Gene Details:

Functional Descriptions:

  • Mutation of the YrAS2388R allele disrupts its resistance to Pst in synthetic hexaploid wheat; transgenic plants with YrAS2388R show resistance to eleven Pst races in common wheat and one race of P. striiformis f. sp. hordei in barley.
  • We reveal that YrAS2388 encodes a typical nucleotide oligomerization domain-like receptor (NLR). The Pst-resistant allele YrAS2388R has duplicated 3 untranslated regions and is characterized by alternative splicing in the nucleotide-binding domain.
  • The cloning of YrAS2388R will facilitate breeding for stripe rust resistance in wheat and other Triticeae species
  • YrAS2388R confers resistance to wheat stripe rust
  • YrAS2388R suppression might conceivably be caused by close homologues of NLR4DS-1 that are present in Triticeae.

Literature:

Gene Resources:

Sequences:

cDNA Sequence
  • >TraesCS4D02G004100.1
    ACAAGCTGAACAACTGTATTGGCAAGACTACAGCAACACCGGAAGGCAGAGGAATTCAACCAATTCAAGGTGTTGATTGCCACATCCCATTGGATCGCTTGTAGCTCCCCGATCTGGATCTGGATAACTAGCTACAGTAGTACGACTCTGGATGGCTGCTATATATCTCCCTCATTTGATCTGCATCGGCTGCTCACTCCTCATCACGCATCTCTCCACTTGATTCAAGTACCAGCTGAAAACGCGAGCCAAGCCTGCACCTACTTCCCAGAGAGCAAGGGAGGGAGATCTATCTAGTTTTTGCTCTGAAATAAGGGTGAACCCAAGATCCGTCTCTGATCTCTCCAGTCGATTCAAGTACCAGCTCAAGTGTGAGCTAACCCTGCAACAAATGGCGGGGGTTCTGGATGCTTTGGCATCTTACGTGACCAGCATGCTTGCCGAGATGGCCAAAGAGGAGGTGGCCATGCTAATCGGCGTAACCGATGGGATCAAAGACCTAAGCATCAAGCTTGGGGACCTCAAGAATTTCCTTGCTGATGCTGATAGGAGGAACATTACCGATGATAGTGTGCGGGGGTGGGTGGGCGAACTGAAGCGTGCCATGTACTTGGCCACTGACATCGTCGACCTATGTCAGCTCAAGGCCATGGAGCAAGGTCAAACAAAGGACAGGGGGTGCCTTAACCCTTTGCTCTTTTGCATGCGGAATCCACTCCACGCCCACGACATCGGCACCCGCATCAAGCTGCTCAACCAAAATTTGGATGATATTTGCAAGAGGGGCAGCAGTTTCAATTTCATCAAGCTAGAAGCCTACCAAGACCAAAAGACCACTCGGTCTCCCGCCACTGACCGGAAAACAAATGCACTGATTGAGCGGTCCGGTGTGGTTGGAGAGAAGATCGAGGAGGACACGAGGGCACTTGTGGAGGTGCTTACAAGGGAGGCGGTAGGTGACAAGAGTGGTCGCCTCATTGTGGTCGCCATTGTTGGTATCGGAGGGATTGGTAAGACTACCCTCGGCAAGAAGGTCTTCAATGATGAGGCCATCGAAGGCAAGTTTACTAAGAAGATATGGCTTAGCATCACACAAGATTTCACCGATGTTGAGTTGTTAAGTACGACCATCACTGCCATTGGGGCAGATCTTCCTGGAGGGGGTGGGGCTCCAGACAAGGCCCTACTTGTCGATGCTCTCAAGAACGCCATCAAGGACAAGAAGTTCTTTCTTGTACTAGATGACCTGTGGGATGTCGATGCATGGAACAAACATCTAATGACTCCCTTTAGCTATGGTGGCCCCGGTAGTAGAGTCCTCATCACCACCAGACATGACACTGTAGCCCGAAGCATGAAAGCCTTTCATCCCTACCATCATGTTGACAAATTAGCTCCAGAAGATGCTTGGTCGTTGCTCAAGAAGCAGGTACTCACAGGAGAGGAAAATGAACCAGAAGTTGATATGCTAGAAGATATTGGCCTGCAGATTATAGCAAAATGTGATGGCTTACCACTTGCTGTAAAAGTTATGGGTGGACTCCTATGCAAGAAGGAGAAAACACGACGTGATTGGCAAGACGTCTTGAATGATGATATGTGGTCAGTATCTCAAATGTCAAAGGAACTAAATTATGCCATATATCTTAGCTATCAGGATTTGTCCCCTTACTTAAAACAGTGCTTCTTGCACTTCTCCCTCAAACCAAAAAAGACAGTGATAAATGATACTGAAATTGTGTCCATGTGGGTTGGTGAAGGATTGGTTGAAGGAGACACATATAGTCGTAGTTTGGAAGAAGGGAATAAGTACTATAAGGAGCTAATAGTAAGGAACCTTATAGAGGTAGATACAGATTACCCTAGTCAACTTATTAGCAACATGCATGATGTCATTCGCTCATTTGCTCAATTCGTAGCTAGGGATGAAGCACTGTTAGTTCATAGTGGAGAGACCATTAAAAAAAAACTTGGAGCTCAAAGTTTTCTTAGGTTGTCTATAGAAACCAAAGGAGTAGAATGCGATGAATTTGAGTGGAGGTATTTAAGAGAGCAGAAATCTCTTAGGACACTGATAGTAACTGGAAACCTCAAACTTCAGTCTGGTGATTCATTGGTTACCTTTTCTAGTCTACGGACTCTACATATTGAATCTGCAAATATTGCTGCACTGGTTGAATGCATGTACCAACTCAAGCACTTGAGATATTTGTCATTAAAGAGGACTGATATTTGTAGACTACCAGAGAACATCCATGAGATGAAATTCCTACAGCATATTGACCTTGAATATTGTGAAAGTTTCATGAAACTTCCTGATAGCATTATCAAGCTGCAAGGCTTGAGATATCTTGACATGGATGACACACGTGTAAGTAGTATTCCTAGGGGTTTCAGAGCTCTTACAAATTTGAGTGCACTCTTTGGGTTTCCAGCCTATACTGATGGTGACTGGTGTAGTTTGGAAGAGTTGGGGTCTCTTTCCCAGCTCAATAAACTTTCTCTAGAGAGCCTAGAAAATGTATCTAGTACCTTGTTGGCTGCAAAGGCAAGGGTAGATGCAAAGAAACAACTCACCTCTCTTGGTTTGAAATGTGGTGGTAGAGTGGGAGATGGGTTGGTCCAAGGAGAAGTCTCTGAGTCTAAGGAGGAGGAGCAAATAATTGAGGCGGTGTTTGATGTGCTCTGTCCTCAGCCTTGCATAGAACACATCAGCATAGAAAGATATTTTGGTCGTCGGCTGCCAAGATGGATGGCGTCCACAGCTATGGTGCCCCTTGAGAGCTTGAAGATTGTAGCCCTCGAACACCTGCCCTGCTGCACCCAACTCCCAGATGGCTTGTGCAGGCTCCCGTATTTGGAGTGGATAAAAGTGGACGGGGCTCCAGTAATCAAGTGTATTGGTCCTGAATTCGTTCAACAGTACAATCAGCTGCACCGTCCTTCATCTCAGTTGGCTGCTACGTTTCCCAAACTCCAGAAGTTGAGTTTTTTCTCAATGGAGGAATGGGAGGAGTGGGTTTGGGAGACAGAAGTGAAATCTATGCCCTTATTAGAGGACCTTCGTATCACTTCTTGCAGACTGGGTCGTATGCCTCCAGGACTTATGTCTCATGCGATGGCGTTGAAGAAGCTAAGAATATGGAACGTCCAATGTCTCCACTCTCTAGAGAACTTTGTTTCTGTAGTTGAGCTCGACCTGTATGACATACCTGAATTGGCCATGATCTCCAATCTTCCAAAATTACAAAAGCTTACAATCGAGTATTGCCCAAAGCTCGAGATGCTGCAGGAGATGGCTGCAGTCCGGAGACTCGAGCTGAGAGTTTTCCGCTGGGAAAATCAACTTCCAGTCTACCTGCAAACTGTGAAGCCTAGTCATTTGCTGCTGACCTGCAACCTAGCGGTACTCACTTCCATGGCTGAGGGTGAATCTAGCTCCGAGTGGGACAAGTTCAGTCATATCAAGCACGTCGAGGCTTATGCAGAGGATGGAGGAGATGAGAAGAAATGGCACATCTTCTACACATCTGAGTCCTCCAACATGGAGACAAATATTCATCAGGATCGATTGGTCGAAGAAGAGGAGTAGGCTGAAACTCCAGCCGAACGAGGAAGGACCATATGATGCAATGATATATATATATATAAGGATATGGGGAAAGCATCATACACTTACCTGCAGAGATTCAGACACCACACTAATTTCTTGAGAAGTGTGACATATACACTTATGAATTTAGAGATGTAAAGTTCGTGGCGGACTATCTAGCTGGTGAAGAAACATGGTGACCTTGGCAAGGCTCTCCTTTGTTTAGTGCAAGCAACTAATGGAGTTTAGACTACTCTGCTTTGCTCTGTTCTCTGAAAGCAGCTCAGGTTGCAGGTCCTCTGAAGCAGCTGCGTTTTTCTTTTTCTTTTTTCGCGGGTGTCTTTCATTCGTTCTCTGGAAAACTATGTTTATTTCTGATAGACCAGTCAATAGTCTACTGGTATTTCAGCTTTTAATTTCTACTGCAACAACACAAATGACTGTCAGAAAGTGGAGTTTATTCAAGCTTCCGGCTGCTGATTTGTAACTGTATGTCATAGGAATTCAGAATCAGAGTGATGTATACTGGGACCAAACAAATGTTGGTGAGATCCTGGTCCACGAAGGTCACGACGATGACCTGCTGACTGGATGTTCTAGCTATCTTTAGTTTCTTCAATTAGTGAAATCAAATTAAGTTCAGCTTTCTTCTGGGGCTCTGTCTATGCTCTGGACGGAAGCAACTAACTTGGGTTACAAGTTATGTCTCTGGAACACTAAATACTGTTAGAACAAACCCAATCGAAATGTACTAATGCTCTGCACCTGTGAGCCAATCAAACGGATGTATATCAAAGAGAGGCATCATATTATTTTGCCTTGCT
CDS Sequence
  • >TraesCS4D02G004100.1
    ATGGCGGGGGTTCTGGATGCTTTGGCATCTTACGTGACCAGCATGCTTGCCGAGATGGCCAAAGAGGAGGTGGCCATGCTAATCGGCGTAACCGATGGGATCAAAGACCTAAGCATCAAGCTTGGGGACCTCAAGAATTTCCTTGCTGATGCTGATAGGAGGAACATTACCGATGATAGTGTGCGGGGGTGGGTGGGCGAACTGAAGCGTGCCATGTACTTGGCCACTGACATCGTCGACCTATGTCAGCTCAAGGCCATGGAGCAAGGTCAAACAAAGGACAGGGGGTGCCTTAACCCTTTGCTCTTTTGCATGCGGAATCCACTCCACGCCCACGACATCGGCACCCGCATCAAGCTGCTCAACCAAAATTTGGATGATATTTGCAAGAGGGGCAGCAGTTTCAATTTCATCAAGCTAGAAGCCTACCAAGACCAAAAGACCACTCGGTCTCCCGCCACTGACCGGAAAACAAATGCACTGATTGAGCGGTCCGGTGTGGTTGGAGAGAAGATCGAGGAGGACACGAGGGCACTTGTGGAGGTGCTTACAAGGGAGGCGGTAGGTGACAAGAGTGGTCGCCTCATTGTGGTCGCCATTGTTGGTATCGGAGGGATTGGTAAGACTACCCTCGGCAAGAAGGTCTTCAATGATGAGGCCATCGAAGGCAAGTTTACTAAGAAGATATGGCTTAGCATCACACAAGATTTCACCGATGTTGAGTTGTTAAGTACGACCATCACTGCCATTGGGGCAGATCTTCCTGGAGGGGGTGGGGCTCCAGACAAGGCCCTACTTGTCGATGCTCTCAAGAACGCCATCAAGGACAAGAAGTTCTTTCTTGTACTAGATGACCTGTGGGATGTCGATGCATGGAACAAACATCTAATGACTCCCTTTAGCTATGGTGGCCCCGGTAGTAGAGTCCTCATCACCACCAGACATGACACTGTAGCCCGAAGCATGAAAGCCTTTCATCCCTACCATCATGTTGACAAATTAGCTCCAGAAGATGCTTGGTCGTTGCTCAAGAAGCAGGTACTCACAGGAGAGGAAAATGAACCAGAAGTTGATATGCTAGAAGATATTGGCCTGCAGATTATAGCAAAATGTGATGGCTTACCACTTGCTGTAAAAGTTATGGGTGGACTCCTATGCAAGAAGGAGAAAACACGACGTGATTGGCAAGACGTCTTGAATGATGATATGTGGTCAGTATCTCAAATGTCAAAGGAACTAAATTATGCCATATATCTTAGCTATCAGGATTTGTCCCCTTACTTAAAACAGTGCTTCTTGCACTTCTCCCTCAAACCAAAAAAGACAGTGATAAATGATACTGAAATTGTGTCCATGTGGGTTGGTGAAGGATTGGTTGAAGGAGACACATATAGTCGTAGTTTGGAAGAAGGGAATAAGTACTATAAGGAGCTAATAGTAAGGAACCTTATAGAGGTAGATACAGATTACCCTAGTCAACTTATTAGCAACATGCATGATGTCATTCGCTCATTTGCTCAATTCGTAGCTAGGGATGAAGCACTGTTAGTTCATAGTGGAGAGACCATTAAAAAAAAACTTGGAGCTCAAAGTTTTCTTAGGTTGTCTATAGAAACCAAAGGAGTAGAATGCGATGAATTTGAGTGGAGGTATTTAAGAGAGCAGAAATCTCTTAGGACACTGATAGTAACTGGAAACCTCAAACTTCAGTCTGGTGATTCATTGGTTACCTTTTCTAGTCTACGGACTCTACATATTGAATCTGCAAATATTGCTGCACTGGTTGAATGCATGTACCAACTCAAGCACTTGAGATATTTGTCATTAAAGAGGACTGATATTTGTAGACTACCAGAGAACATCCATGAGATGAAATTCCTACAGCATATTGACCTTGAATATTGTGAAAGTTTCATGAAACTTCCTGATAGCATTATCAAGCTGCAAGGCTTGAGATATCTTGACATGGATGACACACGTGTAAGTAGTATTCCTAGGGGTTTCAGAGCTCTTACAAATTTGAGTGCACTCTTTGGGTTTCCAGCCTATACTGATGGTGACTGGTGTAGTTTGGAAGAGTTGGGGTCTCTTTCCCAGCTCAATAAACTTTCTCTAGAGAGCCTAGAAAATGTATCTAGTACCTTGTTGGCTGCAAAGGCAAGGGTAGATGCAAAGAAACAACTCACCTCTCTTGGTTTGAAATGTGGTGGTAGAGTGGGAGATGGGTTGGTCCAAGGAGAAGTCTCTGAGTCTAAGGAGGAGGAGCAAATAATTGAGGCGGTGTTTGATGTGCTCTGTCCTCAGCCTTGCATAGAACACATCAGCATAGAAAGATATTTTGGTCGTCGGCTGCCAAGATGGATGGCGTCCACAGCTATGGTGCCCCTTGAGAGCTTGAAGATTGTAGCCCTCGAACACCTGCCCTGCTGCACCCAACTCCCAGATGGCTTGTGCAGGCTCCCGTATTTGGAGTGGATAAAAGTGGACGGGGCTCCAGTAATCAAGTGTATTGGTCCTGAATTCGTTCAACAGTACAATCAGCTGCACCGTCCTTCATCTCAGTTGGCTGCTACGTTTCCCAAACTCCAGAAGTTGAGTTTTTTCTCAATGGAGGAATGGGAGGAGTGGGTTTGGGAGACAGAAGTGAAATCTATGCCCTTATTAGAGGACCTTCGTATCACTTCTTGCAGACTGGGTCGTATGCCTCCAGGACTTATGTCTCATGCGATGGCGTTGAAGAAGCTAAGAATATGGAACGTCCAATGTCTCCACTCTCTAGAGAACTTTGTTTCTGTAGTTGAGCTCGACCTGTATGACATACCTGAATTGGCCATGATCTCCAATCTTCCAAAATTACAAAAGCTTACAATCGAGTATTGCCCAAAGCTCGAGATGCTGCAGGAGATGGCTGCAGTCCGGAGACTCGAGCTGAGAGTTTTCCGCTGGGAAAATCAACTTCCAGTCTACCTGCAAACTGTGAAGCCTAGTCATTTGCTGCTGACCTGCAACCTAGCGGTACTCACTTCCATGGCTGAGGGTGAATCTAGCTCCGAGTGGGACAAGTTCAGTCATATCAAGCACGTCGAGGCTTATGCAGAGGATGGAGGAGATGAGAAGAAATGGCACATCTTCTACACATCTGAGTCCTCCAACATGGAGACAAATATTCATCAGGATCGATTGGTCGAAGAAGAGGAGTAG
Protein Sequence
  • >TraesCS4D02G004100.1
    MAGVLDALASYVTSMLAEMAKEEVAMLIGVTDGIKDLSIKLGDLKNFLADADRRNITDDSVRGWVGELKRAMYLATDIVDLCQLKAMEQGQTKDRGCLNPLLFCMRNPLHAHDIGTRIKLLNQNLDDICKRGSSFNFIKLEAYQDQKTTRSPATDRKTNALIERSGVVGEKIEEDTRALVEVLTREAVGDKSGRLIVVAIVGIGGIGKTTLGKKVFNDEAIEGKFTKKIWLSITQDFTDVELLSTTITAIGADLPGGGGAPDKALLVDALKNAIKDKKFFLVLDDLWDVDAWNKHLMTPFSYGGPGSRVLITTRHDTVARSMKAFHPYHHVDKLAPEDAWSLLKKQVLTGEENEPEVDMLEDIGLQIIAKCDGLPLAVKVMGGLLCKKEKTRRDWQDVLNDDMWSVSQMSKELNYAIYLSYQDLSPYLKQCFLHFSLKPKKTVINDTEIVSMWVGEGLVEGDTYSRSLEEGNKYYKELIVRNLIEVDTDYPSQLISNMHDVIRSFAQFVARDEALLVHSGETIKKKLGAQSFLRLSIETKGVECDEFEWRYLREQKSLRTLIVTGNLKLQSGDSLVTFSSLRTLHIESANIAALVECMYQLKHLRYLSLKRTDICRLPENIHEMKFLQHIDLEYCESFMKLPDSIIKLQGLRYLDMDDTRVSSIPRGFRALTNLSALFGFPAYTDGDWCSLEELGSLSQLNKLSLESLENVSSTLLAAKARVDAKKQLTSLGLKCGGRVGDGLVQGEVSESKEEEQIIEAVFDVLCPQPCIEHISIERYFGRRLPRWMASTAMVPLESLKIVALEHLPCCTQLPDGLCRLPYLEWIKVDGAPVIKCIGPEFVQQYNQLHRPSSQLAATFPKLQKLSFFSMEEWEEWVWETEVKSMPLLEDLRITSCRLGRMPPGLMSHAMALKKLRIWNVQCLHSLENFVSVVELDLYDIPELAMISNLPKLQKLTIEYCPKLEMLQEMAAVRRLELRVFRWENQLPVYLQTVKPSHLLLTCNLAVLTSMAEGESSSEWDKFSHIKHVEAYAEDGGDEKKWHIFYTSESSNMETNIHQDRLVEEEE