Gene Details:

• Gene ID: MELO3C016678P1
• Gene Family: SRS Family
• Description: SRS Family protein
• Species: Cucumis melo
• Source: STAT family gene from PlantTFDB

Protein Features:

• SuperFamily:  SSF55550
• Gene3D:  G3DSA:3.30.505.10
• PROSITE profile:  PS50001
• InterPro:  IPR000980

Annotation Proteins:

• Refseq:  XP_008452431.1  — PREDICTED: uncharacterized protein LOC103493465 isoform X2
• Swissprot:  Q56XZ1  — SHB_ARATH; SH2 domain-containing protein B
• TrEMBL:  A0A1S3BTU9  — A0A1S3BTU9_CUCME; uncharacterized protein LOC103493465 isoform X2
• STRING:  XP_008452431.1  — (Cucumis melo)

Family Introduction:

• The CudA and ECudA proteins share a 120 amino acid core of homology, and clustered point mutations introduced into two highly conserved motifs within the ECudA core region decrease its specific DNA binding in vitro. This region, the presumptive DNA-binding domain, is similar in sequence to domains in two Arabidopsis proteins and one Oryza protein. Significantly, these are the only proteins in the two plant species that contain an SH2 domain. Such a structure, with a DNA-binding domain located upstream of an SH2 domain, suggests that the plant proteins are orthologous to metazoan STATs. Consistent with this notion, the DNA sequence of the CudA half site, GAA, is identical to metazoan STAT half sites, although the relative positions of the two halves of the dyad are reversed. These results define a hitherto unrecognised class of transcription factors and suggest a model for the evolution of STATs and their DNA-binding sites.

Literature:

• A new family of transcription factors.   DOI:  10.1242/dev.026377 ;  PMID:  18701541

Sequences: