Gene Details:

• Gene ID: AA21G00471
• Gene Family: MYB Family
• Description: MYB Family protein
• Species: Aethionema arabicum
• Source: MYB family gene from PlantTFDB

Protein Features:

• Gene3D:  G3DSA:1.10.10.60
• PROSITE profile:  PS51294
• SuperFamily:  SSF46689
• SMART:  SM00717
• Pfam:  PF00249
• InterPro:  IPR009057    IPR017930    IPR001005

Annotation Proteins:

• Refseq:  XP_006397940.1  — transcription factor MYB12
• Swissprot:  O22264  — MYB12_ARATH; Transcription factor MYB12
• TrEMBL:  V4LHW8  — V4LHW8_EUTSA; Uncharacterized protein
• STRING:  XP_006397940.1  — (Eutrema salsugineum)

Gene Ontology:

• GO:0009651  — Biological Process — response to salt stress
• GO:0009723  — Biological Process — response to ethylene
• GO:0009733  — Biological Process — response to auxin
• GO:0009813  — Biological Process — flavonoid biosynthetic process
• GO:0045893  — Biological Process — positive regulation of transcription, DNA-templated
• GO:0005634  — Cellular Component — nucleus
• GO:0003677  — Molecular Function — DNA binding

Family Introduction:

• MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain.The first MYB gene identified was the ‘oncogene’ v-Myb derived from the avian myeloblastosis virus . Evidence obtained from sequence comparisons indicates that v-Myb may have originated from a vertebrate gene, which mutated once it became part of the virus. Many vertebrates contain three genes related to v-Myb c-Myb, A-Myb and B-Myb and other similar genes have been identified in insects, plants, fungi and slime moulds. The encoded proteins are crucial to the control of proliferation and differentiation in a number of cell types, and share the conserved MYB DNA-binding domain. This domain generally comprises up to three imperfect repeats, each forming a helix-turn-helix structure of about 53 amino acids. Three regularly spaced tryptophan residues, which form a tryptophan cluster in the three-dimensional helix-turn-helix structure, are characteristic of a MYB repeat. The three repeats in c-Myb are referred to as R1, R2 and R3; and repeats from other MYB proteins are categorised according to their similarity to either R1, R2 or R3.
• In contrast to animals, plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain. MYB proteins can be classified into three subfamilies depending on the number of adjacent repeats in the MYB domain (one, two or three). We refer to MYB-like proteins with one repeat as ‘MYB1R factors’, with two as ‘R2R3-type MYB’ factors, and with three repeats as ‘MYB3R’ factors.

Literature:

• The R2R3-MYB gene family in Arabidopsis thaliana.   DOI:  10.1016/s1369-5266(00)00199-0 ;  PMID:  11597504

Sequences: