Information report for TaGSK3
Gene Details
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Functional Descriptions
- GLYCOGEN SYNTHASE KINASE 3 (GSK3) physically interacts with VRN1 and regulates its accumulation to mediate flowering in wheat.
- These results indicated that the over-accumulated GSK3 protein readily promotes the degradation of VRN1 in the gain-of-function GSK3 mutant.
- Our study provides direct evidence that GSK3, the core kinase in the BR signaling pathway, regulates flowering in wheat by modulating the protein stability of VRN1.
- Specifically, phosphorylation by GSK3 may enhance the activity and stability of Rht-B1b, allowing it to inhibit the activities of its target transcription factors.
- Taken together, we reveal a positive regulatory mechanism for the Green Revolution protein Rht-B1b by GSK3, which might have contributed to the Green Revolution in wheat.
Functional Keywords
- kinase , br , br-signaling , protein-kinase , flowering
Literature and News
Gene Resources
- NCBI ID: 101669861
- UniProt accessions: A0A3B6GTC0
- EnsemblPlants: TraesCS3D02G137200.1
- Gramene: TraesCS3D02G137200.1
- GO: GO:0004674 , GO:0004676 , GO:0004677 , GO:0004679 , GO:0004694 , GO:0004711 , GO:0005524 , GO:0005634
- OMA: DAPPPXX
- InterPro: IPR000719 , IPR008271 , IPR011009 , IPR017441 , IPR039192 , IPR050591
- PANTHER: PTHR24057 , PTHR24057:SF5
- SUPFAM: SSF56112
- PROSITE: PS00107 , PS00108 , PS50011
- Gene3D: 1.10.510.10 , 3.30.200.20
- CDD: cd14137
Homologs
- Brachypodium distachyon: Bradi2g06490
- Oryza sativa: LOC_Os01g10840, OsGSK1
Sequences
cDNA Sequence
- >TraesCS3D02G137200.1
ATGGAGGCGCCGCCGGGGCCGGAGCCCATGGTGCTGGACGCGCCGCCCCCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAACGGCGAGCCGAAGAGGACAATTAGCTACATGGCTGAGCGGGTGGTAGGAACTGGTTCATTTGGGATTGTCTTCCAGGCTAAGTGCTTGGAGACTGGAGAGACTGTTGCCATCAAGAAGGTGCTGCAGGATCGCCGTTACAAGAACCGTGAGCTGCAGCTTATGCGCTCCATGGACCATCCCAATGTCGTCTCTCTGAAGCACTGCTTCTTCTCGACCACAAGTAGGGATGAGCTGTTCCTGAACCTTGTCATGGAGTATGTCCCTGAGACTCTATATCGTGTGCTCAAGCACTATAGCAATGCCAACCAGCGGATGCCGCTTATCTATGTCAAGCTTTACATGTATCAGCTTTTTAGAGGGCTAGCTTATGTTCATACTGTTCCAGGAGTTTGCCACAGGGATGTGAAACCACAAAATGTTTTGGTTGATCCTCTAACCCATCAAGTCAAGATCTGTGACTTTGGAAGTGCAAAAGTTCTGGTACCTGGTGAACCCAACATAGCATACATATGCTCTCGCTACTATCGTGCTCCTGAGCTCATATTTGGTGCAACTGAATATACAACTTCAATAGACATATGGTCAGCTGGATGTGTTCTTGCAGAGCTACTTCTTGGTCAGCCTCTGTTTCCAGGAGAGACTGCGGTTGATCAGCTAGTGGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAAATTCGGTGCATGAACCCCAACTATACCGAGTTCAGGTTTCCTCAGATTAAGGCTCATCCTTGGCACAAGATTTTCCACAAGAGGATGCCCGCTGAAGCTATAGATCTTGCCTCCCGCCTTCTCCAGTATTCACCAAATCTACGTTGCACTGCTCTTGATGCATGTGCACATTCCTTCTTTGATGAGCTACGTGAGCCGAATGCACGCTTGCCGAATGGCCGCCCATTCCCTCCTTTGTTCAACTTCAAACCTGAACTAGCGAACGCCTCTCCAGAGCTCATCAACAGGCTTGTTCCGGAACATGTTCGACGGCAAAATGGCCCCAACTTCGCCCATGCTGGGAGCTAGACGGGCGCGCCCGCATCGCCCATATTTTTTGTTTGTCCGCCATCATCGAAGAATCAACTCTCTCTCCTAAATCCTGAGGAGAGACCGATCCAGTGCCAGTGCCAGTGAAAGAAGTACAACTATGTAAATTACCTGACCTTGGAAGAATCGTTGTTGTTGTTGCCGGTGCCGGCCATGTTTAAGTACATGGCGGCACATGTTGGTTGAGTTGTTACTTATTATTAGTAGGTAAGAGCAATGATGTAGGAGGTGGAGACATATGTTAATGCTAGGTCTGTGACCTGTTTTAAGTACATTTTTGTAATGCTTGGTAGTGGTACTGTAATGCGGCAGTAGCTGCTCCATGTTTTGTCCCTTGTCCCTGATGTAAATGTCGTCGTCCTGCAGCAAATGACTCTTCTTCTC
CDS Sequence
- >TraesCS3D02G137200.1
ATGGAGGCGCCGCCGGGGCCGGAGCCCATGGTGCTGGACGCGCCGCCCCCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAACGGCGAGCCGAAGAGGACAATTAGCTACATGGCTGAGCGGGTGGTAGGAACTGGTTCATTTGGGATTGTCTTCCAGGCTAAGTGCTTGGAGACTGGAGAGACTGTTGCCATCAAGAAGGTGCTGCAGGATCGCCGTTACAAGAACCGTGAGCTGCAGCTTATGCGCTCCATGGACCATCCCAATGTCGTCTCTCTGAAGCACTGCTTCTTCTCGACCACAAGTAGGGATGAGCTGTTCCTGAACCTTGTCATGGAGTATGTCCCTGAGACTCTATATCGTGTGCTCAAGCACTATAGCAATGCCAACCAGCGGATGCCGCTTATCTATGTCAAGCTTTACATGTATCAGCTTTTTAGAGGGCTAGCTTATGTTCATACTGTTCCAGGAGTTTGCCACAGGGATGTGAAACCACAAAATGTTTTGGTTGATCCTCTAACCCATCAAGTCAAGATCTGTGACTTTGGAAGTGCAAAAGTTCTGGTACCTGGTGAACCCAACATAGCATACATATGCTCTCGCTACTATCGTGCTCCTGAGCTCATATTTGGTGCAACTGAATATACAACTTCAATAGACATATGGTCAGCTGGATGTGTTCTTGCAGAGCTACTTCTTGGTCAGCCTCTGTTTCCAGGAGAGACTGCGGTTGATCAGCTAGTGGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAAATTCGGTGCATGAACCCCAACTATACCGAGTTCAGGTTTCCTCAGATTAAGGCTCATCCTTGGCACAAGATTTTCCACAAGAGGATGCCCGCTGAAGCTATAGATCTTGCCTCCCGCCTTCTCCAGTATTCACCAAATCTACGTTGCACTGCTCTTGATGCATGTGCACATTCCTTCTTTGATGAGCTACGTGAGCCGAATGCACGCTTGCCGAATGGCCGCCCATTCCCTCCTTTGTTCAACTTCAAACCTGAACTAGCGAACGCCTCTCCAGAGCTCATCAACAGGCTTGTTCCGGAACATGTTCGACGGCAAAATGGCCCCAACTTCGCCCATGCTGGGAGCTAG
Protein Sequence
- >TraesCS3D02G137200.1
MEAPPGPEPMVLDAPPPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGEPKRTISYMAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDRRYKNRELQLMRSMDHPNVVSLKHCFFSTTSRDELFLNLVMEYVPETLYRVLKHYSNANQRMPLIYVKLYMYQLFRGLAYVHTVPGVCHRDVKPQNVLVDPLTHQVKICDFGSAKVLVPGEPNIAYICSRYYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGETAVDQLVEIIKVLGTPTREEIRCMNPNYTEFRFPQIKAHPWHKIFHKRMPAEAIDLASRLLQYSPNLRCTALDACAHSFFDELREPNARLPNGRPFPPLFNFKPELANASPELINRLVPEHVRRQNGPNFAHAGS