Gene Details:

• Gene ID: AT5G63470.2
• Gene Name: MLE2.10, NFYC4, NF-YC4
• Gene Family: NF-YC Family
• Description: NF-YC Family protein
• Species: Arabidopsis thaliana
• Source: NF-YC family gene from PlantTFDB

Protein Features:

• Pfam:  PF00808
• SuperFamily:  SSF47113
• Gene3D:  G3DSA:1.10.20.10
• InterPro:  IPR003958    IPR009072

Annotation Proteins:

• Refseq:  NP_001032130.1  — nuclear factor Y, subunit C4
• Refseq:  NP_201152.1  — nuclear factor Y, subunit C4
• Swissprot:  Q9FMV5  — NFYC4_ARATH; Nuclear transcription factor Y subunit C-4
• TrEMBL:  A0A384KX14  — A0A384KX14_ARATH; NF-YC4
• TrEMBL:  B9DG64  — B9DG64_ARATH; AT5G63470 protein
• STRING:  AT5G63470.1  — (Arabidopsis thaliana)

Gene Ontology:

• GO:0006355  — Biological Process — regulation of transcription, DNA-templated
• GO:0009738  — Biological Process — abscisic acid-activated signaling pathway
• GO:0010468  — Biological Process — regulation of gene expression
• GO:0048586  — Biological Process — regulation of long-day photoperiodism, flowering
• GO:0051247  — Biological Process — positive regulation of protein metabolic process
• GO:2000905  — Biological Process — negative regulation of starch metabolic process
• GO:0005634  — Cellular Component — nucleus
• GO:0005829  — Cellular Component — cytosol
• GO:0003677  — Molecular Function — DNA binding
• GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
• GO:0005515  — Molecular Function — protein binding
• GO:0046982  — Molecular Function — protein heterodimerization activity

Family Introduction:

• NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).
• As with NF-YA, NF-YB and NF-YC families have well-described subunit interaction and DNA-binding domains ( Kim et al., 1996; Sinha et al., 1996; McNabb et al., 1997; Romier et al., 2003). The conserved regions of NF-YB and NF-YC have structural and amino acid homology to histone fold motifs. Specifically, NF-YB is related to the histone fold motifs of H2B histones, while NF-YC subunits are related to H2A histones (Mantovani, 1999).

Literature:

• Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.   DOI:  10.1104/pp.108.130591 ;  PMID:  19019982

Sequences: