Gene Details:

  • Gene ID: kfl00079_0440
  • Gene Family: bZIP Family
  • Description: bZIP Family protein
  • Species: Klebsormidium flaccidum
  • Source: bZIP family gene from PlantTFDB

Protein Features:

Annotation Proteins:

  • Refseq:  XP_002980439.2  — transcription factor TGA2.3 isoform X2
  • Refseq:  XP_024529114.1  — transcription factor TGA2.3
  • Refseq:  XP_024536795.1  — transcription factor TGA2.3 isoform X1
  • Refseq:  XP_024544912.1  — transcription factor TGA2.3 isoform X2
  • Swissprot:  O24160  — TGA21_TOBAC; TGACG-sequence-specific DNA-binding protein TGA-2.1
  • Swissprot:  P23923  — HBP1B_WHEAT; Transcription factor HBP-1b(c38)
  • TrEMBL:  A0A1Y1HW44  — A0A1Y1HW44_KLENI; BZIP transcription factor
  • STRING:  EFJ22847  — (Selaginella moellendorffii)

Gene Ontology:

  • GO:0009410  — Biological Process — response to xenobiotic stimulus
  • GO:0045892  — Biological Process — negative regulation of transcription, DNA-templated
  • GO:0045893  — Biological Process — positive regulation of transcription, DNA-templated
  • GO:0005634  — Cellular Component — nucleus
  • GO:0005737  — Cellular Component — cytoplasm
  • GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
  • GO:0043565  — Molecular Function — sequence-specific DNA binding

Family Introduction:

  • The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
  • Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Literature:

Sequences:

CDS Sequence:
  • >kfl00079_0440|Klebsormidium_flaccidum|bZIP|kfl00079_0440
Protein Sequence:
  • >kfl00079_0440|Klebsormidium_flaccidum|bZIP|kfl00079_0440
    MASTLTPALAAGINSEVFSGKSQKTSDMSAPRDNNGAYDLADLDGTPMNFGIAEDDDVGGRGNGANGGAWNDTPMSPRSPSSDGGDMDEYKDQGSPSNKRPGDSDKKSEGPDKTLRRLAQNREAARKSRLRKKAYVQQLESSRIRLQQLEQELQRARQQGVYHGDGAAGGGGTLPGLNSNPNPGAAQFDLEYGRWVEEHSRQTSELRTAVNQRSTDDELRTLVDQCLAHYDELFKLKSQAAKMDVFHLVSGMWKTPAERCFMWMGGFRPSEMLKIIIPQVEPLTEQQLMAICNLQQSSQQAEDALSQGMESLQQSLADTLSAGNMSASSNVANYMGQMAMAMGKLGTLESFVRQADSLRQQSLQQMHRTLNIRQSAKGFLAMADYHARLRALSSLWAARPRD