Information report for Lr67
Gene Details
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Functional Descriptions
- The Lr67 resistance gene encodes a predicted hexose transporter (Lr67res) that differs from the susceptible form of the same protein (Lr67sus) by two amino acids that are conserved in orthologous hexose transporters.
- We use comparative genomics, mutagenesis and transformation to isolate the wheat Lr67 gene on chromosome 4DL, which confers partial resistance to all three wheat rust pathogen species and powdery mildew.
- Sugar uptake assays show that Lr67sus, and related proteins encoded by homeoalleles, function as high-affinity glucose transporters.
- Lr67res exerts a dominant-negative effect through heterodimerization with these functional transporters to reduce glucose uptake.
- Lr67 and Lr34 rust resistance genes have much in common – they confer broad spectrum resistance to multiple pathogens in wheat.
Functional Keywords
Literature and News
- A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat. DOI: 10.1038/ng.3439 ; PMID: 26551671
- Lr67 and Lr34rust resistance genes have much in common – they confer broad spectrum resistance to multiple pathogens in wheat. DOI: 10.1186/1471-2229-13-96 ; PMID: 23819608
Gene Resources
- NCBI ID: 123098224
- UniProt accessions: W5ELX6
- EnsemblPlants: TraesCS4D02G243100.1
- Gramene: TraesCS4D02G243100.1
- GO: GO:0015145 , GO:0015293 , GO:0016020
- OMA: VMVVFAC
- ExpressionAtlas: TraesCS4D02G243100
- InterPro: IPR003663 , IPR005828 , IPR005829 , IPR020846 , IPR036259 , IPR044778 , IPR045262
- PANTHER: PTHR23500 , PTHR23500:SF357
- SUPFAM: SSF103473
- PROSITE: PS00216 , PS50850
- Gene3D: 1.20.1250.20
- OrthoDB: W5ELX6
- SMR: W5ELX6
- CDD: cd17361
Sequences
cDNA Sequence
- >TraesCS4D02G243100.1
TCCCATCTCCAATCCCCTTCCTTTGGCTCTCCTCGTGTGCTTCTGTGGAGAAACACTCGCTGCTTGTCTAGCTTCCATTATATCGGCGTAGCTTGACCGGCCGGCTTGCGAAGATGCCGGGCGGGGGGTTCGCCGTGTCGGCGCCGTCCGGCGTGGAGTTCGAGGCCAAGATCACGCCCATCGTCATCATCTCCTGCATCATGGCGGCCACCGGCGGCCTCATGTTCGGCTACGACGTCGGCATCTCAGGCGGAGTGACATCGATGGACGATTTCCTGCGTGAGTTCTTCCCGGCGGTGCTGCGCCGGAAGAACCAGGACAAGGAGAGCAACTACTGCAAGTACGACAACCAGGGCCTGCAGCTCTTCACCTCGTCGCTCTACCTCGCCGGCCTCACCGCCACCTTCTTCGCCTCCTACACCACCCGCCGCCTCGGACGCCGCCTCACCATGCTCATCGCCGGCGTCTTCTTCATCATCGGCGTCATCTTCAACGGGGCCGCCCAGAACCTCGCCATGCTCATCATCGGCAGGATCCTGCTTGGTTGCGGCGTCGGCTTCGCCAACCAGGCCGTTCCCCTGTTCCTGTCGGAGATCGCGCCGACGAGGATCCGCGGCGGGCTCAACATCCTGTTCCAGCTGAACGTGACCATCGGCATCCTGTTCGCGAACCTGGTGAACTACGGCACGAGCAAGATCCACCCGTGGGGCTGGCGGCTGTCGCTGTCGCTGGCCGGCATCCCGGCGGCGATGCTCACCCTGGGCGCGCTCTTCGTCACCGACACCCCCAACAGCCTCATCGAGCGCGGCCACCTGGAGGAGGGCAAGGCGGTGCTCAAGCGGATCCGCGGCACCGACAACGTGGAGCCGGAGTTCAACGAGATCGTGGAGGCGAGCCGCATCGCGCAGGAGGTGAAGCACCCGTTCCGGAACCTGCTCCAGCGCCGGAACCGCCCGCAGCTGGTCATCGCCGTGCTGCTCCAGATCTTCCAGCAGTTCACGGGGATCAACGCCATCATGTTCTACGCCCCCGTGCTGTTCAACACGCTCGGGTTCAAGAGCGACGCGTCGCTCTACTCGGCGGTGATCACGGGCGCCGTCAACGTGCTGGCCACGCTGGTGTCGGTGTACGCCGTGGACCGCGCCGGGCGGCGCGCGCTGCTGCTGGAGGCTGGCGTGCAGATGTTCCTGTCGCAGGTGGTGATCGCCGTGGTGCTGGGCATCAAGGTGACGGACAAGTCGGACAACCTGGGCCACGGGTGGGCCATCCTGGTGGTGGTCATGGTGTGCACCTACGTGGCCTCCTTCGCCTGGTCCTGGGGCCCGCTGGGGTGGCTCATCCCCAGCGAGACGTTCCCGCTGGAGACGCGGTCGGCGGGGCAGAGCGTGACGGTGTGCGTCAACCTGCTCTTCACCTTCCTCATCGCGCAGGCCTTCCTCTCCATGCTCTGCCACCTCAAGTTCGCCATCTTCATCTTCTTCTCGGCCTGGGTGCTCGTCATGTCCGTCTTCGTGCTCTTCTTCCTCCCGGAGACCAAGAACGTGCCCATCGAGGAGATGACCGACAAGGTGTGGAAGCAGCACTGGTTCTGGAAGAGATTCATGGACGACGACGACCACCACCACAACATCGCCAACGGCAAGAACGCCACCGTCTGAAAAGTGTTGCTCCTACTATGTAAATGTAACGCTGCCTGCCTGCCTGCACAACTCGACTTAGAAAGAAGAAAGATGGATACTGAGCTTTATCAATCGATCTTATCTCGATCGAGTGCAGACACTTTCAGTCGCGAGCCCAACTATTGCACTGCTTCCATTTCCATATGCGACGAGGAACAGCAGGCAGTGTGGTAGCAAACCTTGCAGTTCTATATACACTCGGTCCCAAAATAAGCACGTCAATTATTTTGGGACAGAGGGTAGCAGTGTAGTGTATTTCGGTGTTTCTTGTTTAGTGGTAGTATCCTTTATGTGTCTATTTGTTTGGAAGTTGGTCTCTGACAATGCGAGCCTACCTGTATACAGCACCTTGTAAAACTGATGTTGCGATTCGTCAATGCACAGCAGTAATGTTCCAC
CDS Sequence
- >TraesCS4D02G243100.1
ATGCCGGGCGGGGGGTTCGCCGTGTCGGCGCCGTCCGGCGTGGAGTTCGAGGCCAAGATCACGCCCATCGTCATCATCTCCTGCATCATGGCGGCCACCGGCGGCCTCATGTTCGGCTACGACGTCGGCATCTCAGGCGGAGTGACATCGATGGACGATTTCCTGCGTGAGTTCTTCCCGGCGGTGCTGCGCCGGAAGAACCAGGACAAGGAGAGCAACTACTGCAAGTACGACAACCAGGGCCTGCAGCTCTTCACCTCGTCGCTCTACCTCGCCGGCCTCACCGCCACCTTCTTCGCCTCCTACACCACCCGCCGCCTCGGACGCCGCCTCACCATGCTCATCGCCGGCGTCTTCTTCATCATCGGCGTCATCTTCAACGGGGCCGCCCAGAACCTCGCCATGCTCATCATCGGCAGGATCCTGCTTGGTTGCGGCGTCGGCTTCGCCAACCAGGCCGTTCCCCTGTTCCTGTCGGAGATCGCGCCGACGAGGATCCGCGGCGGGCTCAACATCCTGTTCCAGCTGAACGTGACCATCGGCATCCTGTTCGCGAACCTGGTGAACTACGGCACGAGCAAGATCCACCCGTGGGGCTGGCGGCTGTCGCTGTCGCTGGCCGGCATCCCGGCGGCGATGCTCACCCTGGGCGCGCTCTTCGTCACCGACACCCCCAACAGCCTCATCGAGCGCGGCCACCTGGAGGAGGGCAAGGCGGTGCTCAAGCGGATCCGCGGCACCGACAACGTGGAGCCGGAGTTCAACGAGATCGTGGAGGCGAGCCGCATCGCGCAGGAGGTGAAGCACCCGTTCCGGAACCTGCTCCAGCGCCGGAACCGCCCGCAGCTGGTCATCGCCGTGCTGCTCCAGATCTTCCAGCAGTTCACGGGGATCAACGCCATCATGTTCTACGCCCCCGTGCTGTTCAACACGCTCGGGTTCAAGAGCGACGCGTCGCTCTACTCGGCGGTGATCACGGGCGCCGTCAACGTGCTGGCCACGCTGGTGTCGGTGTACGCCGTGGACCGCGCCGGGCGGCGCGCGCTGCTGCTGGAGGCTGGCGTGCAGATGTTCCTGTCGCAGGTGGTGATCGCCGTGGTGCTGGGCATCAAGGTGACGGACAAGTCGGACAACCTGGGCCACGGGTGGGCCATCCTGGTGGTGGTCATGGTGTGCACCTACGTGGCCTCCTTCGCCTGGTCCTGGGGCCCGCTGGGGTGGCTCATCCCCAGCGAGACGTTCCCGCTGGAGACGCGGTCGGCGGGGCAGAGCGTGACGGTGTGCGTCAACCTGCTCTTCACCTTCCTCATCGCGCAGGCCTTCCTCTCCATGCTCTGCCACCTCAAGTTCGCCATCTTCATCTTCTTCTCGGCCTGGGTGCTCGTCATGTCCGTCTTCGTGCTCTTCTTCCTCCCGGAGACCAAGAACGTGCCCATCGAGGAGATGACCGACAAGGTGTGGAAGCAGCACTGGTTCTGGAAGAGATTCATGGACGACGACGACCACCACCACAACATCGCCAACGGCAAGAACGCCACCGTCTGA
Protein Sequence
- >TraesCS4D02G243100.1
MPGGGFAVSAPSGVEFEAKITPIVIISCIMAATGGLMFGYDVGISGGVTSMDDFLREFFPAVLRRKNQDKESNYCKYDNQGLQLFTSSLYLAGLTATFFASYTTRRLGRRLTMLIAGVFFIIGVIFNGAAQNLAMLIIGRILLGCGVGFANQAVPLFLSEIAPTRIRGGLNILFQLNVTIGILFANLVNYGTSKIHPWGWRLSLSLAGIPAAMLTLGALFVTDTPNSLIERGHLEEGKAVLKRIRGTDNVEPEFNEIVEASRIAQEVKHPFRNLLQRRNRPQLVIAVLLQIFQQFTGINAIMFYAPVLFNTLGFKSDASLYSAVITGAVNVLATLVSVYAVDRAGRRALLLEAGVQMFLSQVVIAVVLGIKVTDKSDNLGHGWAILVVVMVCTYVASFAWSWGPLGWLIPSETFPLETRSAGQSVTVCVNLLFTFLIAQAFLSMLCHLKFAIFIFFSAWVLVMSVFVLFFLPETKNVPIEEMTDKVWKQHWFWKRFMDDDDHHHNIANGKNATV