Information report for 444176
Gene Details
Functional Annotation
- Refseq: XP_002979367.1 — basic leucine zipper 6
- Refseq: XP_024519851.1 — basic leucine zipper 6
- TrEMBL: D8S7L3 — D8S7L3_SELML; Uncharacterized protein
- STRING: EFJ19775 — (Selaginella moellendorffii)
- GO:0006355 — Biological Process — regulation of transcription, DNA-templated
- GO:0003700 — Molecular Function — transcription factor activity, sequence-specific DNA binding
- GO:0043565 — Molecular Function — sequence-specific DNA binding
Family Introduction
- The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.
- Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.
Literature and News
Gene Resources
Sequences
CDS Sequence:
- >444176|Selaginella_moellendorffii|bZIP|444176
ATGAAGATGTTGGAGTTAATTGATTCGGACTCGTTTGCATGTTTTGGGTCGTCGAAGAATGCGTTTCCACCTGGGTTTAGGTTTCATCCGACAGACGAGGAACTTGTACTGTATTACTTGAAGAAGAAGATATGTCGGAAGAGGATTCTGCTGGATGCCATCGCTGAGACTGACGTGTATAAGTGGGATCCTGAGGACTTGCCTGATCTGTCTAAATTAAAAACTGGGGACCGGCAGTGGTTCTTCTTTAGCCCCAGAGATCGAAAGTATCCTAACGGAGCACGGTCAAACAGGGCAACAAAGCACGGGTATTGGAAAGCTACGGGAAAGGATCGAATTATTACGTGCAACTCACGTGCTGTTGGAGTTAAGAAGACCCTAGTCTATTATAAAGGCCGAGCACCAGTAGGCGAGCGAACAGACTGGGTGATGCATGAGTATACTATGGATGAAGAAGAGCTGAAAAGGTGTCAGAATGTCCATGACTACTATGCGCTTTACAAGGTCTTTAAGAAAAGTGGGCCTGGTCCTAAGAATAATGAGCAGTATGGTGCACCTTTTAGAGAAGAGGACTGGGTTGATGATGAATGTCCAAGTGCCAAAGCCTCTGTTCGCCCGGTTGATGATGAATGCCCAAGTGCCAAGGCCTCTGTCCGCCAAGACACTTCCGCAAAGCATGTCAACGAAGCTCCTTCTGTAGATGGTGGACTTGAGGAGTTGTTGAACAATACTGCAGATGAGGCTGTGCTTGTTGAGCCACTTTGTGCCGACTATGATTATGCCCTAGAGCAGCTTGTATATGAGGAAGATACTGAAAGTACATTGCTAGATCATTCATCAAGGGAAGTTAATTTTCCCAATCATAGTGCTGTGATTGCCCCAGGCTGCCAGCATTACCATGTGAAGGAAAGCTTTGACCTGACACAGTCAGGCACGTCACAGCTACAGTTGCATGAGGCACCAGAGGTCACATCTGCTCCCGTTAGTTGGGAACAACAGCGGCATGTGGTGGAAGAGGATTTCCTTGAAGATTATCTGGAGATGAATGACCTTCTTGGTCCAGAGCCAAGCATTCAGAACTTTGATAATCCGGAGCTGGGTGTTAAAAACTTTGATGAGGCCGGACCAAGTGGTCAAAACTTTGATAAGCCTGCTGGAAACTTCGAGGATTTGCAATTCGATTACTTGGATGGGTTGACAGAATTTGACTTGTATCATGACACACCCTTTCTTCTTGATGATATTAGAACAACTGATGTGGGGCAAATTACTGAACCATACATGAACAACTTTGTGAATGGTGCTGTAAATCCTGTTTCAACAACGTATTTAAGCACTTTTCAGAATGAAATGGTGAACCATCAGCCAATGTACTTGAATAATGGAGAACAGATTAGCAATCAACTGTGGACACATGATCAAAGGTTTAACATCTATAACCCCAGTGAGGCAAATCAGTTGGTTGTTCCTCCAGCTATATCAGGTGTTGTGTATGATAGTAATTTGGCAAATCATCCTATGGGCGCAAGTCAGAATCAAATAGTCAGACAGGATGATGGTACACCGTCATGGTTCTCCTCTCAGTTGTGGGCCTTTGTGGATTCTATACCTACCACTCCTGCTGCAGCTGCTGAAAGTCCTCTGGTTAATGGGGCTTTCAAGCGCATGTCTAGCTTTAGTAAGTTGAGAATAAACGCCAGGAACATGAATGTTGTGGCAGGTAATACTGTAACTTCAAGCAGTTCGGGCAACTCTAAGAATGGGGTTTTTTATTTTTCTTTTCTTGGAATACTTTGTGCAATCTTATGTGTGTTAGTAGGAACATTTGTTAAAGTCTTTGGGAGATACATATCCTCTTAA ATGTCGAGCTCGCAGCTCGGGCGAAGCGACAAATCCTCCTCAAGGTGTGTAAACTGGGGGCATTCCATGGCGCTCAATCACCTCCCGCCGAAGAGTCCAGCGATTCCATCCTCTACTTCGTCGTCCCAGCCGTGCGTTGGGCCGCCCTACCCTGGATGCGTGGTTAGAGTTCCTGGCTATGGCGCCGCGGCTGTGGCGCATCACCATCGCCGGAGCCCATCCGCGAGCTTTGTCCCGGACGTGGAGCCCTCTTGGCTCGAGGAGCTGCTCGATTCGCCCAAGGCGCCCGAGAGGCCGTCGCGCGCGTCTCACAGGCGATCCGCCAGCGACAGCATCACCTTCTTGGAGGCTCCATCCAACCTCCGAAAGATCGATGACATTGCCGAGGAGGACGAGTGCTACTTCGATCGGGAAGAACAGCAGCTCGCGGCCATGTTTAGCGACGTCGTCCAGATATCCGATGGAGGATGGTCTCAGCAAGATCGAAGAGCTCCTCATCCCTTCCGGACTTTTCCTGGAGATTTGAGCTACGTTGGTGGATCAAGGATGGGGAATGACGCCGAGCAGCAGCATGACAACGAGCAGTCACAGCTCCAGGGCGATCAGAGCGCTGATTCCAAGCGCTCCAAGAGGCAATCAGCCCAGCGCTCCAGAGTGCGAAAACTTCAATACATTCATGAGCTGGAGGGTAACGTCAGTGACTTACAGAATGAGGTGTCTGGGCTGTCGACACAAGTGGCACTGCTCGAGCACCAGCGCCTGGCGCTTCACTTGGACAACGCAGCCCTCAAGCAGAACGTTGCTGGTCTGGCTCAGGATGCCCGGATTAAAGATGCTCACAACGAGGCCCTGAAGAAAGAGATCCAGAGGTTGAGATTCTTGAAGCAGCAGCAGCAACGACTTAGGCAGCAGCTGGCTTTAGCTTCTTCGGCAGCAGGAAATAATGTAGAGACGACGACAACAACAACAACAACAACAACGAAACATGTGAGGCGAGCAAGCGCGGGGTCAGTCCAGGATCTGGGCTCCTCGGCGGCAGCAGACGTCCTCGATTACTCCTTTGTAAAGTTTGTCGAGAAGACTGACAGTCCGGTGCTGCGTTCCAGCTGCACCATGGCCGGGAATGGCAAGAGCTTAGAAGTTGGAGCGAGCAGGCTCTCCGGAGCACCACCAGGTTTCATCGTCCACAACCATTTGTAG
Protein Sequence:
- >444176|Selaginella_moellendorffii|bZIP|444176
MSSSQLGRSDKSSSRCVNWGHSMALNHLPPKSPAIPSSTSSSQPCVGPPYPGCVVRVPGYGAAAVAHHHRRSPSASFVPDVEPSWLEELLDSPKAPERPSRASHRRSASDSITFLEAPSNLRKIDDIAEEDECYFDREEQQLAAMFSDVVQISDGGWSQQDRRAPHPFRTFPGDLSYVGGSRMGNDAEQQHDNEQSQLQGDQSADSKRSKRQSAQRSRVRKLQYIHELEGNVSDLQNEVSGLSTQVALLEHQRLALHLDNAALKQNVAGLAQDARIKDAHNEALKKEIQRLRFLKQQQQRLRQQLALASSAAGNNVETTTTTTTTTTKHVRRASAGSVQDLGSSAAADVLDYSFVKFVEKTDSPVLRSSCTMAGNGKSLEVGASRLSGAPPGFIVHNHL*