Gene Details:

• Gene ID:
• Gene Symbol: Pm4
• Gene Name:
• Genome: Chinese_Spring1.0
• Species: Triticum aestivum

Functional Descriptions:

• Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins.
• Pm4 encodes a putative chimeric protein of a serine/threonine kinase and multiple C2 domains and transmembrane regions, a unique domain architecture among known resistance proteins.
• Pm4 undergoes constitutive alternative splicing, generating two isoforms with different protein domain topologies that are both essential for resistance function.
• Pm4 reveals additional diversity of immune receptor architecture to be explored for breeding and suggests an endoplasmatic reticulum-based molecular mechanism of Pm4-mediated race-specific resistance.

Function-related keywords:

• kinase ,  resistance ,  architecture ,  breeding ,  protein-kinase ,  receptor-kinase ,  powdery-mildew ,  mildew-resistance ,  mildew ,  powdery-mildew-resistance ,  protein

Literature:

• Author Correction: Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins.   DOI:  10.1038/s41477-023-01375-3 ;  PMID:  36869130

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Orthologs:

Sequences: