Gene Details:

• Gene ID: Zm00001eb001260
• Gene Symbol: ZmCDKA2 CDKA1 cdc2
• Gene Name: cell division control protein homolog2
• Genome: Zm-B73-REFERENCE-NAM-5.0
• Species: Zea mays

Functional Descriptions:

• We studied maize CDKA2;1a and CDKB1;1, two of the main types of CDKs that control the cell cycle in plants. These kinases could be activated by the classical mechanism and by the association of CycD2;2a to a phosphorylated intermediate in its activation loop, a previously unproven mechanism for the activation of plant CDKs.
• As a positive control of phosphatase activity and antibody recognition, CDKA2;1a phosphorylated at T161 in complex with CycD2;2a was included in treatments.
• These experiments show that CDKA2;1a can be activated by at least two mechanisms, the classic one in which CDKA2;1a associates with CycD2;2a, provoking a partial activation; then, CDK in the complex can be efficiently phosphorylated by Cak1p, causing total activation of CDK.

Function-related keywords:

• cell-cycle ,  phosphatase

Literature:

• Maize CDKA2;1a and CDKB1;1 kinases have different requirements for their activation and participate in substrate recognition.   DOI:  10.1111/febs.16659 ;  PMID:  36259272

Related News:

Gene Resources:

• NCBI ID: LOC542270
• UniProt accessions: A0A1D6JLC2 ,  B6TA79

Sequences:

Source: Genetic information comes from the article