for cell division and cell growth through modulating microtubule homeostasis.   DOI:  10.1111/nph.18839 ;  PMID:  36843261
• Epigenetic Mutation in a Tubulin-Folding Cofactor B (ZmTFCB) Gene Arrests Kernel Development in Maize.   DOI:  10.1093/pcp/pcac092 ;  PMID:  35771678

Related News:

• PCE | 山东大学杨中宝课题组揭示氮信号调控植物耐铝性的新机制

Gene Resources:

• NCBI ID: 100193227
• UniProt accessions: A0A096S3I6

Sequences:

Source: Genetic information comes from the article