Gene Details:

  • Gene ID: AT3G12250.4
  • Gene Name: BZIP45, TGA6
  • Gene Family: bZIP Family
  • Description: bZIP Family protein
  • Species: Arabidopsis thaliana
  • Source: bZIP family gene from PlantTFDB

Protein Features:

Annotation Proteins:

  • Refseq:  NP_001030678.1  — TGACG motif-binding factor 6
  • Swissprot:  Q39140  — TGA6_ARATH; Transcription factor TGA6
  • TrEMBL:  F4J8P7  — F4J8P7_ARATH; TGACG motif-binding factor 6
  • STRING:  AT3G12250.4  — (Arabidopsis thaliana)

Gene Ontology:

  • GO:0006355  — Biological Process — regulation of transcription, DNA-templated
  • GO:0009410  — Biological Process — response to xenobiotic stimulus
  • GO:0009627  — Biological Process — systemic acquired resistance
  • GO:0005634  — Cellular Component — nucleus
  • GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
  • GO:0005515  — Molecular Function — protein binding
  • GO:0016787  — Molecular Function — hydrolase activity
  • GO:0043565  — Molecular Function — sequence-specific DNA binding
  • GO:0046872  — Molecular Function — metal ion binding

Family Introduction:

  • The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
  • Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Literature:

Sequences:

CDS Sequence:
  • >AT3G12250.4|Arabidopsis_thaliana|bZIP|AT3G12250.4
    ATGGCTGATACCAGTTCAAGGACTGATGTCTCAACTGATGGTGACACAGATCATAGAGATCTGGGGTTTTATTATCTCTACAATGTCACTCCTGGGAGGCTTGTACCGGAATCCCTTGGTAAAACTTGGGGCATTCTACCGTCTGATAGAGGGCATATGCATGCTGCTGCCTCTGATTCCAGTGATCGATCAAAGGATAAGTTGGATCAAAAGACCCTTCGTAGGCTTGCTCAAAATCGTGAGGCAGCAAGAAAAAGCAGATTGAGGAAGAAGGCGTATGTTCAGCAGCTGGAGAATAGTCGATTAAAGCTGACTCAACTTGAGCAGGAGCTGCAAAGAGCAAGACAGCAGGGAGTTTTCATCTCAAGTTCAGGAGACCAAGCTCATTCTACTGGTGGCAATGGGGCTTTGGCATTTGATGCAGAACACTCACGATGGCTTGAAGAAAAGAACAGGCAAATGAACGAGCTGAGATCTGCCCTGAATGCTCATGCAGGTGATACTGAGCTCCGGATAATTGTGGATGGAGTGATGGCTCACTATGAGGAGCTTTTCAGGATTAAGAGCAATGCAGCTAAGAATGATGTCTTCCACTTGTTATCTGGAATGTGGAAAACACCAGCTGAGCGATGTTTCTTGTGGCTTGGCGGGTTCCGCTCATCCGAACTTCTCAAGCTTCTTGCGAATCAGCTAGAGCCCATGACAGAACGACAGGTAATGGGCATCAATAGCTTGCAGCAGACGTCGCAGCAGGCAGAAGATGCTTTATCTCAAGGGATGGAGAGTTTACAGCAATCCCTAGCTGATACTTTATCCAGTGGAACTCTTGGTTCCAGTTCATCGGATAATGTCGCGAGCTACATGGGTCAGATGGCCATGGCAATGGGGCAGTTAGGCACCCTCGAAGGATTCATACGCCAGGCTGATAACTTGAGGCTGCAAACACTACAACAGATGCTTCGAGTATTAACAACACGTCAGTCAGCTCGTGCTCTTCTTGCTATACACGATTATTCATCTCGATTACGTGCTCTTAGTTCCTTGTGGCTTGCCCGGCCAAGAGAGTGA
Protein Sequence:
  • >AT3G12250.4|Arabidopsis_thaliana|bZIP|AT3G12250.4
    MADTSSRTDVSTDGDTDHRDLGFYYLYNVTPGRLVPESLGKTWGILPSDRGHMHAAASDSSDRSKDKLDQKTLRRLAQNREAARKSRLRKKAYVQQLENSRLKLTQLEQELQRARQQGVFISSSGDQAHSTGGNGALAFDAEHSRWLEEKNRQMNELRSALNAHAGDTELRIIVDGVMAHYEELFRIKSNAAKNDVFHLLSGMWKTPAERCFLWLGGFRSSELLKLLANQLEPMTERQVMGINSLQQTSQQAEDALSQGMESLQQSLADTLSSGTLGSSSSDNVASYMGQMAMAMGQLGTLEGFIRQADNLRLQTLQQMLRVLTTRQSARALLAIHDYSSRLRALSSLWLARPRE