Information report for ZmABCB1|Br2
Gene Details
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Functional Descriptions
- Map-based cloning revealed that the d2014 gene is a novel Br2 allele with a splicing variation, resulting in a higher expression of Br2-T02 instead of normal Br2-T01.
- Maize brachytic2 (Br2) suppresses the elongation of lower internodes for excessive auxin accumulation in the intercalary meristem region.
- Br2 encodes a P-glycoprotein1 (PGP1) protein that functions in auxin efflux, and our in situ hybridization assay showed that Br2 was mainly expressed in vascular bundles of the node and internode.
- The maize Br2 and sorghum orthologue dwarf3 (dw3) exhibit reduced auxin transport and shortened statures, and auxin transport is crucial for regulating internode elongation.
- The Br2/PGP1-dependent low auxin level in the intercalary meristem region is crucial for internode elongation.
- Br2/PGP1 transports auxin from node to internode through the vascular bundles.
- Brachytic2/ZmABCB1 functions in IAA export from intercalary meristems.
Functional Keywords
Literature and News
- Maize brachytic2 (br2) suppresses the elongation of lower internodes for excessive auxin accumulation in the intercalary meristem region. DOI: 10.1186/s12870-019-2200-5 ; PMID: 31881837
- Hormonal regulation of inflorescence and intercalary meristems in grasses. DOI: 10.1016/j.pbi.2023.102451 ; PMID: 37739867
- Leaf angle: a target of genetic improvement in cereal crops tailored for high-density planting. DOI: 10.1111/pbi.13780 ; PMID: 35075761
- Brachytic2/ZmABCB1 functions in IAA export from intercalary meristems. DOI: 10.1093/jxb/erq180 ; PMID: 20581123
Gene Resources
- NCBI ID: LOC100384057
- UniProt accessions: A0A1D6KLY8 , A0A1D6KLY9 , A0A2P1BTK0
- EMBL: MG256511
- InterPro: IPR003439 , IPR003593 , IPR011527 , IPR017871 , IPR027417 , IPR036640 , IPR039421
- PANTHER: PTHR43394 , PTHR43394:SF11
- SUPFAM: SSF52540 , SSF90123
- PROSITE: PS00211 , PS50893 , PS50929
- Gene3D: 1.20.1560.10 , 3.40.50.300
- SMR: A0A2P1BTK0
- CDD: cd03249 , cd18577 , cd18578
Homologs
- Arabidopsis thaliana: AT3G28860, AT1G02520, AT3G28390, AT1G02530, AT3G28380, AT3G28345, AT3G28360, AT3G28415
- Capsicum annuum: T459_05266
- Citrullus lanatus: Cla97C05G096620
- Cucumis sativus: Csa_3G873270
- Glycine max: GLYMA_17G259100
- Oryza sativa: SD8, OsABCB14
- Solanum lycopersicum: Solyc02g071350.3
Sequences
cDNA Sequence
- >Zm00001eb038710_T001
GTGCCGCATGCATCCATTCCCATTCGTTTTCCACAGTACATGTAGGAGTACTGTGCAAGTAGGGTCCGTACATTCAGTCTCTCTCACTAGTTGGACTCTTCTACTGCTACAAAGACATGAGCTGCCGGGAATGGGAACCGGAGGAGCGAGCGAGCCTGACGGTCTCACACACACAGTCACACTCCCAAGCCAATTATTATAAGAGGCGAGATGAGCAACTCCAGCTCTTAACCAATCCACTCCTCCTCCCTCTCCACCTCCTCTGCTTTGCTCTGCCACTCTGCTGAGGTGGGGGGCAGAGGAGCTCCCCCTCCCTCCTCTCCCCTCCTCGCCATGTCTAGCAGCGACCCGGAGGAGATCAGGGCGCGCGTCGTCGTTCTCGGTTCGCCCCATGCCGACGGCGGCGACGAGTGGGCCCGGCCCGAGCTCGAGGCCTTCCATCTGCCGTCTCCCGCCCACCAGCCTCCTGGCTTCCTAGCCGGGCAACCGGAAGCAGCAGAGCAACCCACGCTCCCTGCTCCTGCTGGCCGCAGCAGCAGCAGCAGCAACACGCCTACTACATCTGCCGGTGGCGGCGCTGCTCCTCCTCCTCCTTCTTCGCCTCCCCCTCCGCCGGCTTCTCTGGAGACCGAGCAGCCGCCCAATGCCAGGCCAGCCTCCGCCGGCGCCAATGACAGCAAGAAGCCCACCCCGCCCGCCGCCCTGCGCGACCTCTTCCGCTTCGCCGACGGCCTCGACTGCGCGCTCATGCTCATCGGCACCCTCGGCGCGCTCGTCCACGGCTGCTCGCTCCCCGTCTTCCTCCGCTTCTTCGCCGACCTCGTCGACTCCTTCGGCTCCCACGCCGACGACCCGGACACCATGGTCCGCCTCGTCGTCAAGTACGCCTTCTACTTCCTCGTCGTCGGAGCGGCAATCTGGGCATCCTCGTGGGCAGAGATCTCTTGCTGGATGTGGACCGGCGAGCGGCAGTCGACGCGGATGCGGATCCGGTACCTGGACGCGGCGCTGCGGCAGGACGTGTCCTTCTTCGACACCGACGTGCGGGCCTCGGACGTGATCTACGCCATCAACGCGGACGCCGTGGTGGTGCAGGACGCCATCAGCGAGAAGCTGGGCAACCTCATCCACTACATGGCCACCTTCGTGGCCGGCTTCGTCGTGGGGTTCACGGCCGCGTGGCAGCTGGCGCTGGTCACGCTGGCCGTGGTGCCGCTCATCGCCGTCATCGGCGGGCTGAGCGCCGCCGCGCTCGCCAAGCTCTCGTCCCGCAGCCAGGACGCGCTCTCGGGCGCCAGCGGCATCGCGGAGCAGGCGCTCGCGCAGATACGGATCGTGCAGGCGTTCGTTGGCGAGGAGCGCGAGATGCGGGCCTACTCGGCGGCGCTGGCCGTGGCGCAGAGGATCGGCTACCGCAGCGGCTTCGCCAAGGGGCTCGGCCTCGGCGGCACCTACTTCACCGTCTTCTGCTGCTACGGGCTCCTGCTCTGGTACGGCGGCCACCTCGTGCGCGCCCAGCACACCAACGGCGGGCTCGCCATCGCCACCATGTTCTCCGTCATGATCGGCGGACTGGCCCTCGGGCAGTCGGCGCCGAGCATGGCCGCGTTCGCCAAGGCGCGTGTGGCGGCTGCCAAGATCTTCCGCATCATCGACCACAGGCCGGGCATCTCCTCGCGCGACGGCGCGGAGCCAGAGTCGGTGACGGGGCGGGTGGAGATGCGGGGCGTGGACTTCGCGTACCCGTCGCGGCCGGACGTCCCCATCCTGCGCGGCTTCTCGCTGAGCGTGCCCGCCGGGAAGACCATCGCGCTGGTGGGCAGCTCCGGCTCCGGGAAGAGCACGGTGGTGTCGCTCATCGAGAGATTCTACGACCCCAGCGCAGGGCAAATCCTGCTGGACGGGCACGACCTCAGGTCGCTGGAGCTGCGGTGGCTGCGGCGGCAGATCGGGCTGGTGAGCCAGGAGCCGGCGCTGTTCGCGACGAGCATCAGGGAGAACCTGCTGCTGGGGCGGGACAGCCAGAGCGCGACGCTGGCGGAGATGGAGGAGGCGGCCAGGGTGGCCAACGCCCACTCCTTCATCATCAAACTCCCCGACGGCTACGACACGCAGGTTGGGGAGCGCGGCCTGCAGCTCTCCGGTGGGCAGAAGCAGCGCATCGCCATCGCCCGCGCCATGCTCAAGAACCCCGCCATCCTGCTGCTGGACGAGGCCACCAGCGCGCTGGACTCCGAGTCTGAGAAGCTCGTGCAGGAGGCGCTGGACCGCTTCATGATCGGGCGCACCACCCTGGTGATCGCGCACAGGCTGTCCACCATCCGCAAGGCCGACGTGGTGGCCGTGCTGCAGGGCGGCGCCGTCTCCGAGATGGGCGCGCACGACGAGCTGATGGCCAAGGGCGAGAACGGCACCTACGCCAAGCTCATCCGCATGCAGGAGCAGGCGCACGAGGCGGCGCTCGTCAACGCCCGCCGCAGCAGCGCCAGGCCCTCCAGCGCCCGCAACTCCGTCAGCTCGCCCATCATGACGCGCAACTCCTCCTACGGCCGCTCCCCCTACTCCCGCCGCCTCTCCGACTTCTCCACCTCCGACTTCACCCTCTCCATCCACGACCCGCACCACCACCACCGGACCATGGCGGACAAGCAGCTGGCGTTCCGCGCCGGCGCCAGCTCCTTCCTGCGCCTCGCCAGGATGAACTCGCCCGAGTGGGCCTACGCGCTCGCCGGCTCCATCGGCTCCATGGTCTGCGGCTCCTTCAGCGCCATCTTCGCCTACATCCTCAGCGCCGTGCTCAGCGTCTACTACGCGCCGGACCCGCGGTACATGAAGCGCGAGATCGCAAAATACTGCTACCTGCTCATCGGCATGTCCTCCGCGGCGCTGCTGTTCAACACGGTGCAGCACGTGTTCTGGGACACGGTGGGCGAGAACCTGACCAAGCGGGTGCGCGAGAAGATGTTCGCCGCCGTGCTCCGCAACGAGATCGCCTGGTTCGACGCGGACGAGAACGCCAGCGCGCGCGTGGCCGCCAGGCTAGCGCTGGACGCCCAGAACGTGCGCTCCGCCATCGGGGACCGCATCTCCGTCATCGTCCAGAACTCGGCGCTGATGCTGGTGGCCTGCACCGCGGGGTTCGTCCTCCAGTGGCGCCTCGCGCTCGTGCTCCTCGCCGTGTTCCCGCTCGTCGTGGGCGCCACCGTGCTGCAGAAGATGTTCATGAAGGGCTTCTCGGGGGACCTGGAGGCCGCGCACGCCAGGGCCACGCAGATCGCGGGCGAGGCCGTGGCCAACCTGCGCACCGTGGCCGCGTTCAACGCGGAGCGCAAGATCACGGGGCTGTTCGAGGCCAACCTGCGCGGCCCGCTCCGGCGCTGCTTCTGGAAGGGGCAGATCGCCGGCAGCGGCTACGGCGTGGCGCAGTTCCTGCTGTACGCGTCCTACGCGCTGGGGCTGTGGTACGCGGCGTGGCTGGTGAAGCACGGCGTGTCCGACTTCTCGCGCACCATCCGCGTGTTCATGGTGCTGATGGTGTCCGCGAACGGCGCCGCCGAGACGCTGACGCTGGCGCCGGACTTCATCAAGGGCGGGCGCGCGATGCGGTCGGTGTTCGAGACGATCGACCGCAAGACGGAGGTGGAGCCCGACGACGTGGACGCGGCGCCGGTGCCGGAGCGGCCGAGGGGCGAGGTGGAGCTGAAGCACGTGGACTTCTCGTACCCGTCGCGGCCGGACATCCAGGTGTTCCGCGACCTGAGCCTCCGTGCGCGCGCCGGGAAGACGCTGGCGCTGGTGGGGCCGAGCGGGTGCGGCAAGAGCTCGGTGCTGGCTCTGGTGCAGCGGTTCTACGAGCCCACGTCCGGGCGCGTGCTCCTGGACGGCAAGGACGTGCGCAAGTACAACCTGCGGGCGCTGCGGCGCGTGGTGGCGGTGGTACCGCAGGAGCCGTTCCTGTTCGCGGCGAGCATCCACGAGAACATCGCGTACGGGCGCGAGGGCGCGACGGAGGCGGAGGTGGTGGAGGCGGCGGCGCAGGCGAACGCGCACCGGTTCATCGCGGCGCTGCCGGAGGGGTACCGGACGCAGGTGGGCGAGCGCGGGGTGCAGCTGTCGGGGGGGCAGCGGCAGCGGATCGCGATCGCGCGCGCGCTGGTGAAGCAGGCGGCCATCGTGCTGCTGGACGAGGCGACCAGCGCGCTGGACGCCGAGTCGGAGCGGTGCGTGCAGGAGGCGCTGGAGCGCGCGGGGTCCGGGCGCACCACCATCGTGGTGGCGCACCGGCTGGCCACGGTGCGCGGCGCGCACACCATCGCGGTCATCGACGACGGCAAGGTGGCGGAGCAGGGGTCGCACTCGCACCTGCTCAAGCACCATCCCGACGGGTGCTACGCGCGGATGCTGCAGCTGCAGCGGCTGACGGGCGCGGCGGCCGGGCCCGGGCCGTCGACCTCGTGCAACGGGGCCGCGTAGGACGGAATGGATGGATGGATGGGTTTGGTTCCTCGAGAGATTGATGGGTGAGGAAGCTGAAGCTCCGGATCAAATGGTGGTACTCCATGATCGCAACAATGAGGGGAAAAAAAGAAAGGAGAAAATACGGTGGTTCATATGATTGTACAATTTGACGATCTGTTTGAGTCGGGGTTTTAGGATGATGTAAACCTTCACTCGCCTTTTTTTTACTCTTGTTTCTCATCCGCATCAGTATCATCTATCTACATACAGTGTCAGAGATGGGAACTGATCCGCATCATCATCTACCTCCCAAGGCACCCCAGATTGTATTAATGTACTTAGTTAGCCTGTTTTATATATACTTATAAGTACC
CDS Sequence
- >Zm00001eb038710_T001
ATGTCTAGCAGCGACCCGGAGGAGATCAGGGCGCGCGTCGTCGTTCTCGGTTCGCCCCATGCCGACGGCGGCGACGAGTGGGCCCGGCCCGAGCTCGAGGCCTTCCATCTGCCGTCTCCCGCCCACCAGCCTCCTGGCTTCCTAGCCGGGCAACCGGAAGCAGCAGAGCAACCCACGCTCCCTGCTCCTGCTGGCCGCAGCAGCAGCAGCAGCAACACGCCTACTACATCTGCCGGTGGCGGCGCTGCTCCTCCTCCTCCTTCTTCGCCTCCCCCTCCGCCGGCTTCTCTGGAGACCGAGCAGCCGCCCAATGCCAGGCCAGCCTCCGCCGGCGCCAATGACAGCAAGAAGCCCACCCCGCCCGCCGCCCTGCGCGACCTCTTCCGCTTCGCCGACGGCCTCGACTGCGCGCTCATGCTCATCGGCACCCTCGGCGCGCTCGTCCACGGCTGCTCGCTCCCCGTCTTCCTCCGCTTCTTCGCCGACCTCGTCGACTCCTTCGGCTCCCACGCCGACGACCCGGACACCATGGTCCGCCTCGTCGTCAAGTACGCCTTCTACTTCCTCGTCGTCGGAGCGGCAATCTGGGCATCCTCGTGGGCAGAGATCTCTTGCTGGATGTGGACCGGCGAGCGGCAGTCGACGCGGATGCGGATCCGGTACCTGGACGCGGCGCTGCGGCAGGACGTGTCCTTCTTCGACACCGACGTGCGGGCCTCGGACGTGATCTACGCCATCAACGCGGACGCCGTGGTGGTGCAGGACGCCATCAGCGAGAAGCTGGGCAACCTCATCCACTACATGGCCACCTTCGTGGCCGGCTTCGTCGTGGGGTTCACGGCCGCGTGGCAGCTGGCGCTGGTCACGCTGGCCGTGGTGCCGCTCATCGCCGTCATCGGCGGGCTGAGCGCCGCCGCGCTCGCCAAGCTCTCGTCCCGCAGCCAGGACGCGCTCTCGGGCGCCAGCGGCATCGCGGAGCAGGCGCTCGCGCAGATACGGATCGTGCAGGCGTTCGTTGGCGAGGAGCGCGAGATGCGGGCCTACTCGGCGGCGCTGGCCGTGGCGCAGAGGATCGGCTACCGCAGCGGCTTCGCCAAGGGGCTCGGCCTCGGCGGCACCTACTTCACCGTCTTCTGCTGCTACGGGCTCCTGCTCTGGTACGGCGGCCACCTCGTGCGCGCCCAGCACACCAACGGCGGGCTCGCCATCGCCACCATGTTCTCCGTCATGATCGGCGGACTGGCCCTCGGGCAGTCGGCGCCGAGCATGGCCGCGTTCGCCAAGGCGCGTGTGGCGGCTGCCAAGATCTTCCGCATCATCGACCACAGGCCGGGCATCTCCTCGCGCGACGGCGCGGAGCCAGAGTCGGTGACGGGGCGGGTGGAGATGCGGGGCGTGGACTTCGCGTACCCGTCGCGGCCGGACGTCCCCATCCTGCGCGGCTTCTCGCTGAGCGTGCCCGCCGGGAAGACCATCGCGCTGGTGGGCAGCTCCGGCTCCGGGAAGAGCACGGTGGTGTCGCTCATCGAGAGATTCTACGACCCCAGCGCAGGGCAAATCCTGCTGGACGGGCACGACCTCAGGTCGCTGGAGCTGCGGTGGCTGCGGCGGCAGATCGGGCTGGTGAGCCAGGAGCCGGCGCTGTTCGCGACGAGCATCAGGGAGAACCTGCTGCTGGGGCGGGACAGCCAGAGCGCGACGCTGGCGGAGATGGAGGAGGCGGCCAGGGTGGCCAACGCCCACTCCTTCATCATCAAACTCCCCGACGGCTACGACACGCAGGTTGGGGAGCGCGGCCTGCAGCTCTCCGGTGGGCAGAAGCAGCGCATCGCCATCGCCCGCGCCATGCTCAAGAACCCCGCCATCCTGCTGCTGGACGAGGCCACCAGCGCGCTGGACTCCGAGTCTGAGAAGCTCGTGCAGGAGGCGCTGGACCGCTTCATGATCGGGCGCACCACCCTGGTGATCGCGCACAGGCTGTCCACCATCCGCAAGGCCGACGTGGTGGCCGTGCTGCAGGGCGGCGCCGTCTCCGAGATGGGCGCGCACGACGAGCTGATGGCCAAGGGCGAGAACGGCACCTACGCCAAGCTCATCCGCATGCAGGAGCAGGCGCACGAGGCGGCGCTCGTCAACGCCCGCCGCAGCAGCGCCAGGCCCTCCAGCGCCCGCAACTCCGTCAGCTCGCCCATCATGACGCGCAACTCCTCCTACGGCCGCTCCCCCTACTCCCGCCGCCTCTCCGACTTCTCCACCTCCGACTTCACCCTCTCCATCCACGACCCGCACCACCACCACCGGACCATGGCGGACAAGCAGCTGGCGTTCCGCGCCGGCGCCAGCTCCTTCCTGCGCCTCGCCAGGATGAACTCGCCCGAGTGGGCCTACGCGCTCGCCGGCTCCATCGGCTCCATGGTCTGCGGCTCCTTCAGCGCCATCTTCGCCTACATCCTCAGCGCCGTGCTCAGCGTCTACTACGCGCCGGACCCGCGGTACATGAAGCGCGAGATCGCAAAATACTGCTACCTGCTCATCGGCATGTCCTCCGCGGCGCTGCTGTTCAACACGGTGCAGCACGTGTTCTGGGACACGGTGGGCGAGAACCTGACCAAGCGGGTGCGCGAGAAGATGTTCGCCGCCGTGCTCCGCAACGAGATCGCCTGGTTCGACGCGGACGAGAACGCCAGCGCGCGCGTGGCCGCCAGGCTAGCGCTGGACGCCCAGAACGTGCGCTCCGCCATCGGGGACCGCATCTCCGTCATCGTCCAGAACTCGGCGCTGATGCTGGTGGCCTGCACCGCGGGGTTCGTCCTCCAGTGGCGCCTCGCGCTCGTGCTCCTCGCCGTGTTCCCGCTCGTCGTGGGCGCCACCGTGCTGCAGAAGATGTTCATGAAGGGCTTCTCGGGGGACCTGGAGGCCGCGCACGCCAGGGCCACGCAGATCGCGGGCGAGGCCGTGGCCAACCTGCGCACCGTGGCCGCGTTCAACGCGGAGCGCAAGATCACGGGGCTGTTCGAGGCCAACCTGCGCGGCCCGCTCCGGCGCTGCTTCTGGAAGGGGCAGATCGCCGGCAGCGGCTACGGCGTGGCGCAGTTCCTGCTGTACGCGTCCTACGCGCTGGGGCTGTGGTACGCGGCGTGGCTGGTGAAGCACGGCGTGTCCGACTTCTCGCGCACCATCCGCGTGTTCATGGTGCTGATGGTGTCCGCGAACGGCGCCGCCGAGACGCTGACGCTGGCGCCGGACTTCATCAAGGGCGGGCGCGCGATGCGGTCGGTGTTCGAGACGATCGACCGCAAGACGGAGGTGGAGCCCGACGACGTGGACGCGGCGCCGGTGCCGGAGCGGCCGAGGGGCGAGGTGGAGCTGAAGCACGTGGACTTCTCGTACCCGTCGCGGCCGGACATCCAGGTGTTCCGCGACCTGAGCCTCCGTGCGCGCGCCGGGAAGACGCTGGCGCTGGTGGGGCCGAGCGGGTGCGGCAAGAGCTCGGTGCTGGCTCTGGTGCAGCGGTTCTACGAGCCCACGTCCGGGCGCGTGCTCCTGGACGGCAAGGACGTGCGCAAGTACAACCTGCGGGCGCTGCGGCGCGTGGTGGCGGTGGTACCGCAGGAGCCGTTCCTGTTCGCGGCGAGCATCCACGAGAACATCGCGTACGGGCGCGAGGGCGCGACGGAGGCGGAGGTGGTGGAGGCGGCGGCGCAGGCGAACGCGCACCGGTTCATCGCGGCGCTGCCGGAGGGGTACCGGACGCAGGTGGGCGAGCGCGGGGTGCAGCTGTCGGGGGGGCAGCGGCAGCGGATCGCGATCGCGCGCGCGCTGGTGAAGCAGGCGGCCATCGTGCTGCTGGACGAGGCGACCAGCGCGCTGGACGCCGAGTCGGAGCGGTGCGTGCAGGAGGCGCTGGAGCGCGCGGGGTCCGGGCGCACCACCATCGTGGTGGCGCACCGGCTGGCCACGGTGCGCGGCGCGCACACCATCGCGGTCATCGACGACGGCAAGGTGGCGGAGCAGGGGTCGCACTCGCACCTGCTCAAGCACCATCCCGACGGGTGCTACGCGCGGATGCTGCAGCTGCAGCGGCTGACGGGCGCGGCGGCCGGGCCCGGGCCGTCGACCTCGTGCAACGGGGCCGCGTAG
Protein Sequence
- >Zm00001eb038710_P001
MSSSDPEEIRARVVVLGSPHADGGDEWARPELEAFHLPSPAHQPPGFLAGQPEAAEQPTLPAPAGRSSSSSNTPTTSAGGGAAPPPPSSPPPPPASLETEQPPNARPASAGANDSKKPTPPAALRDLFRFADGLDCALMLIGTLGALVHGCSLPVFLRFFADLVDSFGSHADDPDTMVRLVVKYAFYFLVVGAAIWASSWAEISCWMWTGERQSTRMRIRYLDAALRQDVSFFDTDVRASDVIYAINADAVVVQDAISEKLGNLIHYMATFVAGFVVGFTAAWQLALVTLAVVPLIAVIGGLSAAALAKLSSRSQDALSGASGIAEQALAQIRIVQAFVGEEREMRAYSAALAVAQRIGYRSGFAKGLGLGGTYFTVFCCYGLLLWYGGHLVRAQHTNGGLAIATMFSVMIGGLALGQSAPSMAAFAKARVAAAKIFRIIDHRPGISSRDGAEPESVTGRVEMRGVDFAYPSRPDVPILRGFSLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPSAGQILLDGHDLRSLELRWLRRQIGLVSQEPALFATSIRENLLLGRDSQSATLAEMEEAARVANAHSFIIKLPDGYDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGRTTLVIAHRLSTIRKADVVAVLQGGAVSEMGAHDELMAKGENGTYAKLIRMQEQAHEAALVNARRSSARPSSARNSVSSPIMTRNSSYGRSPYSRRLSDFSTSDFTLSIHDPHHHHRTMADKQLAFRAGASSFLRLARMNSPEWAYALAGSIGSMVCGSFSAIFAYILSAVLSVYYAPDPRYMKREIAKYCYLLIGMSSAALLFNTVQHVFWDTVGENLTKRVREKMFAAVLRNEIAWFDADENASARVAARLALDAQNVRSAIGDRISVIVQNSALMLVACTAGFVLQWRLALVLLAVFPLVVGATVLQKMFMKGFSGDLEAAHARATQIAGEAVANLRTVAAFNAERKITGLFEANLRGPLRRCFWKGQIAGSGYGVAQFLLYASYALGLWYAAWLVKHGVSDFSRTIRVFMVLMVSANGAAETLTLAPDFIKGGRAMRSVFETIDRKTEVEPDDVDAAPVPERPRGEVELKHVDFSYPSRPDIQVFRDLSLRARAGKTLALVGPSGCGKSSVLALVQRFYEPTSGRVLLDGKDVRKYNLRALRRVVAVVPQEPFLFAASIHENIAYGREGATEAEVVEAAAQANAHRFIAALPEGYRTQVGERGVQLSGGQRQRIAIARALVKQAAIVLLDEATSALDAESERCVQEALERAGSGRTTIVVAHRLATVRGAHTIAVIDDGKVAEQGSHSHLLKHHPDGCYARMLQLQRLTGAAAGPGPSTSCNGAA