Gene Details:

• Gene ID: AT5G08190.2
• Gene Name: NF-YB12, T22D6_130
• Gene Family: NF-YB Family
• Description: NF-YB Family protein
• Species: Arabidopsis thaliana
• Source: NF-YB family gene from PlantTFDB

Protein Features:

• Gene3D:  G3DSA:1.10.20.10
• SuperFamily:  SSF47113
• Pfam:  PF00808
• PRINTS:  PR00615
• PROSITE pattern:  PS00685
• InterPro:  IPR009072    IPR003958    IPR003956

Annotation Proteins:

• Refseq:  NP_001078545.1  — nuclear factor Y, subunit B12
• Swissprot:  P49592  — NC2B_ARATH; Protein Dr1 homolog
• TrEMBL:  Q9LEY8  — Q9LEY8_ARATH; DR1-like protein
• STRING:  XP_006288820.1  — (Capsella rubella)
• STRING:  XP_010454589.1  — (Camelina sativa)

Gene Ontology:

• GO:0006355  — Biological Process — regulation of transcription, DNA-templated
• GO:0005634  — Cellular Component — nucleus
• GO:0003677  — Molecular Function — DNA binding
• GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
• GO:0046982  — Molecular Function — protein heterodimerization activity

Family Introduction:

• NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).
• As with NF-YA, NF-YB and NF-YC families have well-described subunit interaction and DNA-binding domains ( Kim et al., 1996; Sinha et al., 1996; McNabb et al., 1997; Romier et al., 2003). The conserved regions of NF-YB and NF-YC have structural and amino acid homology to histone fold motifs. Specifically, NF-YB is related to the histone fold motifs of H2B histones, while NF-YC subunits are related to H2A histones (Mantovani, 1999).

Literature:

• Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.   DOI:  10.1104/pp.108.130591 ;  PMID:  19019982

Sequences: