Information report for ZmBiP1;ZmHsp70-11
Gene Details
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Functional Descriptions
- Maize ZmBiP1 plays a role in heat stress tolerance.
- The expression levels of ER stress-responsive marker genes, including ZmBiP1 (BINDING PROTEIN 1), ZmBiP2, ZmPDIL1-1 (PROTEIN DISULFIDE ISOMERASE-LIKE PROTEIN 1-1), ZmPDIL2-2, ZmCNX1 (CALNEXIN) and ZmCRT1a (CALRETICULIN 1a).
- the comparative transcriptome analysis revealed specific functions of the ZmMs33 gene in impairing the expression of ROS-related genes.
Functional Keywords
Literature and News
Gene Resources
- NCBI ID: ZmBiP1
- UniProt accessions: P24067
- EMBL: M59449 , U58208
- AlphaFoldDB: P24067
- EnsemblPlants: Zm00001eb229930_T002
- Gramene: Zm00001eb229930_T002
- KEGG: zma:732808
- OMA: GHEVEHA
- ExpressionAtlas: Zm00001eb229930
- InterPro: IPR013126 , IPR018181 , IPR029047 , IPR029048 , IPR042050 , IPR043129
- PANTHER: PTHR19375
- SUPFAM: SSF100920 , SSF100934 , SSF53067
- PROSITE: PS00014 , PS00297 , PS00329 , PS01036
- Gene3D: 1.20.1270.10 , 2.60.34.10 , 3.30.420.40 , 3.90.640.10
- OrthoDB: P24067
- SMR: P24067
- CDD: cd10241
Sequences
cDNA Sequence
- >Zm00001eb229930_T001
AAAAGCCGTCCCTCCGTCTCCGTCTCTCCATCAGACAGACGCAGACTCTCTCACCCGACTCGTCAGACGTCAGCCAGCAGTTCGAAACCAAGGATTGATCCAGGAGCTTCCGGAAGGCGAGGCGCGCGCGCAGCGTCGAGGTGCTGGTGCCGGTGCCGCCCATGGATCGGGCTCGCGGATCCGCGTTCCTGCTCGGCGTCCTGCTCGCAGGATCCTTGTTCGCGTTTTCAGTTGCCAAAGAGGAGACCAAGAAGCTCGGGACCGTGATCGGTATCGATCTCGGTACCACCTACTCCTGTGTCGGTGTGTACAAGAACGGTCATGTCGAGATCATCGCCAATGACCAGGGTAACCGTATCACACCCTCATGGGTTGCCTTCACCGATAGCGAGAGGCTCATCGGTGAGGCTGCCAAGAACCAGGCAGCCGTCAACCCTGAGAGGACCATCTTTGACGTCAAGCGTCTCATCGGAAGAAAGTTCGCGGACAAGGAAGTCCAGAGGGACATGAAACTTGTTCCCTACAAGATTATTAACAAGGATGGCAAGCCCTACATTCAGGTCAAGATCAAGGATGGGGAGAACAAGGTCTTCAGCCCTGAGGAGATCAGTGCCATGATTCTTGGCAAGATGAAGGATACTGCTGAGGCATACCTTGGCAAGAAGATCAATGATGCTGTCGTCACTGTTCCTGCGTACTTCAATGATGCGCAGAGGCAGGCAACCAAGGATGCTGGTGTCATTGCCGGCCTCAATGTTGCTAGGATCATCAATGAGCCAACTGCTGCTGCTATTGCCTATGGTTTGGACAAGAAGGGTGGCGAGAAGAACATCCTTGTCTTTGACCTTGGTGGTGGTACTTTTGATGTCAGTATCTTGACCATTGACAACGGTGTGTTTGAGGTGCTGGCCACCAATGGTGACACTCATCTTGGAGGTGAGGACTTTGACCAGAGGATCATGGAGTACTTCATCAAGTTGATCAAGAAGAAGTACAGCAAGGACATCAGCAAGGACAACCGTGCTCTTGGAAAGCTGAGGAGGGAAGCCGAGCGCGCCAAGAGAGCCCTCAGCAACCAGCACCAGGTCCGTGTTGAGATCGAGTCCCTCTTTGACGGGACCGATTTCTCGGAGCCGCTGACCCGTGCCAGGTTTGAGGAGCTGAACAACGACCTCTTCCGCAAGACCATGGGCCCTGTCAAGAAGGCCATGGAGGATGCTGGCCTTGAGAAGAGCCAGATCCATGAGATCGTCCTGGTTGGTGGAAGCACCAGGATTCCCAAGGTCCAGCAGCTCCTGCGGGACTACTTCGACGGCAAGGAGCCCAACAAGGGTGTCAACCCTGATGAGGCTGTTGCCTTTGGTGCCGCTGTGCAGGGAAGCATCTTGAGCGGCGAGGGTGGTGACGAGACCAAAGATATCCTCCTCCTTGATGTGGCTCCCCTCACCCTGGGTATCGAGACCGTCGGTGGAGTCATGACCAAGTTGATCCCGAGGAACACTGTCATCCCGACCAAGAAGTCGCAGGTGTTCACCACCTACCAGGACCAGCAGACCACTGTCTCCATCCAGGTCTTTGAGGGTGAGCGCAGTATGACCAAGGACTGCCGTCTTCTCGGCAAGTTCGACCTCAACGGCATTGCGCCAGCTCCAAGGGGCACACCCCAGATCGAGGTGACCTTCGAGGTGGACGCCAACGGTATCCTAAACGTGAAGATCACGATCACGAACGAGAAGGGGCGGCTGAGCCAGGAGGAGATCGACCGCATGGTGCGGGAGGCGGAGGAGTTCGCGGAGGAGGACAAGAAGGTGAAGGAGCGGATCGACGCCCGCAACCAGCTGGAGACGTACGTGTACAACATGAAGAACACGGTGGGCGACAAGGACAAGCTCGCGGACAAGCTGGAGGCGGAGGAGAAGGAGAAGGTGGAGGAGGCCCTCAAGGAGGCGCTGGAGTGGCTGGACGACAACCAGTCGGCCGAGAAGGAGGACTACGAGGAGAAGCTCAAGGAGGTGGAGGCCGTGTGCAACCCCATCGTGTCGGCCGTGTACCAGCGGTCGGGCGGCGCCCCTGGCGGTGACGCTGACGGCGGTGTTGACGACGACCACGACGAGCTGTAGATGGTTGTAGATGGTGGTGGTGACGTGGAGTGCCGGGAGCCGAGCCAAATTTTGTAACGGTGTTTAGCGGCGGACAATACTTATTACTAATCTTGGTGCTGCTCTGCCAATAGCCGTGCTGAGCGTAGTAACTGTTTGTTTGTAATTTTTTTTCTTCTACTTCCTTGGTTGTTCAGGATTCGCATTCGAATTTTATGTGAAAAAAAGAAGGCGCGCTTTTAAAATCTTGCATTTGCCCCCTTGTGGTAATAATGCTAATTAAATGGTGCAAAGTAGATTGCTTGTGACTGGGTTTCGTGTGAGTTGGGATGTTAGATTTGAATGAGTTCTTCAAGAGATTCTCATCCATACCACCATTTTAGGTGCAATTTTAATCTATTCACTACTTTTTCTTCGAGTTGTCATTATTGCCCCACAATCAACTTTTTCAAAGTGCAGACTTGGGAACAGATTAGAGTTCAGAATATTTTATCAAGAGCACAGTGTTTATTTATAGTTTACTTCGACCCTATTCTGTTGTCGTTTTAGCCATTTATTACATGGAATAAGGATTAAA - >Zm00001eb229930_T002
AAAAGCCGTCCCTCCGTCTCCGTCTCTCCATCAGACAGACGCAGACTCTCTCACCCGACTCGTCAGACGTCAGCCAGCAGTTCGAAACCAAGGATTGATCCAGGAGCTTCCGGAAGGCGAGGCGCGCGCGCAGCGTCGAGGTGCTGGTGCCGGTGCCGCCCATGGATCGGGCTCGCGGATCCGCGTTCCTGCTCGGCGTCCTGCTCGCAGGATCCTTGTTCGCGTTTTCAGTTGCCAAAGAGGAGACCAAGAAGCTCGGGACCGTGATCGGTATCGATCTCGGTACCACCTACTCCTGTGTCGGTGTGTACAAGAACGGTCATGTCGAGATCATCGCCAATGACCAGGGTAACCGTATCACACCCTCATGGGTTGCCTTCACCGATAGCGAGAGGCTCATCGGTGAGGCTGCCAAGAACCAGGCAGCCGTCAACCCTGAGAGGACCATCTTTGACGTCAAGCGTCTCATCGGAAGAAAGTTCGCGGACAAGGAAGTCCAGAGGGACATGAAACTTGTTCCCTACAAGATTATTAACAAGGATGGCAAGCCCTACATTCAGGTCAAGATCAAGGATGGGGAGAACAAGGTCTTCAGCCCTGAGGAGATCAGTGCCATGATTCTTGGCAAGATGAAGGATACTGCTGAGGCATACCTTGGCAAGAAGATCAATGATGCTGTCGTCACTGTTCCTGCGTACTTCAATGATGCGCAGAGGCAGGCAACCAAGGATGCTGGTGTCATTGCCGGCCTCAATGTTGCTAGGATCATCAATGAGCCAACTGCTGCTGCTATTGCCTATGGTTTGGACAAGAAGGGTGGCGAGAAGAACATCCTTGTCTTTGACCTTGGTGGTGGTACTTTTGATGTCAGTATCTTGACCATTGACAACGGTGTGTTTGAGGTGCTGGCCACCAATGGTGACACTCATCTTGGAGGTGAGGACTTTGACCAGAGGATCATGGAGTACTTCATCAAGTTGATCAAGAAGAAGTACAGCAAGGACATCAGCAAGGACAACCGTGCTCTTGGAAAGCTGAGGAGGGAAGCCGAGCGCGCCAAGAGAGCCCTCAGCAACCAGCACCAGGTCCGTGTTGAGATCGAGTCCCTCTTTGACGGGACCGATTTCTCGGAGCCGCTGACCCGTGCCAGGTTTGAGGAGCTGAACAACGACCTCTTCCGCAAGACCATGGGCCCTGTCAAGAAGGCCATGGAGGATGCTGGCCTTGAGAAGAGCCAGATCCATGAGATCGTCCTGGTTGGTGGAAGCACCAGGATTCCCAAGGTCCAGCAGCTCCTGCGGGACTACTTCGACGGCAAGGAGCCCAACAAGGGTGTCAACCCTGATGAGGCTGTTGCCTTTGGTGCCGCTGTGCAGGGAAGCATCTTGAGCGGCGAGGGTGGTGACGAGACCAAAGATATCCTCCTCCTTGATGTGGCTCCCCTCACCCTGGGTATCGAGACCGTCGGTGGAGTCATGACCAAGTTGATCCCGAGGAACACTGTCATCCCGACCAAGAAGTCGCAGGTGTTCACCACCTACCAGGACCAGCAGACCACTGTCTCCATCCAGGTCTTTGAGGGTGAGCGCAGTATGACCAAGGACTGCCGTCTTCTCGGCAAGTTCGACCTCAACGGCATTGCGCCAGCTCCAAGGGGCACACCCCAGATCGAGGTGACCTTCGAGGTGGACGCCAACGGTATCCTAAACGTGAAGATCACGATCACGAACGAGAAGGGGCGGCTGAGCCAGGAGGAGATCGACCGCATGGTGCGGGAGGCGGAGGAGTTCGCGGAGGAGGACAAGAAGGTGAAGGAGCGGATCGACGCCCGCAACCAGCTGGAGACGTACGTGTACAACATGAAGAACACGGTGGGCGACAAGGACAAGCTCGCGGACAAGCTGGAGGCGGAGGAGAAGGAGAAGGTGGAGGAGGCCCTCAAGGAGGCGCTGGAGTGGCTGGACGACAACCAGTCGGCCGAGAAGGAGGACTACGAGGAGAAGCTCAAGGAGGTGGAGGCCGTGTGCAACCCCATCGTGTCGGCCGTGTACCAGCGGTCGGGCGGCGCCCCTGGCGGTGACGCTGACGGCGGTGTTGACGACGACCACGACGAGCTGTAGATGGTTGTAGATGGTGGTGGTGACGTGGAGTGCCGGGAGCCGAGCCAAATTTTGTAACGGTGTTTAGCGGCGGACAATACTTATTACTAATCTTGGTGCTGCTCTGCCAATAGCCGTGCTGAGCGTAGTAACTGTTTGTTTGTAATTTTTTTTCTTCTACTTCCTTGGTTGTTCAGGATTCGCATTCGAATTTTATGTGAAAAAAAGAAGGCGCGCTTTTAAAATCTTGCATTTGCCCCCTTGTGGTAATAATGCTAATTAAATGGTGCAAAGTAGATTGCTTGTGACTGGGTTTCGTGTGAGTTGGGATGTTAGATTTGAATGAGTTCTTCAAGAGATTCTCATCCATACCACCATTTTAGGTGCAATTTTAATCTATTCACTACTTTTTCTTCGAGTTGTCATTATTGCCCCACAATCAACTTTTTCAAAGTGCAGACTTGGGAACAGATTAGAGTTCAGAATATTTTATCAAGAGCACAGTGTTTATTTATAGTTTACTTCGACCCTATTCTGTTGTCGTTTTAGCCATTTATTACATGGAATAAGGATTAAA
CDS Sequence
- >Zm00001eb229930_T001
ATGGATCGGGCTCGCGGATCCGCGTTCCTGCTCGGCGTCCTGCTCGCAGGATCCTTGTTCGCGTTTTCAGTTGCCAAAGAGGAGACCAAGAAGCTCGGGACCGTGATCGGTATCGATCTCGGTACCACCTACTCCTGTGTCGGTGTGTACAAGAACGGTCATGTCGAGATCATCGCCAATGACCAGGGTAACCGTATCACACCCTCATGGGTTGCCTTCACCGATAGCGAGAGGCTCATCGGTGAGGCTGCCAAGAACCAGGCAGCCGTCAACCCTGAGAGGACCATCTTTGACGTCAAGCGTCTCATCGGAAGAAAGTTCGCGGACAAGGAAGTCCAGAGGGACATGAAACTTGTTCCCTACAAGATTATTAACAAGGATGGCAAGCCCTACATTCAGGTCAAGATCAAGGATGGGGAGAACAAGGTCTTCAGCCCTGAGGAGATCAGTGCCATGATTCTTGGCAAGATGAAGGATACTGCTGAGGCATACCTTGGCAAGAAGATCAATGATGCTGTCGTCACTGTTCCTGCGTACTTCAATGATGCGCAGAGGCAGGCAACCAAGGATGCTGGTGTCATTGCCGGCCTCAATGTTGCTAGGATCATCAATGAGCCAACTGCTGCTGCTATTGCCTATGGTTTGGACAAGAAGGGTGGCGAGAAGAACATCCTTGTCTTTGACCTTGGTGGTGGTACTTTTGATGTCAGTATCTTGACCATTGACAACGGTGTGTTTGAGGTGCTGGCCACCAATGGTGACACTCATCTTGGAGGTGAGGACTTTGACCAGAGGATCATGGAGTACTTCATCAAGTTGATCAAGAAGAAGTACAGCAAGGACATCAGCAAGGACAACCGTGCTCTTGGAAAGCTGAGGAGGGAAGCCGAGCGCGCCAAGAGAGCCCTCAGCAACCAGCACCAGGTCCGTGTTGAGATCGAGTCCCTCTTTGACGGGACCGATTTCTCGGAGCCGCTGACCCGTGCCAGGTTTGAGGAGCTGAACAACGACCTCTTCCGCAAGACCATGGGCCCTGTCAAGAAGGCCATGGAGGATGCTGGCCTTGAGAAGAGCCAGATCCATGAGATCGTCCTGGTTGGTGGAAGCACCAGGATTCCCAAGGTCCAGCAGCTCCTGCGGGACTACTTCGACGGCAAGGAGCCCAACAAGGGTGTCAACCCTGATGAGGCTGTTGCCTTTGGTGCCGCTGTGCAGGGAAGCATCTTGAGCGGCGAGGGTGGTGACGAGACCAAAGATATCCTCCTCCTTGATGTGGCTCCCCTCACCCTGGGTATCGAGACCGTCGGTGGAGTCATGACCAAGTTGATCCCGAGGAACACTGTCATCCCGACCAAGAAGTCGCAGGTGTTCACCACCTACCAGGACCAGCAGACCACTGTCTCCATCCAGGTCTTTGAGGGTGAGCGCAGTATGACCAAGGACTGCCGTCTTCTCGGCAAGTTCGACCTCAACGGCATTGCGCCAGCTCCAAGGGGCACACCCCAGATCGAGGTGACCTTCGAGGTGGACGCCAACGGTATCCTAAACGTGAAGATCACGATCACGAACGAGAAGGGGCGGCTGAGCCAGGAGGAGATCGACCGCATGGTGCGGGAGGCGGAGGAGTTCGCGGAGGAGGACAAGAAGGTGAAGGAGCGGATCGACGCCCGCAACCAGCTGGAGACGTACGTGTACAACATGAAGAACACGGTGGGCGACAAGGACAAGCTCGCGGACAAGCTGGAGGCGGAGGAGAAGGAGAAGGTGGAGGAGGCCCTCAAGGAGGCGCTGGAGTGGCTGGACGACAACCAGTCGGCCGAGAAGGAGGACTACGAGGAGAAGCTCAAGGAGGTGGAGGCCGTGTGCAACCCCATCGTGTCGGCCGTGTACCAGCGGTCGGGCGGCGCCCCTGGCGGTGACGCTGACGGCGGTGTTGACGACGACCACGACGAGCTGTAG - >Zm00001eb229930_T002
ATGGATCGGGCTCGCGGATCCGCGTTCCTGCTCGGCGTCCTGCTCGCAGGATCCTTGTTCGCGTTTTCAGTTGCCAAAGAGGAGACCAAGAAGCTCGGGACCGTGATCGGTATCGATCTCGGTACCACCTACTCCTGTGTCGGTGTGTACAAGAACGGTCATGTCGAGATCATCGCCAATGACCAGGGTAACCGTATCACACCCTCATGGGTTGCCTTCACCGATAGCGAGAGGCTCATCGGTGAGGCTGCCAAGAACCAGGCAGCCGTCAACCCTGAGAGGACCATCTTTGACGTCAAGCGTCTCATCGGAAGAAAGTTCGCGGACAAGGAAGTCCAGAGGGACATGAAACTTGTTCCCTACAAGATTATTAACAAGGATGGCAAGCCCTACATTCAGGTCAAGATCAAGGATGGGGAGAACAAGGTCTTCAGCCCTGAGGAGATCAGTGCCATGATTCTTGGCAAGATGAAGGATACTGCTGAGGCATACCTTGGCAAGAAGATCAATGATGCTGTCGTCACTGTTCCTGCGTACTTCAATGATGCGCAGAGGCAGGCAACCAAGGATGCTGGTGTCATTGCCGGCCTCAATGTTGCTAGGATCATCAATGAGCCAACTGCTGCTGCTATTGCCTATGGTTTGGACAAGAAGGGTGGCGAGAAGAACATCCTTGTCTTTGACCTTGGTGGTGGTACTTTTGATGTCAGTATCTTGACCATTGACAACGGTGTGTTTGAGGTGCTGGCCACCAATGGTGACACTCATCTTGGAGGTGAGGACTTTGACCAGAGGATCATGGAGTACTTCATCAAGTTGATCAAGAAGAAGTACAGCAAGGACATCAGCAAGGACAACCGTGCTCTTGGAAAGCTGAGGAGGGAAGCCGAGCGCGCCAAGAGAGCCCTCAGCAACCAGCACCAGGTCCGTGTTGAGATCGAGTCCCTCTTTGACGGGACCGATTTCTCGGAGCCGCTGACCCGTGCCAGGTTTGAGGAGCTGAACAACGACCTCTTCCGCAAGACCATGGGCCCTGTCAAGAAGGCCATGGAGGATGCTGGCCTTGAGAAGAGCCAGATCCATGAGATCGTCCTGGTTGGTGGAAGCACCAGGATTCCCAAGGTCCAGCAGCTCCTGCGGGACTACTTCGACGGCAAGGAGCCCAACAAGGGTGTCAACCCTGATGAGGCTGTTGCCTTTGGTGCCGCTGTGCAGGGAAGCATCTTGAGCGGCGAGGGTGGTGACGAGACCAAAGATATCCTCCTCCTTGATGTGGCTCCCCTCACCCTGGGTATCGAGACCGTCGGTGGAGTCATGACCAAGTTGATCCCGAGGAACACTGTCATCCCGACCAAGAAGTCGCAGGTGTTCACCACCTACCAGGACCAGCAGACCACTGTCTCCATCCAGGTCTTTGAGGGTGAGCGCAGTATGACCAAGGACTGCCGTCTTCTCGGCAAGTTCGACCTCAACGGCATTGCGCCAGCTCCAAGGGGCACACCCCAGATCGAGGTGACCTTCGAGGTGGACGCCAACGGTATCCTAAACGTGAAGATCACGATCACGAACGAGAAGGGGCGGCTGAGCCAGGAGGAGATCGACCGCATGGTGCGGGAGGCGGAGGAGTTCGCGGAGGAGGACAAGAAGGTGAAGGAGCGGATCGACGCCCGCAACCAGCTGGAGACGTACGTGTACAACATGAAGAACACGGTGGGCGACAAGGACAAGCTCGCGGACAAGCTGGAGGCGGAGGAGAAGGAGAAGGTGGAGGAGGCCCTCAAGGAGGCGCTGGAGTGGCTGGACGACAACCAGTCGGCCGAGAAGGAGGACTACGAGGAGAAGCTCAAGGAGGTGGAGGCCGTGTGCAACCCCATCGTGTCGGCCGTGTACCAGCGGTCGGGCGGCGCCCCTGGCGGTGACGCTGACGGCGGTGTTGACGACGACCACGACGAGCTGTAG
Protein Sequence
- >Zm00001eb229930_P001
MDRARGSAFLLGVLLAGSLFAFSVAKEETKKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDSERLIGEAAKNQAAVNPERTIFDVKRLIGRKFADKEVQRDMKLVPYKIINKDGKPYIQVKIKDGENKVFSPEEISAMILGKMKDTAEAYLGKKINDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSILTIDNGVFEVLATNGDTHLGGEDFDQRIMEYFIKLIKKKYSKDISKDNRALGKLRREAERAKRALSNQHQVRVEIESLFDGTDFSEPLTRARFEELNNDLFRKTMGPVKKAMEDAGLEKSQIHEIVLVGGSTRIPKVQQLLRDYFDGKEPNKGVNPDEAVAFGAAVQGSILSGEGGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSMTKDCRLLGKFDLNGIAPAPRGTPQIEVTFEVDANGILNVKITITNEKGRLSQEEIDRMVREAEEFAEEDKKVKERIDARNQLETYVYNMKNTVGDKDKLADKLEAEEKEKVEEALKEALEWLDDNQSAEKEDYEEKLKEVEAVCNPIVSAVYQRSGGAPGGDADGGVDDDHDEL - >Zm00001eb229930_P002
MDRARGSAFLLGVLLAGSLFAFSVAKEETKKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDSERLIGEAAKNQAAVNPERTIFDVKRLIGRKFADKEVQRDMKLVPYKIINKDGKPYIQVKIKDGENKVFSPEEISAMILGKMKDTAEAYLGKKINDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSILTIDNGVFEVLATNGDTHLGGEDFDQRIMEYFIKLIKKKYSKDISKDNRALGKLRREAERAKRALSNQHQVRVEIESLFDGTDFSEPLTRARFEELNNDLFRKTMGPVKKAMEDAGLEKSQIHEIVLVGGSTRIPKVQQLLRDYFDGKEPNKGVNPDEAVAFGAAVQGSILSGEGGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSMTKDCRLLGKFDLNGIAPAPRGTPQIEVTFEVDANGILNVKITITNEKGRLSQEEIDRMVREAEEFAEEDKKVKERIDARNQLETYVYNMKNTVGDKDKLADKLEAEEKEKVEEALKEALEWLDDNQSAEKEDYEEKLKEVEAVCNPIVSAVYQRSGGAPGGDADGGVDDDHDEL