Gene Details:

• Gene ID: XP_010106869.1
• Gene Family: HB-other Family
• Description: HB-other Family protein
• Species: Morus notabilis
• Source: HB-other family gene from PlantTFDB

Protein Features:

• SuperFamily:  SSF46689
• SMART:  SM00389
• Gene3D:  G3DSA:1.10.10.60
• PROSITE profile:  PS50071
• Pfam:  PF00046
• PROSITE pattern:  PS00027
• Gene3D:  G3DSA:1.20.5.170
• InterPro:  IPR009057    IPR001356    IPR017970

Annotation Proteins:

• Refseq:  XP_024028318.1  — PH, RCC1 and FYVE domains-containing protein 1, partial
• Swissprot:  Q947D2  — PRAF1_ARATH; PH, RCC1 and FYVE domains-containing protein 1
• TrEMBL:  W9RV99  — W9RV99_9ROSA; E3 ubiquitin-protein ligase HERC2
• STRING:  XP_010106869.1  — (Morus notabilis)

Gene Ontology:

• GO:0005634  — Cellular Component — nucleus
• GO:0003677  — Molecular Function — DNA binding
• GO:0016874  — Molecular Function — ligase activity
• GO:0046872  — Molecular Function — metal ion binding

Family Introduction:

• A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Literature:

• The true story of the HD-Zip family.   DOI:  10.1016/j.tplants.2007.08.003 ;  PMID:  17698401

Sequences: