Gene Details:

  • Gene ID: Manes.12G140100.2.p
  • Gene Family: bZIP Family
  • Description: bZIP Family protein
  • Species: Manihot esculenta
  • Source: bZIP family gene from PlantTFDB

Protein Features:

Annotation Proteins:

  • Refseq:  XP_021631324.1  — transcription factor TGA1-like isoform X2
  • Swissprot:  Q39237  — TGA1_ARATH; Transcription factor TGA1
  • TrEMBL:  A0A2C9UWD0  — A0A2C9UWD0_MANES; Uncharacterized protein
  • STRING:  cassava4.1_011813m  — (Manihot esculenta)

Gene Ontology:

  • GO:0006355  — Biological Process — regulation of transcription, DNA-templated
  • GO:0042742  — Biological Process — defense response to bacterium
  • GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
  • GO:0043565  — Molecular Function — sequence-specific DNA binding
  • GO:0044212  — Molecular Function — transcription regulatory region DNA binding

Family Introduction:

  • The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
  • Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Literature:

Sequences:

CDS Sequence:
  • >Manes.12G140100.2.p|Manihot_esculenta|bZIP|Manes.12G140100.2.p
    ATGAACTCTCCATCTACACAGTTTGTCTCCCCAGGAAGGATGGGTATGTATGAGCCTATCCACCAGATTGGCATGTGGGGAGAAAATTTTAAGAGTAATGGAATTTCAAATGCATCACCATCAATGTTTATACCTGGCAATCCAAATTCATCTCAGTCAATACTAATACCAGCAGAGACAAAGCTAGACAATCAGTCAGAAGATACTTCACATGGTACACTTGGGCCTTCTTCTAGCAAATATGATCAAGAAGCAAGTAAACCCATTGACAAGGTACAAAGACGTCTTGCACAAAACCGTGAGGCTGCTCGTAAAAGCCGTCTAAGGAAAAAGGCGTATGTTCAGCAGTTAGAATCAAGTCGTTTAAAGCTGTTTCAGTTGGAGCAGGAGCTTGAAAGGGCTAGACATCAGGGTCTATATGTAGGTGGGTTGGAAACTAGTCAGATGGGGTTTGCGGGGCCAATTAACCCAGGTATTGCCAATTTTGAGATGGAGTATGGTCACTGGTTGGAAGAACAAAATAAAAACATTCACGATTTAAGGAATGCTTTAAATGCTCATATAAGTGATAATGAGCTTCGCATACTCGTAGATACTGGCATAAACCACTATTCTGAACTTTTTCGCATGAAAGCAACTGCTGCAAAGGCTGATGTTTTCTATCTGATGTCTGGAATGTGGAAATCATCAGCTGAACGGTTTTTCTTATGGATAGGAGGATTTCGCCCCTCAGAGCTTCTTAAGGTTCTCAAGCCTCAGCTTGAGCCCTTGACAGATCAACAACTTTTGGACGTCTCTAACCTGAAGCAATCATGCCAGCAGGCAGAAGATGCTCTTTCACAAGGTATGGAAAAACTCCAGCAAACTCTTGCTGAGACAGTAGCAGCTGGTCGACTGGGAGAAGCAAGTCATATGCCACAGATGGATACTGCAATGGAGAAGTTGGAAGGTTTGGTCCGCTTTGTGCAGCAGGATATGAGATTCCCTCCAATCATAATACAATATCCTGAAGTAGATCGTCTATCTGAAGGGGAATCTGACCAATCTACATCAGAATAG
Protein Sequence:
  • >Manes.12G140100.2.p|Manihot_esculenta|bZIP|Manes.12G140100.2.p
    MNSPSTQFVSPGRMGMYEPIHQIGMWGENFKSNGISNASPSMFIPGNPNSSQSILIPAETKLDNQSEDTSHGTLGPSSSKYDQEASKPIDKVQRRLAQNREAARKSRLRKKAYVQQLESSRLKLFQLEQELERARHQGLYVGGLETSQMGFAGPINPGIANFEMEYGHWLEEQNKNIHDLRNALNAHISDNELRILVDTGINHYSELFRMKATAAKADVFYLMSGMWKSSAERFFLWIGGFRPSELLKVLKPQLEPLTDQQLLDVSNLKQSCQQAEDALSQGMEKLQQTLAETVAAGRLGEASHMPQMDTAMEKLEGLVRFVQQDMRFPPIIIQYPEVDRLSEGESDQSTSE*