Gene Details:
- Gene ID: TraesCS3D02G137200
- Gene Symbol: TaGSK3
- Gene Name: GLYCOGEN SYNTHASE KINASE 3
- Genome: Chinese_Spring1.0
- Species: Triticum aestivum
Functional Descriptions:
- GLYCOGEN SYNTHASE KINASE 3 (GSK3) physically interacts with VRN1 and regulates its accumulation to mediate flowering in wheat.
- These results indicated that the over-accumulated GSK3 protein readily promotes the degradation of VRN1 in the gain-of-function GSK3 mutant.
- Our study provides direct evidence that GSK3, the core kinase in the BR signaling pathway, regulates flowering in wheat by modulating the protein stability of VRN1.
- Specifically, phosphorylation by GSK3 may enhance the activity and stability of Rht-B1b, allowing it to inhibit the activities of its target transcription factors.
- Taken together, we reveal a positive regulatory mechanism for the Green Revolution protein Rht-B1b by GSK3, which might have contributed to the Green Revolution in wheat.
Function-related keywords:
- kinase , br , br-signaling , protein-kinase , flowering
Literature:
- GSK3 regulates VRN1 to control flowering time in wheat. DOI: 10.1111/jipb.13507 ; PMID: 37199274
- GSK3 phosphorylates and regulates the Green Revolution protein Rht-B1b to reduce plant height in wheat. DOI: 10.1093/plcell/koad090 ; PMID: 36945740
Related News:
Gene Resources:
- NCBI ID: 101669861
- UniProt accessions: A0A3B6GTC0
Sequences:
cDNA Sequence
- >TraesCS3D02G137200.1
ATGGAGGCGCCGCCGGGGCCGGAGCCCATGGTGCTGGACGCGCCGCCCCCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAACGGCGAGCCGAAGAGGACAATTAGCTACATGGCTGAGCGGGTGGTAGGAACTGGTTCATTTGGGATTGTCTTCCAGGCTAAGTGCTTGGAGACTGGAGAGACTGTTGCCATCAAGAAGGTGCTGCAGGATCGCCGTTACAAGAACCGTGAGCTGCAGCTTATGCGCTCCATGGACCATCCCAATGTCGTCTCTCTGAAGCACTGCTTCTTCTCGACCACAAGTAGGGATGAGCTGTTCCTGAACCTTGTCATGGAGTATGTCCCTGAGACTCTATATCGTGTGCTCAAGCACTATAGCAATGCCAACCAGCGGATGCCGCTTATCTATGTCAAGCTTTACATGTATCAGCTTTTTAGAGGGCTAGCTTATGTTCATACTGTTCCAGGAGTTTGCCACAGGGATGTGAAACCACAAAATGTTTTGGTTGATCCTCTAACCCATCAAGTCAAGATCTGTGACTTTGGAAGTGCAAAAGTTCTGGTACCTGGTGAACCCAACATAGCATACATATGCTCTCGCTACTATCGTGCTCCTGAGCTCATATTTGGTGCAACTGAATATACAACTTCAATAGACATATGGTCAGCTGGATGTGTTCTTGCAGAGCTACTTCTTGGTCAGCCTCTGTTTCCAGGAGAGACTGCGGTTGATCAGCTAGTGGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAAATTCGGTGCATGAACCCCAACTATACCGAGTTCAGGTTTCCTCAGATTAAGGCTCATCCTTGGCACAAGATTTTCCACAAGAGGATGCCCGCTGAAGCTATAGATCTTGCCTCCCGCCTTCTCCAGTATTCACCAAATCTACGTTGCACTGCTCTTGATGCATGTGCACATTCCTTCTTTGATGAGCTACGTGAGCCGAATGCACGCTTGCCGAATGGCCGCCCATTCCCTCCTTTGTTCAACTTCAAACCTGAACTAGCGAACGCCTCTCCAGAGCTCATCAACAGGCTTGTTCCGGAACATGTTCGACGGCAAAATGGCCCCAACTTCGCCCATGCTGGGAGCTAGACGGGCGCGCCCGCATCGCCCATATTTTTTGTTTGTCCGCCATCATCGAAGAATCAACTCTCTCTCCTAAATCCTGAGGAGAGACCGATCCAGTGCCAGTGCCAGTGAAAGAAGTACAACTATGTAAATTACCTGACCTTGGAAGAATCGTTGTTGTTGTTGCCGGTGCCGGCCATGTTTAAGTACATGGCGGCACATGTTGGTTGAGTTGTTACTTATTATTAGTAGGTAAGAGCAATGATGTAGGAGGTGGAGACATATGTTAATGCTAGGTCTGTGACCTGTTTTAAGTACATTTTTGTAATGCTTGGTAGTGGTACTGTAATGCGGCAGTAGCTGCTCCATGTTTTGTCCCTTGTCCCTGATGTAAATGTCGTCGTCCTGCAGCAAATGACTCTTCTTCTC
CDS Sequence
- >TraesCS3D02G137200.1
ATGGAGGCGCCGCCGGGGCCGGAGCCCATGGTGCTGGACGCGCCGCCCCCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNAACGGCGAGCCGAAGAGGACAATTAGCTACATGGCTGAGCGGGTGGTAGGAACTGGTTCATTTGGGATTGTCTTCCAGGCTAAGTGCTTGGAGACTGGAGAGACTGTTGCCATCAAGAAGGTGCTGCAGGATCGCCGTTACAAGAACCGTGAGCTGCAGCTTATGCGCTCCATGGACCATCCCAATGTCGTCTCTCTGAAGCACTGCTTCTTCTCGACCACAAGTAGGGATGAGCTGTTCCTGAACCTTGTCATGGAGTATGTCCCTGAGACTCTATATCGTGTGCTCAAGCACTATAGCAATGCCAACCAGCGGATGCCGCTTATCTATGTCAAGCTTTACATGTATCAGCTTTTTAGAGGGCTAGCTTATGTTCATACTGTTCCAGGAGTTTGCCACAGGGATGTGAAACCACAAAATGTTTTGGTTGATCCTCTAACCCATCAAGTCAAGATCTGTGACTTTGGAAGTGCAAAAGTTCTGGTACCTGGTGAACCCAACATAGCATACATATGCTCTCGCTACTATCGTGCTCCTGAGCTCATATTTGGTGCAACTGAATATACAACTTCAATAGACATATGGTCAGCTGGATGTGTTCTTGCAGAGCTACTTCTTGGTCAGCCTCTGTTTCCAGGAGAGACTGCGGTTGATCAGCTAGTGGAGATTATCAAGGTTCTTGGTACTCCAACCCGTGAGGAAATTCGGTGCATGAACCCCAACTATACCGAGTTCAGGTTTCCTCAGATTAAGGCTCATCCTTGGCACAAGATTTTCCACAAGAGGATGCCCGCTGAAGCTATAGATCTTGCCTCCCGCCTTCTCCAGTATTCACCAAATCTACGTTGCACTGCTCTTGATGCATGTGCACATTCCTTCTTTGATGAGCTACGTGAGCCGAATGCACGCTTGCCGAATGGCCGCCCATTCCCTCCTTTGTTCAACTTCAAACCTGAACTAGCGAACGCCTCTCCAGAGCTCATCAACAGGCTTGTTCCGGAACATGTTCGACGGCAAAATGGCCCCAACTTCGCCCATGCTGGGAGCTAG
Protein Sequence
- >TraesCS3D02G137200.1
MEAPPGPEPMVLDAPPPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGEPKRTISYMAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDRRYKNRELQLMRSMDHPNVVSLKHCFFSTTSRDELFLNLVMEYVPETLYRVLKHYSNANQRMPLIYVKLYMYQLFRGLAYVHTVPGVCHRDVKPQNVLVDPLTHQVKICDFGSAKVLVPGEPNIAYICSRYYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGETAVDQLVEIIKVLGTPTREEIRCMNPNYTEFRFPQIKAHPWHKIFHKRMPAEAIDLASRLLQYSPNLRCTALDACAHSFFDELREPNARLPNGRPFPPLFNFKPELANASPELINRLVPEHVRRQNGPNFAHAGS