Gene Details:

Protein Features:

Annotation Proteins:

  • Refseq:  XP_011460752.1  — PREDICTED: homogentisate 1,2-dioxygenase
  • Swissprot:  Q9ZRA2  — HGD_ARATH; Homogentisate 1,2-dioxygenase
  • TrEMBL:  A0A2P6QAB8  — A0A2P6QAB8_ROSCH; Putative homogentisate 1,2-dioxygenase
  • STRING:  EMJ15072  — (Prunus persica)

Gene Ontology:

  • GO:0006355  — Biological Process — regulation of transcription, DNA-templated
  • GO:0006559  — Biological Process — L-phenylalanine catabolic process
  • GO:0006572  — Biological Process — tyrosine catabolic process
  • GO:0055114  — Biological Process — oxidation-reduction process
  • GO:1902000  — Biological Process — homogentisate catabolic process
  • GO:0005829  — Cellular Component — cytosol
  • GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
  • GO:0004411  — Molecular Function — homogentisate 1,2-dioxygenase activity
  • GO:0043565  — Molecular Function — sequence-specific DNA binding

Family Introduction:

  • The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
  • Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Literature:

Sequences:

CDS Sequence:
  • >mrna27194.1-v1.0-hybrid|Fragaria_vesca|bZIP|mrna27194.1-v1.0-hybrid
    ATGGACCAGCCACCGATCACCGCCAAAACCTCCGGCTCCGATTCCCTCTCCTCCGCCGTCGACCTCCCTTACCAGTCCGGCTTCCACAACCACTTCTCCTCCGAAGCTCTCCCCGGCGCTCTCCCCTCCGGCCAGAGCAGCCCCCTCCTCTGCCCCTACGGCCTCTACGCCGAGCAAATCTCCGGCACCTCCTTCACCTCGCCGCGCAAGCTCAACCTCCGCTCCTGGCTCTACCGGATCAAGCCTTCCGTCACTCACGAGCCTTTCAAGCCGCTCCGGCCCAGCCACGGCCGGCTCGTCAGCGAGTTCAACGACTCCAACAGCTTCACCACGCCGACTCAGCTGCGGTGGAAGCCGGTGGATGTTCCGGAGACGCCGACGGACTTTGTGCAGGGGTTGTACACTGTGTGCGGCGCTGGGAGCTCGTTCCTCCGCCATGGCTTTGCTATTCACATGTACACTGCGAACAAGTCGATGGATGATCGTGCCTTTTGCAATGCTGATGGAGATTTCTTGATAGTCCCTCAATTAGGGAGGCTTTGGATCACTACAGAGTGCGGAAAATTGAATGTTTCTCCTGGTGAAGTTGCTGTATTACCTCAAGGATTTCGATTTGCAGTAGACCTTCCTGATGGCCCGTCACGAGGTTATGTAGCTGAAGTTTTTGGCACCCATTTTCAACTCCCTGAACTTGGCCCAATAGGAGCTAATGGCCTAGCTGCTCCAAGGGATTTTCTTGTTCCCACTGCATGGTTTGAGGAAAGTACCCGTCCAGGCTACATTATTATACAAAAATATGGTGGAGAACTTTTTACTGCAAAGCAGGATTTCTCTCCATTCAATGTGGTTGCTTGGCATGGTAATTATGCTCCATATAAGTATGATCTGACCAAGTTCTGCCCATTCAACACGGTCTTGTTTGATCATGGTGACCCTTCAGTAAATACAGTATTGACAGCACCAACTGATAAACCTGGTGTTGCATTGCTCGATTTCGCCATATTTCCTCCTCGATGGTTGGTTGCTGAACATACATTTCGACCTCCATACTACCACCGGAATTGTATGAGTGAATTCATGGGCCTCATTTACGGTGGATATGAGGCAAAAGCAGATGGGTTTCTTCCAGGTGGTGCAAGCCTCCATAGCTGTATGACTCCCCATGGTCCTGATACAAAGACATATGAGGCTACAATTGCACGTGGGAATGATGTAGGACCACATAAAATAAGTGATACTATGGCTTTTATGTTTGAATCGTGTTTAGTCCCCCGAATTTGCTCATGGGCTCTTGAGTCTCCCCTCATAGATCATGACTATTACCAGTGCTGGATTGGACTAAGATCACACTTCACAGGCACAAAGGCAGATGCTAAAGATGGAAATATCCAGAATGACTTTCCAGCTTCTCCTTCTTCTTCTTCCTCCCTTCACCCTCACCTCCCTCCCCAGCTGTTGCTAGCTGTCTCGAGCTCCCCCTCCCCCCATCATGACTCAGAATTGGGCGCCCTTCCCCCACCACAGAATAATGCCCTCCATGGCCAACTTTCTCCCCTCCTCCACCGCCGCCCTCAACCACCCCCTTCTTCTCCTCCTCCCCCTCAGCAGCAGTCTTCTTCCTGCTGGATGGACGAGTTCCTTGACTTCTCCTCCGCCCGGCGCGGGGCGCACCGCCGCTCCGCCAGCGACTCCATTGCGTTCCTCGAGTCGCCGCTTAACGTGCTCGACGACGTCGACCATAGGAACCCCACCGTCCACGGCGCCAACAACATTGCAGGATCGTTCGATCGACTCGACGACGAGCAGCTCATGTCCATGTTCTCCGACGACATCGCCGTCCCTCCCACCGTCACGTCGTCCTCGAACCCTTCCTCGCCGTCCGACCAGAACAGCAACAACGACGAGATTATGAACACCAACAATAGTAACGGCAACAACGACGAGAATTTTAACAATATTAACGGCCACAGTGTTAATCACCGGCCGTTGATGCAGCTCAGGATCGACGGCCACCAGCAGCCGAAGAGCGAGCCCGGCGAGGTTGATAGCTCCTGCGATCCCAACGACCCGCATTCTCAGTCCCCCCGCGCGCCACCGCCGACTTCCCCTGCCGATCCCAAGAGGGTAAAAAGAATCTTGGCAAATCGGCAATCGGCGCAGAGGTCCAGAGTGAGAAAGCTACAGTACATATCGGAGCTCGAACGCAGCGTCACATCATTACAGTCGGAGGTGTCGGCGCTTTCACCCAGGGTTGCATTTCTAGATCACCAGAGGTTGATTCTCAATGTGGATAACAGTGCTCTCAAGCAAAGGATTGCTGCTTTGGCGCAAGATAAGCTCTTCAAAGATGCTCATCAAGAGGCATTGAAGAAGGAAATAGAGAGATTAAGGCAGGTTTATCACCACCAAACCCTAAAGAAGATGGAGAACAACAGCAATAATAACAACCAAAACACCGCCGCAGCTCCACCGCAACATCATCACAACGCGGCGGACATCATGCTCTGTACGGATCACAATAAGGAGCAGCAGCAGATTCTAAATTGA
Protein Sequence:
  • >mrna27194.1-v1.0-hybrid|Fragaria_vesca|bZIP|mrna27194.1-v1.0-hybrid
    MDQPPITAKTSGSDSLSSAVDLPYQSGFHNHFSSEALPGALPSGQSSPLLCPYGLYAEQISGTSFTSPRKLNLRSWLYRIKPSVTHEPFKPLRPSHGRLVSEFNDSNSFTTPTQLRWKPVDVPETPTDFVQGLYTVCGAGSSFLRHGFAIHMYTANKSMDDRAFCNADGDFLIVPQLGRLWITTECGKLNVSPGEVAVLPQGFRFAVDLPDGPSRGYVAEVFGTHFQLPELGPIGANGLAAPRDFLVPTAWFEESTRPGYIIIQKYGGELFTAKQDFSPFNVVAWHGNYAPYKYDLTKFCPFNTVLFDHGDPSVNTVLTAPTDKPGVALLDFAIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIYGGYEAKADGFLPGGASLHSCMTPHGPDTKTYEATIARGNDVGPHKISDTMAFMFESCLVPRICSWALESPLIDHDYYQCWIGLRSHFTGTKADAKDGNIQNDFPASPSSSSSLHPHLPPQLLLAVSSSPSPHHDSELGALPPPQNNALHGQLSPLLHRRPQPPPSSPPPPQQQSSSCWMDEFLDFSSARRGAHRRSASDSIAFLESPLNVLDDVDHRNPTVHGANNIAGSFDRLDDEQLMSMFSDDIAVPPTVTSSSNPSSPSDQNSNNDEIMNTNNSNGNNDENFNNINGHSVNHRPLMQLRIDGHQQPKSEPGEVDSSCDPNDPHSQSPRAPPPTSPADPKRVKRILANRQSAQRSRVRKLQYISELERSVTSLQSEVSALSPRVAFLDHQRLILNVDNSALKQRIAALAQDKLFKDAHQEALKKEIERLRQVYHHQTLKKMENNSNNNNQNTAAAPPQHHHNAADIMLCTDHNKEQQQILN*