Gene Details:

Functional Descriptions:

  • These observations indicated that this promoter polymorphism might be responsible for the natural variations in TaHMA2b-7A expression that ultimately lead to plant Cd resistance and grain Cd accumulation in wheat plants.
  • Natural variations in TaHMA2b-7A determine wheat Cd resistance.
  • Functional gene analysis identified the plasma membrane-localized heavy metal ATPase TaHMA2b-7A as a crucial Cd exporter regulating long-distance Cd translocation in wheat.
  • Our results identified TaHMA2b-7A as a key candidate gene responsible for the differential plant Cd resistance and grain Cd accumulation between the two contrasting wheat genotypes.

Literature:

Gene Resources:

Sequences:

cDNA Sequence
  • >TraesCS7A02G420000.1
    ACTGCACAGGATCCTCCATAAATACTCTCGCCCCCCCTCCCAACAAGTCCCGCAGCTAAGCTAGCGCACCACCACCACACATCCTGCCTCCCTGCTTCCGCCTCCAACTGCGACGCCGGCCGGCAGGTCACATACGAGGGTCGCCGGCGCCGGGTCGGGTGTTCTTTCCACAGGACCAAGAAAACGCCAAGAGTGCGAGGGAGGGAGATGGCGGGCAGGCAGGAGAAGAGCTACTTCGACGTGCTGGGCATCTGCTGCCCGTCGGAGGTGCCGCTGGTGGAGAAGCTCCTCGAGCCGCTCGCCGGCGTGCACAAGGTCACCGTCGTCGTGCCCTCCCGGACCGTCATCGTCGTGCACGACGCCGCCGCCATCTCCCAGGCCCAGATCGTCAAGGCGCTGAACCAGGCAAGGCTAGAGGCGTCGGTGCGGGCGTACGGCGGCGCAGGCCAGAACAAGATCAACAAATGGCCGAGCCCCTACGTGCTCGTCTGCGGCGTCCTCCTGGTCGTCTCGCTCTTCGAGCACTTCTGGCGCCCGCTGAGGTGGCTCGCGCTCGTCGCCACGGCCGCCGGCCTGCCGCCCATCGTTCTCAGAAGCGTCGCCGCCGCGCGGAGGCTCACCCTGGACGTCAACATACTCATGCTCATCGCAGTTGCTGGGGCAATTGCACTCAAGGACTACTCCGAGGCTGGCTTCATCGTCTTCCTCTTCACCACGGCCGAGTGGCTCGAGACAAGGGCGAGCTGCAAGGCCACTGCCGGGATGGCGTCGCTGATGAGCATGGCACCACAGAACGCCGTGCTAGCAGAGACGGGGCAGGTGGTCGCGGCCCAGGACGTGAAGGTCAACACGGTGATCGCTGTCAAGGCGGGGGAGGTCGTTCCGATAGACGGCGTCGTCGTCGACGGGCGGAGCGAGGTCGACGAGCAGACCCTCACCGGAGAGTCCTTCCCGGTGGCCAAACAGACGGACTCGGAGGTCTGGGCCGGCACCCTCAACATAGACGGCTACATTTCCGTGAGGACCACGGCCATGGCCGACAACTCGGCGGTGGCCAAGATGGCGAGGCTGGTTGAAGAGGCCCAGAACAGCAGATCGGAGACGCAGAGGCTCATCGACACCTGCGCCAAGTACTACACGCCTGCGGTGATCGTCATGGCAGCGGCGGTGGCGGTGACGCCAGTGATCGTGAGAGCGCGCAACCTCAGGCACTGGTTTCAGCTGGCCCTGGTGCTTCTGGTGAGCGCCTGCCCGTGCGCTCTGGTTCTGTCGACGCCGGTCGCCACCTTCTGTGCGCTGCTCAAGGCCGCCAGGACCGGGCTGCTCATCAAAGGAGGGGATGTGCTCGAGTCCTTGGCCGGGATCAAAGTCGCGGCTTTCGACAAAACCGGCACAATCACTAGCGGAGAGTTCTCCGTCGCGGAGTTCCGGGCAGTCGGAGAACGTGTTACAAAGCAACAGCTGCTCTACTGGGTGTCGAGCGTGGAGAGCAGGTCGAGCCACCCAATGGCAGCTGCCCTTGTTGATTGTGCTCGATCAAACTCGGTGGAACCGAAATCGGAGAATGTGGTGGAGTTTCAGATTTACCCCGGTGAGGGGATTTACGGTGAAATCGACGGGCAAGGCGTATACGTCGGGAACAGAAGAATCTTGTCGAGGGCTTCATGTGAAACAGTTCCAGAGGTAAATGACATCAAAGGGGTCACCGTTGGATACGTGGCCTGCAACAAGGAGTTGGTCGGGCTATTCGGTCTCTCGGACGTCTGCCGAACTGGATCGGCAGAAGCCATCAGGGAGCTGAGATCCATGGGCATCAAGTCAGTGATGCTCACAGGCGATAGCACTGCCGCTGCCACCTATGCCCAGAACCAGCTGGGAAATGTTCTAGCCGAGGTTCACTCTGAACTTTTGCCGGAAGACAAGGTGCGGATCGTCGACGAGCTCAAGGCGAGGGACGGCCCCACGCTGATGGTCGGCGACGGCATGAACGACGCCCCGGCGCTGGCCAGGGCCGACGTCGGCGTCTCCATGGGCGTGTCCGGCTCGGCCGTCGCCATGGAGACGAGCCACGTCACGCTCATGTCCAACGACGTCCGCAGGATCCCCAAGGCCATCCGGCTGGCGAGGAGGACGCGCCGGACCATCGTCACCAACATCGTCTTCTCTGTCGCGACGAAGCTCGCCATCGTCGGGCTCGCGCTCGCCGGGCACCCGCTCGTCTGGGCGGCGGTGCTGGCGGACGTCGGCACGTGCTTGCTGGTGATCATGTACAGCATGATGTTGCTGAGGGGGGGAGACGGCGGGAGGGGGAAGAAATGCTGCGCTTCTTCTCACCATGGATCTCGCCCCGGGAAGCATGGCATGTCCCACCATTGCTCGGGCGGCTGCGCGGATTCGTCGTCTGCTGGTGGCCATGCTTGCGGCGATGAACATCATCAGCACGGGCATGGGCATGGCGACCACAAAGAGCCCGGCACCCCCCACCACCCCCAGAGGCATGGATGTGAAGGTCATGGCCATGGCCACTGCAAAGAACCGAGCAAGCTGCACCCCACGGACAGCCACCACTGTCAAGATCATGGTCAGGGCCACCACCACAGCAAAGAGGCGAGCAGCCAATTGGTGACAAGAAAGAACATTTCCCATGGCCATGGCCAGCGCAAAGAGAAGCACGACGAGCACAGCACCAGCTCGGCCGAGGCAATCCAAGAGCACTCCATACTGATCGACGCGTCAGCTGCTGACCAGCAACAAATCCAATGCAGTCACCAGAGCGAAGAGCACGAGGAGGAAAACTGCGGGCGTCACGCCAAGGCGAAAGCCTGCGCCCCAGCTCCGGCCGACTGCTGCGACACGGTACGCGACGAGGGATGCGGAACCAAAGCGGGGGGCGTGTGCTCGAGCCGGCGGGCCGGTTGCGCTGCCGGAGAAACCAGGCGGTGTTGCCGGAGCGCCAGGGCGAGCAGGTGCGGCGGCGGCGGCGGCCACGCAAGCATGCTGACGATGCCTGAGATCGTGGTGGAGTAGGATGGAACTACTCTACAGTATACATCAGCAGCAGCTCAAGAAGAGGGCTTTGCTGCTGCTGAAAATCGGTGGGGATGGGATGGGATGGGATGGGATGCCGCTTTCTTGCGTCCTTTGCCTGTTGATTGATCCGGCTTCGAGTAACAGTAGAAATGGGATCGTAACGTCCTAATAGGCTCCTTTTAAGAGAAGTTCGTGTTTGTTTTTATATTGGCCAAGGTGTAGCTTACTTGAGTTTTGTGTTTATCAAAGACCTCTAAATCGGCTAGGTTATGAGGAGTCTCCCATGAATGTCACATGGACTTGTGTCTTCAACTGGTAGAATAAAGCAGCCAATGCTCTATGTGTTTCGTAAATCTTCTTCAACTTCGACTACGAATATACGAAAACATAATTTCGTTCATAATAAGACCAAAATAGTCGAAATTACTAAATTCCAAACCACCGAGATTTCGCAACAAATCCGGACGCATCACCTAGCGTTGGATTGGGATCGAGCAGCAGCCATCTTCGTTTGATTTTTCTTCCATTTCTCCACCATCCCGCAATTATTGAGCGGCCGGTTTGCGCCATGATCTTCGTTTGATTTTTCTTCCATTTCTCCACCATCCTGCAATTATTGAGCGGCCGATTTTTCTTCCATTTCTCCACCATCCCACAATTATTGAGCGGCCGATTTGTGCCCCTCAAACATTGCTAGTAGGCAACTTCGAATGCTGCTGATGAGGGAATCATGTACTAGTGTAATGATGTTATTTTCTTGTGGAGTCTTTCATTATAGATTTACACATTGAC
CDS Sequence
  • >TraesCS7A02G420000.1
    ATGGCGGGCAGGCAGGAGAAGAGCTACTTCGACGTGCTGGGCATCTGCTGCCCGTCGGAGGTGCCGCTGGTGGAGAAGCTCCTCGAGCCGCTCGCCGGCGTGCACAAGGTCACCGTCGTCGTGCCCTCCCGGACCGTCATCGTCGTGCACGACGCCGCCGCCATCTCCCAGGCCCAGATCGTCAAGGCGCTGAACCAGGCAAGGCTAGAGGCGTCGGTGCGGGCGTACGGCGGCGCAGGCCAGAACAAGATCAACAAATGGCCGAGCCCCTACGTGCTCGTCTGCGGCGTCCTCCTGGTCGTCTCGCTCTTCGAGCACTTCTGGCGCCCGCTGAGGTGGCTCGCGCTCGTCGCCACGGCCGCCGGCCTGCCGCCCATCGTTCTCAGAAGCGTCGCCGCCGCGCGGAGGCTCACCCTGGACGTCAACATACTCATGCTCATCGCAGTTGCTGGGGCAATTGCACTCAAGGACTACTCCGAGGCTGGCTTCATCGTCTTCCTCTTCACCACGGCCGAGTGGCTCGAGACAAGGGCGAGCTGCAAGGCCACTGCCGGGATGGCGTCGCTGATGAGCATGGCACCACAGAACGCCGTGCTAGCAGAGACGGGGCAGGTGGTCGCGGCCCAGGACGTGAAGGTCAACACGGTGATCGCTGTCAAGGCGGGGGAGGTCGTTCCGATAGACGGCGTCGTCGTCGACGGGCGGAGCGAGGTCGACGAGCAGACCCTCACCGGAGAGTCCTTCCCGGTGGCCAAACAGACGGACTCGGAGGTCTGGGCCGGCACCCTCAACATAGACGGCTACATTTCCGTGAGGACCACGGCCATGGCCGACAACTCGGCGGTGGCCAAGATGGCGAGGCTGGTTGAAGAGGCCCAGAACAGCAGATCGGAGACGCAGAGGCTCATCGACACCTGCGCCAAGTACTACACGCCTGCGGTGATCGTCATGGCAGCGGCGGTGGCGGTGACGCCAGTGATCGTGAGAGCGCGCAACCTCAGGCACTGGTTTCAGCTGGCCCTGGTGCTTCTGGTGAGCGCCTGCCCGTGCGCTCTGGTTCTGTCGACGCCGGTCGCCACCTTCTGTGCGCTGCTCAAGGCCGCCAGGACCGGGCTGCTCATCAAAGGAGGGGATGTGCTCGAGTCCTTGGCCGGGATCAAAGTCGCGGCTTTCGACAAAACCGGCACAATCACTAGCGGAGAGTTCTCCGTCGCGGAGTTCCGGGCAGTCGGAGAACGTGTTACAAAGCAACAGCTGCTCTACTGGGTGTCGAGCGTGGAGAGCAGGTCGAGCCACCCAATGGCAGCTGCCCTTGTTGATTGTGCTCGATCAAACTCGGTGGAACCGAAATCGGAGAATGTGGTGGAGTTTCAGATTTACCCCGGTGAGGGGATTTACGGTGAAATCGACGGGCAAGGCGTATACGTCGGGAACAGAAGAATCTTGTCGAGGGCTTCATGTGAAACAGTTCCAGAGGTAAATGACATCAAAGGGGTCACCGTTGGATACGTGGCCTGCAACAAGGAGTTGGTCGGGCTATTCGGTCTCTCGGACGTCTGCCGAACTGGATCGGCAGAAGCCATCAGGGAGCTGAGATCCATGGGCATCAAGTCAGTGATGCTCACAGGCGATAGCACTGCCGCTGCCACCTATGCCCAGAACCAGCTGGGAAATGTTCTAGCCGAGGTTCACTCTGAACTTTTGCCGGAAGACAAGGTGCGGATCGTCGACGAGCTCAAGGCGAGGGACGGCCCCACGCTGATGGTCGGCGACGGCATGAACGACGCCCCGGCGCTGGCCAGGGCCGACGTCGGCGTCTCCATGGGCGTGTCCGGCTCGGCCGTCGCCATGGAGACGAGCCACGTCACGCTCATGTCCAACGACGTCCGCAGGATCCCCAAGGCCATCCGGCTGGCGAGGAGGACGCGCCGGACCATCGTCACCAACATCGTCTTCTCTGTCGCGACGAAGCTCGCCATCGTCGGGCTCGCGCTCGCCGGGCACCCGCTCGTCTGGGCGGCGGTGCTGGCGGACGTCGGCACGTGCTTGCTGGTGATCATGTACAGCATGATGTTGCTGAGGGGGGGAGACGGCGGGAGGGGGAAGAAATGCTGCGCTTCTTCTCACCATGGATCTCGCCCCGGGAAGCATGGCATGTCCCACCATTGCTCGGGCGGCTGCGCGGATTCGTCGTCTGCTGGTGGCCATGCTTGCGGCGATGAACATCATCAGCACGGGCATGGGCATGGCGACCACAAAGAGCCCGGCACCCCCCACCACCCCCAGAGGCATGGATGTGAAGGTCATGGCCATGGCCACTGCAAAGAACCGAGCAAGCTGCACCCCACGGACAGCCACCACTGTCAAGATCATGGTCAGGGCCACCACCACAGCAAAGAGGCGAGCAGCCAATTGGTGACAAGAAAGAACATTTCCCATGGCCATGGCCAGCGCAAAGAGAAGCACGACGAGCACAGCACCAGCTCGGCCGAGGCAATCCAAGAGCACTCCATACTGATCGACGCGTCAGCTGCTGACCAGCAACAAATCCAATGCAGTCACCAGAGCGAAGAGCACGAGGAGGAAAACTGCGGGCGTCACGCCAAGGCGAAAGCCTGCGCCCCAGCTCCGGCCGACTGCTGCGACACGGTACGCGACGAGGGATGCGGAACCAAAGCGGGGGGCGTGTGCTCGAGCCGGCGGGCCGGTTGCGCTGCCGGAGAAACCAGGCGGTGTTGCCGGAGCGCCAGGGCGAGCAGGTGCGGCGGCGGCGGCGGCCACGCAAGCATGCTGACGATGCCTGAGATCGTGGTGGAGTAG
Protein Sequence
  • >TraesCS7A02G420000.1
    MAGRQEKSYFDVLGICCPSEVPLVEKLLEPLAGVHKVTVVVPSRTVIVVHDAAAISQAQIVKALNQARLEASVRAYGGAGQNKINKWPSPYVLVCGVLLVVSLFEHFWRPLRWLALVATAAGLPPIVLRSVAAARRLTLDVNILMLIAVAGAIALKDYSEAGFIVFLFTTAEWLETRASCKATAGMASLMSMAPQNAVLAETGQVVAAQDVKVNTVIAVKAGEVVPIDGVVVDGRSEVDEQTLTGESFPVAKQTDSEVWAGTLNIDGYISVRTTAMADNSAVAKMARLVEEAQNSRSETQRLIDTCAKYYTPAVIVMAAAVAVTPVIVRARNLRHWFQLALVLLVSACPCALVLSTPVATFCALLKAARTGLLIKGGDVLESLAGIKVAAFDKTGTITSGEFSVAEFRAVGERVTKQQLLYWVSSVESRSSHPMAAALVDCARSNSVEPKSENVVEFQIYPGEGIYGEIDGQGVYVGNRRILSRASCETVPEVNDIKGVTVGYVACNKELVGLFGLSDVCRTGSAEAIRELRSMGIKSVMLTGDSTAAATYAQNQLGNVLAEVHSELLPEDKVRIVDELKARDGPTLMVGDGMNDAPALARADVGVSMGVSGSAVAMETSHVTLMSNDVRRIPKAIRLARRTRRTIVTNIVFSVATKLAIVGLALAGHPLVWAAVLADVGTCLLVIMYSMMLLRGGDGGRGKKCCASSHHGSRPGKHGMSHHCSGGCADSSSAGGHACGDEHHQHGHGHGDHKEPGTPHHPQRHGCEGHGHGHCKEPSKLHPTDSHHCQDHGQGHHHSKEASSQLVTRKNISHGHGQRKEKHDEHSTSSAEAIQEHSILIDASAADQQQIQCSHQSEEHEEENCGRHAKAKACAPAPADCCDTVRDEGCGTKAGGVCSSRRAGCAAGETRRCCRSARASRCGGGGGHASMLTMPEIVVE