Gene Details:

  • Gene ID: Medtr5g054900.3
  • Gene Name: MTR_5g054900
  • Gene Family: bZIP Family
  • Description: bZIP Family protein
  • Species: Medicago truncatula
  • Source: bZIP family gene from PlantTFDB

Protein Features:

Annotation Proteins:

  • Refseq:  XP_013453938.1  — transcription factor TGA2.3 isoform X2
  • Swissprot:  Q41558  — HBP1C_WHEAT; Transcription factor HBP-1b(c1) (Fragment)
  • TrEMBL:  A0A072UDW8  — A0A072UDW8_MEDTR; BZIP family transcription factor
  • TrEMBL:  A0A072UQ51  — A0A072UQ51_MEDTR; BZIP family transcription factor
  • STRING:  AES97469  — (Medicago truncatula)

Gene Ontology:

  • GO:0006355  — Biological Process — regulation of transcription, DNA-templated
  • GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
  • GO:0043565  — Molecular Function — sequence-specific DNA binding

Family Introduction:

  • The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
  • Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Literature:

Sequences:

CDS Sequence:
  • >Medtr5g054900.3|Medicago_truncatula|bZIP|Medtr5g054900.3
    ATGTACAACAAGGGAATAGCTTCCTTGCCTTTGGGGAATTGTCATGTTGAGAATTGGGCTGATTCTGGCGTGGCTGATAATAATAGCCAACAGACTGATGATACTTCCACTGATATTGATATCGATACCGATGATAAACACCAATCCAATGGAGGAAACGCTCACTCTAATAATCAGACCAAGTTCAGAGCTGAAGATCACAAGACCCTTCGCAGACTTGCTCAGAATCGCGAGGCGGCAAGGAAAAGCCGGTTACGGAAGAAGGCATATGTACAGCAGCTGGAGAGCAGTCGAGTCAAGCTTATGCAATTAGAGCAAGAGCTTCAACGAGGCATGTTTATTGCAAATCCTGGAGATCAAGGTCATTCGTCTGTTGGAAATGGTGCTCTAGCATTTGACATGGAATACACCCATTGGGTTGACGAGCATCAACGTATGCTCAATGATCTAAGATCGGCGTTAAATTCTCAAATGGGTGATAATGAATTGCATCTGCTTGTCGATGGTGTTATGTCACATCATAATGAGTTATTTAGGTTAAAGAGCATAGGGGCAAAGACTGATGTATTTCACATGCTCTATGGGTTGTGGAAGACACCAGTAGAAAGATTTTTTATTTGGCATGGTGCATTTCGTTCATCTGAAATTCTCAAGATAGTAAAGAACCACCTCGAGCCGTTAACTGAAAATCAGTTGATGGGAATTTGTAGTCTTCAGCAGTCTACTCAGCAGGCTGAGGATGCTTTATCTCACGGCATGGAAGCATTGAAACAATCTCTTTTAGAAACACTTTCCTCTACCCCCTCAGTATCCGGTACAGGTTCTGGAAATGTATCTGATTACATGGGCCAGATGGCATTTGCAATGAACAAGCTTGCATCCCTAGAGGATTTTCTTCATAAGGCTGACCTCTTGAAGCAAGAAACTCTGCAACAGTTGCAAAGAATTTTGACGACACGTCAGACTGCAAGGGCTCTCCTTGTCAGAAATGATTACATTTCAAGACTACGAGCACTTAGTTCGTTATGGTTGGCACGCCCAAGGGAGTAG
Protein Sequence:
  • >Medtr5g054900.3|Medicago_truncatula|bZIP|Medtr5g054900.3
    MYNKGIASLPLGNCHVENWADSGVADNNSQQTDDTSTDIDIDTDDKHQSNGGNAHSNNQTKFRAEDHKTLRRLAQNREAARKSRLRKKAYVQQLESSRVKLMQLEQELQRGMFIANPGDQGHSSVGNGALAFDMEYTHWVDEHQRMLNDLRSALNSQMGDNELHLLVDGVMSHHNELFRLKSIGAKTDVFHMLYGLWKTPVERFFIWHGAFRSSEILKIVKNHLEPLTENQLMGICSLQQSTQQAEDALSHGMEALKQSLLETLSSTPSVSGTGSGNVSDYMGQMAFAMNKLASLEDFLHKADLLKQETLQQLQRILTTRQTARALLVRNDYISRLRALSSLWLARPRE*