Information report for 447019
Gene Details
Functional Annotation
- Refseq: XP_024517255.1 — homeobox-DDT domain protein RLT1 isoform X1
- TrEMBL: D8SW30 — D8SW30_SELML; Uncharacterized protein
- STRING: EFJ11353 — (Selaginella moellendorffii)
- GO:0006355 — Biological Process — regulation of transcription, DNA-templated
- GO:0005634 — Cellular Component — nucleus
- GO:0003677 — Molecular Function — DNA binding
Family Introduction
- A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.
Literature and News
Gene Resources
- SuperFamily: SSF46689
- SMART: SM00389
- Gene3D: G3DSA:1.10.10.60
- PROSITE profile: PS50071
- Pfam: PF00046
- PROSITE pattern: PS00027
- Gene3D: G3DSA:1.20.5.170
- InterPro: IPR009057 IPR001356 IPR017970
Sequences
CDS Sequence:
- >447019|Selaginella_moellendorffii|HB-other|447019
ATGGAGGGCGACGACAAGCCGCGCAAGGGAGAGGACAAGGATAAGGGTCTCAACACCAAGCGCAAGATGAAGACGCCCTCGCAACTCGAAATTCTCGAGAGGGTCTACGCCGAGGACAAGTACCCCTCCGAGGTGGTCCGCGCGGAGCTCTCCACGAAATTGAGCCTCACGGACAGGCAGCTCCAGATGTGGTTCTGCCACCGGCGGCTCAAGGACAGGAAGGGCGACGAGGGCGGCGCCCCTCCTGGAGCTCCCGCCGCGACCTCGTCAAAGAAGCAAAAGAGGAAGAAGGACAAAGAAGCTGCCACCGGTGCTGGCGGCGCGGCGCTCCTCTTGCTGCCTCCTCCTCCGCCTCTTCCTCCAAATCCAAGCCCAGCGTCCATGCTTGGAGCAGCGGTCGATCTCCCGGATGCCAAAGTAGCAGCAGTGGCAGCGCCGGCGGGTGGCGAGGAAGTCGCCAAGGCGACGACGATGACGACGAAAAAGGAAGGTGGCGGTAAGAAGCGGAGCGCGGCAGCCATGGCCGCCGAGGAGCTCAAGCGCGAGCGGGAGGTGATCACTCTGGTGGAGCAGCAGCTCGGGGAGCCGATCCGAGAGGACGGACCCGTGCTGGGAAGGGAGTTTGATCCGCTCCCTCCCGGACCCTTCGACACTCCTATAGACTCGTCGACGTTCTCGCTCAATGCGGCCGAGCTCAAGGCTCCAGGAGCTCCAGAGTTGGGTAGCAGCCGGCGGACATCCCCGCTGACGAGCAGCAGGACGATTCCCCGGGAGCACCAGTTCATTCCGGAGCATCCAACCGGAGCTCAGTTCCAGCCTTGCAAGCTGGAGAGGGACGGCAAAGGAAAGGCGCAGCAGAGTAGCAGCTCGCTCACGGATGCCAGAGTTCCGAACCTCTCCTTGAATTTCCTGCCGCATGGTGACGCTGATGCCGGCGTGGAGGAGCAGCTACTCAAGCCGTCTCACGTCGTGATTCCTGAAATGCCCGAGCCGCCGCAACCCGGAAGCAGCAAGAAACGCAAGGTCCAGAGTGACGACGCAAAGCTCGCCCGGGAGCTCGAGGCCCAAGAGAAGAAGCTCAAGAGAGAAGCTGAGAAGCAGGAAGCGGCACGCCGCAAGAGGGAAGAGCAGGAGAGAAAAGAGATCGAGAAGATCAACAGAGAGAGGCAGAGGGAGCTGGAGAAGATCAACCGCGAGAGGCAACGCGAGGAGGAGAGACATCAACGCGAGCAGAAGAAAGAACAGGATCGCTTGGAGAGACTGGCTCAAAAGGAGCAGCAACGGCTGGAGAAGTTGCGCTTGAAGGAGGAGGTCCGGCGGCAAAAAGAGGCTGCGAAGCTCCAGGCCGCTTACGAGCGAGCGACCGCAAAGAAGCTTGCCAAGCTTTCCACGGGTCTGATGGACGACGAGCAGCTAGAACTCATGCAGATGGGCGCGTTTGTTCAAGGACTCGTCTCCGGTGATATGGAGGGTGGCTCGGCTTTCGACCCAAGCAAAGTGGAGCTTAAGAAGTACCCGCCAGCTTCAGTGCGGATGAAGAAGGTTCTTGGAGTCTCGCCTTGGGATTCTGTGCAGAACGTTTCCAATCTTCTTATGGTCTGGGGATTCTTGACCACATTCTCGGACGCCATTGGGCTGTGGCCATTTACAGTCGACGAACTCGTCCAGGGGCTTCATGACTTTGATTCCAGGCTCCTCAACGAAACTTACATTGCGCTGCTGAGGACTTTGATCAGAGATGTGGAAGATGCCGCGCAAGCAGCGGCGAGTGGAACCGCTGGAAGTCAGCACGCGATTGCTGTTGCGGCTGGTGGTCACCCGCAGATTGTTGAAGCCGCTTATACGTGGGGTTTTGACATTCAGGAATGGGGCCAGCATATGAGCCCTCTAACGTGGCCAGAGATCCTTAGACAGTTCGCACTGGCAGCCGGTTATGGACCGAGGTGGAAGAAAAAAACGCAGTCACCCGATGCAAAGCCGGATTGTATCGAGATACACGATGGCCACAACGCGAATGCGATCGCGACGCTGCGCTCCGGGGCTGCTGCAGTGAATGCTGTAGCTCTCATGCGTGGCAAGCATGGCACTCGACTAAAGGTGCGCAAGGGCCAGACTCCCAAGCTTACTCCGGGAACTGTCAAGTACGCTGCGTTCCACGTCCTGTCCATTCAAGGCAGCAAGGGCCTTACCATTCTGGAGCTAACAGACAGGATACAGAAATCAGGCCTTCGGGACTTGTCATCGAGCAAGACACCGGAGGCGTCGATCTCAGCTGCCTTGTCCAGAGACACGTATCTGTTTGAGCGTGTTGCGCCGTCAACTTACTGCGTCCGTTCGCCGTTTCGAAGGGACCCGGACGATGCGGAAGATGTGCTGCAAGCTGCACTGGAGAGGACGTATTTGTATCAGACTCGGCAGCTGGACCCGGAGAAGGCAGACGAGGACGTGGAGGATGCCGAGGAGGAGTCCGAAGGCGAAGAGCACGAGGTTGAAGAAGCGGAGCATGAAAGCGAGCATATGGACGCGGAAGTGGAACGGGCCGAGCAGCATCAACAGCACGAGGATGCTCGCGAGCACGACGAGAGCGGGCATGCCTCCGAGAGCTACGAGACTCCACGGAGGGGTAAAGTTATTCTGCGGTTAAAAACGGGGAAGCCTCAAGATAGTGCGGGTGAGGCAACAGCAACAGCAGCAGCTGGAACAGCGGAGAGCTTTGAGACGGAAACACCAGCAGCAGTAGCAGCAGTAGCAGCACTAGCAGATTCCAAGGACGATGCAGTGAGGCACTTGCGGCCCCCGCCTGATGCTCTCAGGAAAGTTGACAATGACGACGAGATGGAAATTGACGAGAGCCAAGCTTTAGATGCGCTCATGGCATGCCTAGACACACGCGGAGCAAGGGAGGCGAGCCTCTATAACATCTTAACTCACATAGGGGGCCCCGTCAGGAAAGCTATGAAGAGTCTTGCTCAGTCGAGAGCGTACGTGGAGTCATCCAAAGGCAAGGCGGAGGGAAGTCCGTCTAGTGGAGTTTTCGGACCGTCGGACGCCTCTCCAGAGGTGCCAAGCGCCATTCCAGTTGAACTTGGAAGGTCCACACTTGAGATCCAGCACGCCATGGATCGCTTCAAGGACCTGGACAGATGGCTCTGGAACCGGTGCTTGGCAAGAGGAGGGAAGAACCTCAAGGCTCTCAGCCTGGGAAACAAACGAGACGTGGAGATGTTGGCCACCTGCGAGCTGTGCCATGGCTTGTACTGGCCGGATGAAAACCACTGCCCGTATTGTCACGCCATGGTTGAGAGCTCCAAGTTCTCTAGTCACGTTCGCGAGTGCGAAAGCAAGCTCGAGGCAAAGCAGGGAATTGGATATCAACTTCTTCCATCTCGGCTACAGCTGCTCAAACAACTCTTGTTGTCTGTGGAGGTGGCTGTTCCAGCGGAAGCGTTCAAGGATTCATGGACGAGTGACTCCCGGAGGATCTGGTGTAGTAATGTCAAGGCTGCATCGTCGTCGAGCGAGCTTCTTGAGGCCCTCACCGAGCTGGAGAGCTGTGTGGACGAGAACTGGATCTCTTCGTCTTTTGAGACTGCAGAAAAGGCCTTGAGCACAACAGCACTGGGGAGCAACTCAAGGAGGAAAAACTTGCCTTGGATCCCGCAGACAACAGCGGCAGTGGCGTTGCGGCTAAGTGCGTTTGATGCAGCCATAGCTTTCAGCACGGAGCAAAGACAGCAGCTGGAGGAGACTTACCAGAACAGCGACCATGGCTTCCACCGCGGGACTGCGGACGAGGCGGCTCCCAACGCAAATGAGTTTGCGGCAAGTCCCCAAGGGACGAGCTCCCCGGACAGCGGCTCACCGCTGGAGGTACAAAACGGGCATGTCCGAATGCGTTCTCCGCAGCACCACCGTTCGAGCTACCTGGAAGAACAGCACGAGGAAGAAGACAATCAACAGCAGGAAGTGGAGAAGCAGCAACAGATGGAGCAGCAGCAGCCGGGAAGAGGCCGTCTGCTGTTCCGTTTTCCTGGACGAAACGTCGAGCACCGTCAACAGGCGCAAGCGGGAGCATCGGGTGGGGGTGGTGAGATGGATGAGAGCTCGGACGAGGACGACGAGGAAGGCCAGGGTTGGGAGAGGCAGGGATCGGACGAGCACTCTTATGAAGATGATCAGCAACACCATCACCAGCAGCACCACCACCACCAGCAACAGGAGGAGGAGGAGGAGGATGAAGAGGAGGGGCAGCAAGCACCGCAACACTTCTACGATCGTCAAGAACAGGAGGAAATCAACAGCATGATAATGGGCGAAGAGGAGAGCTATGATGAGGAGGAAGAGGAGGAAGGCGAGGAACTCCACCGCCAAGAACAGCAGCAGCGGCAACAGCACCATGGACAGCACCATGGAGATTACGAAGAAGAGGAGGAAGTGGAGGAAGAGGAAGTGGAGTTAGAGGAGGAGCTGTCCGAGGAATCGAGCTGA
Protein Sequence:
- >447019|Selaginella_moellendorffii|HB-other|447019
MEGDDKPRKGEDKDKGLNTKRKMKTPSQLEILERVYAEDKYPSEVVRAELSTKLSLTDRQLQMWFCHRRLKDRKGDEGGAPPGAPAATSSKKQKRKKDKEAATGAGGAALLLLPPPPPLPPNPSPASMLGAAVDLPDAKVAAVAAPAGGEEVAKATTMTTKKEGGGKKRSAAAMAAEELKREREVITLVEQQLGEPIREDGPVLGREFDPLPPGPFDTPIDSSTFSLNAAELKAPGAPELGSSRRTSPLTSSRTIPREHQFIPEHPTGAQFQPCKLERDGKGKAQQSSSSLTDARVPNLSLNFLPHGDADAGVEEQLLKPSHVVIPEMPEPPQPGSSKKRKVQSDDAKLARELEAQEKKLKREAEKQEAARRKREEQERKEIEKINRERQRELEKINRERQREEERHQREQKKEQDRLERLAQKEQQRLEKLRLKEEVRRQKEAAKLQAAYERATAKKLAKLSTGLMDDEQLELMQMGAFVQGLVSGDMEGGSAFDPSKVELKKYPPASVRMKKVLGVSPWDSVQNVSNLLMVWGFLTTFSDAIGLWPFTVDELVQGLHDFDSRLLNETYIALLRTLIRDVEDAAQAAASGTAGSQHAIAVAAGGHPQIVEAAYTWGFDIQEWGQHMSPLTWPEILRQFALAAGYGPRWKKKTQSPDAKPDCIEIHDGHNANAIATLRSGAAAVNAVALMRGKHGTRLKVRKGQTPKLTPGTVKYAAFHVLSIQGSKGLTILELTDRIQKSGLRDLSSSKTPEASISAALSRDTYLFERVAPSTYCVRSPFRRDPDDAEDVLQAALERTYLYQTRQLDPEKADEDVEDAEEESEGEEHEVEEAEHESEHMDAEVERAEQHQQHEDAREHDESGHASESYETPRRGKVILRLKTGKPQDSAGEATATAAAGTAESFETETPAAVAAVAALADSKDDAVRHLRPPPDALRKVDNDDEMEIDESQALDALMACLDTRGAREASLYNILTHIGGPVRKAMKSLAQSRAYVESSKGKAEGSPSSGVFGPSDASPEVPSAIPVELGRSTLEIQHAMDRFKDLDRWLWNRCLARGGKNLKALSLGNKRDVEMLATCELCHGLYWPDENHCPYCHAMVESSKFSSHVRECESKLEAKQGIGYQLLPSRLQLLKQLLLSVEVAVPAEAFKDSWTSDSRRIWCSNVKAASSSSELLEALTELESCVDENWISSSFETAEKALSTTALGSNSRRKNLPWIPQTTAAVALRLSAFDAAIAFSTEQRQQLEETYQNSDHGFHRGTADEAAPNANEFAASPQGTSSPDSGSPLEVQNGHVRMRSPQHHRSSYLEEQHEEEDNQQQEVEKQQQMEQQQPGRGRLLFRFPGRNVEHRQQAQAGASGGGGEMDESSDEDDEEGQGWERQGSDEHSYEDDQQHHHQQHHHHQQQEEEEEDEEEGQQAPQHFYDRQEQEEINSMIMGEEESYDEEEEEEGEELHRQEQQQRQQHHGQHHGDYEEEEEVEEEEVELEEELSEESS*