Gene Details:

• Gene ID: MELO3C006183P1
• Gene Family: LBD Family
• Description: LBD Family protein
• Species: Cucumis melo
• Source: LBD family gene from PlantTFDB

Protein Features:

• PROSITE profile:  PS50891
• Pfam:  PF03195
• InterPro:  IPR004883

Annotation Proteins:

• Refseq:  XP_008438149.1  — PREDICTED: LOB domain-containing protein 18
• Swissprot:  O22131  — LBD18_ARATH; LOB domain-containing protein 18
• TrEMBL:  A0A1S3AVS3  — A0A1S3AVS3_CUCME; LOB domain-containing protein 18
• STRING:  XP_008438149.1  — (Cucumis melo)

Gene Ontology:

• GO:0010089  — Biological Process — xylem development
• GO:0010311  — Biological Process — lateral root formation
• GO:0005634  — Cellular Component — nucleus

Family Introduction:

• The in vitro DNA-binding and heterologous transcriptional activation studies presented here indicate that the LBD protein family represents a new class of DNA-binding transcription factors that recognize the cis-element GCGGCG. The DNA-binding activity is present within the LOB domain, which is conserved throughout the 43 Arabidopsis family members as well as LBD proteins in other plant species.
• The LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

Literature:

• LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins.   DOI:  10.1093/nar/gkm775 ;  PMID:  17913740

Sequences: