Gene Details:

Functional Descriptions:

  • Identified ZmSMC2 and ZmSMC4 in maize (Zea mays) and confirmed that ZmSMC2 associates with ZmSMC4 via their hinge domains.
  • Knockdown and knockout of ZmSMC2 and ZmSMC4 result in abnormal location of H3Ser10 phosphorylation.
  • ZmSMC2 and ZmSMC4 are essential for proper chromosome segregation and for H3 phosphorylation at Serine 10 (H3S10ph) at pericentromeres during mitotic division.
  • Taken together, these findings confirm and extend the coordinated role of ZmSMC2 and ZmSMC4 in maintenance of normal chromosome architecture and accurate segregation during mitosis.

Literature:

Gene Resources:

Orthologs:

Sequences:

cDNA Sequence
  • >Zm00001eb291710_T001
    CGAAACCCTCGCACCGTTTCAGTTTTCCCTCCCAAACTTGCCCCAAATATCTAAATCCATCCTCCTTCGCAGGCGCTCCAACTTTCCCCTTCCCGGCAACCACCCTGTGCCTTCCTCGCTGCCTCGATTCCGCTTCTGTGCTCGGCTAGGGAGAGCGGCAGAGTATCAGGCGGGTGACCTCTATCTCGCCGGGGCGGGGCGGGGCGGTGACGCTCGCAATCCCTCGCTTGCTGCTGCATTTTCGAATACTGAGATGGCCATGGAGATGTCCCCGCGGCAGTCGCCTCCGCGGACGCCGCGTAGGGCGGCGAAGCCGCGACTGTTCATCAAGGAGATGGTCCTCCGCAACTTCAAGTCCTACGCAGGGGAGCAGCGCATCGGTCCTTTCCACAAGAGCTTCTCGGCTGTTGTTGGTCCAAATGGCAGTGGAAAGAGTAATGTCATTGACGCAATGCTTTTTGTGTTTGGGAAGCGTGCAAAGCAGATGCGCCTAAACAAGGTCTCCGAGCTCATACACAATTCTTCCAATCATCAGAACCTAGACAGTGCTGGTGTTTCTGTTCATTTTCAAGAAATTATTGACATGGATGATGGGAACTACAGTGCTGTTGAGGGTAGTGACTTTGTCATCTCAAGGGTTGCTTTCCGTGACAACACTTCTAAATACTACATAAATGAGCGTGGAAGCAATTTTACTGAAGTAACTAAACTGCTGAAGGGCAAAGGAGTTGACCTTGATAATAACCGTTTTCTCATCCTCCAGGGTGAGGTTGAGCAAATCTCCCTAATGAAACCAAAGGCTCAAGGTCCACATGATGAAGGTTTTCTAGAGTATCTTGAAGACATAATAGGGACAAACCAGTATGTTGAAAAAATTGAAGAAGCGTACAAGCAACTCGAATTGCTCAATGAAAAGAGAACAGCATCAGTGCAGATGCTAAAATTAGCTGAGAAAGAAAGAGACAGTTTAGAGAGTGCAAAAAATGAGGCTGAAACATACATGCTGAAGGAACTTTTGCTTCTGAAATGGCAAGAAAAGGCAACGAAGCTGGCTTCTGATGATGCTATCTCACGTGTTAATCAGTGTCAGGAGAATGTGGCAGACCTGGAAAAGAATCTTGCCGCTGAAAGGGAGAAGATACACCAGAATTCACAAACTCTGAAGGAAATGGAGGCTATTTACAGTAAACATGTCAAAAGGCAAGAGGACCTTGAAAATAACATGAAGAGCTGCAAAGACCAGTTTAAAGAGTTTGAGAGGAAAGACGTAAAATACAGGGAAGATCTAAAGCATCTTAAGCAGAACATCAAGAAGCTGGATGACAAAGCTGAAAAGGATACATCAAAACGTGATGAAAAAACAAAAGAGATGGAGGAGTCATCCAATCTCATTCCACAGCTGGAGGCAGAAATACCCAAATTGCAAAAGCGACTTAATGAAGAAGAGAAAGTCTTAGAGCAGATCAAAGCATCCTCTCGAGAAGAAACTGAGAGGTTTCGTGCTGAACTTACTCAAGTAAGAACTGAGCTTGAACCATGGGAAAATCAAATTATTGAACATAAAGGAAGGTTGGATGTTGCATCTGCGGAGAAAAAGTTAATGAAACAAAAGCATGATGGAGCACAAGCAGAGTTAACTGATGCACAAAATCAGATGGAAAGTATAAAGGAGAAAGTTAAAACAAAGGATTCATACATTGTGGGGCTTCAAGAAAAAATAGAGAAGCATTTGAATGAAGCATCTGAAGCTCGCAAAATCGAACAGGAATGCCAAAAGCAGGAGGATTCACTGATCCCTCTGGAACAAGCAGCAAGGCAGAAAGTTGCAGAGATGAAAACCACTAGGGATTCTGAGAAGAACCAAAGTACTGCTCTGAAGGCAATTTTGCAAGCCAAGGAATCAAATGAAATACAAGGGATTTATGGCAGGCTTGGTGATCTTGGTGCAATTGATGCAAAATATGACGTGGCCATATCAACATCAGCTTCATCTGGGCTTAATTATATTGTGGTTGAAACAATAAATTCGGCGCAAGCTTGTATTGAGTTGTTACGTAGAAGGAACCGTGAGGAAACTGTAACTTGTTTAATCCTGGAAAAACAAACACACCTCCTTCACAAAATTAAGGAGAAAGTAAAAACACCTGAAGGAGTTCCACGCCTTTTTGATCTAGTAAAGGTTAAAGATGAGAAGCTGAAGTTAGCCTTCTTCCATGTCTTGGGGAATACTGTTGTTGCAAATGATCTTGATCAGGCTTCACGAATTGCATACACTGCAGCAAAGGAGTTCCGTCGGGTAGTTACCCTCGGCGGTGAATTATTTGAGAAGTCTGGTACCATGAGTGGTGGCGGTAAAAGGGTACAACGAGGCATGATGGGAACAGCCATCCGAGAAAGCTTTTCAGAAGAGGCTATTAAAAATGCTGAAAATGAACTAACCAAGCTTGTTGATGAACTCAACAAGTTGCGTGAAAAAATGAATAATGCTAAAAAACAATATCGATCCATGGAAGATGCTAAATCCCGTCTTGAAATGGAATTGGCAAAAGCTAAAAAGGAGGTTGAGAGTATGAATGCACAATATATTTACAATGAAAAGCGACTAGATTCTCTGAAAACCGCTTCACAACCTAAAGCTGACGAGCTTCGCAGAATGCAAGAGCTGGATGGCATCATATCTAGTGAGCAAGCTGAACTAGAGAGGCTCACAAAGTGTTCCAGCAAACTTAAAGATCAGGCTTCGGAACTTCAACAAAAAGTTGAAAATGCTGGAGGGAAGAAGCTGAAGGACCAGAAGACAAAAGTTGGCAACATCCAATCTGAACTTGACAAAACAAGTTCAGAAATCAACAGACACAAAGTCAACGTAACTTCAGGTGAGAAGTTGGTGAAAAGGTTAACCAAGGGCATTGAGGAGTCCAAGAAAGATAGAGAAAAACTTTCTGCTGAAACAGAGAAGATGATGTCTATGTTCAAAGAGATTGAGAAGAAAGCGTTTGTTGTTCAGGAAGAGTATAAGAAAACACAGGAGATGATAGACAACCATAAAGTTGAGCTTGACAAAACTAAGGAAGAATACACCAAACTAAAAAAAGCAATGGATGAACTGAGAGCCACAGAGGTTGACGCTGAGTACAAATTGCAAGATACAAAAAAACTTGCCAAGGAGTGGGAAATGAAGGTGAAAACATTCAAGAAAAGGCTTGATGAAATTCAGATAAATGTTGTTAAACACATGGATCAAATCCAAAAGGATGCTGTTGATCCTGATAAACTCAAAGCGACTCTAGGTGATGAGCAACTAAATGATACATATGACATGAAAAGGGCAATGGAGATGGTAGCATTGTTAGAGGCCCAGATTAAAGATTTGAACCCAAATCTGGATTCCATAGCAGAGTACCGCACAAAGGCTTGCTTGTACGGTGAGCGTGTTGATGAGTTAAATGCTACCACTCAAGAACGTGATGATCTTAAAAAGTTGTACGATGGGTTAAGGAAGAGAAGGCTAGATGAATTCATGGCTGGATTCAACATAATATCTTTGAAACTGAAGGAGATGTACCAGATGATTACTCTTGGAGGTGATGCTGAACTGGAACTTGTTGATTCCTTGGACCCATTTTCAGAAGGTGTTGTTTTCAGTGTGAGGCCCCCAAAGAAAAGCTGGAAAAATATTGCCAATTTATCTGGTGGTGAGAAGACACTTAGTTCACTGGCTTTGGTGTTTGCTCTTCACCACTATAAACCTACTCCTTTATATGTTATGGATGAGATTGATGCTGCGTTGGACTTTAAGAACGTATCAATTGTGGGACACTATGTGAAAGATAGGACCAAAGATGCGCAATTCATCATTATAAGTCTGAGGAACAACATGTTTGAACTAGCCGACAGGTTGGTTGGTATTTACAAGACGGACAATTGCACCAAGAGCATAACGATCAACCCAGGAAGCTTTGCCGAGAGCATGAAAGTAGTGTAGCGTGCTCACCATGGATCCTTCCGCTAAATGTAACCTCCCTAGTGTCCTAAGCGAAACTAACCACTCTGGTGTCCTTCAGCTAAATGTAACCGTTGTAGTGTCCTCGTGGAACCGAGGTTCCTCGGGCATTGTGTTTGCCGTGCACTCTACAAAGCAGTATGCTATGATTAAGTCTGGCTTGACACATTGGTATTTCACTTAGAAGCGGATAGACACTTTTCGGTTGTTTGGGAGCAATAGAATTGGAGAGGATTGAGGGGTTAAAATTCATTCCTGTTTATGTTTTCAAATATTTGTTAGTGG
CDS Sequence
  • >Zm00001eb291710_T001
    ATGGCCATGGAGATGTCCCCGCGGCAGTCGCCTCCGCGGACGCCGCGTAGGGCGGCGAAGCCGCGACTGTTCATCAAGGAGATGGTCCTCCGCAACTTCAAGTCCTACGCAGGGGAGCAGCGCATCGGTCCTTTCCACAAGAGCTTCTCGGCTGTTGTTGGTCCAAATGGCAGTGGAAAGAGTAATGTCATTGACGCAATGCTTTTTGTGTTTGGGAAGCGTGCAAAGCAGATGCGCCTAAACAAGGTCTCCGAGCTCATACACAATTCTTCCAATCATCAGAACCTAGACAGTGCTGGTGTTTCTGTTCATTTTCAAGAAATTATTGACATGGATGATGGGAACTACAGTGCTGTTGAGGGTAGTGACTTTGTCATCTCAAGGGTTGCTTTCCGTGACAACACTTCTAAATACTACATAAATGAGCGTGGAAGCAATTTTACTGAAGTAACTAAACTGCTGAAGGGCAAAGGAGTTGACCTTGATAATAACCGTTTTCTCATCCTCCAGGGTGAGGTTGAGCAAATCTCCCTAATGAAACCAAAGGCTCAAGGTCCACATGATGAAGGTTTTCTAGAGTATCTTGAAGACATAATAGGGACAAACCAGTATGTTGAAAAAATTGAAGAAGCGTACAAGCAACTCGAATTGCTCAATGAAAAGAGAACAGCATCAGTGCAGATGCTAAAATTAGCTGAGAAAGAAAGAGACAGTTTAGAGAGTGCAAAAAATGAGGCTGAAACATACATGCTGAAGGAACTTTTGCTTCTGAAATGGCAAGAAAAGGCAACGAAGCTGGCTTCTGATGATGCTATCTCACGTGTTAATCAGTGTCAGGAGAATGTGGCAGACCTGGAAAAGAATCTTGCCGCTGAAAGGGAGAAGATACACCAGAATTCACAAACTCTGAAGGAAATGGAGGCTATTTACAGTAAACATGTCAAAAGGCAAGAGGACCTTGAAAATAACATGAAGAGCTGCAAAGACCAGTTTAAAGAGTTTGAGAGGAAAGACGTAAAATACAGGGAAGATCTAAAGCATCTTAAGCAGAACATCAAGAAGCTGGATGACAAAGCTGAAAAGGATACATCAAAACGTGATGAAAAAACAAAAGAGATGGAGGAGTCATCCAATCTCATTCCACAGCTGGAGGCAGAAATACCCAAATTGCAAAAGCGACTTAATGAAGAAGAGAAAGTCTTAGAGCAGATCAAAGCATCCTCTCGAGAAGAAACTGAGAGGTTTCGTGCTGAACTTACTCAAGTAAGAACTGAGCTTGAACCATGGGAAAATCAAATTATTGAACATAAAGGAAGGTTGGATGTTGCATCTGCGGAGAAAAAGTTAATGAAACAAAAGCATGATGGAGCACAAGCAGAGTTAACTGATGCACAAAATCAGATGGAAAGTATAAAGGAGAAAGTTAAAACAAAGGATTCATACATTGTGGGGCTTCAAGAAAAAATAGAGAAGCATTTGAATGAAGCATCTGAAGCTCGCAAAATCGAACAGGAATGCCAAAAGCAGGAGGATTCACTGATCCCTCTGGAACAAGCAGCAAGGCAGAAAGTTGCAGAGATGAAAACCACTAGGGATTCTGAGAAGAACCAAAGTACTGCTCTGAAGGCAATTTTGCAAGCCAAGGAATCAAATGAAATACAAGGGATTTATGGCAGGCTTGGTGATCTTGGTGCAATTGATGCAAAATATGACGTGGCCATATCAACATCAGCTTCATCTGGGCTTAATTATATTGTGGTTGAAACAATAAATTCGGCGCAAGCTTGTATTGAGTTGTTACGTAGAAGGAACCGTGAGGAAACTGTAACTTGTTTAATCCTGGAAAAACAAACACACCTCCTTCACAAAATTAAGGAGAAAGTAAAAACACCTGAAGGAGTTCCACGCCTTTTTGATCTAGTAAAGGTTAAAGATGAGAAGCTGAAGTTAGCCTTCTTCCATGTCTTGGGGAATACTGTTGTTGCAAATGATCTTGATCAGGCTTCACGAATTGCATACACTGCAGCAAAGGAGTTCCGTCGGGTAGTTACCCTCGGCGGTGAATTATTTGAGAAGTCTGGTACCATGAGTGGTGGCGGTAAAAGGGTACAACGAGGCATGATGGGAACAGCCATCCGAGAAAGCTTTTCAGAAGAGGCTATTAAAAATGCTGAAAATGAACTAACCAAGCTTGTTGATGAACTCAACAAGTTGCGTGAAAAAATGAATAATGCTAAAAAACAATATCGATCCATGGAAGATGCTAAATCCCGTCTTGAAATGGAATTGGCAAAAGCTAAAAAGGAGGTTGAGAGTATGAATGCACAATATATTTACAATGAAAAGCGACTAGATTCTCTGAAAACCGCTTCACAACCTAAAGCTGACGAGCTTCGCAGAATGCAAGAGCTGGATGGCATCATATCTAGTGAGCAAGCTGAACTAGAGAGGCTCACAAAGTGTTCCAGCAAACTTAAAGATCAGGCTTCGGAACTTCAACAAAAAGTTGAAAATGCTGGAGGGAAGAAGCTGAAGGACCAGAAGACAAAAGTTGGCAACATCCAATCTGAACTTGACAAAACAAGTTCAGAAATCAACAGACACAAAGTCAACGTAACTTCAGGTGAGAAGTTGGTGAAAAGGTTAACCAAGGGCATTGAGGAGTCCAAGAAAGATAGAGAAAAACTTTCTGCTGAAACAGAGAAGATGATGTCTATGTTCAAAGAGATTGAGAAGAAAGCGTTTGTTGTTCAGGAAGAGTATAAGAAAACACAGGAGATGATAGACAACCATAAAGTTGAGCTTGACAAAACTAAGGAAGAATACACCAAACTAAAAAAAGCAATGGATGAACTGAGAGCCACAGAGGTTGACGCTGAGTACAAATTGCAAGATACAAAAAAACTTGCCAAGGAGTGGGAAATGAAGGTGAAAACATTCAAGAAAAGGCTTGATGAAATTCAGATAAATGTTGTTAAACACATGGATCAAATCCAAAAGGATGCTGTTGATCCTGATAAACTCAAAGCGACTCTAGGTGATGAGCAACTAAATGATACATATGACATGAAAAGGGCAATGGAGATGGTAGCATTGTTAGAGGCCCAGATTAAAGATTTGAACCCAAATCTGGATTCCATAGCAGAGTACCGCACAAAGGCTTGCTTGTACGGTGAGCGTGTTGATGAGTTAAATGCTACCACTCAAGAACGTGATGATCTTAAAAAGTTGTACGATGGGTTAAGGAAGAGAAGGCTAGATGAATTCATGGCTGGATTCAACATAATATCTTTGAAACTGAAGGAGATGTACCAGATGATTACTCTTGGAGGTGATGCTGAACTGGAACTTGTTGATTCCTTGGACCCATTTTCAGAAGGTGTTGTTTTCAGTGTGAGGCCCCCAAAGAAAAGCTGGAAAAATATTGCCAATTTATCTGGTGGTGAGAAGACACTTAGTTCACTGGCTTTGGTGTTTGCTCTTCACCACTATAAACCTACTCCTTTATATGTTATGGATGAGATTGATGCTGCGTTGGACTTTAAGAACGTATCAATTGTGGGACACTATGTGAAAGATAGGACCAAAGATGCGCAATTCATCATTATAAGTCTGAGGAACAACATGTTTGAACTAGCCGACAGGTTGGTTGGTATTTACAAGACGGACAATTGCACCAAGAGCATAACGATCAACCCAGGAAGCTTTGCCGAGAGCATGAAAGTAGTGTAG
Protein Sequence
  • >Zm00001eb291710_P001
    MAMEMSPRQSPPRTPRRAAKPRLFIKEMVLRNFKSYAGEQRIGPFHKSFSAVVGPNGSGKSNVIDAMLFVFGKRAKQMRLNKVSELIHNSSNHQNLDSAGVSVHFQEIIDMDDGNYSAVEGSDFVISRVAFRDNTSKYYINERGSNFTEVTKLLKGKGVDLDNNRFLILQGEVEQISLMKPKAQGPHDEGFLEYLEDIIGTNQYVEKIEEAYKQLELLNEKRTASVQMLKLAEKERDSLESAKNEAETYMLKELLLLKWQEKATKLASDDAISRVNQCQENVADLEKNLAAEREKIHQNSQTLKEMEAIYSKHVKRQEDLENNMKSCKDQFKEFERKDVKYREDLKHLKQNIKKLDDKAEKDTSKRDEKTKEMEESSNLIPQLEAEIPKLQKRLNEEEKVLEQIKASSREETERFRAELTQVRTELEPWENQIIEHKGRLDVASAEKKLMKQKHDGAQAELTDAQNQMESIKEKVKTKDSYIVGLQEKIEKHLNEASEARKIEQECQKQEDSLIPLEQAARQKVAEMKTTRDSEKNQSTALKAILQAKESNEIQGIYGRLGDLGAIDAKYDVAISTSASSGLNYIVVETINSAQACIELLRRRNREETVTCLILEKQTHLLHKIKEKVKTPEGVPRLFDLVKVKDEKLKLAFFHVLGNTVVANDLDQASRIAYTAAKEFRRVVTLGGELFEKSGTMSGGGKRVQRGMMGTAIRESFSEEAIKNAENELTKLVDELNKLREKMNNAKKQYRSMEDAKSRLEMELAKAKKEVESMNAQYIYNEKRLDSLKTASQPKADELRRMQELDGIISSEQAELERLTKCSSKLKDQASELQQKVENAGGKKLKDQKTKVGNIQSELDKTSSEINRHKVNVTSGEKLVKRLTKGIEESKKDREKLSAETEKMMSMFKEIEKKAFVVQEEYKKTQEMIDNHKVELDKTKEEYTKLKKAMDELRATEVDAEYKLQDTKKLAKEWEMKVKTFKKRLDEIQINVVKHMDQIQKDAVDPDKLKATLGDEQLNDTYDMKRAMEMVALLEAQIKDLNPNLDSIAEYRTKACLYGERVDELNATTQERDDLKKLYDGLRKRRLDEFMAGFNIISLKLKEMYQMITLGGDAELELVDSLDPFSEGVVFSVRPPKKSWKNIANLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFKNVSIVGHYVKDRTKDAQFIIISLRNNMFELADRLVGIYKTDNCTKSITINPGSFAESMKVV

Source: Genetic information comes from the article