Information report for Lsa009096
Gene Details
Functional Annotation
- Refseq: XP_023756002.1 — SH2 domain-containing protein A isoform X1
- TrEMBL: A0A251TMU5 — A0A251TMU5_HELAN; Putative SH2 domain protein A
- STRING: XP_010274602.1 — (Nelumbo nucifera)
Family Introduction
- The CudA and ECudA proteins share a 120 amino acid core of homology, and clustered point mutations introduced into two highly conserved motifs within the ECudA core region decrease its specific DNA binding in vitro. This region, the presumptive DNA-binding domain, is similar in sequence to domains in two Arabidopsis proteins and one Oryza protein. Significantly, these are the only proteins in the two plant species that contain an SH2 domain. Such a structure, with a DNA-binding domain located upstream of an SH2 domain, suggests that the plant proteins are orthologous to metazoan STATs. Consistent with this notion, the DNA sequence of the CudA half site, GAA, is identical to metazoan STAT half sites, although the relative positions of the two halves of the dyad are reversed. These results define a hitherto unrecognised class of transcription factors and suggest a model for the evolution of STATs and their DNA-binding sites.
Literature and News
Gene Resources
- SuperFamily: SSF55550
- Gene3D: G3DSA:3.30.505.10
- PROSITE profile: PS50001
- InterPro: IPR000980
Sequences
CDS Sequence:
- >Lsa009096|Lactuca_sativa|STAT|gnl|UG|Lsa#S58694322;PUT-187a-Lactuca_sativa-3111
ATGGGCAGTAATGTGGTTGAAGATGGTGGTTACTCTTCGCTAAAAGACTTGAAATTGGAAATCATCACAAACGAGAGCGATCTCGATGCCACTTTTTCTCTTTGCTTTTGGCTGTATCTACCTGCTGATTCATCCCCTTTTCCTTCTACCCTTCTTCGCCAGCATCATTCTGATACAACTAGCTCTACCCCGTTTCTTTCATTGAATGCAAATAAAGAAATCGTGCTTTACCCTATTCTTTCTGTACCAAAAGACACATCAATTCCTGAAGATGTAGCTATGGAAACAGAAATTCCCACTGCAAGAACCAAGATTGATGTCCCTCTAAACAAATGGATTCACATTGGATGTGAGGTTTCTTCTGATACTTTACGACTTTACATTCATGGTGAGATTGTTGGTGAGAATCATGTAGCTTACACTTCTGATAGCTCAAAAAAAGTTTCTTTACTTGGTGCTAACAAAGATGACTCAATTGAGGGTTATCTCTATGGTGTGGAAATGTTGCCTATTACATCTCCTATTAAAGATCACTTTGTTAAGGACCCTCCTATGCAAATACGTGTTGATAGTTCAAGTGCCACTGATATTGAAGAAGACAATGATGGTGTGTGGACTGTTGTTGGTGGTAAGGCTTCTTGCCGTAGGAATTTCTCCTTGGATGTTGTTTTAATGGATGCTTTTGGGCACTTGGTCAACAAAGAAATGGAGGTTGTTGCTACGCTTACATATGCGGACAATTATGCACATGTCGAAAAACCAGATGATGCAGAAGCTCCACTGCTGACAAGTTATGATGGAATCGAGTTTGCTTCATGGGATAGACCAAGTACACTAATTAATGGACGTGCTTCATTTAAGCTCAAGATATCTCAGCTTTCATCGAAATGTGATAACAAGTTGTTTTGTATTAAATTCAACATTCCGAAGATGGGAAGATATCCATTTTTTGAAGTGTTTTCGCGTTCTATTCGGTGTATTTCACGTAATCGTACTACACGTCCATCCACTTTGATATGGAAAAGGTCAACCACTCTTATGCATTCGGTCAATGGAACCTTTGGGCCAGATGGAGGATCCATTGAGCCCGTTAACAATGTGGTTCATGAGGCAAAACCAAGCCCACCATCAAAACGGATCAAGTTAGAACTTGCAAACCCCTTTGTGCATTTAAAGCCTGATGATTCATTCAAGCAAGGATATGAAGAACACCATGAGGTTGATAGATCAAATGGTAGGATTTTGGAAGGTAGAGAAGAAATATACAATTCATCATCTGACACAGATAGTAATACTAATAGTAATAGTAATAGTAGTGAAGCAACAAACTCATGTAAAAGCAATGGGAATCCGGTTTCAGACCTAACTGTATTCAAATACTGCCTTGGAACCCTAACTGAAAAATCTCTTCTTCTAAAAGACCTTGCAACTTCTGCTTCCCAACAAGATGTCATGGACTTTGCCATGCGGGTTTCACAGTTTTCTGGTTGCCTTCATCATCGTAACCAAATAAGAAGTTCAAAGAAGATGATAGAGGAAGGAACAAAGGTCTGGAATTCGGTATTGCAGAATCACCACCATGTGTCATGGGATAATATGATTCCGGTTTTAAGAGACCAGTTTATCAAGATTTCTTCATGTCGGAATAGATTCTTGGTGCATCAGGATTTTGAGGTGTTGAGAAGAATCGGTGGTTGCCAGGACTCAGTGACTCAAGAAAACTTTGAGAAGTTGTGGTGTTGGCTATACCCTGTGGCTTTTGCTTTATCACAAAACGGGCTAAATGAAATGTGGGATTCCAGATGGATTGAAGGACTTGTTACAAAAGAAGAAGCGGAATCTTCACTTCAGGGTCCCACTGGTGGGATTGTGGACCCCGGCACATTCGTCCTCCGGTTTCCTACATCAAGAAGCTGGCCCCACCCTGATGCTGGGAATCTTATTGTCACTTATGTTGGGGCTGATTTTGCCATACACCATAGGCTCCTCTCTCTTGACTTCTTTCACAGTTCTTGTGGCAATGAAACGTTGGGGAAATCATTGAAAGATATGCTGCTTGAAGAGCGTGAGTTATCTCGACTAGGAAGGATTACAACAAGAAGTGTGCGACTTGTTTGA
Protein Sequence:
- >Lsa009096|Lactuca_sativa|STAT|gnl|UG|Lsa#S58694322;PUT-187a-Lactuca_sativa-3111
MGSNVVEDGGYSSLKDLKLEIITNESDLDATFSLCFWLYLPADSSPFPSTLLRQHHSDTTSSTPFLSLNANKEIVLYPILSVPKDTSIPEDVAMETEIPTARTKIDVPLNKWIHIGCEVSSDTLRLYIHGEIVGENHVAYTSDSSKKVSLLGANKDDSIEGYLYGVEMLPITSPIKDHFVKDPPMQIRVDSSSATDIEEDNDGVWTVVGGKASCRRNFSLDVVLMDAFGHLVNKEMEVVATLTYADNYAHVEKPDDAEAPLLTSYDGIEFASWDRPSTLINGRASFKLKISQLSSKCDNKLFCIKFNIPKMGRYPFFEVFSRSIRCISRNRTTRPSTLIWKRSTTLMHSVNGTFGPDGGSIEPVNNVVHEAKPSPPSKRIKLELANPFVHLKPDDSFKQGYEEHHEVDRSNGRILEGREEIYNSSSDTDSNTNSNSNSSEATNSCKSNGNPVSDLTVFKYCLGTLTEKSLLLKDLATSASQQDVMDFAMRVSQFSGCLHHRNQIRSSKKMIEEGTKVWNSVLQNHHHVSWDNMIPVLRDQFIKISSCRNRFLVHQDFEVLRRIGGCQDSVTQENFEKLWCWLYPVAFALSQNGLNEMWDSRWIEGLVTKEEAESSLQGPTGGIVDPGTFVLRFPTSRSWPHPDAGNLIVTYVGADFAIHHRLLSLDFFHSSCGNETLGKSLKDMLLEERELSRLGRITTRSVRLV