Information report for MDP0000282531
Gene Details
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Functional Annotation
- TrEMBL: A0A498HUB1 — A0A498HUB1_MALDO; Glucose-6-phosphate isomerase
- GO:0005975 — Biological Process — carbohydrate metabolic process
- GO:0004553 — Molecular Function — hydrolase activity, hydrolyzing O-glycosyl compounds
Family Introduction
- Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1(BRI1-EMS-SUPPRESSOR 1), accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo.
- BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.
Literature and News
Sequences
CDS Sequence:
- >MDP0000282531|Malus_domestica|BES1|MDP0000282531
ATGACGTCTGACGGAGCAACGTCAGCGGCGAGGACGGCGCGGAGAAAGCCGTCGTGGCGGGAAAGGGAGAACAACCGGCGGAGAGAGAGGAGGAGGAGAGCCATCGCGGCGAAGATATTCACCGGCCTCCGAGCTCAGGGAAACTTCAACCTGCCCAAGCACTGCGACAACAACGAGGTCCTCAAAGCTCTCTGCCTCCAGGCCGGCTGGACCGTCGAGGTGGACGGCACCACCTACCGAAAGGGATTGAAGCCAATTCAAAATGATACGCCGGGCGCATCGACCAAGATAAGCCCATACTCTTCGCTAAATCCGAGTCCAATCCCGTCCTACCAAGTCAGTCCTTCGTCTTCGTGCTATCCCAGTCCCCCCCGTTTCGATCCCAGCACTAATTCATCCAATCCCTGCCACTATCCCCCTTCTACAATCCCATCACCTCTTCCTCCCCTGCGAATTTCCAACAGTGCCCCTGTAACCCCGCCGCTCTCCTCCCCGACCTCCAAACGCCCCAACCCAATTCCCAACTGGGACTCCATCGCTAAACAGTCCATGGGCTCTTTCGATTACCCGTTTTATGCCATCTCCGCTCCGGCGAGCCCGACCCGCCACCACTATACTCATCCTCCAGCTGCCACTATCCCGGAATGTGACGAGTCCGATACTTCCACCGCAGATTCCGGCCAATGGGTTTGCTTCCAGAGATTTGCTCCTTCTCTGTCGGCAATGCCGGCCTCTCCGACCTTCAATCTTGTGAAGCCTGTTTTTGCTCACCAGAATATTCCCGCGGATCAAATTCCGGACGTAAAGCCGTGGATCGGAGAGAAGATTCACGAGGTGGGACTTGATGACTTGGAGCTCACGCTTGGAAATGACTTGGCTGGTGACCCAAATGATAGGAGATCAAGTACACGATTAGTGGAAAAAGTTAACGAAAAAGAGAGGTTGAAAGCGAAAGGCCCATTGAAAAATCCTCAGCCTTTGCTTAGATTGGAATATAAGTTGGTCACTCACACTACCACAGCGCTGCGAGCTGAACTGCAAGCACAGCATGGCAAAGAGATCGGATTTTGCGCAGAAGCTGCTGGACGATCTTCGCGTCCGCAAGGAGAAAATGGGTGCGCCTCAGAGTTCAAACCGTTGGACTTCAATGGCAATGCATATGCTTGTTCCGAGCAGAATCATAGAGGAAGAGCGGATGTAAGCACCAATGGACCGATTGGCTCCGGAGGAAGTAGCAGAACACCGATTGTTCAAGAGGGTTCGAATCAGATTGTTGCTTACGGGAGAGGAGGTAGGAGCTCAGAACCAATGGGAGATTTTTCCGTGGCATTGGCTTTTGCACTTGAAAATGGAGGAAAGCTCGGGAAAGCGGATACATCTAGCAGAAGTCCAATGCTAGGATTTTTGAATCAAATTGGGAGGGGAGCCGTGGAGTTCAGCGAGATGGAAGGAAAAGGTAGCGTCAATAGGCACTTCGGTTCAAGTAACCATTTTCCTAACCTTTCTCATCACCATATCGAAGAAATATCGAGAGGAGCACATAAATTGAATCAGATCCTAGAGGCCTGCTCGAATGGACTTAATGTTGATAGATTTTCAATAGAAGTTGGGAAGGAGTTAGTGAAAGAGGCAATGGATTTGGAAGAGTCCTTGAGAATGCTTGTAAACCTGCAGGAAACTTCTGGTTACATAGTCAGCTCTCAGAGGAAAAATCAGATCACATTGCTAGATGAGGAAGATAATGCTGTCAAAATGGCTGAGGAAAAGCAAATTGATCTGCCAAACTTCTCCTTTGACAAGGGTTCGAGACACGCGCGTAAAAATCAAGAAGTTGGAAGGCCCGGGTTCGAGCAGAAGGTGACTGCAGCTCTAACCTACACTACAGAAGGTAGTGGCTTAAACCGCGAAAAGCAAGGGAAAATAACCTCCTCAACATCAGTTTCTCAGAGGCAATCAGTCAGCTATACCGGAGGTGTCAAGAATCCATCAACAGAACAGAAAGAGTCTAAACCAGAAAAGGAGAGGATTCCAATTGTAATTGCAAAACTAATGGGGCTGAATGAGCTTCCAAAAAACGAAAACTTGAAGCACACCGCGGAGGAAGACTTGAGTTCCAAGTCAAAAAGAGAAAGGCACGTGATAGAGCAAACAACAAATGAAAGCAGTAAGATTTCTGGGGTTAAGACTAAGGATCCTTTGATGCAGAATATGACGTTTGTTTCGCAAGCAGAGAAAAGAATGCTTGCCAATAATATCAGCATTGGGGTAGTTGTTCATGATCCGGAAGAATTTAAACCCGTGGCAATATTAGGAAATGCAACCATCAAATCAGATAAGCACCAAAAACCTAGTCAGACCTTCAAACAGGATAAACCTGTGATGCAAGCAAAACCAGGGTTCAAGGAAATTCGGGTTCCAGTGGAAAAGCAAAATGGGAACAACGTTCTCCCAAGAAATCAGCAGCATAAGCCCCCATACGATGTTGAACTCCAGCAGCAATCCATGGCTTTGAAATCTGAGTCACCGAAAGAAAAGCGCAGACAGGAGACGAAGGAGCGGCAAATTCCACAACCAAAGTTGGTGGCGAAGAAACAACGAAGAAGTGAAATGATATCAAGAAGAAAGTCAAAAGGGGCAGTAGATTTGCAAAAGAAGCAGACACTTGCAGAGCAAACTTGGGTAAATAAGAAAATCGCTAGAGAAGCCGCTGCAACAGTGCAATCCACAAGAGTTCCAAATGGCAAATATCATGAAAATCTGGTCAGAAGCAAAAGTTCCGCTGACTTGAATTTCAACAAGAAAGATTTTTCACCAAACTCCTTGGATCCTCAACAAGCAAAAGAAAATTTTGGCACTCTACCGGCTATGGAGGAGAGATCAGTTCATGCAGCACCACCACTGCAGAAGGCAAAATCTAGAAGAGTGAATAAAAGCGAAATGCCTCAAAGAATCGATGAAGTGGCAACCAGACGAAGCTATGAAAAACGTGGTAGTCACAATGCAACAGAAAAAGTTAGAGCCAGCAGGCTAAAACAAGCTGAGCCACACATCGTCAAGTCCAACAAATCAACAGCAAGCGTTCAACCACTAGATTCAGGGCAAAACCAACATAAAGAAGCAGAGCTGGAGGCTCCCACTTTGTATGATCCCAATGAAGTTGAAAGTCGAAGACTCGAAAAATCACAAACTCTACTTCCAAAGGAAAGTTATGATCAACAAGATCAAGCACCTGCTTTCGGAGATGATGAGTGCATAACTGCATCAATTACAGTTAATGAGAAAAACTTCTCTGCAACGGAGAATGTCACTGTGGCAGTATCTCAAGCCAATCACTGCAACGTGGGAAACCGTGACATTTGTTATGCAGAAGTATTGGAGCACCATAAAGCACTCAACCTGAGAAAACAAGAGCCGACAGAAATTGAAAACCACCTGAAGCAGGTAGTGATCAAGAGCCATCATTTCCTCAACACAGCAGAAGCACTTTTCAAGCTCGACATCCCTTTCAGCATTCTTCACGACAGCGGCCGCGACTGCAACCCAGATGTAGACAGCAAGCTCACATTAGACTGTGCCTACGAAGTAATGAAACGAAAAGGGATAAGGCACGAGCTCAATGTTCATCCTAAATGCGAGAAGGCATCAATAAGTTTTGTCAAAATACGGTCCTTGAATGAGCTGGTTAGGCAACTGCATAAAGATTTCGAGACTCTGAAGTTCTACGGGAGAAAAGGAAAATATGAATGTGAGGCGGAAGCGTATCTGCCCAAAATGCTGGAAAGCGATATGCATAGCTGGGAGCCGGAACTGAATTGCATGTGGGATATGGGTTGGGATAAAACTATGTTTGCAGTTGTTGAAGTAGATGAAGTTGTGAAAGATTTGGAGAGGCTTGTGCTCGGTGGACTTGTAGATGAGCTTACCAGAGACCTCTTTCGCACGGATTGCCAATCATTTATCGGTGTAAACTACGGCCAAGTTGCCGACAACCTACCGCCACCGTCGTCCACCACGAAGCTGCTCCAGTCAACTTCAATCCAGAAGGTTCGGCTTTACGGTTCCGACCCGGCCATAATCAAAGCCCTGGCGAACACCGGCTTGGGTATCGTCATCGGAGCGTCGAACGGCGACATCCCGGGTCTCGCATCCGACCCCAGTTTCGCCAAGAGCTGGGTTGGAGCTAACGTGTCCCCTTTCTACCCGGCGAGCAACATCATCCTCATCACCGTCGGCAACGAGGTCTTGACTTACGGCGACCAGGGCCTGATTTCTCAGCTGGTCCCGGCGATTAAGAATGTTCAAGACGCCCTCACTTCCCTGTCTCTTGGCGGGAAAATCAAGGTCTCCACCGTACACTCCATGGCGATGCTCAAGCATTCCGAGCCGCCGTCCTCCGCAAGGTTCGACCCGGGTTTTGGTGACGTCATAAAGGAGTTGCTTGGGTTTAATAACGCCACCGGTTCGCCTTTCGCTATCAACCCGTACCCGTATTTCGCGTACCGGAGTGACCCGAGACCCGAGACACTGGCTTTTTGCCTATTTCAGCCGAATAATGGGCGGTTCGACTCCAACACAAATATTAAGTACATGAACATGTTCGATGCTCAGGTGGATGCAATAAGATCGGCATTGGACTCTATAGGCTTCAAGGGGGTGGAAATTGTGGTGGCGGAGACCGGATGGCCGTACAAAGGGGACGACAATGAGGTTGGTCCAAGTGTCCAGAACGCGAAAGCTTATAACGGAAACCTGATTGCGCACCTTCGATCAATGGTTGGGACGCCATTGATGCCGGGAAAGTCTGTGGACACTTACCTCTTTGCACTCTACGATGAGAACTTGAAGCCTGGCCCCGTGTCAGAGAGAGCATTTGGTCTCTTCAAGCCTGACCTCACCATGAATTATGATGTTGGTCTCTCTAAGAGCAGCCAGACCCCTACCACGCCCGCCACGCCATCTACGCCCACCACGCCATCCACGCCCCCCACGCCAGCGAATCCATCGGGGCCAAAGCCAAAGAAAGGATCATATTGTGTGCCCAAGGCCGGCGTATCAGACTCTCAGTTACAGGCTAATATAGATTATGTTTGTGGACATGGTTTTGATTGCACTCCAATTCAACCCGGAGGGTCTTGTTTTGAACCAAACACAGCTATGATAGCTGCAACTACCCAGGTGGGAGTACTAAAGATGTATGAAGGAACTTGGGAAGACTCAGAAATGTATACGGAGGGATATCAGTTAATCTGCCTCCTTGATATGTATGTTTGCTTAGGATTTAGGATTCTTTGTGAAGAAATGTTTTGTACATTTTGTGTCATTCTTCTTCCAATAGCTATTACGTTCTACATCACATGGGCTTTCATTAAATTTGTTGATGGTTTATTCTCCCCAATCTACAACCACCTAGGAGTCAATATTTTCGGTCTTGGATTTGCCACCTCCCTCGTCTTCATCTTCTTAGTCGGCGTTTTCATGCAGTCGTGGTTGGGAACTTCTGTTCTTACTCTATGGGAGTGGTTTATTACGAAAATGCCACTTATAAGCTATATCTATGCTGCATCAAAGCAAATTAGCACAGCAATATCACCAGATCAGAGCATAAACGCCTTCAAGGAAGTGGCGATCATAAGGCATCCAAGAATCGGGGAGTATGCATTAGGGTTTATCACTTCAACAGTTGTTCTTGATCAAAGAAACGTAGGAGAAGAGCTATGCTGCGTTTATGTACCTACCAACCATCTTTATCTGGGAGACATTTTTCTGATCAGTCCCAAGGATATTCTGAGACCAAATCTGTCAGTTGGAGAGGGGATTGAAATTGTCATCTCAGGAGGTCTGTCAATACCGCAACTTTTAACTACGGTGGATGCACAAGTCCTTACACCCAGAAGAGTTCCCCACTTTGAAGAGCTACAACAGAAGTTGTCAAACTCAAACAAAGTTTTGCAGAGAAAGTTTAGAGGCTCAAACGCGGCCGGATCGGATCGGGAATGGAGGGAAGAACACCATAGCATAACCCTGAAATGCAGTGAAAAGTCCCTTTAG
Protein Sequence:
- >MDP0000282531|Malus_domestica|BES1|MDP0000282531
MTSDGATSAARTARRKPSWRERENNRRRERRRRAIAAKIFTGLRAQGNFNLPKHCDNNEVLKALCLQAGWTVEVDGTTYRKGLKPIQNDTPGASTKISPYSSLNPSPIPSYQVSPSSSCYPSPPRFDPSTNSSNPCHYPPSTIPSPLPPLRISNSAPVTPPLSSPTSKRPNPIPNWDSIAKQSMGSFDYPFYAISAPASPTRHHYTHPPAATIPECDESDTSTADSGQWVCFQRFAPSLSAMPASPTFNLVKPVFAHQNIPADQIPDVKPWIGEKIHEVGLDDLELTLGNDLAGDPNDRRSSTRLVEKVNEKERLKAKGPLKNPQPLLRLEYKLVTHTTTALRAELQAQHGKEIGFCAEAAGRSSRPQGENGCASEFKPLDFNGNAYACSEQNHRGRADVSTNGPIGSGGSSRTPIVQEGSNQIVAYGRGGRSSEPMGDFSVALAFALENGGKLGKADTSSRSPMLGFLNQIGRGAVEFSEMEGKGSVNRHFGSSNHFPNLSHHHIEEISRGAHKLNQILEACSNGLNVDRFSIEVGKELVKEAMDLEESLRMLVNLQETSGYIVSSQRKNQITLLDEEDNAVKMAEEKQIDLPNFSFDKGSRHARKNQEVGRPGFEQKVTAALTYTTEGSGLNREKQGKITSSTSVSQRQSVSYTGGVKNPSTEQKESKPEKERIPIVIAKLMGLNELPKNENLKHTAEEDLSSKSKRERHVIEQTTNESSKISGVKTKDPLMQNMTFVSQAEKRMLANNISIGVVVHDPEEFKPVAILGNATIKSDKHQKPSQTFKQDKPVMQAKPGFKEIRVPVEKQNGNNVLPRNQQHKPPYDVELQQQSMALKSESPKEKRRQETKERQIPQPKLVAKKQRRSEMISRRKSKGAVDLQKKQTLAEQTWVNKKIAREAAATVQSTRVPNGKYHENLVRSKSSADLNFNKKDFSPNSLDPQQAKENFGTLPAMEERSVHAAPPLQKAKSRRVNKSEMPQRIDEVATRRSYEKRGSHNATEKVRASRLKQAEPHIVKSNKSTASVQPLDSGQNQHKEAELEAPTLYDPNEVESRRLEKSQTLLPKESYDQQDQAPAFGDDECITASITVNEKNFSATENVTVAVSQANHCNVGNRDICYAEVLEHHKALNLRKQEPTEIENHLKQVVIKSHHFLNTAEALFKLDIPFSILHDSGRDCNPDVDSKLTLDCAYEVMKRKGIRHELNVHPKCEKASISFVKIRSLNELVRQLHKDFETLKFYGRKGKYECEAEAYLPKMLESDMHSWEPELNCMWDMGWDKTMFAVVEVDEVVKDLERLVLGGLVDELTRDLFRTDCQSFIGVNYGQVADNLPPPSSTTKLLQSTSIQKVRLYGSDPAIIKALANTGLGIVIGASNGDIPGLASDPSFAKSWVGANVSPFYPASNIILITVGNEVLTYGDQGLISQLVPAIKNVQDALTSLSLGGKIKVSTVHSMAMLKHSEPPSSARFDPGFGDVIKELLGFNNATGSPFAINPYPYFAYRSDPRPETLAFCLFQPNNGRFDSNTNIKYMNMFDAQVDAIRSALDSIGFKGVEIVVAETGWPYKGDDNEVGPSVQNAKAYNGNLIAHLRSMVGTPLMPGKSVDTYLFALYDENLKPGPVSERAFGLFKPDLTMNYDVGLSKSSQTPTTPATPSTPTTPSTPPTPANPSGPKPKKGSYCVPKAGVSDSQLQANIDYVCGHGFDCTPIQPGGSCFEPNTAMIAATTQVGVLKMYEGTWEDSEMYTEGYQLICLLDMYVCLGFRILCEEMFCTFCVILLPIAITFYITWAFIKFVDGLFSPIYNHLGVNIFGLGFATSLVFIFLVGVFMQSWLGTSVLTLWEWFITKMPLISYIYAASKQISTAISPDQSINAFKEVAIIRHPRIGEYALGFITSTVVLDQRNVGEELCCVYVPTNHLYLGDIFLISPKDILRPNLSVGEGIEIVISGGLSIPQLLTTVDAQVLTPRRVPHFEELQQKLSNSNKVLQRKFRGSNAAGSDREWREEHHSITLKCSEKSL