Gene Details:

• Gene ID: Zm00001eb045790
• Gene Symbol: ZmMdh4 mdh4
• Gene Name: malate dehydrogenase4
• Genome: Zm-B73-REFERENCE-NAM-5.0
• Species: Zea mays

Functional Descriptions:

• ZmMdh4 regulates the balance between mitochondrial respiration and glycolysis, ATP production and endosperm development, through a yet unknown feedback regulatory mechanism in mitochondria.
• A regulatory model of ZmMdh4 on storage reserve accumulation in maize.
• ZmMdh4 predominantly catalyzes the conversion from OAA to malate.
• ZmMdh4 affects starch and zein synthesis in the endosperm.
• Here, we characterized a novel naturally occurring maize mdh4-1 mutant, which produces small, opaque kernels and exhibits reduced starch but enhanced lysine content.
• Enzymatic assays demonstrated that ZmMdh4 predominantly catalyses the conversion from OAA to malate.
• Knocking down ZmMdh4 in vivo led to a substantial metabolic shift towards glycolysis and a dramatic disruption in the activity of the mitochondrial complex I, which was correlated with transcriptomic alterations.

Function-related keywords:

• development ,  starch ,  mitochondria ,  endosperm ,  endosperm-development ,  starch-accumulation

Literature:

• Cytosolic malate dehydrogenase 4 modulates cellular energetics and storage reserve accumulation in maize endosperm.   DOI:  10.1111/pbi.13416 ;  PMID:  32436613
• Mining novel kernel size-related genes by pQTL mapping and multi-omics integrative analysis in developing maize kernels.   DOI:  10.1111/pbi.13634 ;  PMID:  34013625
• Multiomics analysis of kernel development in response to short-term heat stress at the grain formation stage in waxy maize.   DOI:  10.1093/jxb/erab286 ;  PMID:  34128533
• SAMBA controls cell division rate during maize development.   DOI:  10.1093/plphys/kiab514 ;  PMID:  34791456

Related News:

• PBJ|河南农业大学汤继华团队揭示玉米胚乳发育新机制

Gene Resources:

• NCBI ID: 542598
• UniProt accessions: Q08062

Sequences:

Source: Genetic information comes from the article