Gene Details:
- Gene ID:
- Gene Symbol: TaHMA2
- Gene Name: P1B-ATPase 2
- Genome: Chinese_Spring1.0
- Species: Triticum aestivum
Functional Descriptions:
- Se treatment significantly decreased the expression of TaHMA2 in root, indicating that the downregulation of TaHMA2 by Se might contribute to the inhibition of Cd root-to-shoot translocation and the final decrease in Cd accumulation in the shoot of winter wheat.
- The downregulation of TaHMA2 and the proportion of active Cd in root reduced the migration of Cd to shoot and the distribution of Cd in shoot.
- Our results showed that TaNramp5, TaHMA3 and TaHMA2 might be responsible for the uptake and transport of Cd in wheat plants.
- The results confirm that Se application limits Cd accumulation in wheat by regulating the subcellular distribution and chemical forms of Cd in winter wheat tissues, as well as the expression of TaNramp5-a, TaNramp5-b and TaHMA2 in root.
Function-related keywords:
- root , shoot , as-transport
Literature:
- (1)Selenium supply alters the subcellular distribution and chemical forms of cadmium and the expression of transporter genes involved in cadmium uptake and translocation in winter wheat (Triticum aestivum). DOI: 10.1186/s12870-020-02763-z ; PMID: 33287728
Related News:
Gene Resources:
Orthologs:
Sequences:
cDNA Sequence
- >JN113581
CAACACCGCACGCCAAGATTGCTCTGCTCTGCTCACCACTCTTCTTGGCTCTCTTGCCGCCGTGTCGCGCGCAGGCAGAGGGGTGGCGGCGGCAGGTGAGGCGCGCAAAGAAGCGGGAGCGGAAGAGCCTGGCCACTCGACGGGAGGGAGCGATGGCGGACTCGACGTCGCCGGCGGCGGCGGCCAGGCTGGAGAAGGGCTACTTCGACGTGCTGGGCATCTGCTGCCCGTCCGAGGTGCCGCTGGTGGAGAAGCTGCTGGAGCCGCTCGCCGGCGTGCACAAGGTCACCGTCGTGGTGCCGTCCCGGACCGTCATCGTCCTCCACGACGCCGCCGCCATCTCCCAGGCCCAGATCGGTAAGCAAGCACACAATCCTCCTCCTCCTCCTCATCCTCTCGCTTTCCCCCGAGATCCCTCTCCCTCGCCGTCGCGCTCGGCCCTCGTGACCGGGTCATCAACTTGTCTTGTTCCTTCGCTCGCCTCGTATGCGCCGGTGAATTTTTTGTCCGTTACCCCGGATGTTCAGGTGAAAACTGCTCGCTTTCGCCGCTGATCAACCTCTCCCCCCGTAATTCGTGGTTGTAATTTGCCGATTGACTCGACGGGAACCGGGGTCGCTGGACTTGGACTGGAACAGAACTGACCGGAGTCGCCGTTGAAACTGGTCCGGGTAAAACCGATCCGGCCTTTCTGGTAGTAGTAACGTGCTGCCCGCCTCATCACCCGGCCGTCCTCATAAATTCTGATGACGACGGCCGGCGTGCACCGACGGGTTTGTTTGGCTTTAAAAAACGGCCGGCCGGCGTGAACCAACTTCACCGTCGCCGGGCTACTGGATTATGGGTTTTGGGATTTAAAAAATATATATACATATCCAAACTTTGTTTATACTTGCAGTTGCAGCGACGGAAGTACATATCGAACCACGTGAAGGATCACGCAAAGTCACTAATTCTTTTCTCATCATCGAGCTTTGTTCTCTCCGAATTTCCTACGCTCTTTCCCTTCTTGTCTTGTCCTTGCTTTTTTTTACTGATTTTCAGTATAGTTTTTTTCTTCACTTTTTGCCATATCTGTTCGTTCACAGAAAATTCTGATTATTATCACAGTAAATAAAATTATGGATTTCACAATTATTTACGTAATCATTTTTTATTTTTTATTATCCTCTGGAACTGTAAATTCTATCTATCCGCGATTCCAGCGTGACTATAACAATATCTCTTTTTTTTTTCTATCCTGCAGTGAGGGCGCTGAACGGGGCGCGGCTGGAGGCGTCGGTGCGGGCCTACGGCGGCGCCGGGCAGAGCAAGGTGTCCAACAAATGGCCCAGCCCGTACGTGCTCGTCTGCGGGGTCCTTCTGGTGGTCTCGCTCTTCGAGCACTTCTGGCGGCCGCTCAGGTGGTTCGCCGTGGCGGGTGCCGCCGCCGGCCTGCCGCCGATCGTGCTCAGGAGCGTCGCCGCCCTCCGCCGGCGCACCATGGACGTCAACATACTCATGCTCATCGCAGGTACGGCTAACACTTCCCTTCTGATGAAGTCAACCGAGGATGATGGATGATGTTCCATGTGATCTGAAGTTTTCACACGCGTGCACACAGCATATGTTTCATGTCACTGGGGCCCGCTTGCCTTTTTCCTGTCTAGATTCATGGCAGTACAGTAGCGCTAGAATTCTTAGATTCATGGCAGTACAGTAGCACTAGAATTCTGCGATCAATATTAATATTTTTGTGCAGTTATATGGTGTCTATCCTTAAATTCATGAATCTTTGGGTCCCCCCACATAGCCTACTAGTTGCAGAGAAATAAAGCTCGTCCATTTTCTAATAAATAAATAAATAAAATAAAATAACTGCCTAGCTAGTTGCAGGGCATAAGATTTAAACTAGTATGTTGATGCCAAACGTGATGCGCTTAACTCGTGTGGAATCTATTAGTTTGGCAGAGGAATCCTTACCGATTCCGGTAAGTTCTTTTGTTTATACACATCTGAATAAAAAAATATGCTTTGAACTAGTTACCACATCAATCCAAAATTAGAAAGAGAGGAAGGCATGAGTAATTTTATAAGTCCAACGCCATACCAATCAGGGCCTTGTTCTAAAAGAAATTTTGTGTCCCTGTCTTCTGTCGCTTCGTATACGCTCAACACCCACTGGTACCCCGGGGAAACACTTTTTTTTTAAAACGGAGGCAAAAGCATTGCCTCATTGATTAATTAAGCAGAAGAGAGTTGCCCAGTTAATTAACGGGAAACCGGGTGAAAACCGCAGACTGAATCACTGGAACTACTGATGATGTTGCTAGGTGTTAAACATTGATGAAAGAAAAGAAGACAAAAGAGTCACCCAGGAAACTGGGGTCAAGGCAGGTTGCTTCCTTGCACCAGTAGGCTCTGGAAAGATACTAAAAGTTTATGTCTTGCTTGCTCAAACTTCCCCTTTCAATTTTTATGTAGGGACCCCCACTTTGCACTGCACTAAAGTGATAGGTTGTTGTGATGGAGGCTAATGTGTATGCTAAATGGACAGAAATCTGCTCCCTTTCCTCTCCATGTGGCGATGTCGCATCTCAGATAGGGTATCGGATTCCACTTAGAACAAGCAACGCTTTGGTAGAATCGGTCTTTCGAGAGTTCTGTTTTTTGTGCTGTCAGGATGGCTCAGTTTCATGAAAGGATCAGCATACGAACTTCGGCCAAGAGTTTTTATTTATTTATTCCAATACTATGCTAGAAAACAAATTTTCTGTTCAGATCTGCAGCAGATAATAATGTGTCAGCATCTCGGATCTTTTGACGGAGATTCAGTTATGAGAGGTGTCAGAGTTTCTATTTGCAGTAGTCATATTTAAGGAAACCTGTATCTAGGAAATTTGCTGCCCGTGTGTGTATCTAATCACCACTTTCTCAAAAAAACCATACACCTGTTGGCACGGACTTGTTGGCGCAATCTACTCGTCTAGGGGGAACGCTATCTTGTCATCGTCACATATTTATAACTATTTCCTTTTGGATGCTCTGCCGTCCCATAAATTGTGGCAATTTTGGCAGGAGATGGATGGTGGCAACAGATAGCCAAAGGGCTCACTTGATTTACTTGCTTTGTTTGCAGTTGCTGGGGCCATTGCTCTGAAGGACTATCCCGAGGCCGGGTTCATCGTCTTCCTCTTCACCATAGCCGAATGGCTCGAGACCAGGGCATGCGGCAAGGTCTGTTGTCCACAAATTCCTTTCACCTAAGAGATCAGAGCTGTGAGGTCCTCTCATGATCCCACTTACCGGGAAAGGGAGCTATTTTTTTCGACGTGGCATGGTTAGGAGCACATATTCGTACTGATGCGGCATGGCAGGGTATGCTGATATTGATGTGCACTAGACCCACTGATGGACTTGTGAACATATTTTGGTGTGCCATTCTAGGCGTAGTAGGTTGGAGTAGAGTCAGGCCTGATTCGCTGATTGTATCGCCTTTTTAGCATACCTCAGCTGTCAATTATCAGCCAATAGACTAATGAACTTTATATCTAGTGGACTCAAACATGCATATACACTCATATCTAGGTGTAAAACATGATTAGGGAAAGCCACACCAATAATTTTTGGAAAGAAGATGAGCTGAAGGCAACTACTAAAAGTAATATCTTCTAAAAAAGCAGCAGTAAACATTAAATATGTCTACATGGGCAATAGTTTTTCTGTTTGGGCTACTTTGTCCCTGAAAAAATCTGATTAAATACTCTTTTGACATGTAGGCCACTGCTGGCATGTCATCACTAATGAGCATGGCACCACAAAATGCTGTTCTAGCAGAGACTGGACAAGTGGTTGCTACCCAGGATGTGAAGATCAATACAGTAATAGCTGTCAAGGCAGGGGAAGTCGTGCCGATCGATGGTGTTGTTGTCGATGGACGGAGTGAGGTCGACGAGAGCACCCTCACTGGGGAGTCCTTCCCGGTGTCCAAGCAGGCAGACTCCCAGGTCTGGGCTGGCACGCTCAACATAGATGGTAAAACATGCTACACTGTCACGGGAATCGACATTTGCTGTGATGCCTAAAATTCACCTCTGGTCGCTGATGATGCGCCGATTCTACATTGGTGATCTCTCAGGTTACATTGCTGTGAGGACAACTGCTATGGCCGACAACTCTGCGGTGGCCAAAATGGCAAGGCTGGTTGAAGAAGCCCAAAACAGTCGGTCCAGTACGCAGAGGCTGATCGACACTTGCGCCAAGTACTACACACCCGGTAAGCCAGATAGAAGGGACTATGCCTGTAGCGAAAATTCAGTCATTGACAGTTGTTGGATCGGACGGTTTTACTTACTGTGATCTTTGGTTGCACCTCGCAGCTGTTATTTTCATGTCTGCAGCAGTGGCAGTGATCCCTGTGTGTGTCAAAGCGCGCAACCTAAGACACTGGTTTGAACTGGCCCTAGTTCTCCTGGTGAGTGCTTGTCCATGTGCTCTGGTGCTGTCGACACCCGTGGCAACCTTCTGCGCGCTGCTGAGGGCCGCGAGGACGGGGCTCCTCATCAAAGGAGGGGATGTGCTCGAGTCCTTGGCCAGTATCAAAGTTGCTGCCTTCGACAAGACTGGTACAATCACTAGGGGTGAGTCCTCTGTCGAGGAGTTTCAGACAGTTGGTGAGCGTGTTTCGAAGCAACAACTTATTTACTGGTGAGTGTGGCTTCCATATCAGAATGCTCAAAGTTCTTCAACGACATTATGTGCTTCGATCTTCTTGTAGTATTTTTAATTTCATGACTGTTGCAGGGTTTCAAGCATCGAGAGCAGGTCGAGCCACCCAATGGCATCTGCTCTTGTTGGTTATGCTCAATCAAACTCTGTAGAGCCAAAATCAGAAAATGTTGCTGAGTTTCAAATCTATCCTGGCGAGGGGATTTACGGTGAGATTGATGGGGAGGGCGTATATGTTGGGAACAAAAGGATCTTGGCAAGGGCATCGTGTCAAACAGGTTGGTGAAATGTGAACTCAGCATTTACATATTCAATGTTGGCAACATTCTTTTGCTATTTACCATTGGACTTACTGTTTAATAAGAGACAAACCTACCCATCCATGAAGTTACTGAAATGAGCATTACTCTGTAACATTAAATTAGTCATTTTTACAGTATATTCTGCTTCATTCTTCTATTTTGTTTAATCGAAACACAGTTTTCTGTTGAAGCCTAGAGCTGTTAACTCATCATGTGCAACTTTTTTTGTTCTATAGTTCCGGACATAGTAGAACACATGAAAGGAGTTACCATCGGATACGTGGCCTGCAACAAGGAATTGATTGGGGTATTCAGCCTCTCGGATTCTTGCCGAACTGGGTCAGCCGAGGCCATCAAGGAGTTGAGATCACTGGGCATCAAGTCAGTGATGCTTACTGGCGATAGTACTGCCGCTGCCACACATGCACAGAACCAGGTAATGATTTATTTTTCTTTTATTGGATTATGTGGATCTTATTGTTTGTGTTTTCCTTTCTCTAGTGGATACAAATGCAACACCTTCTGATGTTGCTGTTTCTTTTCTTTTTGTGGCAGCTGGGGAACATACTAGCTGAGGTTCATGCTGAACTTCTGCCAGAAGACAAAGTGAGAATTGTTGATGAACTGAAGGCAAGAGATGGCCCTACACTGATGATTGGCGACGGCATGAATGATGCCCCGGCACTGGCTAAGGCTGATGTTGGAGTCTCCATGGGCGTGTCCGGTTCAGCCGTCGCAATGGAGACGAGTCACATTACTCTGATGTCAAACGACATCCGCAGGATCCCAAAGGCAATCAAGCTGGCCAGGAGGACGCACCGGACCATCGTCGTGAACATTGTCTTCTCGGTGACCACGAAGCTTGCAATTGTTGGGCTTGCGTTTGCCGGGCATCCGCTTATTTGGGCAGCAGTCCTTGCTGATGTTGGCACATGCTTGCTGGTGATCATGTACAGCATGCTGCTACTGAGGGAGAAGGGCAGTGGAAAGGTGGTGAAGAAATGCTGTGCTTCTTCTCACTCAAAAAAGCATGAGCATAGTACGTCCCACCACCACTGCTCCAATGATCATCAGCATGACCATGTATCTGCAGGCAAGCATTCTTGCCATGACCATCACCATGAGCATGATCACCACAAAGAGCCTAGCAACCTGCATTCCACAGACAAGCATGGCTGCCATGATCATGGCCATGGCCATAGCCACTGCAAAGAGCCGAGCAGCCAGATGGTGACAAGCAAGCATGTTTCCCATGGGCATGGCCATACCCACAACATCTGCAGCCCTCACCCCGCTGTGAGCAAGCATGATTGCCATGACCATGAACATAGCCACCACCAAGAACCCAACAGTTCACATTCTGCCGATGAGCATGATTGCCATGATCACAAGCACTGTGAAGAACCAATCAGCTTGCTTTGTGCCACTGAGCATGCTTGCCACGACCATGAGCAGAACCATGAGCATCATTGCTGTGATGAAGAGCAAACAGTGCATGTAGCAGATACGCATTCCTGCCATGACCATAAGCATGACGACAGTGCGGCTGATCCAGTTCCAGAGCTGTCGATATCTATCGAGAGCGCATTGCCTGATCACCATGAGCAGGAAATCCAGTGCATCAAAGAGCACAAAGAGAAAGCGTGTGGACATCACCTGAAGGTCAAGGATCACGTCCCGGCTCCGACAGATTGCAGCAGGGGAAACTGTCACAGTACGGTGAGCAGCAAGGGATGTGAAAGCAAAGGCAAAGAAGTTTGTTCAAGCTGGCCGGTTGGTCGTACCGGAATAATCCGCAGGTGTTGCAGGACTAGGGCGCGCAGCTGCTGCAGCCACAGCATGTTGAAACTACCTGAGATTATAGTAGAGTAGGATGGAAAGCATAGATGTTATGTTGGTAAGATAACCGAAGCGAGTAATACTATCTAGAAAGAAACAGCACTGCTGAAGTCGCCTGGTCGGCATA
CDS Sequence
- >JN113581
ATGGCGGACTCGACGTCGCCGGCGGCGGCGGCCAGGCTGGAGAAGGGCTACTTCGACGTGCTGGGCATCTGCTGCCCGTCCGAGGTGCCGCTGGTGGAGAAGCTGCTGGAGCCGCTCGCCGGCGTGCACAAGGTCACCGTCGTGGTGCCGTCCCGGACCGTCATCGTCCTCCACGACGCCGCCGCCATCTCCCAGGCCCAGATCGTGAGGGCGCTGAACGGGGCGCGGCTGGAGGCGTCGGTGCGGGCCTACGGCGGCGCCGGGCAGAGCAAGGTGTCCAACAAATGGCCCAGCCCGTACGTGCTCGTCTGCGGGGTCCTTCTGGTGGTCTCGCTCTTCGAGCACTTCTGGCGGCCGCTCAGGTGGTTCGCCGTGGCGGGTGCCGCCGCCGGCCTGCCGCCGATCGTGCTCAGGAGCGTCGCCGCCCTCCGCCGGCGCACCATGGACGTCAACATACTCATGCTCATCGCAGTTGCTGGGGCCATTGCTCTGAAGGACTATCCCGAGGCCGGGTTCATCGTCTTCCTCTTCACCATAGCCGAATGGCTCGAGACCAGGGCATGCGGCAAGGCCACTGCTGGCATGTCATCACTAATGAGCATGGCACCACAAAATGCTGTTCTAGCAGAGACTGGACAAGTGGTTGCTACCCAGGATGTGAAGATCAATACAGTAATAGCTGTCAAGGCAGGGGAAGTCGTGCCGATCGATGGTGTTGTTGTCGATGGACGGAGTGAGGTCGACGAGAGCACCCTCACTGGGGAGTCCTTCCCGGTGTCCAAGCAGGCAGACTCCCAGGTCTGGGCTGGCACGCTCAACATAGATGGTTACATTGCTGTGAGGACAACTGCTATGGCCGACAACTCTGCGGTGGCCAAAATGGCAAGGCTGGTTGAAGAAGCCCAAAACAGTCGGTCCAGTACGCAGAGGCTGATCGACACTTGCGCCAAGTACTACACACCCGCTGTTATTTTCATGTCTGCAGCAGTGGCAGTGATCCCTGTGTGTGTCAAAGCGCGCAACCTAAGACACTGGTTTGAACTGGCCCTAGTTCTCCTGGTGAGTGCTTGTCCATGTGCTCTGGTGCTGTCGACACCCGTGGCAACCTTCTGCGCGCTGCTGAGGGCCGCGAGGACGGGGCTCCTCATCAAAGGAGGGGATGTGCTCGAGTCCTTGGCCAGTATCAAAGTTGCTGCCTTCGACAAGACTGGTACAATCACTAGGGGTGAGTCCTCTGTCGAGGAGTTTCAGACAGTTGGTGAGCGTGTTTCGAAGCAACAACTTATTTACTGGGTTTCAAGCATCGAGAGCAGGTCGAGCCACCCAATGGCATCTGCTCTTGTTGGTTATGCTCAATCAAACTCTGTAGAGCCAAAATCAGAAAATGTTGCTGAGTTTCAAATCTATCCTGGCGAGGGGATTTACGGTGAGATTGATGGGGAGGGCGTATATGTTGGGAACAAAAGGATCTTGGCAAGGGCATCGTGTCAAACAGTTCCGGACATAGTAGAACACATGAAAGGAGTTACCATCGGATACGTGGCCTGCAACAAGGAATTGATTGGGGTATTCAGCCTCTCGGATTCTTGCCGAACTGGGTCAGCCGAGGCCATCAAGGAGTTGAGATCACTGGGCATCAAGTCAGTGATGCTTACTGGCGATAGTACTGCCGCTGCCACACATGCACAGAACCAGCTGGGGAACATACTAGCTGAGGTTCATGCTGAACTTCTGCCAGAAGACAAAGTGAGAATTGTTGATGAACTGAAGGCAAGAGATGGCCCTACACTGATGATTGGCGACGGCATGAATGATGCCCCGGCACTGGCTAAGGCTGATGTTGGAGTCTCCATGGGCGTGTCCGGTTCAGCCGTCGCAATGGAGACGAGTCACATTACTCTGATGTCAAACGACATCCGCAGGATCCCAAAGGCAATCAAGCTGGCCAGGAGGACGCACCGGACCATCGTCGTGAACATTGTCTTCTCGGTGACCACGAAGCTTGCAATTGTTGGGCTTGCGTTTGCCGGGCATCCGCTTATTTGGGCAGCAGTCCTTGCTGATGTTGGCACATGCTTGCTGGTGATCATGTACAGCATGCTGCTACTGAGGGAGAAGGGCAGTGGAAAGGTGGTGAAGAAATGCTGTGCTTCTTCTCACTCAAAAAAGCATGAGCATAGTACGTCCCACCACCACTGCTCCAATGATCATCAGCATGACCATGTATCTGCAGGCAAGCATTCTTGCCATGACCATCACCATGAGCATGATCACCACAAAGAGCCTAGCAACCTGCATTCCACAGACAAGCATGGCTGCCATGATCATGGCCATGGCCATAGCCACTGCAAAGAGCCGAGCAGCCAGATGGTGACAAGCAAGCATGTTTCCCATGGGCATGGCCATACCCACAACATCTGCAGCCCTCACCCCGCTGTGAGCAAGCATGATTGCCATGACCATGAACATAGCCACCACCAAGAACCCAACAGTTCACATTCTGCCGATGAGCATGATTGCCATGATCACAAGCACTGTGAAGAACCAATCAGCTTGCTTTGTGCCACTGAGCATGCTTGCCACGACCATGAGCAGAACCATGAGCATCATTGCTGTGATGAAGAGCAAACAGTGCATGTAGCAGATACGCATTCCTGCCATGACCATAAGCATGACGACAGTGCGGCTGATCCAGTTCCAGAGCTGTCGATATCTATCGAGAGCGCATTGCCTGATCACCATGAGCAGGAAATCCAGTGCATCAAAGAGCACAAAGAGAAAGCGTGTGGACATCACCTGAAGGTCAAGGATCACGTCCCGGCTCCGACAGATTGCAGCAGGGGAAACTGTCACAGTACGGTGAGCAGCAAGGGATGTGAAAGCAAAGGCAAAGAAGTTTGTTCAAGCTGGCCGGTTGGTCGTACCGGAATAATCCGCAGGTGTTGCAGGACTAGGGCGCGCAGCTGCTGCAGCCACAGCATGTTGAAACTACCTGAGATTATAGTAGAGTAG
Protein Sequence
- >JN113581
MADSTSPAAAARLEKGYFDVLGICCPSEVPLVEKLLEPLAGVHKVTVVVPSRTVIVLHDAAAISQAQIVRALNGARLEASVRAYGGAGQSKVSNKWPSPYVLVCGVLLVVSLFEHFWRPLRWFAVAGAAAGLPPIVLRSVAALRRRTMDVNILMLIAVAGAIALKDYPEAGFIVFLFTIAEWLETRACGKATAGMSSLMSMAPQNAVLAETGQVVATQDVKINTVIAVKAGEVVPIDGVVVDGRSEVDESTLTGESFPVSKQADSQVWAGTLNIDGYIAVRTTAMADNSAVAKMARLVEEAQNSRSSTQRLIDTCAKYYTPAVIFMSAAVAVIPVCVKARNLRHWFELALVLLVSACPCALVLSTPVATFCALLRAARTGLLIKGGDVLESLASIKVAAFDKTGTITRGESSVEEFQTVGERVSKQQLIYWVSSIESRSSHPMASALVGYAQSNSVEPKSENVAEFQIYPGEGIYGEIDGEGVYVGNKRILARASCQTVPDIVEHMKGVTIGYVACNKELIGVFSLSDSCRTGSAEAIKELRSLGIKSVMLTGDSTAAATHAQNQLGNILAEVHAELLPEDKVRIVDELKARDGPTLMIGDGMNDAPALAKADVGVSMGVSGSAVAMETSHITLMSNDIRRIPKAIKLARRTHRTIVVNIVFSVTTKLAIVGLAFAGHPLIWAAVLADVGTCLLVIMYSMLLLREKGSGKVVKKCCASSHSKKHEHSTSHHHCSNDHQHDHVSAGKHSCHDHHHEHDHHKEPSNLHSTDKHGCHDHGHGHSHCKEPSSQMVTSKHVSHGHGHTHNICSPHPAVSKHDCHDHEHSHHQEPNSSHSADEHDCHDHKHCEEPISLLCATEHACHDHEQNHEHHCCDEEQTVHVADTHSCHDHKHDDSAADPVPELSISIESALPDHHEQEIQCIKEHKEKACGHHLKVKDHVPAPTDCSRGNCHSTVSSKGCESKGKEVCSSWPVGRTGIIRRCCRTRARSCCSHSMLKLPEIIVE