Information report for TaMSH7-3D;Ph2
Gene Details
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Functional Descriptions
- Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question.
- Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination.
- TaMSH7-3D reduces pollen viability but does not affect plant fertility.
- TaMSH7-3D is expressed in anthers during meiotic prophase I.
- Similar to Ph2 mutant phenotype, we show that mutating MSH7-3D induces a substantial increase in homoeologous recombination (up to 5.5 fold) in wheat-wild relative hybrids, which is also associated with a reduction in homologous recombination.
Functional Keywords
Literature and News
Gene Resources
- NCBI ID: 542874
- UniProt accessions: A0A3B6GPQ1
- AlphaFoldDB: A0A3B6GPQ1
- EnsemblPlants: TraesCS3D02G119400.1
- Gramene: TraesCS3D02G119400.1
- GO: GO:0005524 , GO:0005634 , GO:0006298
- OMA: IKNICHP
- InterPro: IPR000432 , IPR007695 , IPR007696 , IPR007860 , IPR016151
- PANTHER: PTHR11361 , PTHR11361:SF148
- SUPFAM: SSF48334 , SSF52540 , SSF53150 , SSF55271
- PROSITE: PS00486
- Gene3D: 1.10.1420.10 , 3.30.420.110 , 3.40.1170.10 , 3.40.50.300
- SMR: A0A3B6GPQ1
- CDD: cd03286
Sequences
cDNA Sequence
- >TraesCS3D02G119400.1
GCACGCAGGGCGCGAGACGCGAGACGGCGGGGAAAGCGGAAAACCCCCACCCATTTCCCCTCTCCACCGCGCTCGCATTTCCCGCTCGGAAATTCCCCCAAATAATTTCATCTCCCTCCCATTCCCCTCTCCGCTCCCCACCTCCCAGAGAACCCCGCTCCTCCCGCCCGGACGGAGCCACCTCGAGTCGAATCCCGGCCACCGCGATGCAGCCGCGGCGGCAGCAGCAGTCCATCCGCTCCTTCCTCCACCCGCGCCCGAGCCCGGCGCAGGAGGCGTCCGGCGCCGGCACGACCCCCGAGAGGCCCCCGCGGCCCCCCGCCGCGTCGTCGGTCGACGGCATCATGGAGCGGCTCGTGCGTCCGCCGTCGCAGGGGAGAAACAAAGATGCCACTCAGATTAGAAATGCTGAGAGAGCCTTACCTGGTAAAAATGAAGATACCTCAAATGAGCAGCCAAGTGCATCATTCCCTGTACGGTACAACGGCAAATATAGCAGAGGAACTGTGTTATTTGCAGAACATAGCACAGATACCACTCCGCCACAGGAGCCATTGAAGTTCTCTGCAAGGTCTTCCACAGATGAATTTGTTAGAGCAAGCACGCTGTTCCCTGAAATTGGTTCAGATCAAACTCTGCTTCAGGAGTGTCCGAAGAAGTTATCCTCAGAGTGCCCCAGCAACCAGTACGTTCAAGCTAATTCAGTGTTTGAAGCATTTGATGTACAAACTCCATCCCAGGATCCGTTAAAGAGAATCTTTTCTGGGCCTTTTCATGGAGCAGATACACCTTTATCAGAGTATCGTTCATATCCAATTCCTTTGCAGCATCCATCGAAAAAGTTGTCATCGGGCTCTTCTAGTGGTGAATACCTTAGAGCAGTGACACCGCTTGGACTTGATTCGAATGATACTCCTACAGCGAAACACTCAAAGAAGCTATTCTCTGGGTCTTCAGACCATTCATACATTAAAGCAACTAATTTGTTTCCGGAATTTGATTCAAATGGAACTCCGCTGCAGAACCACTCCAATAAGTTCTCAGTATCTATGAACAGTAAGAATATTGGAGCACCTGCTACACTGTTTCCGGAACTTGATTCTGTTCTTCTGAAACCAGAAACTCCAGTGACACAAGCAGTGGCTCCTCGTGGGAAGAGAGTTCAACAGGATCAATGCATGACTGCCAATAACTGTCAGTCTCCTTTGTGGGGTTCAAATAAGAAGGTGAAATCAGCTCATTGTTCTCCAGCTGGGAAAATGGTTCATGATGAAATGGCTGAAAGTGCACGTAGTAAATTTGAATGGCTGAATCCTTTGAATATCAGGGATGCAAATAAAAGGCGGCCAGATGACCCACTTTATGACAAGAGAACTCTTTTTATTCCACCTGATGCACTGAGAAAGATGTCAACATCTCAAAAGCAATACTGGACTATTAAGTGTAAATATATGGATGTTCTCCTCTTCTTCAAAGTGGGGAAGTTTTATGAGCTCTATGAAGTAGATGCTGAGATCGGCCAAAAGGAACTTGATTGGAAAATGACTATTAGTGGGGTGGGAAAATGCCGACAGGTTGGTATTTCAGAGAGTGGGATTGACAATGCTGTTGAAAAGCTTTTAGCTCGGGGATATAAAGTTGGAAGGATAGAACAAATGGAATCTGCAGCACAGGCGAAAGCTAGAGGACCAAATTCAGTTATTGAAAGAAAGTTAGCTCATGTATCCACACCGTCAACTGCAGCTGACAGCAACATAGGGCCTGATGCTGTTCATCTTCTTGCATTGAAAGAGGTTACTCTAGCTTCTAATGGTTCTCGGGTCTACGGATTTGCTTTTCTAGATTATGCTGCACTTAAAATCTGGGTTGGTTCACTTCAAGATGATGATTCTTCTGCAGCTTTGGGGGCTTTGCTGGTGCAGGTTTCCCCGAGGGAGATAATCTATGAATCCTCAGGCCTCTCAAGAGAAAGTCGTAAATCAATGATAAAATATGCCTCAGCAGGCTCTGTGAAAATGCAACTGACCCCACTACCTGGGACAGATTTCTCTGATGCCTCACAAATTCAAATGCTAGTACATTCTAAAGGATACTTTAAAGCATCAACAGATTCTTGGCTATCTGCATTGGATTATTCAGTGAATCAAGATGCAGTTATCTGTGCACTTGGTGGACTTATTGGTCATTTGACTAGACTTATGCTAGACGATGCTCTAAAAAATGGGGAAGTCTTACCTTACAATGTGTACCAAACTTGTTTAAGGATGGATGGTCAGACTCTTGTGAACCTGGAGATTTTCGGCAATAACTTTGATGGTGGCTCATCAGGTACTCTGTACAAGCACCTCAATCACTGCATAACCGCATCTGGTAAGCGGCTTTTAAGAAGATGGATATGCCATCCACTAAAAGATGTCGATGCTATAAATAGAAGGCTTGATATTGTTGAGGGTTTCATTCAACATTGTGGGGTAGGCTCTGTTACACTTGAGCATCTCCGGAAAATTCCTGACCTTGAGAGGTTACTTGGGCGAGTCAGATCTACTGTTGGGCTAACATCTGCTGTCCTGTTGCCTTTTGTTGGTGAAAAGATATTAAAGAGGCGGATTAAAACGTTTTGCATGCTTATCAAGGGCCTCCGGGTTGCAATTGACTTATTAAGTGCCTTGCGTAGAGAGGACCATGGCATTCCAGCGCTGTCAAAATCAGTTGATATTCCAACCCTGAGTTCTCTTGATGAATCAGTCCATCAGTTTGAAGAGGCTATACGCATTGACTTTGAACAGTACCAGGATCATGATATCAAAGACCATGATGCTACCACCTTGGCTAATTTAGTGGAACATTTTGTTGGAAAAGCTACCGAATGGTCTTTGGTAATCAATGCCATCAGCACTGTTGATGTCCTTAGGTCCTTTGCAGCAATGGCATTGTCATCATTTGGCACCATGTGCAGACCACGTATTCTGTTGAAAGACAAATCGCCTATACTTCGGATGAAGGGTCTATGGCATCCATATGCTTTTGCAGAAAGTGGAACTGGGCTTGTGCCAAACGATTTGTCTCTTGGCCAGGATTTATTGGGTCATAATCGCTTTGCATTGTTGTTGACTGGTCCAAATATGGGAGGAAAATCTACAATAATGCGCGCCACCTGCTTGGCTATCGTGCTTGCCCAGCTTGGCTGTTATGTCCCCTGCATATCATGTGAATTGACCCTTGCAGACTCCATCTTTACACGGCTAGGCGCAACGGATCGGATTATGTCTGGAGAAAGTACTTTTCTTGTCGAATGTAGTGAGACTGCATCTGTTCTTCAGAATGCAACTGAGGATTCTCTTGTCTTGCTTGATGAACTTGGCAGAGGAACTAGCACATTTGATGGATACGCGATTGCATATGCAGTATTCCGCCACCTGGTGGAACAGGTGCGATGCCGTCTGCTCTTTGCCACCCACTACCACCCTCTCACCAAGGAGTTCGCCTCCCACCCCCACGTGAGCCTCCAGCACATGGCCTGCATGCTGAGGCCAAGGAGCGGCGGCAACGGCGAGATGGAGCTCACCTTCCTCTACCGTCTTGTGTCAGGCGCCTCTCCGGAGAGCTACGGCCTGCAGGTCGCCACGATGGCGGGGATCCCAAAGTCCATAGTGGAGAAGGCGGCGGTCGCGGGCGAGATGATGAAGTCGAGGATCGCAGGGAACTTCAGGTCGAGCGAAGGGCGAGCGGAGTTCTCCACCCTCCACGAGGACTGGCTGCAGACGATCCTGGCGATCGGCGGCGTCAAGGACGCGCACCTGGACGAGGACACCATGGACACGATGTTCTGCGTCGCCCAGGAGCTCAAGTCTCATTTCAGGAAAGGAGGAAGCTGAGCGCTGAGAAGTCGCCACCGGTAATTATGCGTGGCACCATTAGATGTAGGTAGTCTGAAGGAGGAAGATGAGCACCGAGAAAGTCGCCGCTCACCATTAATCATCAGTGTTTTAATCCGTCCCAGTCGACGGCTTTGTATATATTTACCTCGCGTTTGTAATCACGCAAGCGCACCTGGGCCTGAGTTCATCTGAACTGTCAAAAACTTCATCTCGTAGTTTGTAATCACATGCACATTCCTAGTGATTAGTCGAGAGTTTTGACAAGGCTGGCAAGATCAAGCACCAACACCGCAAGTTCATCAAACTCCATTTGCCTGTATGGACAGCTACAAAGCCCACTTGCAGAGAAAAGGGCTTACCGCCATTTCTCGGACACAAGCATCCCCGTGCGCGCCGAGCTGTCCGTCCTCTCTTCCTACCATCCGC
CDS Sequence
- >TraesCS3D02G119400.1
ATGCAGCCGCGGCGGCAGCAGCAGTCCATCCGCTCCTTCCTCCACCCGCGCCCGAGCCCGGCGCAGGAGGCGTCCGGCGCCGGCACGACCCCCGAGAGGCCCCCGCGGCCCCCCGCCGCGTCGTCGGTCGACGGCATCATGGAGCGGCTCGTGCGTCCGCCGTCGCAGGGGAGAAACAAAGATGCCACTCAGATTAGAAATGCTGAGAGAGCCTTACCTGGTAAAAATGAAGATACCTCAAATGAGCAGCCAAGTGCATCATTCCCTGTACGGTACAACGGCAAATATAGCAGAGGAACTGTGTTATTTGCAGAACATAGCACAGATACCACTCCGCCACAGGAGCCATTGAAGTTCTCTGCAAGGTCTTCCACAGATGAATTTGTTAGAGCAAGCACGCTGTTCCCTGAAATTGGTTCAGATCAAACTCTGCTTCAGGAGTGTCCGAAGAAGTTATCCTCAGAGTGCCCCAGCAACCAGTACGTTCAAGCTAATTCAGTGTTTGAAGCATTTGATGTACAAACTCCATCCCAGGATCCGTTAAAGAGAATCTTTTCTGGGCCTTTTCATGGAGCAGATACACCTTTATCAGAGTATCGTTCATATCCAATTCCTTTGCAGCATCCATCGAAAAAGTTGTCATCGGGCTCTTCTAGTGGTGAATACCTTAGAGCAGTGACACCGCTTGGACTTGATTCGAATGATACTCCTACAGCGAAACACTCAAAGAAGCTATTCTCTGGGTCTTCAGACCATTCATACATTAAAGCAACTAATTTGTTTCCGGAATTTGATTCAAATGGAACTCCGCTGCAGAACCACTCCAATAAGTTCTCAGTATCTATGAACAGTAAGAATATTGGAGCACCTGCTACACTGTTTCCGGAACTTGATTCTGTTCTTCTGAAACCAGAAACTCCAGTGACACAAGCAGTGGCTCCTCGTGGGAAGAGAGTTCAACAGGATCAATGCATGACTGCCAATAACTGTCAGTCTCCTTTGTGGGGTTCAAATAAGAAGGTGAAATCAGCTCATTGTTCTCCAGCTGGGAAAATGGTTCATGATGAAATGGCTGAAAGTGCACGTAGTAAATTTGAATGGCTGAATCCTTTGAATATCAGGGATGCAAATAAAAGGCGGCCAGATGACCCACTTTATGACAAGAGAACTCTTTTTATTCCACCTGATGCACTGAGAAAGATGTCAACATCTCAAAAGCAATACTGGACTATTAAGTGTAAATATATGGATGTTCTCCTCTTCTTCAAAGTGGGGAAGTTTTATGAGCTCTATGAAGTAGATGCTGAGATCGGCCAAAAGGAACTTGATTGGAAAATGACTATTAGTGGGGTGGGAAAATGCCGACAGGTTGGTATTTCAGAGAGTGGGATTGACAATGCTGTTGAAAAGCTTTTAGCTCGGGGATATAAAGTTGGAAGGATAGAACAAATGGAATCTGCAGCACAGGCGAAAGCTAGAGGACCAAATTCAGTTATTGAAAGAAAGTTAGCTCATGTATCCACACCGTCAACTGCAGCTGACAGCAACATAGGGCCTGATGCTGTTCATCTTCTTGCATTGAAAGAGGTTACTCTAGCTTCTAATGGTTCTCGGGTCTACGGATTTGCTTTTCTAGATTATGCTGCACTTAAAATCTGGGTTGGTTCACTTCAAGATGATGATTCTTCTGCAGCTTTGGGGGCTTTGCTGGTGCAGGTTTCCCCGAGGGAGATAATCTATGAATCCTCAGGCCTCTCAAGAGAAAGTCGTAAATCAATGATAAAATATGCCTCAGCAGGCTCTGTGAAAATGCAACTGACCCCACTACCTGGGACAGATTTCTCTGATGCCTCACAAATTCAAATGCTAGTACATTCTAAAGGATACTTTAAAGCATCAACAGATTCTTGGCTATCTGCATTGGATTATTCAGTGAATCAAGATGCAGTTATCTGTGCACTTGGTGGACTTATTGGTCATTTGACTAGACTTATGCTAGACGATGCTCTAAAAAATGGGGAAGTCTTACCTTACAATGTGTACCAAACTTGTTTAAGGATGGATGGTCAGACTCTTGTGAACCTGGAGATTTTCGGCAATAACTTTGATGGTGGCTCATCAGGTACTCTGTACAAGCACCTCAATCACTGCATAACCGCATCTGGTAAGCGGCTTTTAAGAAGATGGATATGCCATCCACTAAAAGATGTCGATGCTATAAATAGAAGGCTTGATATTGTTGAGGGTTTCATTCAACATTGTGGGGTAGGCTCTGTTACACTTGAGCATCTCCGGAAAATTCCTGACCTTGAGAGGTTACTTGGGCGAGTCAGATCTACTGTTGGGCTAACATCTGCTGTCCTGTTGCCTTTTGTTGGTGAAAAGATATTAAAGAGGCGGATTAAAACGTTTTGCATGCTTATCAAGGGCCTCCGGGTTGCAATTGACTTATTAAGTGCCTTGCGTAGAGAGGACCATGGCATTCCAGCGCTGTCAAAATCAGTTGATATTCCAACCCTGAGTTCTCTTGATGAATCAGTCCATCAGTTTGAAGAGGCTATACGCATTGACTTTGAACAGTACCAGGATCATGATATCAAAGACCATGATGCTACCACCTTGGCTAATTTAGTGGAACATTTTGTTGGAAAAGCTACCGAATGGTCTTTGGTAATCAATGCCATCAGCACTGTTGATGTCCTTAGGTCCTTTGCAGCAATGGCATTGTCATCATTTGGCACCATGTGCAGACCACGTATTCTGTTGAAAGACAAATCGCCTATACTTCGGATGAAGGGTCTATGGCATCCATATGCTTTTGCAGAAAGTGGAACTGGGCTTGTGCCAAACGATTTGTCTCTTGGCCAGGATTTATTGGGTCATAATCGCTTTGCATTGTTGTTGACTGGTCCAAATATGGGAGGAAAATCTACAATAATGCGCGCCACCTGCTTGGCTATCGTGCTTGCCCAGCTTGGCTGTTATGTCCCCTGCATATCATGTGAATTGACCCTTGCAGACTCCATCTTTACACGGCTAGGCGCAACGGATCGGATTATGTCTGGAGAAAGTACTTTTCTTGTCGAATGTAGTGAGACTGCATCTGTTCTTCAGAATGCAACTGAGGATTCTCTTGTCTTGCTTGATGAACTTGGCAGAGGAACTAGCACATTTGATGGATACGCGATTGCATATGCAGTATTCCGCCACCTGGTGGAACAGGTGCGATGCCGTCTGCTCTTTGCCACCCACTACCACCCTCTCACCAAGGAGTTCGCCTCCCACCCCCACGTGAGCCTCCAGCACATGGCCTGCATGCTGAGGCCAAGGAGCGGCGGCAACGGCGAGATGGAGCTCACCTTCCTCTACCGTCTTGTGTCAGGCGCCTCTCCGGAGAGCTACGGCCTGCAGGTCGCCACGATGGCGGGGATCCCAAAGTCCATAGTGGAGAAGGCGGCGGTCGCGGGCGAGATGATGAAGTCGAGGATCGCAGGGAACTTCAGGTCGAGCGAAGGGCGAGCGGAGTTCTCCACCCTCCACGAGGACTGGCTGCAGACGATCCTGGCGATCGGCGGCGTCAAGGACGCGCACCTGGACGAGGACACCATGGACACGATGTTCTGCGTCGCCCAGGAGCTCAAGTCTCATTTCAGGAAAGGAGGAAGCTGA
Protein Sequence
- >TraesCS3D02G119400.1
MQPRRQQQSIRSFLHPRPSPAQEASGAGTTPERPPRPPAASSVDGIMERLVRPPSQGRNKDATQIRNAERALPGKNEDTSNEQPSASFPVRYNGKYSRGTVLFAEHSTDTTPPQEPLKFSARSSTDEFVRASTLFPEIGSDQTLLQECPKKLSSECPSNQYVQANSVFEAFDVQTPSQDPLKRIFSGPFHGADTPLSEYRSYPIPLQHPSKKLSSGSSSGEYLRAVTPLGLDSNDTPTAKHSKKLFSGSSDHSYIKATNLFPEFDSNGTPLQNHSNKFSVSMNSKNIGAPATLFPELDSVLLKPETPVTQAVAPRGKRVQQDQCMTANNCQSPLWGSNKKVKSAHCSPAGKMVHDEMAESARSKFEWLNPLNIRDANKRRPDDPLYDKRTLFIPPDALRKMSTSQKQYWTIKCKYMDVLLFFKVGKFYELYEVDAEIGQKELDWKMTISGVGKCRQVGISESGIDNAVEKLLARGYKVGRIEQMESAAQAKARGPNSVIERKLAHVSTPSTAADSNIGPDAVHLLALKEVTLASNGSRVYGFAFLDYAALKIWVGSLQDDDSSAALGALLVQVSPREIIYESSGLSRESRKSMIKYASAGSVKMQLTPLPGTDFSDASQIQMLVHSKGYFKASTDSWLSALDYSVNQDAVICALGGLIGHLTRLMLDDALKNGEVLPYNVYQTCLRMDGQTLVNLEIFGNNFDGGSSGTLYKHLNHCITASGKRLLRRWICHPLKDVDAINRRLDIVEGFIQHCGVGSVTLEHLRKIPDLERLLGRVRSTVGLTSAVLLPFVGEKILKRRIKTFCMLIKGLRVAIDLLSALRREDHGIPALSKSVDIPTLSSLDESVHQFEEAIRIDFEQYQDHDIKDHDATTLANLVEHFVGKATEWSLVINAISTVDVLRSFAAMALSSFGTMCRPRILLKDKSPILRMKGLWHPYAFAESGTGLVPNDLSLGQDLLGHNRFALLLTGPNMGGKSTIMRATCLAIVLAQLGCYVPCISCELTLADSIFTRLGATDRIMSGESTFLVECSETASVLQNATEDSLVLLDELGRGTSTFDGYAIAYAVFRHLVEQVRCRLLFATHYHPLTKEFASHPHVSLQHMACMLRPRSGGNGEMELTFLYRLVSGASPESYGLQVATMAGIPKSIVEKAAVAGEMMKSRIAGNFRSSEGRAEFSTLHEDWLQTILAIGGVKDAHLDEDTMDTMFCVAQELKSHFRKGGS