Information report for 676751286
Gene Details
Functional Annotation
- Refseq: XP_006390615.1 — nuclear transcription factor Y subunit A-3 isoform X1
- Swissprot: Q93ZH2 — NFYA3_ARATH; Nuclear transcription factor Y subunit A-3
- TrEMBL: V4M9Q4 — V4M9Q4_EUTSA; Uncharacterized protein
- STRING: XP_006390615.1 — (Eutrema salsugineum)
- GO:0006355 — Biological Process — regulation of transcription, DNA-templated
- GO:0016602 — Cellular Component — CCAAT-binding factor complex
- GO:0003677 — Molecular Function — DNA binding
- GO:0003700 — Molecular Function — transcription factor activity, sequence-specific DNA binding
Family Introduction
- NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).
- NF-YA proteins are characterized by the presence of Gln(Q)- and Ser/Thr(S/T)-rich NH2 termini, a subunit interaction domain (NF-YB/NF-YC interaction), and a DNA-binding domain (Olesen and Guarente, 1990; Maity and de Crombrugghe, 1992; Xing et al., 1993, 1994). The protein interaction and DNA binding domains are well conserved between plant and other eukaryote lineages.
Literature and News
Gene Resources
Homologs
- Arabidopsis thaliana: AT1G72830.1, AT1G72830.2
- Brassica napus: GSBRNA2T00103376001, GSBRNA2T00003651001, GSBRNA2T00137180001, GSBRNA2T00102603001
- Brassica oleracea: XP_013591675.1, XP_013613967.1, XP_013613958.1, XP_013613954.1, XP_013613950.1, XP_013613943.1, XP_013613936.1, XP_013613932.1, XP_013591680.1, XP_013591679.1, XP_013591678.1, XP_013590425.1, XP_013588663.1, XP_013588662.1
- Brassica rapa: XP_009105949.1, XP_009104842.1
- Raphanus raphanistrum: RrC14313_p1, RrC19079_p1
Sequences
CDS Sequence:
- >676751286|Sisymbrium_irio|NF-YA|676751286
ATGAACCAGAAGAAGAAGGTGGTAGTGGTGCTCATGGCGATGGTGGTTCCCCAGGATAGGTTTGAGAATAGCTTGTTTGACGTTATGCATCAGATGAATAAGAAAGATTCCACTTTGCCGTACCTTAATACTAGCATCTCGTGGGGAGTGCTTCCAACTGAACCCCTAAGCTTGAAAGTTGTGGATGCAACGCCTGAACATGTGCGTACCACAAAGCAAATCAGTTTTCATGACCAGGATTCATCTTCAACTCAGTCCACTGGTCAATCTTATACTGAAGTTGCAAGTAGTGGGGATGATAACCCTTCCAGACAAATCTCGTTCTCAACCAAATCAGATGTTTGTCTAGGATCTGAAGAAACTCAGCGGAAGGGATATGCAGCTAATCCTAAATCAGGTTCGATGACCGGATTCCCGAATATGCAGTTTGCTCCTACGCAGGGTTTCTCCTTTCACTATGCTGATCCACATTTTGGTGGTTTAATGGCTGCAACATATCTGCCACAGGCACAGACATGCAATCCCCAAATGGTGGGTATGGTTCCTGGTCGAGTTCCGCTACCAGTGGAGATCACGGAAACTGAGCCAGTCTTTGTCAATGCGAAGCAGTACCACGCAATCATGAGGAGAAGGCAGCAACGTGCCAAGCTTGAGGCTCAGAACAAATTAATCAAAGCCCGGAAGCCATATCTTCATGAATCTCGACATGTTCATGCTCTTAAAAGGCCAAGAGGATCCGGTGGAAGATTCCTAAACACCAAAAAACTTCAAGAATCTGAACAGGCTGCTGCTAAAGAGCAAGAACATGTCAAGTCGGTCCAACAGGAAAACAGAAAGGCAAACATGTCTAGATTCGAAGCTCATATGCTGCAGCACAACAAAGACCGTGGCTCAACCACCTCTGGCTCTGACATTACATCTGTTTCCGACGGTGCTGATATTTTCGGACACACTGAATTCCAGTTTTCAGGTTTCCCAACTCAGACTAACCGAGCTATGCTAGTTCATGGTCAATCCAATGACATGCATGGAGGTGGGGACTTGCACCATTTCTCTCCGTATCTTCATGAACCTCGACATGTTCATGCTCTTAGAAGGCCAAGAGGAACCGGTGGAAGATTCCCTAACACCAAAAAACTTCTCCAAGAACCCGATCAGGCTTCTGTTAACGAGCAAGAACATGACAAGTCGGTCCAACAGGAAAACAGAAAGCCAAACATGTCTAGATTTGAAGCTCATATGCGGCAGCACAACAAAGACCGTGGCTCGGATATTACATATGTTTCTGAAGATCCTGATATCTTCAGTCACACGGAATTCCAGGTTTCAGGTTTCCCAACTTAG
Protein Sequence:
- >676751286|Sisymbrium_irio|NF-YA|676751286
MNQKKKVVVVLMAMVVPQDRFENSLFDVMHQMNKKDSTLPYLNTSISWGVLPTEPLSLKVVDATPEHVRTTKQISFHDQDSSSTQSTGQSYTEVASSGDDNPSRQISFSTKSDVCLGSEETQRKGYAANPKSGSMTGFPNMQFAPTQGFSFHYADPHFGGLMAATYLPQAQTCNPQMVGMVPGRVPLPVEITETEPVFVNAKQYHAIMRRRQQRAKLEAQNKLIKARKPYLHESRHVHALKRPRGSGGRFLNTKKLQESEQAAAKEQEHVKSVQQENRKANMSRFEAHMLQHNKDRGSTTSGSDITSVSDGADIFGHTEFQFSGFPTQTNRAMLVHGQSNDMHGGGDLHHFSPYLHEPRHVHALRRPRGTGGRFPNTKKLLQEPDQASVNEQEHDKSVQQENRKPNMSRFEAHMRQHNKDRGSDITYVSEDPDIFSHTEFQVSGFPT