Gene Details:

• Gene ID: Aan000839
• Gene Family: E2F/DP Family
• Description: E2F/DP Family protein
• Species: Artemisia annua
• Source: E2F-DP family gene from PlantTFDB

Protein Features:

• Gene3D:  G3DSA:1.10.10.10
• SuperFamily:  SSF144074
• Pfam:  PF16421
• InterPro:  IPR011991    IPR032198

Annotation Proteins:

• Refseq:  XP_022000883.1  — transcription factor-like protein DPB
• Swissprot:  Q9FNY2  — DPB_ARATH; Transcription factor-like protein DPB
• TrEMBL:  A0A251SSS8  — A0A251SSS8_HELAN; Putative winged helix-turn-helix DNA-binding domain, Transcription factor DP
• STRING:  XP_010241817.1  — (Nelumbo nucifera)

Gene Ontology:

• GO:0006355  — Biological Process — regulation of transcription, DNA-templated
• GO:0007049  — Biological Process — cell cycle
• GO:0005667  — Cellular Component — transcription factor complex
• GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding

Family Introduction:

• E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.
• Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

Literature:

• Conserved functions of the pRB and E2F families.   DOI:  10.1038/nrm2469 ;  PMID:  18719710

Sequences: