Gene Details:

• Gene ID: AT2G33500.2
• Gene Name: BBX12
• Gene Family: CO-like Family
• Description: CO-like Family protein
• Species: Arabidopsis thaliana
• Source: CO-like family gene from PlantTFDB

Protein Features:

• PROSITE profile:  PS50119
• SMART:  SM00336
• Pfam:  PF00643
• Pfam:  PF06203
• PROSITE profile:  PS51017
• InterPro:  IPR000315    IPR010402

Annotation Proteins:

• Refseq:  NP_973589.1  — B-box type zinc finger protein with CCT domain-containing protein
• Swissprot:  O22800  — COL14_ARATH; Zinc finger protein CONSTANS-LIKE 14
• TrEMBL:  C0SV72  — C0SV72_ARATH; Uncharacterized protein At2g33500 (Fragment)
• STRING:  AT2G33500.1  — (Arabidopsis thaliana)

Gene Ontology:

• GO:0006355  — Biological Process — regulation of transcription, DNA-templated
• GO:0005634  — Cellular Component — nucleus
• GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
• GO:0005515  — Molecular Function — protein binding
• GO:0008270  — Molecular Function — zinc ion binding

Family Introduction:

• CO(CONSTANS) gene acts between the circadian clock and genes controlling meristem identity.In Arabidopsis, CO transcription factors defined by two conserved domains. The first is a zinc finger region near the amino terminus that resembles B-boxes, which regulate protein-protein interactions in several animal transcription factors. The second is a region of 43 amino acids near the carboxy terminus termed the CCT (CO, CO-like, TOC1) domain. Studies using green fluorescent protein fusions show that the CCT domain is involved in nuclear localization of the CO protein but must have an additional role because the late-flowering co-7 mutant, which has an altered CCT domain, correctly localizes the protein.

Literature:

• The evolution of CONSTANS-like gene families in barley, rice, and Arabidopsis.   DOI:  10.1104/pp.102.016188 ;  PMID:  12692345

Sequences: