Gene Details:

Protein Features:

Annotation Proteins:

  • Refseq:  XP_016508279.1  — PREDICTED: bZIP transcription factor 16-like
  • Refseq:  XP_016508280.1  — PREDICTED: bZIP transcription factor 16-like
  • Swissprot:  Q501B2  — BZP16_ARATH; bZIP transcription factor 16
  • TrEMBL:  A0A2G3DCN2  — A0A2G3DCN2_CAPCH; Uncharacterized protein
  • STRING:  Solyc08g076100.2.1  — (Solanum lycopersicum)

Family Introduction:

  • The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
  • Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Literature:

Sequences:

CDS Sequence:
  • >Niben101Scf01202g00001.1|Nicotiana_benthamiana|bZIP|Niben101Scf01202g00001.1
Protein Sequence:
  • >Niben101Scf01202g00001.1|Nicotiana_benthamiana|bZIP|Niben101Scf01202g00001.1
    MCSSIYSSGILPFSPFAMPSPNGVAEAAVNTSGNAEVDGKSSDGKEKLPIKRSKGSLGSLNMISGKNNEPGKTSGASANGAYSKSAESGSDGSSEGSDANSQNVGVTNEGKIQYDVSATAEAFQNGNSAHSSHNGGASAPHSLINQTMPIMPMCILKTQFKIVYFSYMGAAECDELAQRAEALKEENASLRAELSRLRSEHDQLAAQNASLKERLGEVPEQEDLRPSRNDIHLSKDTQNSSQTEPTQGGQ