Information report for PGSC0003DMP400061924
Gene Details
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Functional Annotation
- Refseq: XP_006350426.1 — PREDICTED: bZIP transcription factor 17-like
- TrEMBL: M1DJZ6 — M1DJZ6_SOLTU; Uncharacterized protein
- STRING: PGSC0003DMT400090249 — (Solanum tuberosum)
- GO:0006355 — Biological Process — regulation of transcription, DNA-templated
- GO:0016021 — Cellular Component — integral component of membrane
- GO:0003700 — Molecular Function — transcription factor activity, sequence-specific DNA binding
- GO:0043565 — Molecular Function — sequence-specific DNA binding
Family Introduction
- The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
- Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.
Literature and News
Gene Resources
Sequences
CDS Sequence:
- >PGSC0003DMP400061924|Solanum_tuberosum|bZIP|PGSC0003DMP400061924
ATGGCCGATCCACCGCCGGCGGAAGAAGCGAACTTCATCGGGGAATTCGACGGTCTTGCAGTTCAACCTCTTGACCGTACTTTTTACGCCCTACACATGACCACAACATACCAAGAAAATGGCGAAGATTTCCCTATGGAATTTCCAAAAGTTAATTTCACAACCGATGCCATCATTCTTGATGAATCATTCAATGATAGTTTTCCAAACCCTACCAATGATGATGCATTTCAAAACCCTAATTGTCTGCCAGATTGTCTCGGGTCGGAGTCGGGTTTGGACTCGAGTCAGATGAACCCGAATAGCTTTGGTCAACCTAAGAGTCAACTGATGGGGAGTTCTGATGATGCTTCTAGAAAATTCAATTCGACCTCAGGATATTGTCTCGGGGAAGCTCCAGTTTCGAACAAACTGGTACATTTTCCCCTAAATTTAGGAAATAATTCAGTAAAAGGTGGAGTTGTAGAAAAGAAACTCAAATTAGAGGGTGTCAATGCTAATATAAGCAACTGTAGCTATTTGTTGAAAAGGAAAAAGAGTAGTGAAGACTCAAATGATGTAGGCAAACACCAAAAATCCACTATATTTTCCTTGTATGACAATGCTAACAATGATGAGGACGAAAAGAGGATGGCTAGGAAAATTAGGAATAGGGAAAGTGCTCACTTGTCAAGGAAAAGAAAAAAACATTATGTTGAGGAATTAGAGAATAAATTTAGAATACTTCAATCAACAATTCAACATTTGAATACAAATTTATCCTATGCAATGGTGGAAAATGTAACTCTAAAGGCACAACTTGGAGGTACTAGTGTACATGCTCAAGTGCCGTCACCCCTCGGGATTTATCCCTATCCTCCTCCATGGATTTCATATACACCATCTTATATGATGAGCCGACAAAGATCTCAAGTGCCATTGGTTCCCATTCCAAAGTTGAAATCACAGGCACTACCACCCGCGCCAAAAAGTAGCAAGAAAGTGGAGAAACAGAAGAGTGAGGTGAAAACAAAGAAGGTTGCTAGTGTTAGCTTCCTTGGTGTGTTGTTCTTCATGCTTCTCTTTGGTGGGTTGGTTCCTTTATTGAAACTTAGATATGGAGGTATTAGGGAACCATCTATGAGTGGAGAGTCTTTTGTGAGTGGATTTTATGTAAAATATCATGGAAGAGTTTTGACTGTTGACGGGCCTGTGAATGGGACTGGTTGTTCTGGGAAATACGGTGGTAAAGATCATAGCTCCCATTGTGGCCGAGGAGGTCAGGGTGAAAGCAATCAGAAAAATACCAATAAGGCTGCAGATGAGTTTGCTCATGTGGGCAATGGTAGTGATCCTCTGGCAGCCTCTATGTATGTCCCAAGGAATGATAAACTTGTTGATATTGATGGGAACTTGATAATTCAATCCGTATTGGCAAGTGAGAAAGCCATGGCATTTCATGGAAGTGCTGATAAGAAAAATAGAGAGGCTGGCCTCGCAGTTCCTGGTGATTTAGCCCCTGCTATCCCAGGAATCCATCCTCGCCTTTATCGAAGTCCTGCAATGGGACAAAACATTCTTGGATCTGAGGAGAAAGAGAATGTAAAGTCAACTATGCAGGAGTGGTACCTTGAAGGTCTTGCTGGACCTTTGTTGAGTTCAGGCATGTGTACAGAAGTGTTCCAGTTTGATACGTCATCTTCTGCTAGAGATATATCTATGGAAGAAAGGCAGAATGGCACGCGCCTCCACAGAAATAGAAGGATCCTCAATGGCCCTCCCATTTCCCTTTCTAGACCCTCTCACAGCTCTGGAGAACAAACTGGAACAGATGGAAAGCGGGAGAATTTCAGCAGGAACAAGTCACTTTCTTCCTTGGTAGTATCTGTTCTGGTTGATGGTGATGGAGATGGCATCATGGGTCCGAAGTCTGTCTCTCGGATATTCATTGTTGTGCTTATTGATAGTGTCAAATATGTCACCTATTCTTGCATGCTTCCATTTATTGATAGTGTTCATGTAGCAGAAGCATCATAA
Protein Sequence:
- >PGSC0003DMP400061924|Solanum_tuberosum|bZIP|PGSC0003DMP400061924
MADPPPAEEANFIGEFDGLAVQPLDRTFYALHMTTTYQENGEDFPMEFPKVNFTTDAIILDESFNDSFPNPTNDDAFQNPNCLPDCLGSESGLDSSQMNPNSFGQPKSQLMGSSDDASRKFNSTSGYCLGEAPVSNKLVHFPLNLGNNSVKGGVVEKKLKLEGVNANISNCSYLLKRKKSSEDSNDVGKHQKSTIFSLYDNANNDEDEKRMARKIRNRESAHLSRKRKKHYVEELENKFRILQSTIQHLNTNLSYAMVENVTLKAQLGGTSVHAQVPSPLGIYPYPPPWISYTPSYMMSRQRSQVPLVPIPKLKSQALPPAPKSSKKVEKQKSEVKTKKVASVSFLGVLFFMLLFGGLVPLLKLRYGGIREPSMSGESFVSGFYVKYHGRVLTVDGPVNGTGCSGKYGGKDHSSHCGRGGQGESNQKNTNKAADEFAHVGNGSDPLAASMYVPRNDKLVDIDGNLIIQSVLASEKAMAFHGSADKKNREAGLAVPGDLAPAIPGIHPRLYRSPAMGQNILGSEEKENVKSTMQEWYLEGLAGPLLSSGMCTEVFQFDTSSSARDISMEERQNGTRLHRNRRILNGPPISLSRPSHSSGEQTGTDGKRENFSRNKSLSSLVVSVLVDGDGDGIMGPKSVSRIFIVVLIDSVKYVTYSCMLPFIDSVHVAEAS*