Information report for 63124
Gene Details
Functional Annotation
- Refseq: XP_002509266.1 — WRKY family transcription factor
- TrEMBL: C1FJ40 — C1FJ40_MICCC; WRKY family transcription factor
- STRING: XP_002509266.1 — (Micromonas sp. RCC299)
- GO:0006355 — Biological Process — regulation of transcription, DNA-templated
- GO:0009723 — Biological Process — response to ethylene
- GO:0009751 — Biological Process — response to salicylic acid
- GO:0009753 — Biological Process — response to jasmonic acid
- GO:1900150 — Biological Process — regulation of defense response to fungus
- GO:1900425 — Biological Process — negative regulation of defense response to bacterium
- GO:0005634 — Cellular Component — nucleus
- GO:0003700 — Molecular Function — transcription factor activity, sequence-specific DNA binding
- GO:0043565 — Molecular Function — sequence-specific DNA binding
- GO:0044212 — Molecular Function — transcription regulatory region DNA binding
Family Introduction
- WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.
- The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).
Literature and News
Gene Resources
Homologs
- Brassica napus: GSBRNA2T00055208001, GSBRNA2T00062034001, GSBRNA2T00105528001
- Brassica oleracea: XP_013587047.1
- Brassica rapa: XP_009117949.1, XP_009148678.1
- Capsicum annuum: CA06g13580
- Citrullus lanatus: Cla010216
- Malus domestica: MDP0000788581
- Populus trichocarpa: Potri.008G091900.2, Potri.008G091900.1
- Raphanus raphanistrum: RrC21319_p1
- Sesamum indicum: XP_011098678.1
- Triticum aestivum: Traes_5BS_C46781248.1, TaWRKY61, Traes_5DS_5DEA5C9E3.1, Traes_1BL_B15990028.1, Traes_5AS_9C6171380.1, Traes_2AS_C407071E4.2
Sequences
CDS Sequence:
- >63124|Micromonas_sp._RCC299|WRKY|63124
ATGGCGACGATTAAGCACCACGAAGATGAACGCCTGAGAGCCGTTGATTTAACTTCTAAACCCTTTGAAGTCAACAACGCAGTGAGCCTCGAGCCCAAGACGGAGCCGTCGTTAGAGTCATCGTCGCATCAGCTGCAGTTTCCGTCTACTTCAATGTCTTTAGCTCCACCGTCGAGACCGCCATTGAAGAGAGCTTCGACTAAAGACCGCCACACCAAGGTCGAAGGTAGAGGGAGGAGGATACGGATGCCCGCCACGTGTGCGGCTAGGATTTTTCAGCTGACTAGAGAGCTTGGTCACAAGTCCGACGGCGAGACGATTCGGTGGCTGCTGGAGAACGCCGAGCCGGCTATTATCGCCGCCACGGGTACGGGAACAGTTCCGGCCATCGCTATGTCGGTTAACGGAACGTTGAAGATCCCAACGACGACGAACGGTGATTCTGACGTGGGAGATAACTCGGCGAAGAAGAGACGTAAGCGACCTTCTAATAGTGAGTATATAGACATAAACGAAGCGGTTACGGTTTCGGTTTCTTCCGGTTTAGCACCAATTTCGTCCGGTTTAGCTCCAATTTCATCCGGTTTAGCTCCGGTTTCTACCGTGGCTCAGCAAACGCTGCCGCAAGGGATGGTTCCGATGTGGGCGATTCCATCGAACGCGGTGATTCCGGCAGTCGGAGCTTTCTTCCTTGTGCCGCACGTCGCTGGTCCGACGAACCAGCCTCAGATGTTAGCTTTTCCGGCTGCTCCGCCGTCGTCTTACGTTGCCGCCGTTCAGCAAGCTTCTTTAATGGCTAGACCACCTTTTGTATCAGTTCCTGACGTTACCCGTTCCACGCCGTCGGTTATGGCTCCGAGTTCAAGCTCCGGCGTAACCAACGGAGGCTCGTCGTCGTCTACGACCAACATGCTCAGAGACTTCTCGCTGGAGATTTACGAGAAACAGGAGCTTCACCAGTTCATGTCCACCACCACCGCACGGTCATCGAACCACTGA ATGGACAACGAGTTCGTTTCCGAGAAATGGGCACCGGAGAGACGCGCGCTTTTCCGATTGTCGACACTCCACGAGACGCCGGCTCACAGCGCACGATCAAAAGTTCGCGCGCCGACCGCCCCCGACGCCCTCTCGAAGCCTCCTCCGCCGATCGCGCTAGCGTTCGACGCGTTTCCACCTTCACTTCACCGCCCCTTCACTCCGGCCATGCCTCCCAGCGAGGACGGGTACCGCTGGCGCAAGTACGGGCAGAAGATCATCAAGGGCGCGGCGTTCCCCCGCTCCTACTACCGATGCACCGCGCCCAACTGCCCCGCGCGCAAGCACGTCGAGGGCGACCCCAAGGATCCCGGTTCCATCGCGTACGAGGGTACCCACAACCACGAGCCCCCCACGGGCTCCAACCGAGGCAAGAAGCGCAAGAGCGTTGACCAAAACTCCAAGCCGCCCCTCTCGCCAAACTCCAAGGCGATGAAGATGAAGACGACGAAGAAGTCCTCGTCCCACCGCAGCTCGGAGCTGCAGAACGTGACCCCGAGGTTCTGGGAACGCGCCGAGGCGCTCGCCATGGAGACCCTCGGCTCGCTCTCCCCGGGAAGCCGCAAGAGGGCGGCGAAGCTGACCAGCTCGCGAAACAAGCGCAAATCTGGCAACGGCCTCGCCGTGCAGGTACCCGACCTCATCTCCGGCGGCGCGCCCACCTCCATCACCGCCGCCCTCGTCCGCGTCGACAGCGGCGACGTCACCAACATCAGCGGCGACGTCACCAACATCAGCGGCTTCACCAACATGGAGATTCCCGCCTCTGCCCGAACGGGCAACACCCGCGTCTCGCCCCGTTCCAAGAAGAACGTCGGCGAGTCGGACAGGGGCGCCAACGGGGAGCTCAAGTCGGTGCGGTCCAAACCGGGTAACCACGTCCCGGTGGGCGGGGCCGGGTACGGTGACCTCGCGTCCACCACGGGCGCGAAGAAGATCAAGCGCCCGAGGCCGCTCATCATCGACGCCGAGGCGGCGGCGGCCATCGAGGATGCGGGGACGCCGCTGCTGACCATCGGGAACGGGCGAGCGGCGGGGGAGGTGCCCGGGCTGCTGAGCGCGAGGCGCAGGGATGGGACCAGTTTGAGGAAGGCGGCCGCGATGGGGTGGGCGTCGCAGACGCCGAGGTCGCCGCTCGTGACCCCCGGGTCCGCGGGAAACGCCCTCATGGAGTCGCTCGCGTACATCACCACCCCCAAGTGA ATGGTTTATGAAGCTACAGCAAGACTCAGAGATCCAGTATATGGCTGTGTGGGCATCATTTCTGCCCTCCAGAAACATGTTTTTCACTTACAATCCGAGTTAAACGAAGCTTTAGCTGAAGTAATGTCTCTCAGAACCCAGGTATCCGATGCTTTATCCTTACCCTCTCTGCTTGAAGGTTCTCCATTCACCCCCGAGAACCATGAGTTTCTCCATTTCCAGAAACCGAGTGAGCAAAATGCATATGCTAATGCCTCGGACGCCTTGCTTCTACTTCCAGAAGCTGCAGATCACTATTGTCTCCAAGAAACTGAAGTTCTTCATCCACTGCCTTACTTGGACATATTGTTTTCTAGTATGGACAACAATAGACTGTCAATATTTGCCTTTCATTCAACACCTTGGGATTTAGTAAAGGCAATGTTCCAAAGCTGCAGATATACTAGTTTCTTCCTACTTTGA
Protein Sequence:
- >63124|Micromonas_sp._RCC299|WRKY|63124
MDNEFVSEKWAPERRALFRLSTLHETPAHSARSKVRAPTAPDALSKPPPPIALAFDAFPPSLHRPFTPAMPPSEDGYRWRKYGQKIIKGAAFPRSYYRCTAPNCPARKHVEGDPKDPGSIAYEGTHNHEPPTGSNRGKKRKSVDQNSKPPLSPNSKAMKMKTTKKSSSHRSSELQNVTPRFWERAEALAMETLGSLSPGSRKRAAKLTSSRNKRKSGNGLAVQVPDLISGGAPTSITAALVRVDSGDVTNISGDVTNISGFTNMEIPASARTGNTRVSPRSKKNVGESDRGANGELKSVRSKPGNHVPVGGAGYGDLASTTGAKKIKRPRPLIIDAEAAAAIEDAGTPLLTIGNGRAAGEVPGLLSARRRDGTSLRKAAAMGWASQTPRSPLVTPGSAGNALMESLAYITTPK*