Gene Details:

  • Gene ID: MELO3C012485P2
  • Gene Family: bZIP Family
  • Description: bZIP Family protein
  • Species: Cucumis melo
  • Source: bZIP family gene from PlantTFDB

Protein Features:

Annotation Proteins:

  • Refseq:  XP_004142384.1  — PREDICTED: transcription factor TGA2-like isoform X1
  • Refseq:  XP_008446973.1  — PREDICTED: transcription factor TGA2-like
  • Refseq:  XP_008446976.1  — PREDICTED: transcription factor TGA2-like
  • Refseq:  XP_011655926.1  — PREDICTED: transcription factor TGA2-like isoform X1
  • Refseq:  XP_011655927.1  — PREDICTED: transcription factor TGA2-like isoform X1
  • Swissprot:  Q39140  — TGA6_ARATH; Transcription factor TGA6
  • TrEMBL:  A0A0A0KV59  — A0A0A0KV59_CUCSA; Uncharacterized protein
  • TrEMBL:  A0A1S3BGZ3  — A0A1S3BGZ3_CUCME; transcription factor TGA2-like
  • STRING:  XP_008446973.1  — (Cucumis melo)
  • STRING:  XP_004142384.1  — (Cucumis sativus)

Gene Ontology:

  • GO:0006355  — Biological Process — regulation of transcription, DNA-templated
  • GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
  • GO:0043565  — Molecular Function — sequence-specific DNA binding

Family Introduction:

  • The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
  • Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Literature:

Sequences:

CDS Sequence:
  • >MELO3C012485P2|Cucumis_melo|bZIP|MELO3C012485P2
    ATGACCGATGTCAGTCCAAGGACTGATATCTCTACTGATGTCGACACCGATGACAAACACCAGAGGCTTGATATGCTTCAACGGAATGCTGTGGCTTCTGATTCCAGTGATCGAACGAAAGATAAGTCTGATCAGAAGACTCTACGCAGGCTTGCACAGAATCGTGAAGCTGCAAGGAAAAGCCGACTGCGAAAAAAAGCATCTCATTAA
Protein Sequence:
  • >MELO3C012485P2|Cucumis_melo|bZIP|MELO3C012485P2
    MTDVSPRTDISTDVDTDDKHQRLDMLQRNAVASDSSDRTKDKSDQKTLRRLAQNREAARKSRLRKKASH*