Information report for ZmMRP4|lpa1
Gene Details
|
|
Functional Descriptions
- The Lpa1 gene encodes for ZmMRP4 (accession number EF586878), a multidrug resistance-associated protein (MRP) belonging to the subfamily of ATP-binding cassette (ABC) transmembrane transporters.
- In this study, we present genetic and molecular analyses of the lpa1-241 mutation that indicate an epigenetic origin of this trait, that is, a paramutagenic interaction that results in meiotically heritable changes in ZmMRP4 gene expression, causing a strong pleiotropic effect on the whole plant.
- Phylogenetic tree using nucleotide and protein sequences revealed a closer relationship of maize lpa1 sequences with Sorghum bicolor, Panicum hallii, Setaria italica and S. viridis. This study offered newer insights into the understanding of the genetic diversity of the lpa1 gene in maize and related crop-species, and information generated here would further help in exploiting the lpa1 mutant for the enhancement of nutritional value in maize kernels.
- A paramutation phenomenon is involved in the genetics of maize low phytic acid1-241 (lpa1-241) trait.
- A gene tagging experiment performed by Shi et al. found that mutations in ZmMRP4 (multidrug resistance-associated proteins 4) gene cause lpa1 phenotype.
Functional Keywords
Literature and News
Gene Resources
- NCBI ID: LOC100217150
- UniProt accessions: A7KVC2
- EMBL: EF586878
- AlphaFoldDB: A7KVC2
- EnsemblPlants: Zm00001eb003490_T001
- Gramene: Zm00001eb003490_T001
- KEGG: zma:100125659
- ExpressionAtlas: Zm00001eb003490
- InterPro: IPR003439 , IPR003593 , IPR011527 , IPR017871 , IPR027417 , IPR036640 , IPR044726 , IPR044746 , IPR050173
- PANTHER: PTHR24223 , PTHR24223:SF189
- SUPFAM: SSF52540 , SSF90123
- PROSITE: PS00211 , PS50893 , PS50929
- Gene3D: 1.20.1560.10 , 3.40.50.300
- OrthoDB: A7KVC2
- SMR: A7KVC2
- CDD: cd03244 , cd03250 , cd18579 , cd18580
Sequences
cDNA Sequence
- >Zm00001eb003490_T001
TGCACGTCATGGTAGTAGCCGGAAGGCAAAGCCGGCTACGAACTCTCCTCCTCTATAAAAACCATCAATCGCCGTTCCATCTGTTTGCAAGCCGACCGAAACCAGGCAGTGGTGTGGAGTGGACACAACACAACAGGAGAGGAGGAAAAGGGAAAACGGAAATTCACTGCTACTACTCCGTCTCCGTACTAGCACGCCCATAACCTCTCTCTCTCTCCTGCCTCTCACCGCATCGTCTTCCTCTCCCCCCACCACACCCCCCACCCGCCGATCCATCCCCCAAAAGCCGAAGCCGAAACCGAAACCTCCCTCCGCACGCCACCTGCTACCACACACACACCCGCGCCGCCGCCCCCACGGCCGGCCGCGCGGAGGTGACTCGAGAAGGACGCAGGAACCAAGGAGAGAGTTTGGTGAGGGGATCAGAGACGTAACCCGCCCGGACCCGGGCTGCATTAGCCGGAATCCCATCCCAGGCGAGCCTCTCTCTCCCCTCCTCGAACCAGGCGCAGGCGAGCGTCTCTGCCCGCCCGCCTGCTGCTACCGCCAAAACGCCTCCTTTGTTGCCATCCGCCGATGCCGTAATCCGCCGCCCAAAGCTCTTCCTTTTTCCCTCTCTCTCGCCCGCGGCCGCACTCCCTGCCCCAGTGCCTGCCGTGGCGAGCCCAACCCCAATGCCTTTTAAACCCCTCCCCGCTCCCTCACTGATCCCCACCGCCTCCCAATGCCGCCCTCCTTCCCCTCCCTCCCGCTCCCGGAGGCCGTTGCCGCCACCGCCCACGCCGCGCTGCTCGCGCTCGCCGCACTCCTGCTCCTCCTCCGCGCCGCGCGCGCGCTCGCCTCCCGCTGCGCGTCATGCCTCAAGGCGCCGCGCCGCCGCGGGGGCCCCGCCGTCGTCGTGGGCGACGGCGCCGGCGGCGCCCTCGCGGCGGCGACTGCCGGCGCCTGGCACAGGGCCGTGCTGGCGTCCTGCGCCTACGCCCTGCTCTCGCAGGTCGCCGTGCTGAGCTACGAGGTGGCCGTCGCCGGCTCGCGCGTCTCGGCGCGGGCGCTGCTGCTGCCGGCCGTGCAGGCGGTGTCCTGGGCCGCGCTGCTGGCGCTCGCGCTTCAGGCCCGCGCCGTCGGCTGGGCCAGGTTCCCTGCGCTGGTGCGGCTCTGGTGGGTGGTCTCCTTCGCGCTCTGCGTTGTCATTGCGTACGACGACTCCAGGCGCCTGATAGGCCAGGGCGCGCGCGCTGTGGATTACGCGCACATGGTTGCCAACTTCGCGTCCGTGCCGGCCCTGGGCTTCCTGTGCTTGGTTGGTGTCATGGGTTCCACCGGTTTGGAATTGGAGTTTACGGAGGATGGCAACGGCCTGCATGAGCCGCTGCTGCTCGGCAGGCAGCGCAGAGAGGCAGAGGAGGAGCTCGGCTGTCTGAGGGTCACTCCCTACGCTGATGCTGGGATCCTCAGCCTTGCAACATTGTCATGGCTTAGTCCGTTGCTCTCTGTTGGTGCGCAGCGGCCACTTGAGTTGGCTGACATACCCTTGCTGGCGCACAAGGACCGTGCAAAGTCATGCTATAAGGCGATGAGCGCTCACTACGAGCGCCAGCGGCTAGAATACCCTGGCAGGGAGCCATCACTCACATGGGCAATACTCAAGTCATTCTGGCGAGAGGCCGCGGTCAATGGCACATTTGCTGCTGTCAACACGATTGTGTCGTATGTTGGACCTTACTTGATCAGCTATTTTGTGGACTACCTCAGTGGCAACATTGCTTTCCCCCATGAAGGTTACATCCTTGCCTCTATATTTTTTGTAGCAAAACTGCTTGAGACACTCACTGCCCGACAGTGGTACTTGGGTGTGGACATCATGGGGATCCATGTCAAGTCTGGCCTCACTGCCATGGTGTATAGGAAGGGTCTCCGACTGTCAAACGCCTCACGGCAGAGCCACACGAGTGGTGAGATTGTGAATTACATGGCCGTCGATGTGCAGCGTGTGGGGGACTATGCATGGTATTTCCATGACATCTGGATGCTTCCCCTGCAGATCATTCTTGCTCTCGCCATCCTGTACAAGAACGTCGGGATCGCCATGGTTTCAACATTGGTAGCAACTGTGCTATCGATCGCAGCCTCTGTTCCTGTGGCAAAGCTGCAGGAGCACTACCAAGATAAGTTAATGGCATCAAAAGATGAGCGCATGCGCAAGACTTCAGAGTGCTTGAAAAATATGAGGATTTTGAAGCTTCAGGCATGGGAGGATCGGTACCGGCTGCAGTTGGAAGAGATGAGGAACGTGGAATGCAGATGGCTTCGGTGGGCTCTGTACTCACAGGCTGCAGTTACATTTGTTTTCTGGAGCTCGCCAATCTTTGTCGCAGTCATAACTTTTGGGACTTGCATATTACTCGGTGGCCAGCTCACTGCAGGAGGGGTTCTATCCGCTTTAGCAACGTTTCGGATCCTCCAAGAGCCTCTGAGGAACTTCCCGGATCTCATCTCTATGATGGCACAGACAAGGGTGTCTTTGGACCGTTTGTCTCATTTTCTGCAGCAAGAAGAACTGCCAGATGACGCAACTATAAATGTTCCACAAAGTAGTACAGATAAGGCAGTCGATATTAAGGATGGCGCATTCTCTTGGAACCCATACACTCTGACCCCTACACTTTCTGATATACACCTTAGTGTAGTGAGAGGCATGAGAGTAGCAGTCTGTGGTGTCATTGGTTCTGGTAAATCAAGTCTACTATCGTCTATACTCGGGGAGATACCCAAATTATGTGGCCATGTCAGGATAAGTGGCACAGCAGCGTATGTTCCTCAGACTGCATGGATACAGTCTGGAAATATTGAGGAGAATATTCTGTTTGGCAGTCAAATGGATAGACAACGTTACAAGAGAGTCATTGCAGCTTGCTGTCTTAAGAAAGATCTTGAGCTGCTCCAGTACGGAGATCAGACTGTTATTGGTGATAGAGGCATTAATTTGAGTGGAGGTCAGAAACAAAGAGTTCAGCTTGCTAGAGCACTCTACCAAGATGCTGATATTTATTTGCTTGATGATCCCTTCAGTGCTGTTGATGCTCATACTGGGAGCGAACTGTTTAAGGAGTATATATTGACTGCACTAGCAACCAAAACAGTAATCTATGTAACACATCAAGTTGAATTTCTACCAGCTGCTGATCTGATATTGGTTCTTAAGGATGGCCATATCACACAAGCTGGAAAGTATGATGATCTTCTGCAAGCTGGAACTGATTTCAATGCTCTGGTTTCTGCTCATAAGGAAGCTATTGAAACCATGGATATATTTGAAGATTCCGATAGTGATACAGTTTCTTCTATTCCCAACAAAAGATTGACACCAAGTATCAGCAATATTGATAACCTGAAAAATAAGATGTGTGAAAATGGACAACCATCTAATACACGGGGAATTAAGGAAAAAAAGAAGAAAGAAGAGCGTAAGAAGAAGCGTACTGTTCAAGAGGAGGAAAGGGAACGTGGAAAAGTGAGCTCCAAAGTTTATTTGTCATACATGGGGGAAGCTTACAAAGGTACACTGATACCACTAATTATCTTGGCTCAAACCATGTTCCAAGTTCTTCAGATTGCGAGCAACTGGTGGATGGCATGGGCAAACCCACAAACAGAAGGAGATGCTCCCAAGACAGATAGTGTGGTCCTTCTGGTTGTTTATATGTCCCTTGCCTTTGGAAGTTCACTATTTGTGTTCATGAGAAGCCTTCTTGTGGCTACGTTTGGTTTAGCAGCTGCCCAGAAGCTTTTTATAAAAATGCTTAGGTGTGTCTTTCGAGCTCCAATGTCATTCTTTGACACCACACCATCTGGTCGGATTTTGAACAGAGTTTCTGTAGATCAAAGTGTTGTGGACCTTGATATAGCGTTCAGACTTGGTGGATTTGCATCAACGACAATTCAACTCCTTGGAATTGTTGCTGTCATGAGCAAAGTCACATGGCAAGTTCTGATTCTTATAGTCCCCATGGCTGTTGCATGCATGTGGATGCAGAGGTATTATATTGCTTCATCAAGGGAACTAACTAGGATTTTGAGTGTTCAGAAGTCTCCAGTGATCCATTTGTTTAGTGAATCAATTGCTGGTGCTGCTACAATAAGGGGTTTTGGTCAAGAGAAGCGGTTTATGAAAAGGAATCTTTATCTTCTTGACTGTTTTGCTCGCCCTTTATTTTCCAGCCTTGCTGCTATTGAATGGCTCTGCCTGCGAATGGAATTGCTTTCGACTTTCGTCTTTGCTTTTTGCATGGCAATACTTGTGAGCTTTCCTCCTGGCACAATCGAACCAAGTATGGCTGGCCTCGCTGTAACATATGGACTTAATTTAAATGCTCGCATGTCAAGATGGATATTGAGCTTCTGTAAATTAGAGAACAGGATAATCTCTGTTGAGCGCATTTATCAATATTGCAGGCTTCCTAGTGAAGCACCATTGATTATTGAGAACTGCCGTCCACCATCATCATGGCCTCAGAATGGAAACATTGAACTGATTGATCTCAAGGTCCGCTACAAGGACGATCTACCATTAGTTCTTCATGGTGTAAGTTGTATGTTTCCTGGCGGGAAAAAGATTGGGATTGTAGGGCGTACTGGAAGCGGTAAATCTACTCTTATTCAGGCCCTTTTCCGCCTAATTGAGCCCACTGGAGGGAAGATTATAATTGACAACATTGACATCTCTGCAATTGGCCTTCATGATCTGCGGTCACGGTTGAGCATCATTCCCCAAGACCCTACATTGTTTGAGGGTACTATCAGAATGAACCTTGATCCTCTTGAGGAGTGCACTGATCAAGAAATTTGGGAGGCACTAGAAAAGTGTCAGCTAGGAGAGGTCATTCGTTCCAAGGAAGAGAAACTTGACAGTCCAGTGCTAGAAAACGGGGATAACTGGAGCGTGGGACAGCGCCAACTTATTGCACTGGGTAGGGCGCTGCTCAAGCAGGCAAAAATTTTGGTACTCGATGAGGCGACAGCATCTGTCGACACAGCAACAGACAATCTTATCCAAAAGATCATCCGCAGTGAATTCAAGGACTGCACAGTCTGTACCATTGCTCACCGTATTCCCACCGTTATTGACAGTGACCTTGTTCTGGTCCTTAGTGATGGTAAAATCGCAGAGTTCGACACGCCCCAGAGGCTTTTAGAGGACAAGTCATCTATGTTCATACAGCTAGTATCGGAATACTCCACTCGGTCGAGCTGTATATAGAGAGGCTTAGCTTAAAACCCCGCCCCAAACCTGGCAACAGAGGCTGGGAGGCAAATAGCCCGTATCTGCCATGCTTGCGCCATAGAGGTCCCTGCGAACACCGGAGGGCGGCGTAGAAGACGAGGTGTACATGAGTGGGAGGAACACTGGGCGTTCCCTGACCTGAATACCGTGGAATCGGCGAGGGAGCGCGGTTGGTATTGGTAGGCACCAGGGGAGGAGTTGGTGACACTAGTACATTACCCGAAGCTGATGCTTCAGTATGTATGTATAACAACAATGCATACTGCTTCTCCCTTTGCAGAGTGGAGAACCAAGGGAATAACTCGTGCGTAATAAGAGGAGAAAGATTTGTTTTTTGGCATC
CDS Sequence
- >Zm00001eb003490_T001
ATGCCGCCCTCCTTCCCCTCCCTCCCGCTCCCGGAGGCCGTTGCCGCCACCGCCCACGCCGCGCTGCTCGCGCTCGCCGCACTCCTGCTCCTCCTCCGCGCCGCGCGCGCGCTCGCCTCCCGCTGCGCGTCATGCCTCAAGGCGCCGCGCCGCCGCGGGGGCCCCGCCGTCGTCGTGGGCGACGGCGCCGGCGGCGCCCTCGCGGCGGCGACTGCCGGCGCCTGGCACAGGGCCGTGCTGGCGTCCTGCGCCTACGCCCTGCTCTCGCAGGTCGCCGTGCTGAGCTACGAGGTGGCCGTCGCCGGCTCGCGCGTCTCGGCGCGGGCGCTGCTGCTGCCGGCCGTGCAGGCGGTGTCCTGGGCCGCGCTGCTGGCGCTCGCGCTTCAGGCCCGCGCCGTCGGCTGGGCCAGGTTCCCTGCGCTGGTGCGGCTCTGGTGGGTGGTCTCCTTCGCGCTCTGCGTTGTCATTGCGTACGACGACTCCAGGCGCCTGATAGGCCAGGGCGCGCGCGCTGTGGATTACGCGCACATGGTTGCCAACTTCGCGTCCGTGCCGGCCCTGGGCTTCCTGTGCTTGGTTGGTGTCATGGGTTCCACCGGTTTGGAATTGGAGTTTACGGAGGATGGCAACGGCCTGCATGAGCCGCTGCTGCTCGGCAGGCAGCGCAGAGAGGCAGAGGAGGAGCTCGGCTGTCTGAGGGTCACTCCCTACGCTGATGCTGGGATCCTCAGCCTTGCAACATTGTCATGGCTTAGTCCGTTGCTCTCTGTTGGTGCGCAGCGGCCACTTGAGTTGGCTGACATACCCTTGCTGGCGCACAAGGACCGTGCAAAGTCATGCTATAAGGCGATGAGCGCTCACTACGAGCGCCAGCGGCTAGAATACCCTGGCAGGGAGCCATCACTCACATGGGCAATACTCAAGTCATTCTGGCGAGAGGCCGCGGTCAATGGCACATTTGCTGCTGTCAACACGATTGTGTCGTATGTTGGACCTTACTTGATCAGCTATTTTGTGGACTACCTCAGTGGCAACATTGCTTTCCCCCATGAAGGTTACATCCTTGCCTCTATATTTTTTGTAGCAAAACTGCTTGAGACACTCACTGCCCGACAGTGGTACTTGGGTGTGGACATCATGGGGATCCATGTCAAGTCTGGCCTCACTGCCATGGTGTATAGGAAGGGTCTCCGACTGTCAAACGCCTCACGGCAGAGCCACACGAGTGGTGAGATTGTGAATTACATGGCCGTCGATGTGCAGCGTGTGGGGGACTATGCATGGTATTTCCATGACATCTGGATGCTTCCCCTGCAGATCATTCTTGCTCTCGCCATCCTGTACAAGAACGTCGGGATCGCCATGGTTTCAACATTGGTAGCAACTGTGCTATCGATCGCAGCCTCTGTTCCTGTGGCAAAGCTGCAGGAGCACTACCAAGATAAGTTAATGGCATCAAAAGATGAGCGCATGCGCAAGACTTCAGAGTGCTTGAAAAATATGAGGATTTTGAAGCTTCAGGCATGGGAGGATCGGTACCGGCTGCAGTTGGAAGAGATGAGGAACGTGGAATGCAGATGGCTTCGGTGGGCTCTGTACTCACAGGCTGCAGTTACATTTGTTTTCTGGAGCTCGCCAATCTTTGTCGCAGTCATAACTTTTGGGACTTGCATATTACTCGGTGGCCAGCTCACTGCAGGAGGGGTTCTATCCGCTTTAGCAACGTTTCGGATCCTCCAAGAGCCTCTGAGGAACTTCCCGGATCTCATCTCTATGATGGCACAGACAAGGGTGTCTTTGGACCGTTTGTCTCATTTTCTGCAGCAAGAAGAACTGCCAGATGACGCAACTATAAATGTTCCACAAAGTAGTACAGATAAGGCAGTCGATATTAAGGATGGCGCATTCTCTTGGAACCCATACACTCTGACCCCTACACTTTCTGATATACACCTTAGTGTAGTGAGAGGCATGAGAGTAGCAGTCTGTGGTGTCATTGGTTCTGGTAAATCAAGTCTACTATCGTCTATACTCGGGGAGATACCCAAATTATGTGGCCATGTCAGGATAAGTGGCACAGCAGCGTATGTTCCTCAGACTGCATGGATACAGTCTGGAAATATTGAGGAGAATATTCTGTTTGGCAGTCAAATGGATAGACAACGTTACAAGAGAGTCATTGCAGCTTGCTGTCTTAAGAAAGATCTTGAGCTGCTCCAGTACGGAGATCAGACTGTTATTGGTGATAGAGGCATTAATTTGAGTGGAGGTCAGAAACAAAGAGTTCAGCTTGCTAGAGCACTCTACCAAGATGCTGATATTTATTTGCTTGATGATCCCTTCAGTGCTGTTGATGCTCATACTGGGAGCGAACTGTTTAAGGAGTATATATTGACTGCACTAGCAACCAAAACAGTAATCTATGTAACACATCAAGTTGAATTTCTACCAGCTGCTGATCTGATATTGGTTCTTAAGGATGGCCATATCACACAAGCTGGAAAGTATGATGATCTTCTGCAAGCTGGAACTGATTTCAATGCTCTGGTTTCTGCTCATAAGGAAGCTATTGAAACCATGGATATATTTGAAGATTCCGATAGTGATACAGTTTCTTCTATTCCCAACAAAAGATTGACACCAAGTATCAGCAATATTGATAACCTGAAAAATAAGATGTGTGAAAATGGACAACCATCTAATACACGGGGAATTAAGGAAAAAAAGAAGAAAGAAGAGCGTAAGAAGAAGCGTACTGTTCAAGAGGAGGAAAGGGAACGTGGAAAAGTGAGCTCCAAAGTTTATTTGTCATACATGGGGGAAGCTTACAAAGGTACACTGATACCACTAATTATCTTGGCTCAAACCATGTTCCAAGTTCTTCAGATTGCGAGCAACTGGTGGATGGCATGGGCAAACCCACAAACAGAAGGAGATGCTCCCAAGACAGATAGTGTGGTCCTTCTGGTTGTTTATATGTCCCTTGCCTTTGGAAGTTCACTATTTGTGTTCATGAGAAGCCTTCTTGTGGCTACGTTTGGTTTAGCAGCTGCCCAGAAGCTTTTTATAAAAATGCTTAGGTGTGTCTTTCGAGCTCCAATGTCATTCTTTGACACCACACCATCTGGTCGGATTTTGAACAGAGTTTCTGTAGATCAAAGTGTTGTGGACCTTGATATAGCGTTCAGACTTGGTGGATTTGCATCAACGACAATTCAACTCCTTGGAATTGTTGCTGTCATGAGCAAAGTCACATGGCAAGTTCTGATTCTTATAGTCCCCATGGCTGTTGCATGCATGTGGATGCAGAGGTATTATATTGCTTCATCAAGGGAACTAACTAGGATTTTGAGTGTTCAGAAGTCTCCAGTGATCCATTTGTTTAGTGAATCAATTGCTGGTGCTGCTACAATAAGGGGTTTTGGTCAAGAGAAGCGGTTTATGAAAAGGAATCTTTATCTTCTTGACTGTTTTGCTCGCCCTTTATTTTCCAGCCTTGCTGCTATTGAATGGCTCTGCCTGCGAATGGAATTGCTTTCGACTTTCGTCTTTGCTTTTTGCATGGCAATACTTGTGAGCTTTCCTCCTGGCACAATCGAACCAAGTATGGCTGGCCTCGCTGTAACATATGGACTTAATTTAAATGCTCGCATGTCAAGATGGATATTGAGCTTCTGTAAATTAGAGAACAGGATAATCTCTGTTGAGCGCATTTATCAATATTGCAGGCTTCCTAGTGAAGCACCATTGATTATTGAGAACTGCCGTCCACCATCATCATGGCCTCAGAATGGAAACATTGAACTGATTGATCTCAAGGTCCGCTACAAGGACGATCTACCATTAGTTCTTCATGGTGTAAGTTGTATGTTTCCTGGCGGGAAAAAGATTGGGATTGTAGGGCGTACTGGAAGCGGTAAATCTACTCTTATTCAGGCCCTTTTCCGCCTAATTGAGCCCACTGGAGGGAAGATTATAATTGACAACATTGACATCTCTGCAATTGGCCTTCATGATCTGCGGTCACGGTTGAGCATCATTCCCCAAGACCCTACATTGTTTGAGGGTACTATCAGAATGAACCTTGATCCTCTTGAGGAGTGCACTGATCAAGAAATTTGGGAGGCACTAGAAAAGTGTCAGCTAGGAGAGGTCATTCGTTCCAAGGAAGAGAAACTTGACAGTCCAGTGCTAGAAAACGGGGATAACTGGAGCGTGGGACAGCGCCAACTTATTGCACTGGGTAGGGCGCTGCTCAAGCAGGCAAAAATTTTGGTACTCGATGAGGCGACAGCATCTGTCGACACAGCAACAGACAATCTTATCCAAAAGATCATCCGCAGTGAATTCAAGGACTGCACAGTCTGTACCATTGCTCACCGTATTCCCACCGTTATTGACAGTGACCTTGTTCTGGTCCTTAGTGATGGTAAAATCGCAGAGTTCGACACGCCCCAGAGGCTTTTAGAGGACAAGTCATCTATGTTCATACAGCTAGTATCGGAATACTCCACTCGGTCGAGCTGTATATAG
Protein Sequence
- >Zm00001eb003490_P001
MPPSFPSLPLPEAVAATAHAALLALAALLLLLRAARALASRCASCLKAPRRRGGPAVVVGDGAGGALAAATAGAWHRAVLASCAYALLSQVAVLSYEVAVAGSRVSARALLLPAVQAVSWAALLALALQARAVGWARFPALVRLWWVVSFALCVVIAYDDSRRLIGQGARAVDYAHMVANFASVPALGFLCLVGVMGSTGLELEFTEDGNGLHEPLLLGRQRREAEEELGCLRVTPYADAGILSLATLSWLSPLLSVGAQRPLELADIPLLAHKDRAKSCYKAMSAHYERQRLEYPGREPSLTWAILKSFWREAAVNGTFAAVNTIVSYVGPYLISYFVDYLSGNIAFPHEGYILASIFFVAKLLETLTARQWYLGVDIMGIHVKSGLTAMVYRKGLRLSNASRQSHTSGEIVNYMAVDVQRVGDYAWYFHDIWMLPLQIILALAILYKNVGIAMVSTLVATVLSIAASVPVAKLQEHYQDKLMASKDERMRKTSECLKNMRILKLQAWEDRYRLQLEEMRNVECRWLRWALYSQAAVTFVFWSSPIFVAVITFGTCILLGGQLTAGGVLSALATFRILQEPLRNFPDLISMMAQTRVSLDRLSHFLQQEELPDDATINVPQSSTDKAVDIKDGAFSWNPYTLTPTLSDIHLSVVRGMRVAVCGVIGSGKSSLLSSILGEIPKLCGHVRISGTAAYVPQTAWIQSGNIEENILFGSQMDRQRYKRVIAACCLKKDLELLQYGDQTVIGDRGINLSGGQKQRVQLARALYQDADIYLLDDPFSAVDAHTGSELFKEYILTALATKTVIYVTHQVEFLPAADLILVLKDGHITQAGKYDDLLQAGTDFNALVSAHKEAIETMDIFEDSDSDTVSSIPNKRLTPSISNIDNLKNKMCENGQPSNTRGIKEKKKKEERKKKRTVQEEERERGKVSSKVYLSYMGEAYKGTLIPLIILAQTMFQVLQIASNWWMAWANPQTEGDAPKTDSVVLLVVYMSLAFGSSLFVFMRSLLVATFGLAAAQKLFIKMLRCVFRAPMSFFDTTPSGRILNRVSVDQSVVDLDIAFRLGGFASTTIQLLGIVAVMSKVTWQVLILIVPMAVACMWMQRYYIASSRELTRILSVQKSPVIHLFSESIAGAATIRGFGQEKRFMKRNLYLLDCFARPLFSSLAAIEWLCLRMELLSTFVFAFCMAILVSFPPGTIEPSMAGLAVTYGLNLNARMSRWILSFCKLENRIISVERIYQYCRLPSEAPLIIENCRPPSSWPQNGNIELIDLKVRYKDDLPLVLHGVSCMFPGGKKIGIVGRTGSGKSTLIQALFRLIEPTGGKIIIDNIDISAIGLHDLRSRLSIIPQDPTLFEGTIRMNLDPLEECTDQEIWEALEKCQLGEVIRSKEEKLDSPVLENGDNWSVGQRQLIALGRALLKQAKILVLDEATASVDTATDNLIQKIIRSEFKDCTVCTIAHRIPTVIDSDLVLVLSDGKIAEFDTPQRLLEDKSSMFIQLVSEYSTRSSCI