Information report for ZmMYC2b;bhlh91
Gene Details
|
|
Functional Descriptions
- We generated maize mutants in which ZmMYC2a and ZmMYC2b, two transcription factor genes important in JA signaling, were individually or both knocked out.
- ZmMYC2s play important roles in maize responses to simulated herbivory and jasmonate.
- ZmMYC2a and ZmMYC2b played a redundant role in maize resistance to insects and JA signaling.
- CUT&Tag-Seq and dual luciferase assays revealed that ZmMYC2s transactivate the benzoxazinoid and volatile terpene biosynthesis genes IGPS1/3, BX10/11/12/14, and TPS10/2/3/4/5/8 by directly binding to their promoters.
- ZmEREB92 interacts with ZmMYC2 to activate maize terpenoid phytoalexin biosynthesis upon Fusarium graminearum infection through jasmonic acid/ethylene signaling
Functional Keywords
Literature and News
- ZmMYC2s play important roles in maize responses to simulated herbivory and jasmonate. DOI: 10.1111/jipb.13404 ; PMID: 36349965
- Striking a growth-defense balance: Stress regulators that function in maize development. DOI: 10.1111/jipb.13570 ; PMID: 37787439
- ZmEREB92 interacts with ZmMYC2 to activate maize terpenoid phytoalexin biosynthesis upon Fusarium graminearum infection through jasmonic acid/ethylene signaling. DOI: 10.1111/nph.18590 ; PMID: 36319608
Gene Resources
- NCBI ID: LOC103638892
- UniProt accessions: A0A804R5H8
- AlphaFoldDB: A0A804R5H8
- EnsemblPlants: Zm00001eb390330_T001
- Gramene: Zm00001eb390330_T001
- InterPro: IPR011598 , IPR025610 , IPR036638 , IPR045084 , IPR054502
- PANTHER: PTHR11514 , PTHR11514:SF43
- SUPFAM: SSF47459
- PROSITE: PS50888
- Gene3D: 4.10.280.10
- OrthoDB: A0A804R5H8
- CDD: cd11449
Sequences
cDNA Sequence
- >Zm00001eb390330_T001
TGACATGACATGGTTGCGCTCCTAGCAAGCACCAAGCAGGAGGCGGGCTACGAACCCTCCTGAATTGTAGGTCGGTGCTGTGGCCCCGTGGCGAAGGGATGTTGTTTCCCTTCCTGTATTTGTCCTCGCCTCGCCAACCGGACAGGAGGCGGGACAGGCGCCCAGCCTCTGTCACGGGCGTTTTCGCCGCATAATCCCACGGGTTCCGCGTTTCAACCCATTTCCTTCGCCTTTCCCCTTCGCCCTCCATTCTCCGCCCACCGTTTCCTCGGGTCTGCCACGCTACGCCACGCCCATGAACCTGTGGACGGACGACAACGCCTCCATGATGGAGGCCTTCATGGCCTCCGCCGACCTCCCCGCCTACCCCTGGGGGGCGCCGGCCGGGGGCGGCAACCCGCCGCCGCCGCAGATGCCGCCGGCGATGGCGATGGCGCCGGGGTTCAACCAGGACACGCTGCAGCAGCGGCTGCAGGCCATGATCGAGGGGTCCAGGGAGACCTGGACCTACGCCATCTTCTGGCAGTCCTCCCTGGACGCCGCCACCGGCGCGTCGCTGCTAGGCTGGGGCGACGGCTACTACAAGGGCTGCGACGACGACAAGCGCAGGCACCGCCCGCCGCTCACGCCCGCCGCGCAGGCCGAGCAGGAGCACCGCAAGCGCGTGCTCCGCGAGCTCAACTCCCTCATCTCCGGCGGCGCCTCCGCCGCGCCCGCGCCCGCGCCCGACGAGGCCGTCGAGGAGGAGGTCACCGACACCGAGTGGTTCTTCCTCGTCTCCATGACGCAGTCCTTCCTCAACGGCTCGGGCCTCCCCGGCCAGGCGCTCTTCGCGGGCCACCACACCTGGATCGCCGCCGGCCTCTCCTCCGCGCCGTGCGACCGCGCGCGCCAGGCCTACAACTTCGGCCTCCGCACCATGGTCTGCTTCCCCGTCGGCACGGGCGTGCTCGAGCTCGGCTCCACCGACGTCGTGTTCCAGACCGCCGAGACCATGGCCAAGATCCGCTCGCTCTTCGGGGGCGGGCCGGGGGGTGGCTCGTGGCCGCCCGTGCAGCCCCAGGCGGCGCCGCAGCAGCAGCACGCCGCCGAAGCCGACCAGGCGGCGGAGACGGACCCATCCGTGCTGTGGCTCGCCGACGCGCCGGTCGTGGACATCAAGGATTCCTACTCGCACCCGTCGGCGGCCGAGATCTCCGTCTCCAAACCGCCTCCGCCTCCGCCTCCGCCGCAGATTCACTTCGAGAACGGGAGCACGAGCACGCTCACGGAGAACCCCAGCCCCTCCGTGCACGCGCCGCCAGCCCCGCCGGCGCCACCGCAGCGGCAGCAGCAGAATCAGGGCCCGTTCCGCCGGGAGCTCAACTTCTCGGATTTCGCGTCCAATCCTTCCTTGGCGGCGGCCCCGCCGTTCTTCAAGCCCGAGTCCGGCGAGATCCTCAGCTTCGGCGTCGACAGCAACGCCCAGAGGAACCCGTCGCCGGCGCCTCCCGCCAGCCTCACCACCGCTCCCGGCAGCCTATTCTCGCAGTCGCAGCACACGGCGACCGCCGCGGCGAACGACGCGAAGAACAACAACAACAACAACAAGCGTTCGATGGAAGCCACCTCCCTGGCGAGCAACACCAACCACCACCCGCCGCCGGAGGCGGAGAAGCGGCCGCGGAAGCGCGGGCGGAAGCCCGCGAACGGGCGCGAGGAGCCGCTGAACCACGTGGAGGCGGAGCGGCAGCGGCGGGAGAAGCTGAACCAGCGCTTCTACGCGCTGCGCGCCGTGGTGCCCAACGTGTCCAAGATGGACAAGGCGTCGCTGCTCGGCGACGCCATCTCCTACATCAACGAGCTCCGCGGCAAGCTGACGTCGCTGGAGTCGGACAGGGAGACGCTGCAGGCCCAGGTCGAGGCGCTCAAGAAGGAGCGCGACGCGCGGCCGCACCCGCACCCCGCTGCCGGGCTCGGCGGGCACGACGCCGGCGGGCCGCGCTGCCACGCGGTAGAGATCGACGCCAAGATCCTGGGGCTGGAGGCCATGATCCGCGTGCAGTGCCACAAGCGCAACCACCCGTCGGCGCGGCTGATGACGGCGCTCCGCGAGCTCGACCTGGACGTGTACCACGCCAGCGTCTCCGTCGTCAAGGACCTCATGATCCAGCAGGTCGCCGTCAAGATGGCCAGCCGCATGTACTCGCAGGACCAGCTCAGCGCCGCGCTCTACAGCCGCCTTGCGGAGCCCGGGTCTGTCATGGGCAGGTAATCAGGCAGGAGAGCTCATCAGCTCGCCTGTGCCTGCCGGATAGGGACGATACCGATACACTGCTACCCACCACGGGGACTGTCATCGCGGTCACCATGGTTACAAAACACACACACGCACGATAGGCCTTAGAGATTCAGGAGGTGGAGGACGGCGGCGACGATGATGATGCTGGTGTTGTTGAAAACTCTAGAAGGATGGATGGATGATGACACCTAGCTTCCGGCTGCTGTTCATCATCCTCTTGTGTTTTTGCTAGTAGCCTGGTAATTAGCAGGATTAAGCAGCCGTCAAGCGTCACCCCCGTTGTTGTTAATTAAGTACCTGTTGTTGTGAGCTGTGACGACGATGGATCGACCGATGTTTTAGCGTTGGTTGAATCCAAAGCTGTATATAGGATGTATGTATTATTACAGCAGGAATTCGCTTGCAACTGAAGAGTCCGTTTTTTTTATTCAAGTA - >Zm00001eb390330_T002
TGACATGACATGGTTGCGCTCCTAGCAAGCACCAAGCAGGAGGCGGGCTACGAACCCTCCTGAATTGTAGGTCGGTGCTGTGGCCCCGTGGCGAAGGGATGTTGTTTCCCTTCCTGTATTTGTCCTCGCCTCGCCAACCGGACAGGAGGCGGGACAGGCGCCCAGCCTCTGTCACGGGCGTTTTCGCCGCATAATCCCACGGGTTCCGCGTTTCAACCCATTTCCTTCGCCTTTCCCCTTCGCCCTCCATTCTCCGCCCACCGTTTCCTCGGGTCTGCCACGCTACGCCACGCCCATGAACCTGTGGACGGACGACAACGCCTCCATGATGGAGGCCTTCATGGCCTCCGCCGACCTCCCCGCCTACCCCTGGGGGGCGCCGGCCGGGGGCGGCAACCCGCCGCCGCCGCAGATGCCGCCGGCGATGGCGATGGCGCCGGGGTTCAACCAGGACACGCTGCAGCAGCGGCTGCAGGCCATGATCGAGGGGTCCAGGGAGACCTGGACCTACGCCATCTTCTGGCAGTCCTCCCTGGACGCCGCCACCGGCGCGTCGCTGCTAGGCTGGGGCGACGGCTACTACAAGGGCTGCGACGACGACAAGCGCAGGCACCGCCCGCCGCTCACGCCCGCCGCGCAGGCCGAGCAGGAGCACCGCAAGCGCGTGCTCCGCGAGCTCAACTCCCTCATCTCCGGCGGCGCCTCCGCCGCGCCCGCGCCCGCGCCCGACGAGGCCGTCGAGGAGGAGGTCACCGACACCGAGTGGTTCTTCCTCGTCTCCATGACGCAGTCCTTCCTCAACGGCTCGGGCCTCCCCGGCCAGGCGCTCTTCGCGGGCCACCACACCTGGATCGCCGCCGGCCTCTCCTCCGCGCCGTGCGACCGCGCGCGCCAGGCCTACAACTTCGGCCTCCGCACCATGGTCTGCTTCCCCGTCGGCACGGGCGTGCTCGAGCTCGGCTCCACCGACGTCGTGTTCCAGACCGCCGAGACCATGGCCAAGATCCGCTCGCTCTTCGGGGGCGGGCCGGGGGGTGGCTCGTGGCCGCCCGTGCAGCCCCAGGCGGCGCCGCAGCAGCAGCACGCCGCCGAAGCCGACCAGGCGGCGGAGACGGACCCATCCGTGCTGTGGCTCGCCGACGCGCCGGTCGTGGACATCAAGGATTCCTACTCGCACCCGTCGGCGGCCGAGATCTCCGTCTCCAAACCGCCTCCGCCTCCGCCTCCGCCGCAGATTCACTTCGAGAACGGGAGCACGAGCACGCTCACGGAGAACCCCAGCCCCTCCGTGCACGCGCCGCCAGCCCCGCCGGCGCCACCGCAGCGGCAGCAGCAGAATCAGGGCCCGTTCCGCCGGGAGCTCAACTTCTCGGATTTCGCGTCCAATCCTTCCTTGGCGGCGGCCCCGCCGTTCTTCAAGCCCGAGTCCGGCGAGATCCTCAGCTTCGGCGTCGACAGCAACGCCCAGAGGAACCCGTCGCCGGCGCCTCCCGCCAGCCTCACCACCGCTCCCGGCAGCCTATTCTCGCAGTCGCAGCACACGGCGACCGCCGCGGCGAACGACGCGAAGAACAACAACAACAACAACAAGCGTTCGATGGAAGCCACCTCCCTGGCGAGCAACACCAACCACCACCCGCCGCCGGAGGCGGAGAAGCGGCCGCGGAAGCGCGGGCGGAAGCCCGCGAACGGGCGCGAGGAGCCGCTGAACCACGTGGAGGCGGAGCGGCAGCGGCGGGAGAAGCTGAACCAGCGCTTCTACGCGCTGCGCGCCGTGGTGCCCAACGTGTCCAAGATGGACAAGGCGTCGCTGCTCGGCGACGCCATCTCCTACATCAACGAGCTCCGCGGCAAGCTGACGTCGCTGGAGTCGGACAGGGAGACGCTGCAGGCCCAGGTCGAGGCGCTCAAGAAGGAGCGCGACGCGCGGCCGCACCCGCACCCCGCTGCCGGGCTCGGCGGGCACGACGCCGGCGGGCCGCGCTGCCACGCGGTAGAGATCGACGCCAAGATCCTGGGGCTGGAGGCCATGATCCGCGTGCAGTGCCACAAGCGCAACCACCCGTCGGCGCGGCTGATGACGGCGCTCCGCGAGCTCGACCTGGACGTGTACCACGCCAGCGTCTCCGTCGTCAAGGACCTCATGATCCAGCAGGTCGCCGTCAAGATGGCCAGCCGCATGTACTCGCAGGACCAGCTCAGCGCCGCGCTCTACAGCCGCCTTGCGGAGCCCGGGTCTGTCATGGGCAGGTAATCAGGCAGGAGAGCTCATCAGCTCGCCTGTGCCTGCCGGATAGGGACGATACCGATACACTGCTACCCACCACGGGGACTGTCATCGCGGTCACCATGGTTACAAAACACACACACGCACGATAGGCCTTAGAGATTCAGGAGGTGGAGGACGGCGGCGACGATGATGATGCTGGTGTTGTTGAAAACTCTAGAAGGATGGATGGATGATGACACCTAGCTTCCGGCTGCTGTTCATCATCCTCTTGTGTTTTTGCTAGTAGCCTGGTAATTAGCAGGATTAAGCAGCCGTCAAGCGTCACCCCCGTTGTTGTTAATTAAGTACCTGTTGTTGTGAGCTGTGACGACGATGGATCGACCGATGTTTTAGCGTTGGTTGAATCCAAAGCTGTATATAGGATGTATGTATTATTACAGCAGGAATTCGCTTGCAACTGAAGAGTCCGTTTTTTTTATTCAAGTA
CDS Sequence
- >Zm00001eb390330_T001
ATGAACCTGTGGACGGACGACAACGCCTCCATGATGGAGGCCTTCATGGCCTCCGCCGACCTCCCCGCCTACCCCTGGGGGGCGCCGGCCGGGGGCGGCAACCCGCCGCCGCCGCAGATGCCGCCGGCGATGGCGATGGCGCCGGGGTTCAACCAGGACACGCTGCAGCAGCGGCTGCAGGCCATGATCGAGGGGTCCAGGGAGACCTGGACCTACGCCATCTTCTGGCAGTCCTCCCTGGACGCCGCCACCGGCGCGTCGCTGCTAGGCTGGGGCGACGGCTACTACAAGGGCTGCGACGACGACAAGCGCAGGCACCGCCCGCCGCTCACGCCCGCCGCGCAGGCCGAGCAGGAGCACCGCAAGCGCGTGCTCCGCGAGCTCAACTCCCTCATCTCCGGCGGCGCCTCCGCCGCGCCCGCGCCCGCGCCCGACGAGGCCGTCGAGGAGGAGGTCACCGACACCGAGTGGTTCTTCCTCGTCTCCATGACGCAGTCCTTCCTCAACGGCTCGGGCCTCCCCGGCCAGGCGCTCTTCGCGGGCCACCACACCTGGATCGCCGCCGGCCTCTCCTCCGCGCCGTGCGACCGCGCGCGCCAGGCCTACAACTTCGGCCTCCGCACCATGGTCTGCTTCCCCGTCGGCACGGGCGTGCTCGAGCTCGGCTCCACCGACGTCGTGTTCCAGACCGCCGAGACCATGGCCAAGATCCGCTCGCTCTTCGGGGGCGGGCCGGGGGGTGGCTCGTGGCCGCCCGTGCAGCCCCAGGCGGCGCCGCAGCAGCAGCACGCCGCCGAAGCCGACCAGGCGGCGGAGACGGACCCATCCGTGCTGTGGCTCGCCGACGCGCCGGTCGTGGACATCAAGGATTCCTACTCGCACCCGTCGGCGGCCGAGATCTCCGTCTCCAAACCGCCTCCGCCTCCGCCTCCGCCGCAGATTCACTTCGAGAACGGGAGCACGAGCACGCTCACGGAGAACCCCAGCCCCTCCGTGCACGCGCCGCCAGCCCCGCCGGCGCCACCGCAGCGGCAGCAGCAGAATCAGGGCCCGTTCCGCCGGGAGCTCAACTTCTCGGATTTCGCGTCCAATCCTTCCTTGGCGGCGGCCCCGCCGTTCTTCAAGCCCGAGTCCGGCGAGATCCTCAGCTTCGGCGTCGACAGCAACGCCCAGAGGAACCCGTCGCCGGCGCCTCCCGCCAGCCTCACCACCGCTCCCGGCAGCCTATTCTCGCAGTCGCAGCACACGGCGACCGCCGCGGCGAACGACGCGAAGAACAACAACAACAACAACAAGCGTTCGATGGAAGCCACCTCCCTGGCGAGCAACACCAACCACCACCCGCCGCCGGAGGCGGAGAAGCGGCCGCGGAAGCGCGGGCGGAAGCCCGCGAACGGGCGCGAGGAGCCGCTGAACCACGTGGAGGCGGAGCGGCAGCGGCGGGAGAAGCTGAACCAGCGCTTCTACGCGCTGCGCGCCGTGGTGCCCAACGTGTCCAAGATGGACAAGGCGTCGCTGCTCGGCGACGCCATCTCCTACATCAACGAGCTCCGCGGCAAGCTGACGTCGCTGGAGTCGGACAGGGAGACGCTGCAGGCCCAGGTCGAGGCGCTCAAGAAGGAGCGCGACGCGCGGCCGCACCCGCACCCCGCTGCCGGGCTCGGCGGGCACGACGCCGGCGGGCCGCGCTGCCACGCGGTAGAGATCGACGCCAAGATCCTGGGGCTGGAGGCCATGATCCGCGTGCAGTGCCACAAGCGCAACCACCCGTCGGCGCGGCTGATGACGGCGCTCCGCGAGCTCGACCTGGACGTGTACCACGCCAGCGTCTCCGTCGTCAAGGACCTCATGATCCAGCAGGTCGCCGTCAAGATGGCCAGCCGCATGTACTCGCAGGACCAGCTCAGCGCCGCGCTCTACAGCCGCCTTGCGGAGCCCGGGTCTGTCATGGGCAGGTAA - >Zm00001eb390330_T002
ATGAACCTGTGGACGGACGACAACGCCTCCATGATGGAGGCCTTCATGGCCTCCGCCGACCTCCCCGCCTACCCCTGGGGGGCGCCGGCCGGGGGCGGCAACCCGCCGCCGCCGCAGATGCCGCCGGCGATGGCGATGGCGCCGGGGTTCAACCAGGACACGCTGCAGCAGCGGCTGCAGGCCATGATCGAGGGGTCCAGGGAGACCTGGACCTACGCCATCTTCTGGCAGTCCTCCCTGGACGCCGCCACCGGCGCGTCGCTGCTAGGCTGGGGCGACGGCTACTACAAGGGCTGCGACGACGACAAGCGCAGGCACCGCCCGCCGCTCACGCCCGCCGCGCAGGCCGAGCAGGAGCACCGCAAGCGCGTGCTCCGCGAGCTCAACTCCCTCATCTCCGGCGGCGCCTCCGCCGCGCCCGCGCCCGCGCCCGACGAGGCCGTCGAGGAGGAGGTCACCGACACCGAGTGGTTCTTCCTCGTCTCCATGACGCAGTCCTTCCTCAACGGCTCGGGCCTCCCCGGCCAGGCGCTCTTCGCGGGCCACCACACCTGGATCGCCGCCGGCCTCTCCTCCGCGCCGTGCGACCGCGCGCGCCAGGCCTACAACTTCGGCCTCCGCACCATGGTCTGCTTCCCCGTCGGCACGGGCGTGCTCGAGCTCGGCTCCACCGACGTCGTGTTCCAGACCGCCGAGACCATGGCCAAGATCCGCTCGCTCTTCGGGGGCGGGCCGGGGGGTGGCTCGTGGCCGCCCGTGCAGCCCCAGGCGGCGCCGCAGCAGCAGCACGCCGCCGAAGCCGACCAGGCGGCGGAGACGGACCCATCCGTGCTGTGGCTCGCCGACGCGCCGGTCGTGGACATCAAGGATTCCTACTCGCACCCGTCGGCGGCCGAGATCTCCGTCTCCAAACCGCCTCCGCCTCCGCCTCCGCCGCAGATTCACTTCGAGAACGGGAGCACGAGCACGCTCACGGAGAACCCCAGCCCCTCCGTGCACGCGCCGCCAGCCCCGCCGGCGCCACCGCAGCGGCAGCAGCAGAATCAGGGCCCGTTCCGCCGGGAGCTCAACTTCTCGGATTTCGCGTCCAATCCTTCCTTGGCGGCGGCCCCGCCGTTCTTCAAGCCCGAGTCCGGCGAGATCCTCAGCTTCGGCGTCGACAGCAACGCCCAGAGGAACCCGTCGCCGGCGCCTCCCGCCAGCCTCACCACCGCTCCCGGCAGCCTATTCTCGCAGTCGCAGCACACGGCGACCGCCGCGGCGAACGACGCGAAGAACAACAACAACAACAACAAGCGTTCGATGGAAGCCACCTCCCTGGCGAGCAACACCAACCACCACCCGCCGCCGGAGGCGGAGAAGCGGCCGCGGAAGCGCGGGCGGAAGCCCGCGAACGGGCGCGAGGAGCCGCTGAACCACGTGGAGGCGGAGCGGCAGCGGCGGGAGAAGCTGAACCAGCGCTTCTACGCGCTGCGCGCCGTGGTGCCCAACGTGTCCAAGATGGACAAGGCGTCGCTGCTCGGCGACGCCATCTCCTACATCAACGAGCTCCGCGGCAAGCTGACGTCGCTGGAGTCGGACAGGGAGACGCTGCAGGCCCAGGTCGAGGCGCTCAAGAAGGAGCGCGACGCGCGGCCGCACCCGCACCCCGCTGCCGGGCTCGGCGGGCACGACGCCGGCGGGCCGCGCTGCCACGCGGTAGAGATCGACGCCAAGATCCTGGGGCTGGAGGCCATGATCCGCGTGCAGTGCCACAAGCGCAACCACCCGTCGGCGCGGCTGATGACGGCGCTCCGCGAGCTCGACCTGGACGTGTACCACGCCAGCGTCTCCGTCGTCAAGGACCTCATGATCCAGCAGGTCGCCGTCAAGATGGCCAGCCGCATGTACTCGCAGGACCAGCTCAGCGCCGCGCTCTACAGCCGCCTTGCGGAGCCCGGGTCTGTCATGGGCAGGTAA
Protein Sequence
- >Zm00001eb390330_P001
MNLWTDDNASMMEAFMASADLPAYPWGAPAGGGNPPPPQMPPAMAMAPGFNQDTLQQRLQAMIEGSRETWTYAIFWQSSLDAATGASLLGWGDGYYKGCDDDKRRHRPPLTPAAQAEQEHRKRVLRELNSLISGGASAAPAPAPDEAVEEEVTDTEWFFLVSMTQSFLNGSGLPGQALFAGHHTWIAAGLSSAPCDRARQAYNFGLRTMVCFPVGTGVLELGSTDVVFQTAETMAKIRSLFGGGPGGGSWPPVQPQAAPQQQHAAEADQAAETDPSVLWLADAPVVDIKDSYSHPSAAEISVSKPPPPPPPPQIHFENGSTSTLTENPSPSVHAPPAPPAPPQRQQQNQGPFRRELNFSDFASNPSLAAAPPFFKPESGEILSFGVDSNAQRNPSPAPPASLTTAPGSLFSQSQHTATAAANDAKNNNNNNKRSMEATSLASNTNHHPPPEAEKRPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELRGKLTSLESDRETLQAQVEALKKERDARPHPHPAAGLGGHDAGGPRCHAVEIDAKILGLEAMIRVQCHKRNHPSARLMTALRELDLDVYHASVSVVKDLMIQQVAVKMASRMYSQDQLSAALYSRLAEPGSVMGR - >Zm00001eb390330_P002
MNLWTDDNASMMEAFMASADLPAYPWGAPAGGGNPPPPQMPPAMAMAPGFNQDTLQQRLQAMIEGSRETWTYAIFWQSSLDAATGASLLGWGDGYYKGCDDDKRRHRPPLTPAAQAEQEHRKRVLRELNSLISGGASAAPAPAPDEAVEEEVTDTEWFFLVSMTQSFLNGSGLPGQALFAGHHTWIAAGLSSAPCDRARQAYNFGLRTMVCFPVGTGVLELGSTDVVFQTAETMAKIRSLFGGGPGGGSWPPVQPQAAPQQQHAAEADQAAETDPSVLWLADAPVVDIKDSYSHPSAAEISVSKPPPPPPPPQIHFENGSTSTLTENPSPSVHAPPAPPAPPQRQQQNQGPFRRELNFSDFASNPSLAAAPPFFKPESGEILSFGVDSNAQRNPSPAPPASLTTAPGSLFSQSQHTATAAANDAKNNNNNNKRSMEATSLASNTNHHPPPEAEKRPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELRGKLTSLESDRETLQAQVEALKKERDARPHPHPAAGLGGHDAGGPRCHAVEIDAKILGLEAMIRVQCHKRNHPSARLMTALRELDLDVYHASVSVVKDLMIQQVAVKMASRMYSQDQLSAALYSRLAEPGSVMGR