Information report for Gh_Sca040411G01
Gene Details
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Functional Annotation
- Refseq: XP_012451432.1 — PREDICTED: putative protein FAR1-RELATED SEQUENCE 10 isoform X1
- Refseq: XP_012451433.1 — PREDICTED: putative protein FAR1-RELATED SEQUENCE 10 isoform X2
- Refseq: XP_012451434.1 — PREDICTED: putative protein FAR1-RELATED SEQUENCE 10 isoform X2
- Refseq: XP_016683469.1 — PREDICTED: putative protein FAR1-RELATED SEQUENCE 10 isoform X1
- Refseq: XP_016683470.1 — PREDICTED: putative protein FAR1-RELATED SEQUENCE 10 isoform X1
- Refseq: XP_016683472.1 — PREDICTED: putative protein FAR1-RELATED SEQUENCE 10 isoform X2
- Refseq: XP_016683473.1 — PREDICTED: putative protein FAR1-RELATED SEQUENCE 10 isoform X3
- Swissprot: Q9LKR4 — FRS10_ARATH; Putative protein FAR1-RELATED SEQUENCE 10
- TrEMBL: A0A0D2UH57 — A0A0D2UH57_GOSRA; Uncharacterized protein
- TrEMBL: A0A1U8IZD3 — A0A1U8IZD3_GOSHI; Uncharacterized protein
- TrEMBL: A0A1U8J4A6 — A0A1U8J4A6_GOSHI; Uncharacterized protein
- TrEMBL: A0A1U8J5I7 — A0A1U8J5I7_GOSHI; Uncharacterized protein
- STRING: Gorai.010G189600.1 — (Gossypium raimondii)
Family Introduction
- We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.
- We next used a yeast one-hybrid assay to delineate the DNA sequences to which FHY3 and FAR1 bind. GAD-FHY3 or GAD-FAR1 fusion proteins (GAD, GAL4 transcriptional activation domain), but not GAD alone, activated the LacZ reporter genes driven by the FHY1 and FHL promoters. Deletion analysis narrowed down the FHY3/FAR1 binding site to a 39-bp promoter subfragment located on the ‘a’ fragment for both FHY1 and FHL. Notably, these subfragments share a stretch of consensus sequence, 5’-TTCACGCGCC-3’. Mutating the core sequence ‘CACGCGC’ of this motif (m2 and m3 for FHY1, m5 for FHL) abolished the reporter gene activation by both GAD-FHY3 and GAD-FAR1. Mutating the flanking sequences (m1 and m4) did not obviously affect the reporter gene activation by GAD-FAR1, but clearly reduced activation by GAD-FHY3. Thus, ‘CACGCGC’ likely defines a cis-element that confers specific binding for FHY3 and FAR1 and is named FBS for FHY3-FAR1 binding site.
Literature and News
Homologs
- Gossypium arboreum: Cotton_A_18282_BGI-A2_v1.0
- Juglans regia: WALNUT_00030882-RA
- Malus domestica: MDP0000249284
- Manihot esculenta: Manes.07G106900.2.p, Manes.07G106900.1.p, Manes.07G106900.4.p, Manes.07G106900.3.p, Manes.07G106900.8.p, Manes.07G106900.7.p, Manes.07G106900.6.p, Manes.07G106900.5.p
- Populus trichocarpa: Potri.016G007300.1
- Prunus mume: XP_016648404.1, XP_016648403.1, XP_008227430.1
- Prunus persica: Prupe.4G006000.6.p, Prupe.4G006000.4.p, Prupe.4G006000.1.p, Prupe.4G006000.5.p
- Vitis vinifera: GSVIVT01003485001
Sequences
CDS Sequence:
- >Gh_Sca040411G01|Gossypium_hirsutum|FAR1|Gh_Sca040411G01
ATGGTTGCTCCTTATGTTGGAATGGTGTTTAAGACCGACGATGATGCTTTCGAGTATTATGGAAATTTTGCTAGGAAAAATGGGTTTTCCATTAGGAAAGAGAGGTCCAGACTGAGCCCCCAATTGGGGATTTATAAGCGTGATTTTGTTTGCTATCGTTCCGGATTTGCACCGGCAAGGAAAAAGCTTTCTGGGGAACACCATAGAGATAGGAAGTCTGTACGGTGTGGGTGTGATGCTAAGATGTACTTGTCCAAGGAAGTAATAGATGGGGTTTCTCAATGGTTTGTTGTACAGTTTAGCAATGTTCATAATCACGAGCTTTTAGAGGATGACCAGGTCCGTCTCTTGCCTGCATATAGGAAGATTAATGAGGCAGATCAAGAGAGAATTTTACTACTTTCAAAAGCTGGGTTTCCTATACATCGTATAGTGAAGGTTTTGGAGTTGGAAAAAGGCATTCAAGGTGGGCAATTGCCTTTTTTGGAGAGAGATGTTAGGAATTTTGTTCAAAACCGGAAGAAAGTGGTTCAAGAAAATGATGCTTTGCTCAATGAGAAAAGAGAAAATGATACAATGGAACTTCTTGAGGCATGTAAAGCAACAAAAGAGGCTGATCAAGATTTTGTTTATGATTTTACAGTAGATCAGAATGATAAGGTTGAGAACATTGCTTGGTCATATGGTGTCGCTGTTAATTCATATGCCTTGTTTGGTGATGTTGTTTATTTTGACACCACTTACAGATCAATCACATATGATATGCTTTTTGGGGCATGGTTTGGAATTGACAACAATGGTCAACCAATTTTCTTTGGTTGCGTTTTATTGCAGGATGAAACACTGCGCTCCTTTGCATGGGCTATACAG
Protein Sequence:
- >Gh_Sca040411G01|Gossypium_hirsutum|FAR1|Gh_Sca040411G01
MVAPYVGMVFKTDDDAFEYYGNFARKNGFSIRKERSRLSPQLGIYKRDFVCYRSGFAPARKKLSGEHHRDRKSVRCGCDAKMYLSKEVIDGVSQWFVVQFSNVHNHELLEDDQVRLLPAYRKINEADQERILLLSKAGFPIHRIVKVLELEKGIQGGQLPFLERDVRNFVQNRKKVVQENDALLNEKRENDTMELLEACKATKEADQDFVYDFTVDQNDKVENIAWSYGVAVNSYALFGDVVYFDTTYRSITYDMLFGAWFGIDNNGQPIFFGCVLLQDETLRSFAWAIQ