Information report for GSBRNA2T00056359001
Gene Details
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Functional Annotation
- Refseq: XP_009111654.1 — PREDICTED: cytochrome P450 71B13-like isoform X1
- Swissprot: P58051 — C71BE_ARATH; Cytochrome P450 71B14
- TrEMBL: A0A078H6X2 — A0A078H6X2_BRANA; BnaA01g14230D protein
- TrEMBL: A0A3P5ZQJ4 — A0A3P5ZQJ4_BRACM; Uncharacterized protein
- STRING: Bra013842.1-P — (Brassica rapa)
- GO:0055114 — Biological Process — oxidation-reduction process
- GO:0005506 — Molecular Function — iron ion binding
- GO:0016705 — Molecular Function — oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- GO:0020037 — Molecular Function — heme binding
Family Introduction
- Understanding the role of transcription factors (TFs) is essential in reconstructing developmental regulatory networks. The plant-specific GeBP TF family of Arabidopsis thaliana (Arabidopsis) comprises 21 members, all of unknown function. A subset of four members, the founding member GeBP and GeBP-like proteins (GPL) 1, 2, and 3, shares a conserved C-terminal domain.
- Here we report that GeBP/GPL genes represent a newly defined class of leucine-zipper (Leu-zipper) TFs and that they play a redundant role in cytokinin hormone pathway regulation. Specifically, we demonstrate using yeast, in vitro, and split-yellow fluorescent protein in planta assays that GeBP/GPL proteins form homo- and heterodimers through a noncanonical Leu-zipper motif located in the C-terminal domain.
- A triple loss-of-function mutant of the three most closely related genes gebp gpl1 gpl2 shows a reduced sensitivity to exogenous cytokinins in a subset of cytokinin responses such as senescence and growth, whereas root inhibition is not affected. We find that transcript levels of type-A cytokinin response genes, which are involved in the negative feedback regulation of cytokinin signaling, are higher in the triple mutant. Using a GPL version that acts as a constitutive transcriptional activator, we show that the regulation of Arabidopsis response regulators (ARRs) is mediated by at least one additional, as yet unknown, repressor acting genetically downstream in the GeBP/GPL pathway.
- Our results indicate that GeBP/GPL genes encode a new class of unconventional Leu-zipper TF proteins and suggest that their role in the cytokinin pathway is to antagonize the negative feedback regulation on ARR genes to trigger the cytokinin response.
Literature and News
Sequences
CDS Sequence:
- >GSBRNA2T00056359001|Brassica_napus|GeBP|GSBRNA2T00056359001
ATGATTATGTGGTATATCATTGTTGCTGTCGTCATCTTAGCATCTTTACTCTATGGACCTCTAATGTCCCTCAAGTTTGGAAACGTGCCTACCGTTGTGGCGTCATCTCCAGAGACAGTGAAGGATGTCTTAAAAACGTTCGACGCAGATTGTTGTTCGCGACCGTACTTGACGTATGCTGCAAGAATTTCATACAACTTAAACGACCTCGCCTTCTCTCCTTATAGCAAGTACTGGAGGGAAGTACGAAGGATGACAGTTCTTGAGCTCTACACCGCGAAAAGGGTGCAATCGTTTCGGCATATAAGAGAAGAAGAAGTTGCTTCCTTGGTCGAGTTCGTAAAGGGGGCTGCTTTGTTGGGGAACACGGTTAACTTGAGCAACACGTTGATGAAACTGTCTGGAAGTGTGATATGTAGAGTAGGGTTTGGGATAAATCTCAAAGGAAGCAAACTCGAGGATACGTATGAGGAAATCATTCGAGAAACCATGGAGGTGTTGGGAAGCTTCGCAGCAGCTGATTACCTCCCTATCATTGGTCGAATCATCGATAGGGTCACGGGGTTACATAGCAAATGTGAGAAGCAACATATGGAAGATGAGAGTCTTAAAGATGACATCATTGCCTTGCTTCTCAAAATGGAAAGGGGAGAGGCTGGACTTGGAGAGTATCAACTTACTAGAAACCACACCAAAGGGATTCTTCTAAATGTTCTTATTGCTGGAATAGACACTTCTGGCCACACAATAACATGGGCGATGACACATATGATCAAAAACCCAAGAGTTTTGAAGAAAGTGCAAGCCGAGGTAAGAGAAGTGATCCAAAACAAAGACAATATCACAGAAGAAGATATAGAACAACTCGAATATCTCAAAATGGTGATTAAAGAGACGGTAAGGATAAACCCACTTGTCCCACTTCTAATCCCAAGAGAGGCTTCAAAGGATATAAAGATAGCGGGTTACGACATTCCTAAGAAAACATGGATACATGTCAACATTTGGGGTGTTCATAGGAATCCAAACGTTTGGAATGATCCAGAAACATTCATCCCTGAGAGGAGGATGTGCCCTGGTATGGGGATGTGTATGGCTTTGGCACACTTGACTCTTATCAACCTTCTTTATCGATTTGATTGGAAGCTTCCAGTTGGAATGGAGATAGAAGATGTTGATCTTGAAGAATCGTACGGGCTTGTGTGTCCTAAGAAAGTTCTACTTCAACTTGTCCCGATTCCAGTAGCAAGCTTGGAGCTTCTTCTAACAAGCGACCTGCATGTTGAGACTGATGAAGGAGAAAAAGCCAAGAGTGTCAAGAGAGCTTCAGTTTCTGATGGCGAGACCAAGGCAAACTGTTTCCAGCGAATTTGGTCCGAGGAAGATGAGATTGCTTTGTTACAAGGGATCGTGGACTACAAAGAGACTAGTGGGTTAGACCCTTTTAATGGTGAGAGGAAGGCTTTGTATGATCTCCTGAAGCCTCATATCAGTGTCAGTGTCACATCAGTTCAGTTCTTTCAGAAGATAAGGACGCTGAAAAAGAAGTTTAAGAAAGAGAAGAATAAAGGCTCCAAGCCTAACAATCAAAAGTTGTTTCATCTGTCGAAGTTGATTTGGGGAGATGAAGAGATCAGCTATGCCGAGAAAGATGAGTTGAAGACTGGTGAGGGGAGGAAGAGGAGTGTGTTTCAGTTGTGGAGGCATTAG
Protein Sequence:
- >GSBRNA2T00056359001|Brassica_napus|GeBP|GSBRNA2T00056359001
MIMWYIIVAVVILASLLYGPLMSLKFGNVPTVVASSPETVKDVLKTFDADCCSRPYLTYAARISYNLNDLAFSPYSKYWREVRRMTVLELYTAKRVQSFRHIREEEVASLVEFVKGAALLGNTVNLSNTLMKLSGSVICRVGFGINLKGSKLEDTYEEIIRETMEVLGSFAAADYLPIIGRIIDRVTGLHSKCEKQHMEDESLKDDIIALLLKMERGEAGLGEYQLTRNHTKGILLNVLIAGIDTSGHTITWAMTHMIKNPRVLKKVQAEVREVIQNKDNITEEDIEQLEYLKMVIKETVRINPLVPLLIPREASKDIKIAGYDIPKKTWIHVNIWGVHRNPNVWNDPETFIPERRMCPGMGMCMALAHLTLINLLYRFDWKLPVGMEIEDVDLEESYGLVCPKKVLLQLVPIPVASLELLLTSDLHVETDEGEKAKSVKRASVSDGETKANCFQRIWSEEDEIALLQGIVDYKETSGLDPFNGERKALYDLLKPHISVSVTSVQFFQKIRTLKKKFKKEKNKGSKPNNQKLFHLSKLIWGDEEISYAEKDELKTGEGRKRSVFQLWRH*