Gene Details:

• Gene ID: Zm00001eb190920
• Gene Symbol: ZmNANMT ZmCOMT2 ZmCOMT13 nanmt1
• Gene Name: nicotinate N-methyltransferase1
• Genome: Zm-B73-REFERENCE-NAM-5.0
• Species: Zea mays

Functional Descriptions:

• ZmNANMT plays a negative role in the NLR protein Rp1-D21-mediated HR in maize and overexpression of ZmNANMT partially overcomes the autoimmune phenotypes conferred by Rp1-D21.
• ZmNANMT confers multiple disease resistance without agronomic penalty in maize.
• ZmNANMT is a susceptibility gene in response to multiple diseases in maize.
• We previously identified that maize ZmNANMT suppressed the hypersensitive response (HR) mediated by the auto-active nucleotide-binding, leucine-rich repeat (NLR) protein Rp1-D21 when they were transiently co-expressed in Nicotiana benthamiana.
• These results indicated that ZmNANMT plays a negative role in the NLR protein Rp1-D21-mediated HR in maize and overexpression of ZmNANMT partially overcomes the autoimmune phenotypes conferred by Rp1-D21.

Function-related keywords:

• resistance ,  disease ,  disease-resistance

Literature:

• Genome editing of the susceptibility gene ZmNANMT confers multiple disease resistance without agronomic penalty in maize.   DOI:  10.1111/pbi.14078 ;  PMID:  37254611
• Maize nicotinate N-methyltransferase interacts with the NLR protein Rp1-D21 and modulates the hypersensitive response.   DOI:  10.1111/mpp.13044 ;  PMID:  33675291
• Biosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize.   DOI:  10.1093/plphys/kiab496 ;  PMID:  34718797

Related News:

• PBJ | 山东大学王官锋团队通过基因编辑ZmNANMT提高玉米广谱抗性

Gene Resources:

• NCBI ID: 100283243
• UniProt accessions: A0A3L6F1Z0 ,  B6TG62 ,  C0HEH4 ,  Q6VWE9

Sequences:

Source: Genetic information comes from the article