Gene Details:
- Gene ID:
- Gene Symbol: Pm57
- Gene Name: Powdery mildew 57
- Genome: Chinese_Spring1.0
- Species: Triticum aestivum
Functional Descriptions:
- Pm57 from Aegilops searsii encodes a tandem kinase protein and confers wheat powdery mildew resistance.
- The resistance function of Pm57 is validated via independent mutants, gene silencing, and transgenic assays. Stable Pm57 transgenic wheat lines and introgression lines exhibit high levels of all-stage resistance to diverse isolates of the Bgt fungus, and no negative impacts on agronomic parameters are observed in our experimental set-up.
- These results suggest that Pm57 inhibits haustorium formation in Bgt plants and that this process might be correlated with H2O2 accumulation and induced cell death.
- These expression patterns of the Pm57 and PR genes imply that powdery mildew resistance of Pm57 may involve PR genes up-regulated expression.
Function-related keywords:
- kinase , resistance , cell-death , protein-kinase , powdery-mildew , mildew-resistance , mildew , powdery-mildew-resistance , h2o2 , protein
Literature:
- Pm57 from Aegilops searsii encodes a tandem kinase protein and confers wheat powdery mildew resistance. DOI: 10.1038/s41467-024-49257-2 ; PMID: 38839783
Related News:
Gene Resources:
- NCBI ID: OQ675542
- UniProt accessions: A0A3B5Z207
Orthologs:
Sequences:
cDNA Sequence
- >OQ675542
ATGGCGTCTCCTCGCGGCTCCGATGGAGCACCCAAGAGCGAAGACCTTCAGCTCTCCAGCTCTAGTTCCAACTCCAGCTCCAACTTGAGCTCTAGCTCGAGCTCGAGCTTGAGCTCCAGGTCCAGCATAGACAGTACCATGGGCACCAAGTTACAGAAGGCAAAAAGACTTTCAATTGAGCATTTAGAAGTTATCACGGATAATTTCTCCCAAGAACGAGTAATTGGCCGTGGCGGATTTGGAATTGTCTACAAGGGAGTACATGCGAATGGAAAAAATATTGCTGTGAAGGTGCTCCATAAAAACATGACAGGAACCGACGACGGGCAATTCGAACATGAGTTTAAAAACCTGATGCGGCTCAAGCATCAAAACATTGTTCAGTTAGTTGGCTACTGCTATGAAACACAACATAAGCCGATGTTGCATGATGGAGTTGCCATTTTTGCGGACGATATATACAAAGCACTCTGCTTTGAGTATATGGAAAATAGGAGCCTATCAAAGCATATTTCTGTCGAATGTGATGGGCTTGAATGGCACACGCGCTACAAAATTATCAAGGGGATGTGCGAAGGATTAAAATACCTCCACGAAGAATTCAAAGAACCAATTTACCACTTGGACCTAAAACCTGACAACATATTGCTAGATGAGAATATGGTACCAAAACTTGCTGATTTTGGTTCGTCGAAGCTCTTTGGCAAAGAACTAACCATGGTCATCACACAAAATTTTACAGCAACAATTGGGTACATGCCACCGGAATTCATATCTCATCAGATCGTCTCGAAGAAGTTTGATATATTCAGCTTGGGAGTTGTCATGACAAAGATAATTGCAGGACCTAAAGGCAACTCCTTAAGTTTCGAGATGGATTACCAAGACTTTCTTGATCAAGTGCAAAAAAACTGGAGGAACAGGTTGCGGGACACATGGCACAATTCTGAACCAGTACAAGCATATTGCCGGCAAGTGAACGTATGCACAGAAATAGCACTAAGTTGCATGGATGCTGATAGGAATAAAAGACCCAGTATATTGGATATCATTGATAAACTCAACAAGACTGAAACTGTAATCGAGCAGTTGCACCGGGATCACCAATGGACAAGCCAACGCATTACCATGGGTGATGATAAGTTAAAGAATGAAGCTACTCCTTTGAAAGAAAAGAAGAGTGAAAAGGCTACGGAACCAACGAGTCTTACAATCCGATTACTACAAGATATCACACATAATTTCGCCCAGGAGCGGTTAATTGGTCAAGGCGCATATGGAAAAGTTTACATGGGGAAGTTTGGAAATGGAGAAGAAATCGCCGTGAAGTTGCTTTATAATAGCATGCAAGGAGGTAACGATGAACAACTCCAACATGAGTTTGATAACCTTATGATGCTCAAACATCCAAACATTGTACGGATTGTTGGCTACTGTTATGAAACACAACGCCAACATATGGATTTTCAAGGTAAAACAGTTTTTGGTGAAATGACATATAGAGCGCTCTGCCTTGAGTATATGCGCATGGGGAGCCTTCAGAGACATCTTTCCGAAGAATCTAGTGGACTTGACTGGCAAACTCGTTACAAAATTATCAAGGGGACATGTGAGGGATTGGATTACCTATACAGAGGATTCGACAGGCCAATTTTCCATTTGGACATAAAACCCGACAATATACTACTAGATGAGAATATGATGCCCAAGCTTGCTGATGTTGGATTGACCAGGCTCTTTGGCGAAGAACAAACCAGGGTCACGCAGAGTCCTATGGGAACAGTTGAATACATGCCGCCGGAATACTTATTCGGACACCTCATCTCAAGGAAGTTCGACATATTCAGCTTGGGTGTTGTAATGACAAAGATAATTGCAGGGCCTTTGGGCCGCGCCTTAAGTACCGGAATGCCTGAAGAAGCCTTTGTTGATCAAGTATATGAAAACTGGAGGAACAGGCTGGAAGCAACGTGTACTTCTTCAAAGATACTAGATGCATACTGCGAGCAAGTGCAAATATGCACTAAGATAGCATTAAGCTGCGTGGAGACTGAGAGGCACAAAAGACCCAGCATAATGGATATTATTGGTACAATGGATGAGACTGAAAATAAGGTTGAAAAGGCATTGTTCTCATTGTCGGGTAGTATGCATTCATGGCTGCGGAGAGACTTGCTAGAGTTAGAAGCCTTCACAAAAAGTCAAGAGATTCCTAGTGCAGAGACATGTAACGAGTTTCCCGTCCTCCTGCGGATCACGGGGACACCATGGTGTGGCTTGGAAGAGATGCCACGCGCAGGTGTAGACGTCGTGGTTGTGGTCGAGGTTGATTGGTTCATGGTGCTTCAGTGGAGGCTGGATATCATCAAGCAAGCCCTGACGGTGGTCATTGACAAGCTCGGTCGGAAGGACCGACTCTCCATCTTGTCATTTGAGGGCGATGTGCCCCGTATTATGGACCTTATGTTCATGTCCGACAAAGGACGGGATGTAGCCAAGCTGGTGGTCAATCAGCTGACTGCGAACCACGGCTACAACATAATCGTAGCTCTGCGACAGGGAGCTGAGATTCTGAGGGGGCGTCAAGTGGAGAAGAAGGATGGTAGCCGTGTTGGCTGCATCATGTTCTTATCGGACAATAATGACATTCGGATCAAGGACAGGTATGACGAGGAAATCAGCTCCGAATTCCCGGCGTACATCTTCGGCCTCGGGGAGTTACACCACCCGGAGGTCATGAAGTACATAGCCGACAGGACCCGCGGCACCTACTCTTTCGTCCACTATGACATCAACGCGATGAACGATGCCTTCGAGCTTTTCATCAGGGGCCTCACCAAAATCGCCGCAGCATCTGTCAAGATCACCCTCAGTGCTCACAAGGGTGTCTTCATATCATCCATCTACTCCGGCGGATACAACAACCATGTGAGCTCTGACAAACTGTCCGGCGAGATAGACGTCGACAATATGTATGCTGGCGAGCGGAAGAACTTTATCGTCTACCTGACAGTCACCGAGGGCAGCGACAGCAAGCTTATGACCGTCGGTGGCCGGTACCGGAGCTTCATTGCAGACAGAGAGCTGGCCGACACGGACGTGCTTGTCCTGCGACCATCTTCAGCAAGCTTGCTAGGAAACACGGCCATCCACCAAGAGGTGGCGGCCGAGCTCATCCGGATCCAGCTTCTCAAGGGTCTGATCACGATGGGTCGAAACCCTGATTCCCTTGAACAGCTATGGGCCCGTGTCAAGTGCTCAGAGGAGGGTGTCAGCGCACCCGAGGAGACCTTTTTGGAGCTTGGCAACGACGTGGCTGAAATTACAAGGGTCATCACGTACAACACCTCGCCTCCTTACATGATGTCATGGCTGACTTGTCACCTGTGGCAGCGCGCAACCACCAAGGGCGCACGCTGCGTCTCTGGGGCTTTCACTATCCCAGGGCGGCACGAAGATGCAAAAGAGCAAGACGACCCAGCACAATAG
CDS Sequence
- >OQ675542
ATGGCGTCTCCTCGCGGCTCCGATGGAGCACCCAAGAGCGAAGACCTTCAGCTCTCCAGCTCTAGTTCCAACTCCAGCTCCAACTTGAGCTCTAGCTCGAGCTCGAGCTTGAGCTCCAGGTCCAGCATAGACAGTACCATGGGCACCAAGTTACAGAAGGCAAAAAGACTTTCAATTGAGCATTTAGAAGTTATCACGGATAATTTCTCCCAAGAACGAGTAATTGGCCGTGGCGGATTTGGAATTGTCTACAAGGGAGTACATGCGAATGGAAAAAATATTGCTGTGAAGGTGCTCCATAAAAACATGACAGGAACCGACGACGGGCAATTCGAACATGAGTTTAAAAACCTGATGCGGCTCAAGCATCAAAACATTGTTCAGTTAGTTGGCTACTGCTATGAAACACAACATAAGCCGATGTTGCATGATGGAGTTGCCATTTTTGCGGACGATATATACAAAGCACTCTGCTTTGAGTATATGGAAAATAGGAGCCTATCAAAGCATATTTCTGTCGAATGTGATGGGCTTGAATGGCACACGCGCTACAAAATTATCAAGGGGATGTGCGAAGGATTAAAATACCTCCACGAAGAATTCAAAGAACCAATTTACCACTTGGACCTAAAACCTGACAACATATTGCTAGATGAGAATATGGTACCAAAACTTGCTGATTTTGGTTCGTCGAAGCTCTTTGGCAAAGAACTAACCATGGTCATCACACAAAATTTTACAGCAACAATTGGGTACATGCCACCGGAATTCATATCTCATCAGATCGTCTCGAAGAAGTTTGATATATTCAGCTTGGGAGTTGTCATGACAAAGATAATTGCAGGACCTAAAGGCAACTCCTTAAGTTTCGAGATGGATTACCAAGACTTTCTTGATCAAGTGCAAAAAAACTGGAGGAACAGGTTGCGGGACACATGGCACAATTCTGAACCAGTACAAGCATATTGCCGGCAAGTGAACGTATGCACAGAAATAGCACTAAGTTGCATGGATGCTGATAGGAATAAAAGACCCAGTATATTGGATATCATTGATAAACTCAACAAGACTGAAACTGTAATCGAGCAGTTGCACCGGGATCACCAATGGACAAGCCAACGCATTACCATGGGTGATGATAAGTTAAAGAATGAAGCTACTCCTTTGAAAGAAAAGAAGAGTGAAAAGGCTACGGAACCAACGAGTCTTACAATCCGATTACTACAAGATATCACACATAATTTCGCCCAGGAGCGGTTAATTGGTCAAGGCGCATATGGAAAAGTTTACATGGGGAAGTTTGGAAATGGAGAAGAAATCGCCGTGAAGTTGCTTTATAATAGCATGCAAGGAGGTAACGATGAACAACTCCAACATGAGTTTGATAACCTTATGATGCTCAAACATCCAAACATTGTACGGATTGTTGGCTACTGTTATGAAACACAACGCCAACATATGGATTTTCAAGGTAAAACAGTTTTTGGTGAAATGACATATAGAGCGCTCTGCCTTGAGTATATGCGCATGGGGAGCCTTCAGAGACATCTTTCCGAAGAATCTAGTGGACTTGACTGGCAAACTCGTTACAAAATTATCAAGGGGACATGTGAGGGATTGGATTACCTATACAGAGGATTCGACAGGCCAATTTTCCATTTGGACATAAAACCCGACAATATACTACTAGATGAGAATATGATGCCCAAGCTTGCTGATGTTGGATTGACCAGGCTCTTTGGCGAAGAACAAACCAGGGTCACGCAGAGTCCTATGGGAACAGTTGAATACATGCCGCCGGAATACTTATTCGGACACCTCATCTCAAGGAAGTTCGACATATTCAGCTTGGGTGTTGTAATGACAAAGATAATTGCAGGGCCTTTGGGCCGCGCCTTAAGTACCGGAATGCCTGAAGAAGCCTTTGTTGATCAAGTATATGAAAACTGGAGGAACAGGCTGGAAGCAACGTGTACTTCTTCAAAGATACTAGATGCATACTGCGAGCAAGTGCAAATATGCACTAAGATAGCATTAAGCTGCGTGGAGACTGAGAGGCACAAAAGACCCAGCATAATGGATATTATTGGTACAATGGATGAGACTGAAAATAAGGTTGAAAAGGCATTGTTCTCATTGTCGGGTAGTATGCATTCATGGCTGCGGAGAGACTTGCTAGAGTTAGAAGCCTTCACAAAAAGTCAAGAGATTCCTAGTGCAGAGACATGTAACGAGTTTCCCGTCCTCCTGCGGATCACGGGGACACCATGGTGTGGCTTGGAAGAGATGCCACGCGCAGGTGTAGACGTCGTGGTTGTGGTCGAGGTTGATTGGTTCATGGTGCTTCAGTGGAGGCTGGATATCATCAAGCAAGCCCTGACGGTGGTCATTGACAAGCTCGGTCGGAAGGACCGACTCTCCATCTTGTCATTTGAGGGCGATGTGCCCCGTATTATGGACCTTATGTTCATGTCCGACAAAGGACGGGATGTAGCCAAGCTGGTGGTCAATCAGCTGACTGCGAACCACGGCTACAACATAATCGTAGCTCTGCGACAGGGAGCTGAGATTCTGAGGGGGCGTCAAGTGGAGAAGAAGGATGGTAGCCGTGTTGGCTGCATCATGTTCTTATCGGACAATAATGACATTCGGATCAAGGACAGGTATGACGAGGAAATCAGCTCCGAATTCCCGGCGTACATCTTCGGCCTCGGGGAGTTACACCACCCGGAGGTCATGAAGTACATAGCCGACAGGACCCGCGGCACCTACTCTTTCGTCCACTATGACATCAACGCGATGAACGATGCCTTCGAGCTTTTCATCAGGGGCCTCACCAAAATCGCCGCAGCATCTGTCAAGATCACCCTCAGTGCTCACAAGGGTGTCTTCATATCATCCATCTACTCCGGCGGATACAACAACCATGTGAGCTCTGACAAACTGTCCGGCGAGATAGACGTCGACAATATGTATGCTGGCGAGCGGAAGAACTTTATCGTCTACCTGACAGTCACCGAGGGCAGCGACAGCAAGCTTATGACCGTCGGTGGCCGGTACCGGAGCTTCATTGCAGACAGAGAGCTGGCCGACACGGACGTGCTTGTCCTGCGACCATCTTCAGCAAGCTTGCTAGGAAACACGGCCATCCACCAAGAGGTGGCGGCCGAGCTCATCCGGATCCAGCTTCTCAAGGGTCTGATCACGATGGGTCGAAACCCTGATTCCCTTGAACAGCTATGGGCCCGTGTCAAGTGCTCAGAGGAGGGTGTCAGCGCACCCGAGGAGACCTTTTTGGAGCTTGGCAACGACGTGGCTGAAATTACAAGGGTCATCACGTACAACACCTCGCCTCCTTACATGATGTCATGGCTGACTTGTCACCTGTGGCAGCGCGCAACCACCAAGGGCGCACGCTGCGTCTCTGGGGCTTTCACTATCCCAGGGCGGCACGAAGATGCAAAAGAGCAAGACGACCCAGCACAATAG
Protein Sequence
- >OQ675542
MASPRGSDGAPKSEDLQLSSSSSNSSSNLSSSSSSSLSSRSSIDSTMGTKLQKAKRLSIEHLEVITDNFSQERVIGRGGFGIVYKGVHANGKNIAVKVLHKNMTGTDDGQFEHEFKNLMRLKHQNIVQLVGYCYETQHKPMLHDGVAIFADDIYKALCFEYMENRSLSKHISVECDGLEWHTRYKIIKGMCEGLKYLHEEFKEPIYHLDLKPDNILLDENMVPKLADFGSSKLFGKELTMVITQNFTATIGYMPPEFISHQIVSKKFDIFSLGVVMTKIIAGPKGNSLSFEMDYQDFLDQVQKNWRNRLRDTWHNSEPVQAYCRQVNVCTEIALSCMDADRNKRPSILDIIDKLNKTETVIEQLHRDHQWTSQRITMGDDKLKNEATPLKEKKSEKATEPTSLTIRLLQDITHNFAQERLIGQGAYGKVYMGKFGNGEEIAVKLLYNSMQGGNDEQLQHEFDNLMMLKHPNIVRIVGYCYETQRQHMDFQGKTVFGEMTYRALCLEYMRMGSLQRHLSEESSGLDWQTRYKIIKGTCEGLDYLYRGFDRPIFHLDIKPDNILLDENMMPKLADVGLTRLFGEEQTRVTQSPMGTVEYMPPEYLFGHLISRKFDIFSLGVVMTKIIAGPLGRALSTGMPEEAFVDQVYENWRNRLEATCTSSKILDAYCEQVQICTKIALSCVETERHKRPSIMDIIGTMDETENKVEKALFSLSGSMHSWLRRDLLELEAFTKSQEIPSAETCNEFPVLLRITGTPWCGLEEMPRAGVDVVVVVEVDWFMVLQWRLDIIKQALTVVIDKLGRKDRLSILSFEGDVPRIMDLMFMSDKGRDVAKLVVNQLTANHGYNIIVALRQGAEILRGRQVEKKDGSRVGCIMFLSDNNDIRIKDRYDEEISSEFPAYIFGLGELHHPEVMKYIADRTRGTYSFVHYDINAMNDAFELFIRGLTKIAAASVKITLSAHKGVFISSIYSGGYNNHVSSDKLSGEIDVDNMYAGERKNFIVYLTVTEGSDSKLMTVGGRYRSFIADRELADTDVLVLRPSSASLLGNTAIHQEVAAELIRIQLLKGLITMGRNPDSLEQLWARVKCSEEGVSAPEETFLELGNDVAEITRVITYNTSPPYMMSWLTCHLWQRATTKGARCVSGAFTIPGRHEDAKEQDDPAQ