Gene Details:
- Gene ID: Vitvi17g00371
- Gene Symbol: VvLAR2
- Gene Name: leucoanthocyanidin reductase 2
- Genome: Vitis vinifera PN40024.v4
- Species: Vitis vinifera
Functional Descriptions:
- VvLAR1 and VvLAR2 Are Bifunctional Enzymes for Proanthocyanidin Biosynthesis in Grapevine.
- VvLAR1 or VvLAR2 complement the M. truncatula lar:ldox double mutant that also lacks the leucoanthocyanidin dioxygenase (LDOX) required for epicatechin starter unit formation, resulting in increased soluble PA levels, decreased insoluble PA levels, and reduced levels of Cys-C and Cys-EC when compared to the double mutant, and the appearance of catechin, epicatechin, and PA dimers characteristic of the ldox single mutant in young pods.
- VvLAR1 and VvLAR2 Complement MtLAR Activities in M. truncatula lar:ldox Double Mutant.
- VvLAR1 and VvLAR2 function similarly in controlling the degree of PA polymerization and support LAR as a target for molecular breeding to improve the PA composition of wine.
- These data advance our knowledge of PA building blocks and LAR function and provide targets for grapevine breeding to alter PA composition.
Function-related keywords:
Literature:
- VvLAR1 and VvLAR2 Are Bifunctional Enzymes for Proanthocyanidin Biosynthesis in Grapevine. DOI: 10.1104/pp.19.00447 ; PMID: 31092697
Related News:
Gene Resources:
- NCBI ID: MK726358.1
- UniProt accessions: A0A513ZV78
Orthologs:
Sequences:
cDNA Sequence
- >Vitvi17g00371_t001
ATGACTGTTTTGTCTGTGAGTACTCCTCCGGCTCCTCAGGCTCCTCTGGCGGCCACCGGACCTCGGACACTGGTGGTGGGTGCATCCGGGTTCATAGGGCGGTTTGTGGCGGAAGCCAGCCTCTCCTCCGGCCACCCCACCTATGTCCTAGTCCGCTCCTCCGCCACGACCTCCTCTTCCAAGGCCAGCACCATCAAGTCCCTCGAAGACCAGGGCGCCATCCTTGTTACCGGTTCAATAGGGGACAAGGAAGTAATGATAGAGATTCTGAGGAAGTATGAGATAGAAGTGGTGATATCAGCTGTGGGTGGAGCCACTATATTGGACCAGCTCACCCTAGCGGAAGCCATTAAAGCGGTTGGTAGCATTAAGAGGTTCCTTCCATCAGAATTTGGGCACGACATCGACCGAGCGGAACCAGTGGAGCCGGGGCTGACCATGTACATGGAGAAGAGAAAAGTCAGACGGTTCATTGAGGAGGCCGCCATCCCCTACACCTACATCTGCTGCAACTCCATCGCCGCTTGGCCCTACCATGACAATACCCACCCTGCTGACGTCCTCCCACCCTTGGATCGTTTCCATATCTACGGTGATGGCTCTGTCAAAGCTTACTTCGTGGCGGGTACCGACATCGGAAAATTCACAATCAAAACCATAAACGACGATCGAACAGTGAACAAATCGCTTCATTTCCGACCTCCCAGCAATCTTGTAAGCATAAACGAGCTGGCATCACTGTGGGAGAAGAAGATCGGGCGGACGCTCCCCCGTGTAACCGTGGAAGAAGATGACCTACTAGCCGCTGCCGCAGAGATGTGCATTCCCGATAGCATCGTCGCGTCCTTCACTCACGACATCTTCATAAAGGGATGCCAAGTAAATTTCAGCTTGGATAAACCTACAGACCTAGAAGCCACGTCTCTTTATCCGGAGATGCAGTTCAGGACCATAGATGAGTGCTTCGATGAGTTCGTGGAGAAGATAATGGGAGGTCAAGCAGCAGCCGAGAAGGAGGGCATTGTGGTGCCCGCTTCTGCCCCGGATGCTTTGGTCATCACTGCTACCTGCGCCTGA - >Vitvi17g00371_t002
ATGACTGTTTTGTCTGTGAGTACTCCTCCGGCTCCTCAGGCTCCTCTGGCGGCCACCGGACCTCGGACACTGGTGGTGGGTGCATCCGGGTTCATAGGGCGGTTTGTGGCGGAAGCCAGCCTCTCCTCCGGCCACCCCACCTATGTCCTAGTCCGCTCCTCCGCCACGACCTCCTCTTCCAAGGCCAGCACCATCAAGTCCCTCGAAGACCAGGGCGCCATCCTTGTTACCGGTTCAATAGGGGACAAGGAAGTAATGATAGAGATTCTGAGGAAGTATGAGATAGAAGTGGTGATATCAGCTGTGGGTGGAGCCACTATATTGGACCAGCTCACCCTAGCGGAAGCCATTAAAGCGGTTGGTAGCATTAAGAGGTTCCTTCCATCAGAATTTGGGCACGACATCGACCGAGCGGAACCAGTGGAGCCGGGGCTGACCATGTACATGGAGAAGAGAAAAGTCAGACGGTTCATTGAGGAGGCCGCCATCCCCTACACCTACATCTGCTGCAACTCCATCGCCGCTTGGCCCTACCATGACAATACCCACCCTGCTGACGTCCTCCCACCCTTGGATCGTTTCCATATCTACGGTGATGGCTCTGTCAAAGCTTACTTCGTGGCGGGTACCGACATCGGAAAATTCACAATCAAAACCATAAACGACGATCGAACAGTGAACAAATCGCTTCATTTCCGACCTCCCAGCAATCTTGTAAGCATAAACGAGCTGGCATCACTGTGGGAGAAGAAGATCGGGCGGACGCTCCCCCGTGTAACCGTGGAAGAAGATGACCTACTAGCCGCTGCCGCAGAGATGTGCATTCCCGATAGCATCGTCGCGTCCTTCACTCACGACATCTTCATAAAGGGATGCCAAGTAAATTTCAGCTTGGATAAACCTACAGACCTAGAAGCCACGTCTCTTTATCCGGAGATGCAGTTCAGGACCATAGATGAGTGCTTCGATGAGTTCGTGGAGAAGATAATGGGAGGTCAAGCAGCAGCCGAGAAGGAGGGCATTGTGGTGCCCGCTTCTGCCCCGGATGCTTTGGTCATCACTGCTACCTGCGCCTGA
CDS Sequence
- >Vitvi17g00371_t001
ATGACTGTTTTGTCTGTGAGTACTCCTCCGGCTCCTCAGGCTCCTCTGGCGGCCACCGGACCTCGGACACTGGTGGTGGGTGCATCCGGGTTCATAGGGCGGTTTGTGGCGGAAGCCAGCCTCTCCTCCGGCCACCCCACCTATGTCCTAGTCCGCTCCTCCGCCACGACCTCCTCTTCCAAGGCCAGCACCATCAAGTCCCTCGAAGACCAGGGCGCCATCCTTGTTACCGGTTCAATAGGGGACAAGGAAGTAATGATAGAGATTCTGAGGAAGTATGAGATAGAAGTGGTGATATCAGCTGTGGGTGGAGCCACTATATTGGACCAGCTCACCCTAGCGGAAGCCATTAAAGCGGTTGGTAGCATTAAGAGGTTCCTTCCATCAGAATTTGGGCACGACATCGACCGAGCGGAACCAGTGGAGCCGGGGCTGACCATGTACATGGAGAAGAGAAAAGTCAGACGGTTCATTGAGGAGGCCGCCATCCCCTACACCTACATCTGCTGCAACTCCATCGCCGCTTGGCCCTACCATGACAATACCCACCCTGCTGACGTCCTCCCACCCTTGGATCGTTTCCATATCTACGGTGATGGCTCTGTCAAAGCTTACTTCGTGGCGGGTACCGACATCGGAAAATTCACAATCAAAACCATAAACGACGATCGAACAGTGAACAAATCGCTTCATTTCCGACCTCCCAGCAATCTTGTAAGCATAAACGAGCTGGCATCACTGTGGGAGAAGAAGATCGGGCGGACGCTCCCCCGTGTAACCGTGGAAGAAGATGACCTACTAGCCGCTGCCGCAGAGATGTGCATTCCCGATAGCATCGTCGCGTCCTTCACTCACGACATCTTCATAAAGGGATGCCAAGTAAATTTCAGCTTGGATAAACCTACAGACCTAGAAGCCACGTCTCTTTATCCGGAGATGCAGTTCAGGACCATAGATGAGTGCTTCGATGAGTTCGTGGAGAAGATAATGGGAGGTCAAGCAGCAGCCGAGAAGGAGGGCATTGTGGTGCCCGCTTCTGCCCCGGATGCTTTGGTCATCACTGCTACCTGCGCCTGA - >Vitvi17g00371_t002
ATGACTGTTTTGTCTGTGAGTACTCCTCCGGCTCCTCAGGCTCCTCTGGCGGCCACCGGACCTCGGACACTGGTGGTGGGTGCATCCGGGTTCATAGGGCGGTTTGTGGCGGAAGCCAGCCTCTCCTCCGGCCACCCCACCTATGTCCTAGTCCGCTCCTCCGCCACGACCTCCTCTTCCAAGGCCAGCACCATCAAGTCCCTCGAAGACCAGGGCGCCATCCTTGTTACCGGTTCAATAGGGGACAAGGAAGTAATGATAGAGATTCTGAGGAAGTATGAGATAGAAGTGGTGATATCAGCTGTGGGTGGAGCCACTATATTGGACCAGCTCACCCTAGCGGAAGCCATTAAAGCGGTTGGTAGCATTAAGAGGTTCCTTCCATCAGAATTTGGGCACGACATCGACCGAGCGGAACCAGTGGAGCCGGGGCTGACCATGTACATGGAGAAGAGAAAAGTCAGACGGTTCATTGAGGAGGCCGCCATCCCCTACACCTACATCTGCTGCAACTCCATCGCCGCTTGGCCCTACCATGACAATACCCACCCTGCTGACGTCCTCCCACCCTTGGATCGTTTCCATATCTACGGTGATGGCTCTGTCAAAGCTTACTTCGTGGCGGGTACCGACATCGGAAAATTCACAATCAAAACCATAAACGACGATCGAACAGTGAACAAATCGCTTCATTTCCGACCTCCCAGCAATCTTGTAAGCATAAACGAGCTGGCATCACTGTGGGAGAAGAAGATCGGGCGGACGCTCCCCCGTGTAACCGTGGAAGAAGATGACCTACTAGCCGCTGCCGCAGAGATGTGCATTCCCGATAGCATCGTCGCGTCCTTCACTCACGACATCTTCATAAAGGGATGCCAAGTAAATTTCAGCTTGGATAAACCTACAGACCTAGAAGCCACGTCTCTTTATCCGGAGATGCAGTTCAGGACCATAGATGAGTGCTTCGATGAGTTCGTGGAGAAGATAATGGGAGGTCAAGCAGCAGCCGAGAAGGAGGGCATTGTGGTGCCCGCTTCTGCCCCGGATGCTTTGGTCATCACTGCTACCTGCGCCTGA
Protein Sequence
- >Vitvi17g00371_P001
MTVLSVSTPPAPQAPLAATGPRTLVVGASGFIGRFVAEASLSSGHPTYVLVRSSATTSSSKASTIKSLEDQGAILVTGSIGDKEVMIEILRKYEIEVVISAVGGATILDQLTLAEAIKAVGSIKRFLPSEFGHDIDRAEPVEPGLTMYMEKRKVRRFIEEAAIPYTYICCNSIAAWPYHDNTHPADVLPPLDRFHIYGDGSVKAYFVAGTDIGKFTIKTINDDRTVNKSLHFRPPSNLVSINELASLWEKKIGRTLPRVTVEEDDLLAAAAEMCIPDSIVASFTHDIFIKGCQVNFSLDKPTDLEATSLYPEMQFRTIDECFDEFVEKIMGGQAAAEKEGIVVPASAPDALVITATCA - >Vitvi17g00371_P002
MTVLSVSTPPAPQAPLAATGPRTLVVGASGFIGRFVAEASLSSGHPTYVLVRSSATTSSSKASTIKSLEDQGAILVTGSIGDKEVMIEILRKYEIEVVISAVGGATILDQLTLAEAIKAVGSIKRFLPSEFGHDIDRAEPVEPGLTMYMEKRKVRRFIEEAAIPYTYICCNSIAAWPYHDNTHPADVLPPLDRFHIYGDGSVKAYFVAGTDIGKFTIKTINDDRTVNKSLHFRPPSNLVSINELASLWEKKIGRTLPRVTVEEDDLLAAAAEMCIPDSIVASFTHDIFIKGCQVNFSLDKPTDLEATSLYPEMQFRTIDECFDEFVEKIMGGQAAAEKEGIVVPASAPDALVITATCA