Gene Details:

• Gene ID: XP_011090219.1
• Gene Family: NF-YC Family
• Description: NF-YC Family protein
• Species: Sesamum indicum
• Source: NF-YC family gene from PlantTFDB

Protein Features:

• Pfam:  PF00808
• SuperFamily:  SSF47113
• Gene3D:  G3DSA:1.10.20.10
• InterPro:  IPR003958    IPR009072

Annotation Proteins:

• Refseq:  XP_011090215.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_011090217.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552391.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552392.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552393.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552394.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552395.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552396.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552397.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552398.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552399.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552400.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552401.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552402.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552403.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552404.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552405.1  — dr1-associated corepressor-like isoform X1
• Refseq:  XP_020552406.1  — dr1-associated corepressor-like isoform X1
• TrEMBL:  A0A2G9HP45  — A0A2G9HP45_9LAMI; Class 2 transcription repressor NC2, alpha subunit (DRAP1)
• STRING:  Migut.N02403.1.p  — (Erythranthe guttata)

Gene Ontology:

• GO:0046982  — Molecular Function — protein heterodimerization activity

Family Introduction:

• NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).
• As with NF-YA, NF-YB and NF-YC families have well-described subunit interaction and DNA-binding domains ( Kim et al., 1996; Sinha et al., 1996; McNabb et al., 1997; Romier et al., 2003). The conserved regions of NF-YB and NF-YC have structural and amino acid homology to histone fold motifs. Specifically, NF-YB is related to the histone fold motifs of H2B histones, while NF-YC subunits are related to H2A histones (Mantovani, 1999).

Literature:

• Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.   DOI:  10.1104/pp.108.130591 ;  PMID:  19019982

Sequences: