Information report for Lr34;Yr18
Gene Details
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Functional Descriptions
- The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world.
- Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms.
- The wheat gene Lr34 is associated with resistance to two rust diseases of wheat, leaf rust, and stripe rust , as well as powdery mildew.
- Previous studies have localized the codominant gene Lr34 on the short arm of chromosome 7D between the two markers gwm1220 and SWM10. We further reduced the target interval in a map-based cloning approach based on three high-resolution populations.
- The wheat resistance gene Lr34 results in the constitutive induction of multiple defense pathways in transgenic barley.
- The wheat Lr34 multipathogen resistance gene confers resistance to anthracnose and rust in sorghum.
- The wheat Lr34 gene provides resistance against multiple fungal pathogens in barley.
- The durable wheat disease resistance gene Lr34 confers common rust and northern corn leaf blight resistance in maize.
- Lr67 and Lr34 rust resistance genes have much in common–they confer broad spectrum resistance to multiple pathogens in wheat.
- Interestingly, in one genetic background the transgenic Lr34-based resistance resulted in improved seedling resistance without cold treatment. These data indicate that functional variability in Lr34-based resistance can be created using a transgenic approach
Functional Keywords
Literature and News
- A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat. DOI: 10.1126/science.1166453 ; PMID: 19229000
- The wheat resistance gene Lr34 results in the constitutive induction of multiple defense pathways in transgenic barley. DOI: 10.1111/tpj.13001 ; PMID: 26315512
- The wheat Lr34 multipathogen resistance gene confers resistance to anthracnose and rust in sorghum. DOI: 10.1111/pbi.12723 ; PMID: 28301718
- The durable wheat disease resistance gene Lr34 confers common rust and northern corn leaf blight resistance in maize. DOI: 10.1111/pbi.12647 ; PMID: 27734576
- Lr67 and Lr34rust resistance genes have much in common – they confer broad spectrum resistance to multiple pathogens in wheat. DOI: 10.1186/1471-2229-13-96 ; PMID: 23819608
- Functional variability of the Lr34 durable resistance gene in transgenic wheat. DOI: 10.1111/j.1467-7652.2012.00683.x ; PMID: 22321563
Gene Resources
- NCBI ID: FJ436983.1
- UniProt accessions: C0JSA8
- EnsemblPlants: TraesCS7D02G080300.1
- Gramene: TraesCS7D02G080300.1
- GO: GO:0005524 , GO:0005886 , GO:0016887 , GO:0140359
- OMA: WHYYWIS
- ExpressionAtlas: TraesCS7D02G080300
- InterPro: IPR003439 , IPR003593 , IPR013525 , IPR013581 , IPR027417 , IPR034001 , IPR034003 , IPR043926
- PANTHER: PTHR19241
- SUPFAM: SSF52540
- PROSITE: PS50893
- Gene3D: 3.40.50.300
- OrthoDB: C0JSA8
- SMR: C0JSA8
- CDD: cd03232
Sequences
cDNA Sequence
- >TraesCS7D02G080300.1
CATGACTAAAATTGCACTTCAATCTTTTTCCGAAGTCCCGTTTTGCGGTGGCATATATCCAATTTACAAGCTAAAAAAAAGTGCGGTGGGGTTCTTTCCCGTCACAAAGAAAACCCAAAATAAGGCAAATCAGGTCTCCGAATCAGGAGTACTGTGAAGTCTTCACCAGTACCGTATAATACATGACTTATGGCTGTCATCTTCCAGAATGTGCGTTTCCATGCTAATAGTTAGTTTGAAGTCAACACATGACTGGTCTTTCCAACTCTTCTGACTGATGATGTCCGTATGGGAAAAAGCGTGCGTACATGCTCGCCAAAACCTTATATATGTACTCTAAAGAGAAGGAAATGACTGCTTAGAGTACGGCTAGGCAATAGCAAAGGGCGTCGATTTAACTCACCCATCTTGAGATGGAGGGCCTCGCAAGAGAGACCAACCCATCATCCCACCATCAAGATTTCACCGCCTGTGCGAGTGACGAGCGCCCGGATGAGTCCGAGTTAGAATTGGCATCGCGACAGCGCCAGAATGGTGCTGCAAACACCGAGCATGTGAGTGAGAACATGCTGCTTGACAGCAGCAAGTTGGGAGCTCTCAAGAGGCGCGAGTTCTTCGACAACCTGCTAAAGAACCTCGAAGACGACCACCTCCGCTTTCTGCGCGGACAAAAGGAAAGAATTGACAGGGTTGATGTCAAGTTGCCAGCAATAGAGGTGAGGTATAATAATCTGTTTGTGGAGGCAGAGTGCAGAGTTACTAAAGGAAATCACCTGCCATCTCTATGGAATAGTACCAAAGGTGCCTTCTCGGGCCTCGTGAAGTTGCTAGGCTTCGAAACGGAAAGAGCAAAAACCAACGTTCTTGAAGATGTCAGTGGAATCATCAAACCCTGCAGATTGACTCTTCTACTGGGACCTCCTGGATGTGGCAAAAGCACTCTGTTGCGAGCTCTTGCCGGGAAACTAGATAAATCTCTAAAGGTAACAGGGGATATCTCTTATAATGGTTATGAACTTCATGAATTTGTACCTGAGAAAACAGCTGTGTATATCAACCAACATGATCTGCACATAGCTGAGATGACTGTGAGGGAAACTTTAGACTTCTCAGCCCAGTGCCAAGGTGTTGGAAGAAGACCAAAAATACTCAAGGAGGTGAACACAAGGGAGAGTGTGGCTGGGATCATACCTGATGCGGACATCGATCTATACATGAAGGTAGTAGCAGTTGAAGCTTCAGAGCGAAGCCTACAGACAGATTATATTTTGAAGATCATGGGGCTAGAGATATGCGCAGACACGATGGTTGGGGATGCAATGAGAAGAGGAATATCAGGGGGGCAGAAGAAAAGATTAACCACAGCCGAGATGATTGTGGGCCCCGCAAGTGCATACTTTATGGATGAAATATCAAATGGTCTGGATAGCTCTACCACTTTTCAAATAATCAATTGTTTCCAGCAACTGACAAACATCAGCGAGTACACGATGGTTATTTCACTTCTTCAACCAACACCTGAGGTATTTGATCTTTTTGATGACCTCATACTAATGGCAGAAGGGAAGATTATCTACCATGGCCCTCGAAATGAAGCTCTCAATTTTTTTGAGGAGTGTGGGTTCATATGCCCAGAAAGAAAAGCGGCAGCTGACTTTCTTCAAGAGATCTTGTCCTGGAAGGACCAACAACAGTACTGGTTGGGTCCACATGAATCATACAGATATATCTCACCTCATGAATTATCAAGCATGTTCAGGGAGAATCACAGGGGGAGAAAACTACATGAACAAAGTGTACCTCCCAAAAGCCAGTTGGGCAAGGAAGCTTTAGCATTCAATAAGTATTCGCTACAAAAACTGGAAATGTTCAAAGCCTGTGGAGCAAGGGAAGCACTCCTAATGAAAAGGAATATGTTTGTTTATGTCTTCAAAACAGGCCAGCTTGCCATTATTGCACTCGTAACAATGTCTGTATTCCTTCGAACTCGCATGACAATAAGTTTCACTCATGCAAATTACTATATGGGAGCATTATTTTTTTCCATCATGATTATGTTAAATGGCATACCAGAGATGAGCATGCAGATTGGGAGACTCCCAAGTTTTTACAAGCAAAAGAGCTACTATTTCTATTCATCATGGGCATATGCAATACCAGCTTCAGTCCTAAAGGTCCCTATTTCCATACTGGATTCGCTTGTATGGATATCTATCACATATTATGGTATTGGTTATACACCTACTGTTTCAAGGTTCTTCTGCCAGTTTCTGATACTTTGTCTTCTCCATCATTCAGTCACCTCGCAGCATCGATTTATTGCTTCATACTTCCAAACACCTATTGTGTCTTTCTTCTACCTTTTTCTTGCTCTAACAGTATTCCTTACATTCGGAGGCTTCATTCTTCCCAAGACCTCCATGCCAGGATGGTTAAACTGGGGATTTTGGATATCTCCAATGACATATGCAGAAATCAGCATAGTTATTAACGAATTCTTGGCACCAAGATGGCAGAAGGAAAGTATTCAAAACATAACAATTGGGAACCAAATCCTGGTTAATCATGGCCTATATTACAGTTGGCATTATTATTGGATATCCTTTGGAGCCTTGCTTGGATCTATTCTCTTATTTTATATCGCTTTTGGATTGGCACTAGATTACAGAACACCTACAGAAGAATATCATGGAAGCAGGCCTACAAAGAGCTTATGTCAACAGCAGGAAAAAGATTACACTATTCAAAATGAATCTGATGATCAATCAAATATTTCCAAAGCAAAGGTGACTATACCAGTTATGCATCTTCCAATTACATTCCACAATCTGAACTACTACATTGATACCCCACCGGAAATGCTGAAACAAGGCTATCCAACAAGAAGACTTCGACTGCTTAATAACATAACTGGTGCTTTACGTCCCGGTGTTCTTTCTGCACTAATGGGTGTTAGTGGAGCTGGGAAGACAACTCTACTAGATGTATTAGCAGGAAGGAAAACAGGAGGTTATATTGAAGGGGACATAAGAATAGGTGGATATCCCAAGGTGCAGGAAACATTTGTCAGAATCTTGGGTTACTGCGAACAAGTCGACATACATTCCCCACAGCTTACAGTTGAAGAGTCTGTAACTTATTCTGCGTGGCTTCGTCTGCCTTCTCATGTCGACGAACAAACAAGATCTAAATTTGTTGCTGAAGTCCTTGAAACTGTTGAACTAGATCAAATAAAAGATGTCTTAGTGGGGTCACCACAGAAAAATGGATTGTCCATGGAGCAGAGAAAGAGGCTAACGATTGCAGTCGAGCTTGTTTCAAACCCATCAATCATACTAATGGATGAACCAACAACAGGTTTAGATACAAGGTCAGCAGCCATTGTTATTCGTGCAGTCAAAAATATTTGTGAAACAGGAAGGACAGTAGTCTGTACAATCCATCAGCCGAGCACTGAAATTTTTGAGGCATTTGATGAGCTCATATTAATGAAAAGCGGTGGGAAAACAATCTACAGTGGACCAATAGGAGAGCGCTCCTGCAAAGTGATCGAGTACTTTGAGAAAATTTCTGGAGTCCCAAAAATAAAGAGTAACTGCAATCCAGCTACTTGGATGATGGATGTAACATCGACATCAATGGAGGTTCAACACAATATGGACTTTGCAATTTTGTATGAAGAGTCGTCACTGCATAGAGAAGCTGAAGATCTAGTGGAGCAGCTAAGTATCCCATTACCAAATTCAGAAAATCTATGTTTCTCCCATAGTTTTGCACAGAATGGCTGGATTCAACTTAAAGCTTGCTTGTGGAAACAAAACATAACTTACTGGAGGAGTCCTCAGTATAACTTGAGGCGCATTATGATGACTGTCATATCTGCCCTGATCTACGGAATATTGTTCTGGAAGCATGCAAAAGTATTAAACAACGAGCAGGACATGCTCAGTGTTTTTGGTGCAATGTATTTGGGTTTCACCACCATAGGCGCTTATAATGATCAGACAATCATACCATTCAGTACAACTGAGCGTATTGTAATGTATCGTGAGAGATTTGCAGGAATGTATTCATCTTGGTCATATTCATTCGCACAGGCTTTCATTGAGATACCCTATGTATTTATCCAAGTGGTACTGTATACGTTAATTGTCTATCCGTCAACTGGTTATTATTGGACAGCACACAAATTCCTATGGTTCTTCTACACCACATTTTGTTCAATTCTCTCCTATGTTTATGTTGGGTTGCTTCTTGTTTCCATAACCCCCAATGTTCAAGTAGCTACCATACTGGCTTCATTTTTCAACACCATGCAAACACTATTCTCAGGATTTATTTTACCTGCACCTCAAATCCCGAAGTGGTGGACTTGGCTCTACTATCTCACTCCTACATCTTGGGCACTCAATGCCCTCTTGACATCACAATACGGAAACATAGAAAAAGAGGTGAAAGCATTTGGAGAAACTAAATCAGTTTCAATCTTCTTGAATGACTATTTTGGGTTTCATCAAGATAAGTTGAGCGTAGTAGCAGCTGTCCTCGTTGCCTTTCCTTTTGTGTTGATAATCTTGTTTTCGTTGTCCATTGAGAAACTTAATTTCCAGAAGAGGTAAGCAAGTTCTGACATTCCAACAGACATGAATCTGTACATGTTACAGATATAGCTACTTGCCTTTTTTCCAACTGCGAAATGCAGAATCAGAGCTGATTGGGTGGCTATTTTTCTCAAATCTGATGGGTAAACCTCATGAATAAGTAATTGTGTACAATAACTTGATTGTGCTAAGTACGATTGTGAGTTGTAATCTTTTTGTTTCACCGTTC
CDS Sequence
- >TraesCS7D02G080300.1
ATGGAGGGCCTCGCAAGAGAGACCAACCCATCATCCCACCATCAAGATTTCACCGCCTGTGCGAGTGACGAGCGCCCGGATGAGTCCGAGTTAGAATTGGCATCGCGACAGCGCCAGAATGGTGCTGCAAACACCGAGCATGTGAGTGAGAACATGCTGCTTGACAGCAGCAAGTTGGGAGCTCTCAAGAGGCGCGAGTTCTTCGACAACCTGCTAAAGAACCTCGAAGACGACCACCTCCGCTTTCTGCGCGGACAAAAGGAAAGAATTGACAGGGTTGATGTCAAGTTGCCAGCAATAGAGGTGAGGTATAATAATCTGTTTGTGGAGGCAGAGTGCAGAGTTACTAAAGGAAATCACCTGCCATCTCTATGGAATAGTACCAAAGGTGCCTTCTCGGGCCTCGTGAAGTTGCTAGGCTTCGAAACGGAAAGAGCAAAAACCAACGTTCTTGAAGATGTCAGTGGAATCATCAAACCCTGCAGATTGACTCTTCTACTGGGACCTCCTGGATGTGGCAAAAGCACTCTGTTGCGAGCTCTTGCCGGGAAACTAGATAAATCTCTAAAGGTAACAGGGGATATCTCTTATAATGGTTATGAACTTCATGAATTTGTACCTGAGAAAACAGCTGTGTATATCAACCAACATGATCTGCACATAGCTGAGATGACTGTGAGGGAAACTTTAGACTTCTCAGCCCAGTGCCAAGGTGTTGGAAGAAGACCAAAAATACTCAAGGAGGTGAACACAAGGGAGAGTGTGGCTGGGATCATACCTGATGCGGACATCGATCTATACATGAAGGTAGTAGCAGTTGAAGCTTCAGAGCGAAGCCTACAGACAGATTATATTTTGAAGATCATGGGGCTAGAGATATGCGCAGACACGATGGTTGGGGATGCAATGAGAAGAGGAATATCAGGGGGGCAGAAGAAAAGATTAACCACAGCCGAGATGATTGTGGGCCCCGCAAGTGCATACTTTATGGATGAAATATCAAATGGTCTGGATAGCTCTACCACTTTTCAAATAATCAATTGTTTCCAGCAACTGACAAACATCAGCGAGTACACGATGGTTATTTCACTTCTTCAACCAACACCTGAGGTATTTGATCTTTTTGATGACCTCATACTAATGGCAGAAGGGAAGATTATCTACCATGGCCCTCGAAATGAAGCTCTCAATTTTTTTGAGGAGTGTGGGTTCATATGCCCAGAAAGAAAAGCGGCAGCTGACTTTCTTCAAGAGATCTTGTCCTGGAAGGACCAACAACAGTACTGGTTGGGTCCACATGAATCATACAGATATATCTCACCTCATGAATTATCAAGCATGTTCAGGGAGAATCACAGGGGGAGAAAACTACATGAACAAAGTGTACCTCCCAAAAGCCAGTTGGGCAAGGAAGCTTTAGCATTCAATAAGTATTCGCTACAAAAACTGGAAATGTTCAAAGCCTGTGGAGCAAGGGAAGCACTCCTAATGAAAAGGAATATGTTTGTTTATGTCTTCAAAACAGGCCAGCTTGCCATTATTGCACTCGTAACAATGTCTGTATTCCTTCGAACTCGCATGACAATAAGTTTCACTCATGCAAATTACTATATGGGAGCATTATTTTTTTCCATCATGATTATGTTAAATGGCATACCAGAGATGAGCATGCAGATTGGGAGACTCCCAAGTTTTTACAAGCAAAAGAGCTACTATTTCTATTCATCATGGGCATATGCAATACCAGCTTCAGTCCTAAAGGTCCCTATTTCCATACTGGATTCGCTTGTATGGATATCTATCACATATTATGGTATTGGTTATACACCTACTGTTTCAAGGTTCTTCTGCCAGTTTCTGATACTTTGTCTTCTCCATCATTCAGTCACCTCGCAGCATCGATTTATTGCTTCATACTTCCAAACACCTATTGTGTCTTTCTTCTACCTTTTTCTTGCTCTAACAGTATTCCTTACATTCGGAGGCTTCATTCTTCCCAAGACCTCCATGCCAGGATGGTTAAACTGGGGATTTTGGATATCTCCAATGACATATGCAGAAATCAGCATAGTTATTAACGAATTCTTGGCACCAAGATGGCAGAAGGAAAGTATTCAAAACATAACAATTGGGAACCAAATCCTGGTTAATCATGGCCTATATTACAGTTGGCATTATTATTGGATATCCTTTGGAGCCTTGCTTGGATCTATTCTCTTATTTTATATCGCTTTTGGATTGGCACTAGATTACAGAACACCTACAGAAGAATATCATGGAAGCAGGCCTACAAAGAGCTTATGTCAACAGCAGGAAAAAGATTACACTATTCAAAATGAATCTGATGATCAATCAAATATTTCCAAAGCAAAGGTGACTATACCAGTTATGCATCTTCCAATTACATTCCACAATCTGAACTACTACATTGATACCCCACCGGAAATGCTGAAACAAGGCTATCCAACAAGAAGACTTCGACTGCTTAATAACATAACTGGTGCTTTACGTCCCGGTGTTCTTTCTGCACTAATGGGTGTTAGTGGAGCTGGGAAGACAACTCTACTAGATGTATTAGCAGGAAGGAAAACAGGAGGTTATATTGAAGGGGACATAAGAATAGGTGGATATCCCAAGGTGCAGGAAACATTTGTCAGAATCTTGGGTTACTGCGAACAAGTCGACATACATTCCCCACAGCTTACAGTTGAAGAGTCTGTAACTTATTCTGCGTGGCTTCGTCTGCCTTCTCATGTCGACGAACAAACAAGATCTAAATTTGTTGCTGAAGTCCTTGAAACTGTTGAACTAGATCAAATAAAAGATGTCTTAGTGGGGTCACCACAGAAAAATGGATTGTCCATGGAGCAGAGAAAGAGGCTAACGATTGCAGTCGAGCTTGTTTCAAACCCATCAATCATACTAATGGATGAACCAACAACAGGTTTAGATACAAGGTCAGCAGCCATTGTTATTCGTGCAGTCAAAAATATTTGTGAAACAGGAAGGACAGTAGTCTGTACAATCCATCAGCCGAGCACTGAAATTTTTGAGGCATTTGATGAGCTCATATTAATGAAAAGCGGTGGGAAAACAATCTACAGTGGACCAATAGGAGAGCGCTCCTGCAAAGTGATCGAGTACTTTGAGAAAATTTCTGGAGTCCCAAAAATAAAGAGTAACTGCAATCCAGCTACTTGGATGATGGATGTAACATCGACATCAATGGAGGTTCAACACAATATGGACTTTGCAATTTTGTATGAAGAGTCGTCACTGCATAGAGAAGCTGAAGATCTAGTGGAGCAGCTAAGTATCCCATTACCAAATTCAGAAAATCTATGTTTCTCCCATAGTTTTGCACAGAATGGCTGGATTCAACTTAAAGCTTGCTTGTGGAAACAAAACATAACTTACTGGAGGAGTCCTCAGTATAACTTGAGGCGCATTATGATGACTGTCATATCTGCCCTGATCTACGGAATATTGTTCTGGAAGCATGCAAAAGTATTAAACAACGAGCAGGACATGCTCAGTGTTTTTGGTGCAATGTATTTGGGTTTCACCACCATAGGCGCTTATAATGATCAGACAATCATACCATTCAGTACAACTGAGCGTATTGTAATGTATCGTGAGAGATTTGCAGGAATGTATTCATCTTGGTCATATTCATTCGCACAGGCTTTCATTGAGATACCCTATGTATTTATCCAAGTGGTACTGTATACGTTAATTGTCTATCCGTCAACTGGTTATTATTGGACAGCACACAAATTCCTATGGTTCTTCTACACCACATTTTGTTCAATTCTCTCCTATGTTTATGTTGGGTTGCTTCTTGTTTCCATAACCCCCAATGTTCAAGTAGCTACCATACTGGCTTCATTTTTCAACACCATGCAAACACTATTCTCAGGATTTATTTTACCTGCACCTCAAATCCCGAAGTGGTGGACTTGGCTCTACTATCTCACTCCTACATCTTGGGCACTCAATGCCCTCTTGACATCACAATACGGAAACATAGAAAAAGAGGTGAAAGCATTTGGAGAAACTAAATCAGTTTCAATCTTCTTGAATGACTATTTTGGGTTTCATCAAGATAAGTTGAGCGTAGTAGCAGCTGTCCTCGTTGCCTTTCCTTTTGTGTTGATAATCTTGTTTTCGTTGTCCATTGAGAAACTTAATTTCCAGAAGAGGTAA
Protein Sequence
- >TraesCS7D02G080300.1
MEGLARETNPSSHHQDFTACASDERPDESELELASRQRQNGAANTEHVSENMLLDSSKLGALKRREFFDNLLKNLEDDHLRFLRGQKERIDRVDVKLPAIEVRYNNLFVEAECRVTKGNHLPSLWNSTKGAFSGLVKLLGFETERAKTNVLEDVSGIIKPCRLTLLLGPPGCGKSTLLRALAGKLDKSLKVTGDISYNGYELHEFVPEKTAVYINQHDLHIAEMTVRETLDFSAQCQGVGRRPKILKEVNTRESVAGIIPDADIDLYMKVVAVEASERSLQTDYILKIMGLEICADTMVGDAMRRGISGGQKKRLTTAEMIVGPASAYFMDEISNGLDSSTTFQIINCFQQLTNISEYTMVISLLQPTPEVFDLFDDLILMAEGKIIYHGPRNEALNFFEECGFICPERKAAADFLQEILSWKDQQQYWLGPHESYRYISPHELSSMFRENHRGRKLHEQSVPPKSQLGKEALAFNKYSLQKLEMFKACGAREALLMKRNMFVYVFKTGQLAIIALVTMSVFLRTRMTISFTHANYYMGALFFSIMIMLNGIPEMSMQIGRLPSFYKQKSYYFYSSWAYAIPASVLKVPISILDSLVWISITYYGIGYTPTVSRFFCQFLILCLLHHSVTSQHRFIASYFQTPIVSFFYLFLALTVFLTFGGFILPKTSMPGWLNWGFWISPMTYAEISIVINEFLAPRWQKESIQNITIGNQILVNHGLYYSWHYYWISFGALLGSILLFYIAFGLALDYRTPTEEYHGSRPTKSLCQQQEKDYTIQNESDDQSNISKAKVTIPVMHLPITFHNLNYYIDTPPEMLKQGYPTRRLRLLNNITGALRPGVLSALMGVSGAGKTTLLDVLAGRKTGGYIEGDIRIGGYPKVQETFVRILGYCEQVDIHSPQLTVEESVTYSAWLRLPSHVDEQTRSKFVAEVLETVELDQIKDVLVGSPQKNGLSMEQRKRLTIAVELVSNPSIILMDEPTTGLDTRSAAIVIRAVKNICETGRTVVCTIHQPSTEIFEAFDELILMKSGGKTIYSGPIGERSCKVIEYFEKISGVPKIKSNCNPATWMMDVTSTSMEVQHNMDFAILYEESSLHREAEDLVEQLSIPLPNSENLCFSHSFAQNGWIQLKACLWKQNITYWRSPQYNLRRIMMTVISALIYGILFWKHAKVLNNEQDMLSVFGAMYLGFTTIGAYNDQTIIPFSTTERIVMYRERFAGMYSSWSYSFAQAFIEIPYVFIQVVLYTLIVYPSTGYYWTAHKFLWFFYTTFCSILSYVYVGLLLVSITPNVQVATILASFFNTMQTLFSGFILPAPQIPKWWTWLYYLTPTSWALNALLTSQYGNIEKEVKAFGETKSVSIFLNDYFGFHQDKLSVVAAVLVAFPFVLIILFSLSIEKLNFQKR