Information report for MDP0000202128
Gene Details
|
|
Functional Annotation
- GO:0006355 — Biological Process — regulation of transcription, DNA-templated
- GO:0005634 — Cellular Component — nucleus
- GO:0043565 — Molecular Function — sequence-specific DNA binding
- GO:0046982 — Molecular Function — protein heterodimerization activity
Family Introduction
- NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).
- As with NF-YA, NF-YB and NF-YC families have well-described subunit interaction and DNA-binding domains ( Kim et al., 1996; Sinha et al., 1996; McNabb et al., 1997; Romier et al., 2003). The conserved regions of NF-YB and NF-YC have structural and amino acid homology to histone fold motifs. Specifically, NF-YB is related to the histone fold motifs of H2B histones, while NF-YC subunits are related to H2A histones (Mantovani, 1999).
Literature and News
Gene Resources
Homologs
- Cajanus cajan: C.cajan_04261
- Cicer arietinum: XP_004488253.1
- Citrus sinensis: orange1.1g044287m
- Juglans regia: WALNUT_00005387-RA
- Manihot esculenta: Manes.03G193600.1.p, Manes.05G065300.1.p
- Medicago truncatula: Medtr0392s0020.1, Medtr4g119500.1
- Populus trichocarpa: Potri.008G217900.1, Potri.008G210300.1
- Prunus mume: XP_008223170.1
- Prunus persica: Prupe.1G138500.1.p
- Pyrus bretschneideri: Pbr014841.1, Pbr004632.1
- Ricinus communis: 29726.m004023
Sequences
CDS Sequence:
- >MDP0000202128|Malus_domestica|NF-YB|MDP0000202128
ATGGTCGACAATAATAATCCTGGAGCAAGCGGAGCTGCAAAGGATGATGATATTGATGGAGGCATCAAGGAGCAAGACCAGCTGCTGCCAATAGCCAACGTCGGGCGGATCATGAAGCAAATATTGCCACCCAACGCCAAGATCTCAAAGGAGGCCAAGGAAACCATGCAAGAATGCGCGTCGGAGTTCATCAGCTTTGTCACCGGCGAGGCCTCGGAGAAGTGCCGCAAAGAGAGGCGGAAGACCGTGAATGGTGACGATGTCTGCTGGGCGCTAAGAGCGCTGGGTTTCGATGACTACACCGGTCCGTTGCGAAGGTACTTACACAGGTATAGAGAGCAAGAAAGGGATGGAATATCATCGGAGGCTAACAACAATATTAATGAAGATCATCAAAGGATATCGATCAACAATATTCCTCATACAMAAGGATCTAATTATTTCAAAGGATCAAGTACTTCTGGTTACCTGATGGGGTATGTTGATGGCACGTTGTTGTGTCCCCCAAAACATGTTGCGAACTCCACCACTGTCAATCCTRCGTACACGGCTTGGGTTCAACAGGACCAAATGATCCTAAGCTGGATAAATGGATCCTTAAYTGCGTCCGTCCTGTCCGTGGTGGCGAGTAAAGAACAGCTCGAGCTACATGGGAAGCTCTTGAGTAAAGGTGCTACTGTAAACGCCTTTRTTGCTTCCAGAGGCCGTGGTGGTYGTCCTCGTGGTGGTRGGCGAGGCCATGCTTCCAACCGTGGTGGGAATCAAAGAGCCTATAATAATCGYAACAACACCAACATTCCGAATAACCAAGGTCATCCCRCACTGGACTGCTACCAGCGAATGAATGCTGCCTTTGAAGGAAGGATTCCTACCAAAYGTCTTTCGRCCATGACGTCTTCTCCYATCACTCTTAATAAGCAGCAGAATGGCTCTTGGCTACTCGACACCGGTGCCAACGCACATATAACACCAGATATTCAAAATCTGGCCCATCYTAAAGAGTACAATGGTAATGATGGTAWGGGAGGTGTAGGTAAAAGCACTAAGCTTCCTTTCAATGTGTCMGAGTCCATGTCTCAATTTYCTTTGCAACTTATCCACTCTGATGTGTGGTRTTCTCCAATTCAATCCAATGAAGGTTCATTGGACCATCAAGGATACAGGTGCTTGGATATGTCCACACGACGAGTTTATTTGTCTCACCATGTTCTATTCGATGATGACTTCTTCCCTTTTAAAGGGCTCACATCTCCTTCTGAAAGTGTCGCATCACTAGTTACCAATCTTTTACCCGACCTACTTTTTACGTTCCCATTATCCACCGCTTCACCTGAGAGTCCTATTTTGAATYGTCCACCTCCACAAATATCTCCTAACTCTAATCTCTATGCTTCCATACCATCCTATCCTGACCCCACTACTTCTCAACCTAACACATTGCCTACTAAWTTGACAAATTTCCTGTTGAGCCTACGTGTTTCAATCAGGCAGTCAAGCATCAGGAGTGGCGGGATGATATGGTGCAGGAATTCAATGCCCTACAACGGTGTTGAACCTAGAGTTTAG
Protein Sequence:
- >MDP0000202128|Malus_domestica|NF-YB|MDP0000202128
MVDNNNPGASGAAKDDDIDGGIKEQDQLLPIANVGRIMKQILPPNAKISKEAKETMQECASEFISFVTGEASEKCRKERRKTVNGDDVCWALRALGFDDYTGPLRRYLHRYREQERDGISSEANNNINEDHQRISINNIPHTXGSNYFKGSSTSGYLMGYVDGTLLCPPKHVANSTTVNPXYTAWVQQDQMILSWINGSLXASVLSVVASKEQLELHGKLLSKGATVNAFXASRGRGGXPRGGXRGHASNRGGNQRAYNNRNNTNIPNNQGHPXLDCYQRMNAAFEGRIPTKXLSXMTSSPITLNKQQNGSWLLDTGANAHITPDIQNLAHXKEYNGNDGXGGVGKSTKLPFNVSESMSQFXLQLIHSDVWXSPIQSNEGSLDHQGYRCLDMSTRRVYLSHHVLFDDDFFPFKGLTSPSESVASLVTNLLPDLLFTFPLSTASPESPILNXPPPQISPNSNLYASIPSYPDPTTSQPNTLPTXLTNFLLSLRVSIRQSSIRSGGMIWCRNSMPYNGVEPRV