Gene Details:

• Gene ID: cra_locus_14361_iso_2
• Gene Family: HB-other Family
• Description: HB-other Family protein
• Species: Catharanthus roseus
• Source: HB-other family gene from PlantTFDB

Protein Features:

• SuperFamily:  SSF46689
• SMART:  SM00389
• Gene3D:  G3DSA:1.10.10.60
• PROSITE profile:  PS50071
• Pfam:  PF00046
• PROSITE pattern:  PS00027
• Gene3D:  G3DSA:1.20.5.170
• InterPro:  IPR009057    IPR001356    IPR017970

Annotation Proteins:

• Refseq:  XP_027085532.1  — homeobox-leucine zipper protein HDG5-like isoform X3
• Swissprot:  A2ZAI7  — ROC3_ORYSI; Homeobox-leucine zipper protein ROC3
• Swissprot:  Q336P2  — ROC3_ORYSJ; Homeobox-leucine zipper protein ROC3
• TrEMBL:  A0A068VCG2  — A0A068VCG2_COFCA; Uncharacterized protein
• STRING:  XP_009786380.1  — (Nicotiana sylvestris)

Gene Ontology:

• GO:0006355  — Biological Process — regulation of transcription, DNA-templated
• GO:0048497  — Biological Process — maintenance of floral organ identity
• GO:0008289  — Molecular Function — lipid binding
• GO:0043565  — Molecular Function — sequence-specific DNA binding

Family Introduction:

• A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Literature:

• The true story of the HD-Zip family.   DOI:  10.1016/j.tplants.2007.08.003 ;  PMID:  17698401

Sequences: