Gene Details:
- Gene ID: TraesCS6B02G464400
- Gene Symbol: Sr27
- Gene Name: stem resistance
- Genome: Chinese_Spring1.0
- Species: Triticum aestivum
Functional Descriptions:
- The Sr27 resistance gene was first identified in a wheat line carrying an introgression of the 3R chromosome from Imperial rye.
- Sr27 is effective against Ug99 and other recent Pgt strains.
- The top hit (93.6%) was to the 5 end of a high confidence gene (TraesCS6B01G464400) predicted on chromosome 6B and functionally annotated as a disease resistance gene.
Function-related keywords:
Literature:
- Genomics accelerated isolation of a new stem rust avirulence gene-wheat resistance gene pair. DOI: 10.1038/s41477-021-00971-5 ; PMID: 34294906
Related News:
Gene Resources:
- NCBI ID: 123140082
- UniProt accessions: A0A3B6PTX8
Sequences:
cDNA Sequence
- >TraesCS6B02G464400.2
GCAGTTTGCGTACGCGTTTTGGTGAAGGATTACCACACACCGGCCGGATCCCTCCACCCCTCTCTCGTGCTACTGCTCTGCTCTGCCCGCGCGCCCTCGTCTCTCGGTGTCCGAGCTTCACCCCTACTCCTCGATCGCCGGCACGGTGACCGGGTTACGACGCGGCTAGCCGTCTTCTGCTGCAGATAGAATCCCGCCAGAATTATCGACAGATCAAGCTCTAAGCAAGCAAGGATGCCGCGGGTCCGGTGAGAGTGGCGACGGATCCAGCTGCAACCGCACTGCTCCGAGTTGCAACTAGTGAAGAAATTCCAGATCCCGCTAGGCTAGGGTCTAGACTTGGCGCAAACTTTCTTGTTCGATCACTGGCCGTGCATTCGAGCTTTTAGGCCATGGAGGCGGCTCTGGTGACTGTGGCGACGGGGGTCCTCAAACCTGTCCTGGTGAAGCTGGCCACCCTGCTCGGGGACGAGTACAAGCGTTTTAAGGGTGTGCGCAAGGAGATCAGGTCTCTCACTCATGAACTCGCCGCCATGGAGGCTTTTCTCCTCAAGATGTCGGAGGAGGAAGATCCTGATGTGCAGGATAAAGTCTGGATGAATGAGGTGCGGGAGCTGTCCTATGACCTGGAGGATGTCATCGATGACTTCATGCAAAGTGTTGGTGACAAAGAAGAAAAGCCAGATGGCTTCATTGAGAAGATCAAGAGCTCTCTAGGGAAGTTGGGAAATATGAAGGATCGTCATCGAATTGGCAAGGAGATACATGATCTGAAGAATCAGATCATTGAGGTGGGCGACAGGAATGCAAGGTACAAGGGACGTGAGATCTTCTCCAAGGCCGTCAATGCGACCGTTGACCCTAGAGCTCTTGCTATCTTTGAGCATGCATCAAAGCTCGTCGGAATTGATGAACCCAAGGCTAAGCTGATCAAGTTGTTAACTGACGAGGATGGAGTTGCATCAACACAACAACAAGTGAAGATGGTCTCCATTGTTGGATCGGGAGGAATGGGCAAAACAACTCTTGCAAACCAAGTGTATCAAGAGCTGAAAGAGAAATTCAAGTGTAAAGCTTTCATTTCAGTGTCACGAAATCCAGATATGACAAATATCTTGAGAACCCTCCTTAGTGAAGTTGGGTGTCAAGATTATGCTGACACTGAAGCAGGGAGCATACAACAACTAATAAGAAAGATTACCGACTACCTAGCAGAAAAAAGGTATATTATAGTGATTGACGACATATGGGATGTTAAAACATGGGACGTTATTAAGTGCGCATTCCCCATGACCAGATGCGGTGGTGTAATAATCACCACTACACGGCTGAGTGATGTTGCATGTTCGTGTCATTCATCAATCGGTGGCCATATTTATAATATAAGGCCTCTTAATATGCAGCACTCAAGACAACTATTCTACAGAAGATTATTCAGCTCCGAAGAAGATTGCCCTTCATCGCTCGTGAAAGTTTCTAATCAAATCTTGGAAAAATGTGATGGGATGCCTTTGGCAATCATTGCTATAGCTGGTTTGTTGGCTAACACAGGAAGATCAGAGCATCTATGGAACCAAGTGAAAGATTCAATTGGTCGTACACTTGAAAGGAATCCTAGTGTCGAAGTAATGATCAAGATATTGTCACTTAGTTACTTTGATCTTCCTCCGCATCTAAAAACATGTCTCTTGTATCTCAGTATATTTCCGGAAGATTCTATTATTGAGAAGAAAACACTAATATCAGGCTGGATAGCCGAAGGATTCATTCACAAAGAAGGTAGATATACTGTATATGAGGTAGGAGTGAGGTGTTTTAATGAGCTCGTCAACAGGAGTTTGATCCAACCTGTGAAGGCAGGTAGGTTTAGGGGGAAGAGCTGTCGAGTTCACGACACAATTCTTGATTTCATAGTATCCAAGTCTATTGAAGAGAACTTTGTTACTTTCATTGGTGTCCCCAATTTAAATACCATGGCACAAAGCAAAGCCCGTCGTCTCTCCATTCAAGTTGAAGCGGAAGGGATGCCGATGAACCTGATATTATCTCATGTCCGATCACTTAACGTGTTCGGGAATACAGTGAGTATTCCTTCGATCATGGAGTTCAGGCATTTGCGTGTCCTTGATTTTGGAGGAAACAGACTATTGGAAAACCGTCATCTCGCGTATGTAGGGATGCTATTTCAGCTAAGGTATCTCAACATTTACATGACAGCAGTAAGCGAGCTCCCGGAACAAATCAGACACTTACAGTGCTTAGAGATGTTGGACATCAGGCGTACAAAGGTGTCTGAGTTGCCAGCCAGTATTGCCAATCTCGGCAAACTTGCACACTTACTTCTTAGCTCAGATACTGGCACAAATGTTAAGTTTCCCGACGGAATTGCTAAGATGCAAGCACTGGAGGCTTTGCATAGTGTTAACACCTGCAATCAGTCATATAACTTTCTGCAAGGGCTTGGTGAGCTAAAGAATCTGAGGAAGCTGGGCATTAACTATCGGGGTGTTGCCCAGGAAGACAAGGAAGTTATTGCTTCTTCTCTCGGTTTGCCGGACACGGTATATACCATGATTGCTACATGCGGTCTCAAGACTAATCACGACACTCCTGACGAATGCGCTCAGGTTCTTCTCAAGCCCTGCAGTTCTTCATGA - >TraesCS6B02G464400.1
GCAGTTTGCGTACGCGTTTTGGTGAAGGATTACCACACACCGGCCGGATCCCTCCACCCCTCTCTCGTGCTACTGCTCTGCTCTGCCCGCGCGCCCTCGTCTCTCGGTGTCCGAGCTTCACCCCTACTCCTCGATCGCCGGCACGGTGACCGGGTTACGACGCGGCTAGCCGTCTTCTGCTGCAGATAGAATCCCGCCAGAATTATCGACAGATCAAGCTCTAAGCAAGCAAGGATGCCGCGGGTCCGGTGAGAGTGGCGACGGATCCAGCTGCAACCGCACTGCTCCGAGTTGCAACTAGTGAAGAAATTCCAGATCCCGCTAGGCTAGGGTCTAGACTTGGCGCAAACTTTCTTGTTCGATCACTGGCCGTGCATTCGAGCTTTTAGGCCATGGAGGCGGCTCTGGTGACTGTGGCGACGGGGGTCCTCAAACCTGTCCTGGTGAAGCTGGCCACCCTGCTCGGGGACGAGTACAAGCGTTTTAAGGGTGTGCGCAAGGAGATCAGGTCTCTCACTCATGAACTCGCCGCCATGGAGGCTTTTCTCCTCAAGATGTCGGAGGAGGAAGATCCTGATGTGCAGGATAAAGTCTGGATGAATGAGGTGCGGGAGCTGTCCTATGACCTGGAGGATGTCATCGATGACTTCATGCAAAGTGTTGGTGACAAAGAAGAAAAGCCAGATGGCTTCATTGAGAAGATCAAGAGCTCTCTAGGGAAGTTGGGAAATATGAAGGATCGTCATCGAATTGGCAAGGAGATACATGATCTGAAGAATCAGATCATTGAGGTGGGCGACAGGAATGCAAGGTACAAGGGACGTGAGATCTTCTCCAAGGCCGTCAATGCGACCGTTGACCCTAGAGCTCTTGCTATCTTTGAGCATGCATCAAAGCTCGTCGGAATTGATGAACCCAAGGCTAAGCTGATCAAGTTGTTAACTGACGAGGATGGAGTTGCATCAACACAACAACAAGTGAAGATGGTCTCCATTGTTGGATCGGGAGGAATGGGCAAAACAACTCTTGCAAACCAAGTGTATCAAGAGCTGAAAGAGAAATTCAAGTGTAAAGCTTTCATTTCAGTGTCACGAAATCCAGATATGACAAATATCTTGAGAACCCTCCTTAGTGAAGTTGGGTGTCAAGATTATGCTGACACTGAAGCAGGGAGCATACAACAACTAATAAGAAAGATTACCGACTACCTAGCAGAAAAAAGGTATATTATAGTGATTGACGACATATGGGATGTTAAAACATGGGACGTTATTAAGTGCGCATTCCCCATGACCAGATGCGGTGGTGTAATAATCACCACTACACGGCTGAGTGATGTTGCATGTTCGTGTCATTCATCAATCGGTGGCCATATTTATAATATAAGGCCTCTTAATATGCAGCACTCAAGACAACTATTCTACAGAAGATTATTCAGCTCCGAAGAAGATTGCCCTTCATCGCTCGTGAAAGTTTCTAATCAAATCTTGGAAAAATGTGATGGGATGCCTTTGGCAATCATTGCTATAGCTGGTTTGTTGGCTAACACAGGAAGATCAGAGCATCTATGGAACCAAGTGAAAGATTCAATTGGTCGTACACTTGAAAGGAATCCTAGTGTCGAAGTAATGATCAAGATATTGTCACTTAGTTACTTTGATCTTCCTCCGCATCTAAAAACATGTCTCTTGTATCTCAGTATATTTCCGGAAGATTCTATTATTGAGAAGAAAACACTAATATCAGGCTGGATAGCCGAAGGATTCATTCACAAAGAAGGTAGATATACTGTATATGAGGTAGGAGTGAGGTGTTTTAATGAGCTCGTCAACAGGAGTTTGATCCAACCTGTGAAGGCAGGTAGGTTTAGGGGGAAGAGCTGTCGAGTTCACGACACAATTCTTGATTTCATAGTATCCAAGTCTATTGAAGAGAACTTTGTTACTTTCATTGGTGTCCCCAATTTAAATACCATGGCACAAAGCAAAGCCCGTCGTCTCTCCATTCAAGTTGAAGCGGAAGGGATGCCGATGAACCTGATATTATCTCATGTCCGATCACTTAACGTGTTCGGGAATACAGTGAGTATTCCTTCGATCATGGAGTTCAGGCATTTGCGTGTCCTTGATTTTGGAGGAAACAGACTATTGGAAAACCGTCATCTCGCGTATGTAGGGATGCTATTTCAGCTAAGGTATCTCAACATTTACATGACAGCAGTAAGCGAGCTCCCGGAACAAATCAGACACTTACAGTGCTTAGAGATGTTGGACATCAGGCGTACAAAGGTGTCTGAGTTGCCAGCCAGTATTGCCAATCTCGGCAAACTTGCACACTTACTTCTTAGCTCAGATACTGGCACAAATGTTAAGTTTCCCGACGGAATTGCTAAGATGCAAGCACTGGAGGCTTTGCATAGTGTTAACACCTGCAATCAGTCATATAACTTTCTGCAAGGGCTTGGTGAGCTAAAGAATCTGAGGAAGCTGGGCATTAACTATCGGGGTGTTGCCCAGGAAGACAAGGAAGTTATTGCTTCTTCTCTCGGTTTGCCGGACACGGTATATACCATGATTGCTACATGCGGTCTCAAGACTAATCACGACACTCCTGACGAATGCGCTCAGGTTCTTCTCAAGCCCTGCAGTTCTTCATGA
CDS Sequence
- >TraesCS6B02G464400.2
ATGGAGGCGGCTCTGGTGACTGTGGCGACGGGGGTCCTCAAACCTGTCCTGGTGAAGCTGGCCACCCTGCTCGGGGACGAGTACAAGCGTTTTAAGGGTGTGCGCAAGGAGATCAGGTCTCTCACTCATGAACTCGCCGCCATGGAGGCTTTTCTCCTCAAGATGTCGGAGGAGGAAGATCCTGATGTGCAGGATAAAGTCTGGATGAATGAGGTGCGGGAGCTGTCCTATGACCTGGAGGATGTCATCGATGACTTCATGCAAAGTGTTGGTGACAAAGAAGAAAAGCCAGATGGCTTCATTGAGAAGATCAAGAGCTCTCTAGGGAAGTTGGGAAATATGAAGGATCGTCATCGAATTGGCAAGGAGATACATGATCTGAAGAATCAGATCATTGAGGTGGGCGACAGGAATGCAAGGTACAAGGGACGTGAGATCTTCTCCAAGGCCGTCAATGCGACCGTTGACCCTAGAGCTCTTGCTATCTTTGAGCATGCATCAAAGCTCGTCGGAATTGATGAACCCAAGGCTAAGCTGATCAAGTTGTTAACTGACGAGGATGGAGTTGCATCAACACAACAACAAGTGAAGATGGTCTCCATTGTTGGATCGGGAGGAATGGGCAAAACAACTCTTGCAAACCAAGTGTATCAAGAGCTGAAAGAGAAATTCAAGTGTAAAGCTTTCATTTCAGTGTCACGAAATCCAGATATGACAAATATCTTGAGAACCCTCCTTAGTGAAGTTGGGTGTCAAGATTATGCTGACACTGAAGCAGGGAGCATACAACAACTAATAAGAAAGATTACCGACTACCTAGCAGAAAAAAGGTATATTATAGTGATTGACGACATATGGGATGTTAAAACATGGGACGTTATTAAGTGCGCATTCCCCATGACCAGATGCGGTGGTGTAATAATCACCACTACACGGCTGAGTGATGTTGCATGTTCGTGTCATTCATCAATCGGTGGCCATATTTATAATATAAGGCCTCTTAATATGCAGCACTCAAGACAACTATTCTACAGAAGATTATTCAGCTCCGAAGAAGATTGCCCTTCATCGCTCGTGAAAGTTTCTAATCAAATCTTGGAAAAATGTGATGGGATGCCTTTGGCAATCATTGCTATAGCTGGTTTGTTGGCTAACACAGGAAGATCAGAGCATCTATGGAACCAAGTGAAAGATTCAATTGGTCGTACACTTGAAAGGAATCCTAGTGTCGAAGTAATGATCAAGATATTGTCACTTAGTTACTTTGATCTTCCTCCGCATCTAAAAACATGTCTCTTGTATCTCAGTATATTTCCGGAAGATTCTATTATTGAGAAGAAAACACTAATATCAGGCTGGATAGCCGAAGGATTCATTCACAAAGAAGGTAGATATACTGTATATGAGGTAGGAGTGAGGTGTTTTAATGAGCTCGTCAACAGGAGTTTGATCCAACCTGTGAAGGCAGGTAGGTTTAGGGGGAAGAGCTGTCGAGTTCACGACACAATTCTTGATTTCATAGTATCCAAGTCTATTGAAGAGAACTTTGTTACTTTCATTGGTGTCCCCAATTTAAATACCATGGCACAAAGCAAAGCCCGTCGTCTCTCCATTCAAGTTGAAGCGGAAGGGATGCCGATGAACCTGATATTATCTCATGTCCGATCACTTAACGTGTTCGGGAATACAGTGAGTATTCCTTCGATCATGGAGTTCAGGCATTTGCGTGTCCTTGATTTTGGAGGAAACAGACTATTGGAAAACCGTCATCTCGCGTATGTAGGGATGCTATTTCAGCTAAGGTATCTCAACATTTACATGACAGCAGTAAGCGAGCTCCCGGAACAAATCAGACACTTACAGTGCTTAGAGATGTTGGACATCAGGCGTACAAAGGTGTCTGAGTTGCCAGCCAGTATTGCCAATCTCGGCAAACTTGCACACTTACTTCTTAGCTCAGATACTGGCACAAATGTTAAGTTTCCCGACGGAATTGCTAAGATGCAAGCACTGGAGGCTTTGCATAGTGTTAACACCTGCAATCAGTCATATAACTTTCTGCAAGGGCTTGGTGAGCTAAAGAATCTGAGGAAGCTGGGCATTAACTATCGGGGTGTTGCCCAGGAAGACAAGGAAGTTATTGCTTCTTCTCTCGGTTTGCCGGACACGGTATATACCATGATTGCTACATGCGGTCTCAAGACTAATCACGACACTCCTGACGAATGCGCTCAGGTTCTTCTCAAGCCCTGCAGTTCTTCATGA - >TraesCS6B02G464400.1
ATGGAGGCGGCTCTGGTGACTGTGGCGACGGGGGTCCTCAAACCTGTCCTGGTGAAGCTGGCCACCCTGCTCGGGGACGAGTACAAGCGTTTTAAGGGTGTGCGCAAGGAGATCAGGTCTCTCACTCATGAACTCGCCGCCATGGAGGCTTTTCTCCTCAAGATGTCGGAGGAGGAAGATCCTGATGTGCAGGATAAAGTCTGGATGAATGAGGTGCGGGAGCTGTCCTATGACCTGGAGGATGTCATCGATGACTTCATGCAAAGTGTTGGTGACAAAGAAGAAAAGCCAGATGGCTTCATTGAGAAGATCAAGAGCTCTCTAGGGAAGTTGGGAAATATGAAGGATCGTCATCGAATTGGCAAGGAGATACATGATCTGAAGAATCAGATCATTGAGGTGGGCGACAGGAATGCAAGGTACAAGGGACGTGAGATCTTCTCCAAGGCCGTCAATGCGACCGTTGACCCTAGAGCTCTTGCTATCTTTGAGCATGCATCAAAGCTCGTCGGAATTGATGAACCCAAGGCTAAGCTGATCAAGTTGTTAACTGACGAGGATGGAGTTGCATCAACACAACAACAAGTGAAGATGGTCTCCATTGTTGGATCGGGAGGAATGGGCAAAACAACTCTTGCAAACCAAGTGTATCAAGAGCTGAAAGAGAAATTCAAGTGTAAAGCTTTCATTTCAGTGTCACGAAATCCAGATATGACAAATATCTTGAGAACCCTCCTTAGTGAAGTTGGGTGTCAAGATTATGCTGACACTGAAGCAGGGAGCATACAACAACTAATAAGAAAGATTACCGACTACCTAGCAGAAAAAAGGTATATTATAGTGATTGACGACATATGGGATGTTAAAACATGGGACGTTATTAAGTGCGCATTCCCCATGACCAGATGCGGTGGTGTAATAATCACCACTACACGGCTGAGTGATGTTGCATGTTCGTGTCATTCATCAATCGGTGGCCATATTTATAATATAAGGCCTCTTAATATGCAGCACTCAAGACAACTATTCTACAGAAGATTATTCAGCTCCGAAGAAGATTGCCCTTCATCGCTCGTGAAAGTTTCTAATCAAATCTTGGAAAAATGTGATGGGATGCCTTTGGCAATCATTGCTATAGCTGGTTTGTTGGCTAACACAGGAAGATCAGAGCATCTATGGAACCAAGTGAAAGATTCAATTGGTCGTACACTTGAAAGGAATCCTAGTGTCGAAGTAATGATCAAGATATTGTCACTTAGTTACTTTGATCTTCCTCCGCATCTAAAAACATGTCTCTTGTATCTCAGTATATTTCCGGAAGATTCTATTATTGAGAAGAAAACACTAATATCAGGCTGGATAGCCGAAGGATTCATTCACAAAGAAGGTAGATATACTGTATATGAGGTAGGAGTGAGGTGTTTTAATGAGCTCGTCAACAGGAGTTTGATCCAACCTGTGAAGGCAGGTAGGTTTAGGGGGAAGAGCTGTCGAGTTCACGACACAATTCTTGATTTCATAGTATCCAAGTCTATTGAAGAGAACTTTGTTACTTTCATTGGTGTCCCCAATTTAAATACCATGGCACAAAGCAAAGCCCGTCGTCTCTCCATTCAAGTTGAAGCGGAAGGGATGCCGATGAACCTGATATTATCTCATGTCCGATCACTTAACGTGTTCGGGAATACAGTGAGTATTCCTTCGATCATGGAGTTCAGGCATTTGCGTGTCCTTGATTTTGGAGGAAACAGACTATTGGAAAACCGTCATCTCGCGTATGTAGGGATGCTATTTCAGCTAAGGTATCTCAACATTTACATGACAGCAGTAAGCGAGCTCCCGGAACAAATCAGACACTTACAGTGCTTAGAGATGTTGGACATCAGGCGTACAAAGGTGTCTGAGTTGCCAGCCAGTATTGCCAATCTCGGCAAACTTGCACACTTACTTCTTAGCTCAGATACTGGCACAAATGTTAAGTTTCCCGACGGAATTGCTAAGATGCAAGCACTGGAGGCTTTGCATAGTGTTAACACCTGCAATCAGTCATATAACTTTCTGCAAGGGCTTGGTGAGCTAAAGAATCTGAGGAAGCTGGGCATTAACTATCGGGGTGTTGCCCAGGAAGACAAGGAAGTTATTGCTTCTTCTCTCGGTTTGCCGGACACGGTATATACCATGATTGCTACATGCGGTCTCAAGACTAATCACGACACTCCTGACGAATGCGCTCAGGTTCTTCTCAAGCCCTGCAGTTCTTCATGA
Protein Sequence
- >TraesCS6B02G464400.2
MEAALVTVATGVLKPVLVKLATLLGDEYKRFKGVRKEIRSLTHELAAMEAFLLKMSEEEDPDVQDKVWMNEVRELSYDLEDVIDDFMQSVGDKEEKPDGFIEKIKSSLGKLGNMKDRHRIGKEIHDLKNQIIEVGDRNARYKGREIFSKAVNATVDPRALAIFEHASKLVGIDEPKAKLIKLLTDEDGVASTQQQVKMVSIVGSGGMGKTTLANQVYQELKEKFKCKAFISVSRNPDMTNILRTLLSEVGCQDYADTEAGSIQQLIRKITDYLAEKRYIIVIDDIWDVKTWDVIKCAFPMTRCGGVIITTTRLSDVACSCHSSIGGHIYNIRPLNMQHSRQLFYRRLFSSEEDCPSSLVKVSNQILEKCDGMPLAIIAIAGLLANTGRSEHLWNQVKDSIGRTLERNPSVEVMIKILSLSYFDLPPHLKTCLLYLSIFPEDSIIEKKTLISGWIAEGFIHKEGRYTVYEVGVRCFNELVNRSLIQPVKAGRFRGKSCRVHDTILDFIVSKSIEENFVTFIGVPNLNTMAQSKARRLSIQVEAEGMPMNLILSHVRSLNVFGNTVSIPSIMEFRHLRVLDFGGNRLLENRHLAYVGMLFQLRYLNIYMTAVSELPEQIRHLQCLEMLDIRRTKVSELPASIANLGKLAHLLLSSDTGTNVKFPDGIAKMQALEALHSVNTCNQSYNFLQGLGELKNLRKLGINYRGVAQEDKEVIASSLGLPDTVYTMIATCGLKTNHDTPDECAQVLLKPCSSS - >TraesCS6B02G464400.1
MEAALVTVATGVLKPVLVKLATLLGDEYKRFKGVRKEIRSLTHELAAMEAFLLKMSEEEDPDVQDKVWMNEVRELSYDLEDVIDDFMQSVGDKEEKPDGFIEKIKSSLGKLGNMKDRHRIGKEIHDLKNQIIEVGDRNARYKGREIFSKAVNATVDPRALAIFEHASKLVGIDEPKAKLIKLLTDEDGVASTQQQVKMVSIVGSGGMGKTTLANQVYQELKEKFKCKAFISVSRNPDMTNILRTLLSEVGCQDYADTEAGSIQQLIRKITDYLAEKRYIIVIDDIWDVKTWDVIKCAFPMTRCGGVIITTTRLSDVACSCHSSIGGHIYNIRPLNMQHSRQLFYRRLFSSEEDCPSSLVKVSNQILEKCDGMPLAIIAIAGLLANTGRSEHLWNQVKDSIGRTLERNPSVEVMIKILSLSYFDLPPHLKTCLLYLSIFPEDSIIEKKTLISGWIAEGFIHKEGRYTVYEVGVRCFNELVNRSLIQPVKAGRFRGKSCRVHDTILDFIVSKSIEENFVTFIGVPNLNTMAQSKARRLSIQVEAEGMPMNLILSHVRSLNVFGNTVSIPSIMEFRHLRVLDFGGNRLLENRHLAYVGMLFQLRYLNIYMTAVSELPEQIRHLQCLEMLDIRRTKVSELPASIANLGKLAHLLLSSDTGTNVKFPDGIAKMQALEALHSVNTCNQSYNFLQGLGELKNLRKLGINYRGVAQEDKEVIASSLGLPDTVYTMIATCGLKTNHDTPDECAQVLLKPCSSS