Information report for XP_010532504.1
Gene Details
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Functional Annotation
- Refseq: XP_010532502.1 — PREDICTED: protein FAR-RED ELONGATED HYPOCOTYL 3
- Refseq: XP_010532503.1 — PREDICTED: protein FAR-RED ELONGATED HYPOCOTYL 3
- Refseq: XP_010532504.1 — PREDICTED: protein FAR-RED ELONGATED HYPOCOTYL 3
- Refseq: XP_019057594.1 — PREDICTED: protein FAR-RED ELONGATED HYPOCOTYL 3
- Refseq: XP_019057595.1 — PREDICTED: protein FAR-RED ELONGATED HYPOCOTYL 3
- Swissprot: Q9LIE5 — FHY3_ARATH; Protein FAR-RED ELONGATED HYPOCOTYL 3
- TrEMBL: A0A1J3CXP8 — A0A1J3CXP8_NOCCA; Protein FAR-RED ELONGATED HYPOCOTYL 3
- STRING: XP_010532502.1 — (Tarenaya hassleriana)
- GO:0009585 — Biological Process — red, far-red light phototransduction
- GO:0010218 — Biological Process — response to far red light
- GO:0042753 — Biological Process — positive regulation of circadian rhythm
- GO:0045893 — Biological Process — positive regulation of transcription, DNA-templated
- GO:0005634 — Cellular Component — nucleus
- GO:0003700 — Molecular Function — transcription factor activity, sequence-specific DNA binding
- GO:0008270 — Molecular Function — zinc ion binding
Family Introduction
- We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.
- We next used a yeast one-hybrid assay to delineate the DNA sequences to which FHY3 and FAR1 bind. GAD-FHY3 or GAD-FAR1 fusion proteins (GAD, GAL4 transcriptional activation domain), but not GAD alone, activated the LacZ reporter genes driven by the FHY1 and FHL promoters. Deletion analysis narrowed down the FHY3/FAR1 binding site to a 39-bp promoter subfragment located on the ‘a’ fragment for both FHY1 and FHL. Notably, these subfragments share a stretch of consensus sequence, 5’-TTCACGCGCC-3’. Mutating the core sequence ‘CACGCGC’ of this motif (m2 and m3 for FHY1, m5 for FHL) abolished the reporter gene activation by both GAD-FHY3 and GAD-FAR1. Mutating the flanking sequences (m1 and m4) did not obviously affect the reporter gene activation by GAD-FAR1, but clearly reduced activation by GAD-FHY3. Thus, ‘CACGCGC’ likely defines a cis-element that confers specific binding for FHY3 and FAR1 and is named FBS for FHY3-FAR1 binding site.
Literature and News
Homologs
- Arabidopsis thaliana: AT3G22170.2, AT3G22170.1, AT3G22170
- Brassica oleracea: XP_013586359.1, XP_013607599.1, XP_013607605.1
- Brassica rapa: XP_009145427.1, XP_009145426.1, XP_009145425.1, XP_009145428.1, XP_009109171.1, XP_009109179.1
- Ziziphus jujuba: XP_015880907.1
Sequences
CDS Sequence:
- >XP_010532504.1|Tarenaya_hassleriana|FAR1|XP_010532504.1
ATGGATATAAATCTCCGGTTACCTTCAGGTGACCAGAGCAAAGAAGATGGTGAGGAGAGAGGTATCGATAATGTGTTGGAGGACGAACATAAATTACATAATGGTGATATGGAAATCGGCAAAATGGAGGATGTTACAGTTGAGGTGCAAGCTGATGATAGTGTAGGCATGGTCCCAACAGCAGAGTTGGTTGAGTACAAAGAGGGTATGAATCTTGAACCTCTCAATGGTATGGAATTCGAGTCCCATAGCGAAGCTTATTCATTCTATCAAGAATATGCACGGGCAATGGGTTTCAACACTGCGATACAGAACAGTCGTCGTTCAAAAACAACAAGAGAGTTTATCGATGCAAAATTCGCCTGCTCTAGGTATGGTACCAAAAGAGAATACGACAAGTCCTTCAACAAACCTCGTGTTAGTCAAAACAAGCAAGAGCCGGAAAACATGGCTGGTCGAAGGGCATGTGGAAAAACAGACTGCAAAGCAAGCATGCATGTAAAGAGAAGGCCTGATGGGAAATGGATTATTCATAGCTTTGTGAGGGAGCATAATCATGAGCTTTTACCTGCGCAAGCTGTGAGTGAACAGACTAGAAAGATATATGCAGCAATGGCTAGACAGTTTGCTGAATACAAGACTGTTATTAGCCTAAATAACAATACTAAAAGCTCATTTGAAAAAGGTCGGAATTCAGCAGTGGAAACCGGGGATATCAAGATCTTGCTTGATTTCTTATCTAGGATGCAAAGTATGAACTCCAACTTCTTTTATGCTGTAGATCTTGGTGACGATCAGCAACTGAAGACTGTATTTTGGGTGGATGCAAAAAGCAGACATGATTACGGCAGTTTTTGTGATGTTGTCTCTCTTGACACCACTTATGTAAGAAACAAGTACAGGATGCCACTTGCCATTTTTGTTGGAGTAAACCAGCACTATCAGTTCATGGTACTCGGGTGTGCTGTAATATCGGATGAGAGTGCGACCACATTTTCTTGGATAATGCATACTTGGCTCAAAGCAATGGGTGGACTAGCTCCCAAGGTTATAATCACTGAGCAGGACAGTGTTATGAACTCTGTTGTTCCTGAGGTCTTCCCCAATACCCGTCATTGCTTTTTCCTTTGGCACGTATTGGTAAAGGTATCTGAGAATCTTGGTCAGGTAATCAAGCAACACGATAATTTTACACCGAAGTTTGAAAAGTGCATCTATAAATCCTGGAGAGATGAAGACTTTGCAAGAAGGTGGTGGAAGATCCTTGATAGATTTGGTCTCAAAGAGGATCAATGGATGCAGTCACTATATGAAGACTGCAGGAAATGGGTGCCGGCCTACATGACTGATGTTCTTTTGGCAGGGATGTCTACTTCTCAAAGAACTGATAGTATTAACGCCTTCTTCGACAAGTACTTGCATAAAAAGACAAGCGTACAAGAGTTTGTGAAGTTGTATGATGCGATTCTGCAAGATAGATATGAAGAGGAAGCCAAAGCTGATTCTGATGCATGGAATAAGCAGCCGACCATGAAGTCTCCGTCACCATTTGAGAAAAGCGTTTCTGAAATCTATACTCCCGCAGTATTCAGAAAATTTCAGGTTGAAGTTTTGGGTGCGATTGCATGTAGTCCAAGAGAGGAGAACAGAGATGGAACATGCTTCATTTTCAGAGTTCAGGATTTCGAAAAGAACCAGGACTTTGTAGTTACTTGGAACCAAACAAAGTCTCAGGTTTCTTGCATTTGCCGGTTATTTGAGTACAAAGGTTATCTCTGTAGACATGCACTTAATGTTCTCCAGCGTTGCCATCTCTCCTCCATCCCGTCTCGGTATATATTGAAGCGGTGGACAAAAGATGCAAAAAACCGGGATTTTACTGGAGAACCCGAACGGTTACAGACAAGGCTGCAACGGTATAATGATTTGTGCCGGAGAGCCCTGAAACTGAGTGAGGAGGCATCTTTTTCTCAAGAGAGTTACAACATTGCATACCGTGCCATTGAAGAAGCTTTAGAAAACTGTGCCGGTGTTAATACCGCCGGGAAAAGCCCTCAGGAACTGGTCACTTCCCCAACTCAAGGTCTGATCTCTGTTGAAGAGGATAACCAGAGCAGAAGTACAGGCAAGACAAGCAAGAAAAAGAATCCGACAAAGAAAAGAAAAGTAAACTCGGAGCAGGAGGTCATGCCAGTTGGAGCACCAGAAAATATGCAACAGATGGATAAATTAAGTCCAAGAACAGTCAGCATCGAGAGTTATTATGCCACACAGCCGAGTGTGCAAGGAATGGTTCAGCTGAACTTAATGGCGCCAACTCGGGAGAGTTTCTACGGGAATCAACAAATTCAAGGATTGGGGCAGTTAAACTCGATAGCATCGAGCCATGGCAGTTACTACAGTGCTCAGCAAGGGATTCCCGAGATGTCAGGATTGGATTTCTTCAGACCTTCCGCTTTTTCATACGACATTCGGGACGACCCGAATGTCAGGACGGCTCAGCTTCACAACAACGCCTCTAGACATCCCCCGTGA
Protein Sequence:
- >XP_010532504.1|Tarenaya_hassleriana|FAR1|XP_010532504.1
MDINLRLPSGDQSKEDGEERGIDNVLEDEHKLHNGDMEIGKMEDVTVEVQADDSVGMVPTAELVEYKEGMNLEPLNGMEFESHSEAYSFYQEYARAMGFNTAIQNSRRSKTTREFIDAKFACSRYGTKREYDKSFNKPRVSQNKQEPENMAGRRACGKTDCKASMHVKRRPDGKWIIHSFVREHNHELLPAQAVSEQTRKIYAAMARQFAEYKTVISLNNNTKSSFEKGRNSAVETGDIKILLDFLSRMQSMNSNFFYAVDLGDDQQLKTVFWVDAKSRHDYGSFCDVVSLDTTYVRNKYRMPLAIFVGVNQHYQFMVLGCAVISDESATTFSWIMHTWLKAMGGLAPKVIITEQDSVMNSVVPEVFPNTRHCFFLWHVLVKVSENLGQVIKQHDNFTPKFEKCIYKSWRDEDFARRWWKILDRFGLKEDQWMQSLYEDCRKWVPAYMTDVLLAGMSTSQRTDSINAFFDKYLHKKTSVQEFVKLYDAILQDRYEEEAKADSDAWNKQPTMKSPSPFEKSVSEIYTPAVFRKFQVEVLGAIACSPREENRDGTCFIFRVQDFEKNQDFVVTWNQTKSQVSCICRLFEYKGYLCRHALNVLQRCHLSSIPSRYILKRWTKDAKNRDFTGEPERLQTRLQRYNDLCRRALKLSEEASFSQESYNIAYRAIEEALENCAGVNTAGKSPQELVTSPTQGLISVEEDNQSRSTGKTSKKKNPTKKRKVNSEQEVMPVGAPENMQQMDKLSPRTVSIESYYATQPSVQGMVQLNLMAPTRESFYGNQQIQGLGQLNSIASSHGSYYSAQQGIPEMSGLDFFRPSAFSYDIRDDPNVRTAQLHNNASRHPP