Information report for ZmGSK2;ZmSK1
Gene Details
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Functional Descriptions
- ZmGSK2 was highly and ubiquitously expressed in maize tissues. Heterologous expression of ZmGSK2 carrying a point mutation in Arabidopsis resulted in a stunted growth phenotype, which could be partially rescued by bikinin, a strong activator of BR signaling. Growth responses of maize roots and aerial parts were affected when seedling roots were treated with epibrassinolide or bikinin.
- Our results suggest that ZmGSK2 is the ortholog of BIN2 and plays a critical role in mediating BR signaling. This study highlights the function of BR pathway key member in maize development and site-directed mutation of ZmGSK2 TREE domain, which extends a strategy to manipulate BR signaling in maize.
- In this study, we identified ZmGSK2 as the maize ortholog of BIN2 and point mutation of ZmGSK2 showed a bri1-like phenotype similar with other BR signaling mutants.
- ZmGSK2 is a candidate gene for drought tolerance,involved in BR biosynthesis.
Functional Keywords
Literature and News
Gene Resources
- NCBI ID: Zm00001eb074610
- UniProt accessions: A0A804QLC6
- AlphaFoldDB: A0A804QLC6
- EnsemblPlants: Zm00001eb338190_T001
- Gramene: Zm00001eb338190_T001
- InterPro: IPR000719 , IPR008271 , IPR011009 , IPR017441 , IPR039192 , IPR050591
- PANTHER: PTHR24057 , PTHR24057:SF5
- SUPFAM: SSF56112
- PROSITE: PS00107 , PS00108 , PS50011
- Gene3D: 1.10.510.10 , 3.30.200.20
- OrthoDB: A0A804QLC6
- CDD: cd14137
Sequences
cDNA Sequence
- >Zm00001eb338190_T002
AAGCGAGGCAGGCAGCGGCTGTCCCGAGCTGTCGAAAGCGAGGCGCGGCGGCAGTCCTCGCAGCAGGGCCGACCGGTCAAAAGCACTGCTGCTCCACACCACCCCCACCATCCCTTTCCCCAACCCCCGAAGCCGAGCCAGCGAACCACCCCGCCCGCAGCCGCAAGCAAGCAGCCAAGCAGTGTGAACTGACCGTCCGTTCCGTCCAGCCCACCATGGAGGCGCCGCCGGTACCGGAGCTCATGGATCTGGACGCGCCCCCTCCCGCCGCAGCCGACGCCGCAGCCGCGGCGCCGGTTCCCCCCGCCGTCAGCGACAAGAAGAAGGAAGGGGAAGGGGGAGACACTGTTACGGGTCACATCATCTCCACCACCATCGGTGGGAAGAACGGCGAGCCGAAGCGGACCATCAGTTACATGGCAGAACGTGTCGTGGGTACGGGCTCATTTGGGATCGTCTTCCAGGCTAAGTGTTTGGAGACTGGAGAGACCTTCGCCATTAAGAAGGTGCTGCAGGATCGGCGTTACAAGAACCGGGAGCTGCAACTTATGCGTGCCATGGAGCACCCCAACGTCATCTGCCTGAAGCACTGCTTCTTCTCAACAACGAGCAGGGACGAGTTGTTTCTAAACCTTGTCATGGAATTTGTCCCCGAGACCCTGTACCGTGTCCTGAAGCACTACAGCAACGCGAACCAGAGGATGCCTCTTATCTACGTCAAGCTCTACATGTATCAGCTTTTCAGAGGCCTAGCCTATATTCATAATGTACCAGGAGTCTGCCATAGGGATGTAAAGCCACAAAACGTTTTGGTTGATCCTCTCACCCACCAGGTCAAGCTCTGTGACTTTGGTAGCGCAAAAGTCCTGATTCCTGGTGAACCGAACATATCTTACATATGCTCTCGTTATTATCGTGCTCCAGAGCTCATATTTGGAGCGACGGAGTATACAACTTCAATAGACATATGGTCAGCTGGCTGTGTTCTAGCTGAGTTGCTTCTTGGTCAGCCACTGTTTCCGGGAGAGAGTGCTGTTGATCAGTTGGTAGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAGATACGATGCATGAATCCCAACTATACTGAGTTCAGGTTTCCTCAGATAAAGGCTCATCCGTGGCACAAGATTTTCCACAAGAGAATGCCTCCGGAAGCCATTGACCTTGCTTCCCGTCTCCTTCAGTATTCGCCAAGTCTTCGCTGCTCTGCTCTTGATGCATGCGCTCATCCCTTCTTTGATGAGCTCCGGGCGCCGAATGCACGTCTACCAAACGGCCGTCCATTCCCTCCGCTCTTTAACTTCAAACATGAGCTAGCAAATGCCTCCCCGGACCTCATCAACAGGCTTGTACCGGAGCAGATTAGACGGCAGAACGGTGTCAACTTTGGGCATACCGGGAGCTAGGAGGGCAGGCGGCTGCCATGGTCAAGTTTTTGGTCTTGGTACCCCATGTGCAGGGCCGATTGCAGGTGACGGTGATATTGCTGCACCATCTGGAGAGGAGGGGCTCAGCAGTACCTGAGAGAGCTGAAACTATGTAAATTATCTGACCGCGAAGGAGTACGGCCAGTGTTAAGCCAGTAAACTGGCGCATGTTGGTCCAGAGTAGTTAAGAATGTAGCAGGTGGAGACTGGTAAATGCCTAGGGTCGTTTTTAGTTGTTGTTACTAGTATTTTGTAATGTAATGTTCGTCGGTACTTCCCAGCAGTAGTGTAGCTGCTCATGTTTTGTTCGCCCGTCATGATGTAAATGATCATCACCCAACTGGAACCCCTGTTATCTCGTTACATGCTTAGGCCTCTGATCGTTCCGTAGTTGCTGTGATAGAGCTCTGACAAGTCTGAGCAGGAAAGTGGGTAGGAATTGCTTCTGGTGAAATCTGGACAAGTTTTGTCGAATACAGATGCATCTGCTGATT - >Zm00001eb338190_T001
AAGCGAGGCAGGCAGCGGCTGTCCCGAGCTGTCGAAAGCGAGGCGCGGCGGCAGTCCTCGCAGCAGGGCCGACCGGTCAAAAGCACTGCTGCTCCACACCACCCCCACCATCCCTTTCCCCAACCCCCGAAGCCGAGCCAGCGAACCACCCCGCCCGCAGCCGCAAGCAAGCAGCCAAGCAGTGTGAACTGACCGTCCGTTCCGTCCAGCCCACCATGGAGGCGCCGCCGGTACCGGAGCTCATGGATCTGGACGCGCCCCCTCCCGCCGCAGCCGACGCCGCAGCCGCGGCGCCGGTTCCCCCCGCCGTCAGCGACAAGAAGAAGGAAGGGGAAGGGGGAGACACTGTTACGGGTCACATCATCTCCACCACCATCGGTGGGAAGAACGGCGAGCCGAAGCGGACCATCAGTTACATGGCAGAACGTGTCGTGGGTACGGGCTCATTTGGGATCGTCTTCCAGGCTAAGTGTTTGGAGACTGGAGAGACCTTCGCCATTAAGAAGGTGCTGCAGGATCGGCGTTACAAGAACCGGGAGCTGCAACTTATGCGTGCCATGGAGCACCCCAACGTCATCTGCCTGAAGCACTGCTTCTTCTCAACAACGAGCAGGGACGAGTTGTTTCTAAACCTTGTCATGGAATTTGTCCCCGAGACCCTGTACCGTGTCCTGAAGCACTACAGCAACGCGAACCAGAGGATGCCTCTTATCTACGTCAAGCTCTACATGTATCAGCTTTTCAGAGGCCTAGCCTATATTCATAATGTACCAGGAGTCTGCCATAGGGATGTAAAGCCACAAAACGTTTTGGTTGATCCTCTCACCCACCAGGTCAAGCTCTGTGACTTTGGTAGCGCAAAAGTCCTGATTCCTGGTGAACCGAACATATCTTACATATGCTCTCGTTATTATCGTGCTCCAGAGCTCATATTTGGAGCGACGGAGTATACAACTTCAATAGACATATGGTCAGCTGGCTGTGTTCTAGCTGAGTTGCTTCTTGGTCAGCCACTGTTTCCGGGAGAGAGTGCTGTTGATCAGTTGGTAGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAGATACGATGCATGAATCCCAACTATACTGAGTTCAGGTTTCCTCAGATAAAGGCTCATCCGTGGCACAAGATTTTCCACAAGAGAATGCCTCCGGAAGCCATTGACCTTGCTTCCCGTCTCCTTCAGTATTCGCCAAGTCTTCGCTGCTCTGCTCTTGATGCATGCGCTCATCCCTTCTTTGATGAGCTCCGGGCGCCGAATGCACGTCTACCAAACGGCCGTCCATTCCCTCCGCTCTTTAACTTCAAACATGAGCTAGCAAATGCCTCCCCGGACCTCATCAACAGGCTTGTACCGGAGCAGATTAGACGGCAGAACGGTGTCAACTTTGGGCATACCGGGAGCTAGGAGGGCAGGCGGCTGCCATGGTCAAGTTTTTGGTCTTGGTACCCCATGTGCAGGGCCGATTGCAGGTGACGGTGATATTGCTGCACCATCTGGAGAGGAGGGGCTCAGCAGTACCTGAGAGAGCTGAAACTATGTAAATTATCTGACCGCGAAGGAGTACGGCCAGTGTTAAGCCAGTAAACTGGCGCATGTTGGTCCAGAGTAGTTAAGAATGTAGCAGGTGGAGACTGGTAAATGCCTAGGGTCGTTTTTAGTTGTTGTTACTAGTATTTTGTAATGTAATGTTCGTCGGTACTTCCCAGCAGTAGTGTAGCTGCTCATGTTTTGTTCGCCCGTCATGATGTAAATGATCATCACCCAACTGGAACCCCTGTTATCTCGTTACATGCTTAGGCCTCTGATCGTTCCGTAGTTGCTGTGATAGAGCTCTGACAAGTCTGAGCAGGAAAGTGGGTAGGAATTGCTTCTGGTGAAATCTGGACAAGTTTTGTCGAATACAGATGCATCTGCTGATT - >Zm00001eb338190_T003
AAGCGAGGCAGGCAGCGGCTGTCCCGAGCTGTCGAAAGCGAGGCGCGGCGGCAGTCCTCGCAGCAGGGCCGACCGGTCAAAAGCACTGCTGCTCCACACCACCCCCACCATCCCTTTCCCCAACCCCCGAAGCCGAGCCAGCGAACCACCCCGCCCGCAGCCGCAAGCAAGCAGCCAAGCAGTGTGAACTGACCGTCCGTTCCGTCCAGCCCACCATGGAGGCGCCGCCGGTACCGGAGCTCATGGATCTGGACGCGCCCCCTCCCGCCGCAGCCGACGCCGCAGCCGCGGCGCCGGTTCCCCCCGCCGTCAGCGACAAGAAGAAGGAAGGGGAAGGGGGAGACACTGTTACGGGTCACATCATCTCCACCACCATCGGTGGGAAGAACGGCGAGCCGAAGCGGACCATCAGTTACATGGCAGAACGTGTCGTGGGTACGGGCTCATTTGGGATCGTCTTCCAGGCTAAGTGTTTGGAGACTGGAGAGACCTTCGCCATTAAGAAGGTGCTGCAGGATCGGCGTTACAAGAACCGGGAGCTGCAACTTATGCGTGCCATGGAGCACCCCAACGTCATCTGCCTGAAGCACTGCTTCTTCTCAACAACGAGCAGGGACGAGTTGTTTCTAAACCTTGTCATGGAATTTGTCCCCGAGACCCTGTACCGTGTCCTGAAGCACTACAGCAACGCGAACCAGAGGATGCCTCTTATCTACGTCAAGCTCTACATGTATCAGCTTTTCAGAGGCCTAGCCTATATTCATAATGTACCAGGAGTCTGCCATAGGGATGTAAAGCCACAAAACGTTTTGGTTGATCCTCTCACCCACCAGGTCAAGCTCTGTGACTTTGGTAGCGCAAAAGTCCTGATTCCTGGTGAACCGAACATATCTTACATATGCTCTCGTTATTATCGTGCTCCAGAGCTCATATTTGGAGCGACGGAGTATACAACTTCAATAGACATATGGTCAGCTGGCTGTGTTCTAGCTGAGTTGCTTCTTGGTCAGCCACTGTTTCCGGGAGAGAGTGCTGTTGATCAGTTGGTAGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAGATACGATGCATGAATCCCAACTATACTGAGTTCAGGTTTCCTCAGATAAAGGCTCATCCGTGGCACAAGATTTTCCACAAGAGAATGCCTCCGGAAGCCATTGACCTTGCTTCCCGTCTCCTTCAGTATTCGCCAAGTCTTCGCTGCTCTGCTCTTGATGCATGCGCTCATCCCTTCTTTGATGAGCTCCGGGCGCCGAATGCACGTCTACCAAACGGCCGTCCATTCCCTCCGCTCTTTAACTTCAAACATGAGCTAGCAAATGCCTCCCCGGACCTCATCAACAGGCTTGTACCGGAGCAGATTAGACGGCAGAACGGTGTCAACTTTGGGCATACCGGGAGCTAGGAGGGCAGGCGGCTGCCATGGTCAAGTTTTTGGTCTTGGTACCCCATGTGCAGGGCCGATTGCAGGTGACGGTGATATTGCTGCACCATCTGGAGAGGAGGGGCTCAGCAGTACCTGAGAGAGCTGAAACTATGTAAATTATCTGACCGCGAAGGAGTACGGCCAGTGTTAAGCCAGTAAACTGGCGCATGTTGGTCCAGAGTAGTTAAGAATGTAGCAGGTGGAGACTGGTAAATGCCTAGGGTCGTTTTTAGTTGTTGTTACTAGTATTTTGTAATGTAATGTTCGTCGGTACTTCCCAGCAGTAGTGTAGCTGCTCATGTTTTGTTCGCCCGTCATGATGTAAATGATCATCACCCAACTGGAACCCCTGTTATCTCGTTACATGCTTAGGCCTCTGATCGTTCCGTAGTTGCTGTGATAGAGCTCTGACAAGTCTGAGCAGGAAAGTGGGTAGGAATTGCTTCTGGTGAAATCTGGACAAGTTTTGTCGAATACAGATGCATCTGCTGATT
CDS Sequence
- >Zm00001eb338190_T002
ATGGAGGCGCCGCCGGTACCGGAGCTCATGGATCTGGACGCGCCCCCTCCCGCCGCAGCCGACGCCGCAGCCGCGGCGCCGGTTCCCCCCGCCGTCAGCGACAAGAAGAAGGAAGGGGAAGGGGGAGACACTGTTACGGGTCACATCATCTCCACCACCATCGGTGGGAAGAACGGCGAGCCGAAGCGGACCATCAGTTACATGGCAGAACGTGTCGTGGGTACGGGCTCATTTGGGATCGTCTTCCAGGCTAAGTGTTTGGAGACTGGAGAGACCTTCGCCATTAAGAAGGTGCTGCAGGATCGGCGTTACAAGAACCGGGAGCTGCAACTTATGCGTGCCATGGAGCACCCCAACGTCATCTGCCTGAAGCACTGCTTCTTCTCAACAACGAGCAGGGACGAGTTGTTTCTAAACCTTGTCATGGAATTTGTCCCCGAGACCCTGTACCGTGTCCTGAAGCACTACAGCAACGCGAACCAGAGGATGCCTCTTATCTACGTCAAGCTCTACATGTATCAGCTTTTCAGAGGCCTAGCCTATATTCATAATGTACCAGGAGTCTGCCATAGGGATGTAAAGCCACAAAACGTTTTGGTTGATCCTCTCACCCACCAGGTCAAGCTCTGTGACTTTGGTAGCGCAAAAGTCCTGATTCCTGGTGAACCGAACATATCTTACATATGCTCTCGTTATTATCGTGCTCCAGAGCTCATATTTGGAGCGACGGAGTATACAACTTCAATAGACATATGGTCAGCTGGCTGTGTTCTAGCTGAGTTGCTTCTTGGTCAGCCACTGTTTCCGGGAGAGAGTGCTGTTGATCAGTTGGTAGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAGATACGATGCATGAATCCCAACTATACTGAGTTCAGGTTTCCTCAGATAAAGGCTCATCCGTGGCACAAGATTTTCCACAAGAGAATGCCTCCGGAAGCCATTGACCTTGCTTCCCGTCTCCTTCAGTATTCGCCAAGTCTTCGCTGCTCTGCTCTTGATGCATGCGCTCATCCCTTCTTTGATGAGCTCCGGGCGCCGAATGCACGTCTACCAAACGGCCGTCCATTCCCTCCGCTCTTTAACTTCAAACATGAGCTAGCAAATGCCTCCCCGGACCTCATCAACAGGCTTGTACCGGAGCAGATTAGACGGCAGAACGGTGTCAACTTTGGGCATACCGGGAGCTAG - >Zm00001eb338190_T001
ATGGAGGCGCCGCCGGTACCGGAGCTCATGGATCTGGACGCGCCCCCTCCCGCCGCAGCCGACGCCGCAGCCGCGGCGCCGGTTCCCCCCGCCGTCAGCGACAAGAAGAAGGAAGGGGAAGGGGGAGACACTGTTACGGGTCACATCATCTCCACCACCATCGGTGGGAAGAACGGCGAGCCGAAGCGGACCATCAGTTACATGGCAGAACGTGTCGTGGGTACGGGCTCATTTGGGATCGTCTTCCAGGCTAAGTGTTTGGAGACTGGAGAGACCTTCGCCATTAAGAAGGTGCTGCAGGATCGGCGTTACAAGAACCGGGAGCTGCAACTTATGCGTGCCATGGAGCACCCCAACGTCATCTGCCTGAAGCACTGCTTCTTCTCAACAACGAGCAGGGACGAGTTGTTTCTAAACCTTGTCATGGAATTTGTCCCCGAGACCCTGTACCGTGTCCTGAAGCACTACAGCAACGCGAACCAGAGGATGCCTCTTATCTACGTCAAGCTCTACATGTATCAGCTTTTCAGAGGCCTAGCCTATATTCATAATGTACCAGGAGTCTGCCATAGGGATGTAAAGCCACAAAACGTTTTGGTTGATCCTCTCACCCACCAGGTCAAGCTCTGTGACTTTGGTAGCGCAAAAGTCCTGATTCCTGGTGAACCGAACATATCTTACATATGCTCTCGTTATTATCGTGCTCCAGAGCTCATATTTGGAGCGACGGAGTATACAACTTCAATAGACATATGGTCAGCTGGCTGTGTTCTAGCTGAGTTGCTTCTTGGTCAGCCACTGTTTCCGGGAGAGAGTGCTGTTGATCAGTTGGTAGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAGATACGATGCATGAATCCCAACTATACTGAGTTCAGGTTTCCTCAGATAAAGGCTCATCCGTGGCACAAGATTTTCCACAAGAGAATGCCTCCGGAAGCCATTGACCTTGCTTCCCGTCTCCTTCAGTATTCGCCAAGTCTTCGCTGCTCTGCTCTTGATGCATGCGCTCATCCCTTCTTTGATGAGCTCCGGGCGCCGAATGCACGTCTACCAAACGGCCGTCCATTCCCTCCGCTCTTTAACTTCAAACATGAGCTAGCAAATGCCTCCCCGGACCTCATCAACAGGCTTGTACCGGAGCAGATTAGACGGCAGAACGGTGTCAACTTTGGGCATACCGGGAGCTAG - >Zm00001eb338190_T003
ATGGAGGCGCCGCCGGTACCGGAGCTCATGGATCTGGACGCGCCCCCTCCCGCCGCAGCCGACGCCGCAGCCGCGGCGCCGGTTCCCCCCGCCGTCAGCGACAAGAAGAAGGAAGGGGAAGGGGGAGACACTGTTACGGGTCACATCATCTCCACCACCATCGGTGGGAAGAACGGCGAGCCGAAGCGGACCATCAGTTACATGGCAGAACGTGTCGTGGGTACGGGCTCATTTGGGATCGTCTTCCAGGCTAAGTGTTTGGAGACTGGAGAGACCTTCGCCATTAAGAAGGTGCTGCAGGATCGGCGTTACAAGAACCGGGAGCTGCAACTTATGCGTGCCATGGAGCACCCCAACGTCATCTGCCTGAAGCACTGCTTCTTCTCAACAACGAGCAGGGACGAGTTGTTTCTAAACCTTGTCATGGAATTTGTCCCCGAGACCCTGTACCGTGTCCTGAAGCACTACAGCAACGCGAACCAGAGGATGCCTCTTATCTACGTCAAGCTCTACATGTATCAGCTTTTCAGAGGCCTAGCCTATATTCATAATGTACCAGGAGTCTGCCATAGGGATGTAAAGCCACAAAACGTTTTGGTTGATCCTCTCACCCACCAGGTCAAGCTCTGTGACTTTGGTAGCGCAAAAGTCCTGATTCCTGGTGAACCGAACATATCTTACATATGCTCTCGTTATTATCGTGCTCCAGAGCTCATATTTGGAGCGACGGAGTATACAACTTCAATAGACATATGGTCAGCTGGCTGTGTTCTAGCTGAGTTGCTTCTTGGTCAGCCACTGTTTCCGGGAGAGAGTGCTGTTGATCAGTTGGTAGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAGATACGATGCATGAATCCCAACTATACTGAGTTCAGGTTTCCTCAGATAAAGGCTCATCCGTGGCACAAGATTTTCCACAAGAGAATGCCTCCGGAAGCCATTGACCTTGCTTCCCGTCTCCTTCAGTATTCGCCAAGTCTTCGCTGCTCTGCTCTTGATGCATGCGCTCATCCCTTCTTTGATGAGCTCCGGGCGCCGAATGCACGTCTACCAAACGGCCGTCCATTCCCTCCGCTCTTTAACTTCAAACATGAGCTAGCAAATGCCTCCCCGGACCTCATCAACAGGCTTGTACCGGAGCAGATTAGACGGCAGAACGGTGTCAACTTTGGGCATACCGGGAGCTAG
Protein Sequence
- >Zm00001eb338190_P002
MEAPPVPELMDLDAPPPAAADAAAAAPVPPAVSDKKKEGEGGDTVTGHIISTTIGGKNGEPKRTISYMAERVVGTGSFGIVFQAKCLETGETFAIKKVLQDRRYKNRELQLMRAMEHPNVICLKHCFFSTTSRDELFLNLVMEFVPETLYRVLKHYSNANQRMPLIYVKLYMYQLFRGLAYIHNVPGVCHRDVKPQNVLVDPLTHQVKLCDFGSAKVLIPGEPNISYICSRYYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGESAVDQLVEIIKVLGTPTREEIRCMNPNYTEFRFPQIKAHPWHKIFHKRMPPEAIDLASRLLQYSPSLRCSALDACAHPFFDELRAPNARLPNGRPFPPLFNFKHELANASPDLINRLVPEQIRRQNGVNFGHTGS - >Zm00001eb338190_P001
MEAPPVPELMDLDAPPPAAADAAAAAPVPPAVSDKKKEGEGGDTVTGHIISTTIGGKNGEPKRTISYMAERVVGTGSFGIVFQAKCLETGETFAIKKVLQDRRYKNRELQLMRAMEHPNVICLKHCFFSTTSRDELFLNLVMEFVPETLYRVLKHYSNANQRMPLIYVKLYMYQLFRGLAYIHNVPGVCHRDVKPQNVLVDPLTHQVKLCDFGSAKVLIPGEPNISYICSRYYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGESAVDQLVEIIKVLGTPTREEIRCMNPNYTEFRFPQIKAHPWHKIFHKRMPPEAIDLASRLLQYSPSLRCSALDACAHPFFDELRAPNARLPNGRPFPPLFNFKHELANASPDLINRLVPEQIRRQNGVNFGHTGS - >Zm00001eb338190_P003
MEAPPVPELMDLDAPPPAAADAAAAAPVPPAVSDKKKEGEGGDTVTGHIISTTIGGKNGEPKRTISYMAERVVGTGSFGIVFQAKCLETGETFAIKKVLQDRRYKNRELQLMRAMEHPNVICLKHCFFSTTSRDELFLNLVMEFVPETLYRVLKHYSNANQRMPLIYVKLYMYQLFRGLAYIHNVPGVCHRDVKPQNVLVDPLTHQVKLCDFGSAKVLIPGEPNISYICSRYYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGESAVDQLVEIIKVLGTPTREEIRCMNPNYTEFRFPQIKAHPWHKIFHKRMPPEAIDLASRLLQYSPSLRCSALDACAHPFFDELRAPNARLPNGRPFPPLFNFKHELANASPDLINRLVPEQIRRQNGVNFGHTGS