Information report for IGS.gm_20_00224
Gene Details
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Functional Annotation
- Refseq: XP_005844912.1 — hypothetical protein CHLNCDRAFT_138475
- TrEMBL: E1ZN50 — E1ZN50_CHLVA; Uncharacterized protein
- STRING: XP_005844912.1 — (Chlorella variabilis)
- GO:0042538 — Biological Process — hyperosmotic salinity response
- GO:0045893 — Biological Process — positive regulation of transcription, DNA-templated
- GO:0005634 — Cellular Component — nucleus
- GO:0005783 — Cellular Component — endoplasmic reticulum
- GO:0003700 — Molecular Function — transcription factor activity, sequence-specific DNA binding
- GO:0043565 — Molecular Function — sequence-specific DNA binding
Family Introduction
- The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
- Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.
Literature and News
Gene Resources
Sequences
CDS Sequence:
- >IGS.gm_20_00224|Chlorella_variabilis_NC64A|bZIP|IGS.gm_20_00224
ATGGCAGCAGCGCCCGCTCCAGAAGACACTTGGGGCGAGCTGCTGCTGGACGGGCTCCCGAATGTGGGACTACTGGACGACCTGCAGCTCGACTGCGGGCTGAGTGATGTGGGGCTGCCGCCCGGCCTGCACGACCTGGAGTGCTTGGACTTAGACGATCTGGGCGCCGCCGGCGGCGGCGCGGCCCCCGCCAGTTCCGACCTGCTGGAGAGCCTGCAGCTGGATGCCTTCTCGCATCCCGCCAGCAGCAGCGACGCGCGGCACTCGCCCAGCGACAGCGGCAGCGACTCGCCCGTGGTGCTGCCGCTGGTGGGCGCCGCGCCGGCCGCCCCCGCCACCGGCCCCCGCCAGGGCACGCCGCCGCGCGGCGCGGATGCCAGCCCCGCCACTTCGGAGAGCGAGACCAACGGCGGCGGCCGCTCCGGCAGCCCGGCGGCCGCCACCAGCCAGCGCGGGGCGCAGGCGGGCGGCGCAGCGGCCGCCCAGCAGCCACAGCGGCCGCTGAGCGAGGAGGAGAAGCGACTGGCGCGCATGCAGCGCAACCGCGAGAACGCGCAGCTGTCCCGGCAGCGCAAGAAGCAGCAGATGTCGGAGCTGGAGGCGCGCTGCGGCACGCTGACGCAGCGCAACGCGCAGCTGGCGGCCACGGTGCAGCGGCTGACCGCCGAAAACATGCAGCTGAGGCAGCAGCTGGTGCTGGTGTGCCAGCAGGCGGGGCGCGCGACTGGCGCAGCTGGCGCCAAGCCCGCCGCCGGCGCCGCAGCCGCAGCAGCCGCCGCCCAGGCGGGCAAGGTGGCGGGCGCAGCCCAGGCTCCCGCCACCGTTGCCGCAGCAGCAGCCAAGGGCGCGCAGCCGGCAGCGGGAGCAGCGCCTGCGGGCGTGGCCCCCAAGGGCGTGATTCCCCAGTGGCCCCTGCTCCCCTTTGGCTTCCTGCCTAAGGTCACCTTCTCTGTGCAGCAGTCTGGCCGCCCCACCGGCCAGCCAGCAGCAGCAGCAGCAGCCGCAGCCGCAGCGCCCGCCAAGCCGGCACAGCCAGCTGCTGCTGGCGCGGCCCGGGCCGCGCCCGCCGCGCCGGCGGCTGCCCGCCCGCCCAAGCGCGCCAAGACTGCTGCGGCAGGCGCCAGCAGCGCCTTGCTGGCCCTCTTCACCCTCTTCATGTTTGCGGGACCCCTCACGCCGGCGCCGCTGGCAGCCCCCGGCGCCAGCAGCGCCAGCGCCGCCGCCAGCATCGCGGCCGCGGCCGGCGCCCAGCGCATGCTGCAGGCCCTGCCAGAGTCGGCGGCGGCGCCGTTTCTGGACGGCGGCGAGGCGGCGGCGGGCGGCGGGCGCCGGCTGCAGGCGCTGCCCGCGGCGGCGTCCGAGGGGCAGGCGCCGCCGCGCGCGCTGCCCGCCGGCGGCGGCCGCCTGCACCAGCTGCTCAACAGCACGCTGCAGGCGCTGATGGAGGAGCCGGGCAACGCGGCGCTGGAGGCGGCGGCGCTGCAGCGCCTGCAGGAGCTGGGGCCCGTGGCGCTGCTGCTGGATGCCGACGGCGGCGCGGGCGCCGGCCCGCTGGCCGCCTCGGCCGCCTTCCCGCGCCTGGCGGGGCAGCTGTTTGGCGGCGCGGGGCTGGAGGTGCCCCAGATGTGCCACAAGGTGCTGGAGTTTGACGCTGCCTCGGTGCCGCACGCGGTGCGCAGCAGGCGCAGCCTGGAGCGGTACGTGCTCGGCGCCACGGGCTTCCGCGGCCGCAGCCTGGCGGCGGCCACGGCCGACGGCGGCGGCGGCGGCGCCGCCGCCGCAGACCCCGAGCCGCTCCGCATCGAGCAGCCGGCGGCGGCGGGCGGCGAGGAGGGCGGCGGCGAGGAGGACGGCGGCGGCGGCGGCGGCACCGCGCTGCTGCCGCGCGGCGGCGTCGCCGCTGGCCCGGTGCTCGTGTCGGTGCTGCTGCCCGCCAACGCCAGCGGCGGCGTCAAGCTGGCGTCCGTGGACAAGGTGTTTGTGGTGCTGCTGCACCCGCAGGACAAGTACCTCACCTACTCGTGCCCCCTGCCCCGCCCCGTGTTCCTGTGA
Protein Sequence:
- >IGS.gm_20_00224|Chlorella_variabilis_NC64A|bZIP|IGS.gm_20_00224
MAAAPAPEDTWGELLLDGLPNVGLLDDLQLDCGLSDVGLPPGLHDLECLDLDDLGAAGGGAAPASSDLLESLQLDAFSHPASSSDARHSPSDSGSDSPVVLPLVGAAPAAPATGPRQGTPPRGADASPATSESETNGGGRSGSPAAATSQRGAQAGGAAAAQQPQRPLSEEEKRLARMQRNRENAQLSRQRKKQQMSELEARCGTLTQRNAQLAATVQRLTAENMQLRQQLVLVCQQAGRATGAAGAKPAAGAAAAAAAAQAGKVAGAAQAPATVAAAAAKGAQPAAGAAPAGVAPKGVIPQWPLLPFGFLPKVTFSVQQSGRPTGQPAAAAAAAAAAPAKPAQPAAAGAARAAPAAPAAARPPKRAKTAAAGASSALLALFTLFMFAGPLTPAPLAAPGASSASAAASIAAAAGAQRMLQALPESAAAPFLDGGEAAAGGGRRLQALPAAASEGQAPPRALPAGGGRLHQLLNSTLQALMEEPGNAALEAAALQRLQELGPVALLLDADGGAGAGPLAASAAFPRLAGQLFGGAGLEVPQMCHKVLEFDAASVPHAVRSRRSLERYVLGATGFRGRSLAAATADGGGGGAAAADPEPLRIEQPAAAGGEEGGGEEDGGGGGGTALLPRGGVAAGPVLVSVLLPANASGGVKLASVDKVFVVLLHPQDKYLTYSCPLPRPVFL*